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Methods for determining ldl cholesterol treatment

a technology for ldl cholesterol and treatment, applied in disease diagnosis, biological material analysis, instruments, etc., can solve the problems of limited breadth of cvd risk factors, achieve optimal assessment of cvd risk of patient, increase fiber and essential fatty acids, and improve physical activity

Inactive Publication Date: 2018-10-25
BOSTON HEART DIAGNOSTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is a diagnostic panel that can provide more detailed information about a person's risk for cardiovascular disease by analyzing the levels of certain proteins and glucose metabolism. This information helps healthcare professionals develop personalized treatment plans for patients. The panel is designed to provide greater accuracy and speed in assessing CVD risk than traditional methods, and can help improve treatment outcomes.

Problems solved by technology

Diagnostic screening panels for assessing cardiovascular risk exist; however, these tests are limited in the breadth of CVD risk factors.

Method used

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  • Methods for determining ldl cholesterol treatment
  • Methods for determining ldl cholesterol treatment
  • Methods for determining ldl cholesterol treatment

Examples

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Embodiment Construction

[0048]The present invention pertains to a diagnostic solution comprising an extended risk assessment panel for cardiovascular disease. The present invention also pertains to a personalized treatment solution for the treatment of CVD in an individual.

1. Definitions

[0049]The term “adiponectin”, as used herein, refers to a protein hormone made in a person's fat, but only in subcutaneous fat, and not in visceral fat (the fat around a person's middle portion that increases his or her waist size). High levels of adiponectin indicate protection from heart disease, while low levels increase CVD risk in overweight or obese subjects.

[0050]The term “alkaline phosphatase”, as used herein, refers to a measure of liver function and bile flow, as well as bone status. An alkaline phosphatase value between 33 U / L and 130 U / L is considered normal; whereas, an elevated value may indicate obstruction of bile flow, excess breakdown of bone, or malignancy.

[0051]The term “a-1 HDL particle” or “a-1”, as us...

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Abstract

Disclosed is a personalized diagnostic and treatment solution for cardiovascular disease. The invention comprises an extended CVD risk assessment panel, combining tests for traditional and new important risk markers, and methods for devising a personalized treatment plan for a patient via the use of a CVD diagnosis and treatment protocol algorithm. The new important risk markers include HDL subpopulation profile by two-dimensional gel-electrophoresis, plasma sterols, direct measurement of sdLDL-C, determination of CRP molecular forms, glycated albumin as a percentile of total albumin, and other specialized testing pertaining to apolipoprotein E and Factor V Leiden genotyping, NT-proBNP and adiponectin. This solution provides a more complete risk assessment of an individual than merely measuring traditional CVD risk markers, and enables the healthcare practitioner to optimize therapy for patients with or without established CVD. This solution presents the advantages of greater accuracy, savings in time and cost over existing testing and treatment methods.

Description

REFERENCE TO RELATED APPLICATIONS[0001]The present application is a continuation of U.S. non-provisional application Ser. No. 13 / 945,436, filed Jul. 18, 2013, which is a continuation of U.S. non-provisional application Ser. No. 13 / 658,387, filed Oct. 23, 2012, which is a continuation of U.S. non-provisional application Ser. No. 12 / 472,351, filed on May 26, 2009, which claims the benefit of and priority to U.S. provisional patent applications having Ser. No. 61 / 056,163, filed on May 27, 2008, and 61 / 084,909, filed on Jul. 30, 2008. Each of the above-referenced applications is incorporated by reference.TECHNICAL FIELD[0002]The present invention relates generally to cardiovascular disease (CVD) risk assessment, diagnosis and treatment thereof. Specifically, the present invention pertains to a diagnosis and personalized treatment solution based on results from testing utilizing an extended CVD risk assay panel that measures the combination of traditional risk factors and new important r...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G01N33/92
CPCG01N33/92G01N2800/52
Inventor ASZTALOS, BELA F.SCHAEFER, ERNST J.
Owner BOSTON HEART DIAGNOSTICS
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