Compositions of nitrates and methods of use thereof
a technology of nitrates and nitrates, which is applied in the direction of drug compositions, dispersed delivery, cardiovascular disorders, etc., can solve the problems of increasing the metabolic cost of exercise, insufficient and contradictory information on the role of no in healthy subjects and in particular in athletes during work or exercise, and increasing the oxygen consumption of dogs
Pending Publication Date: 2022-08-11
HEARTBEET LTD
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Benefits of technology
[0013]In some implementations, the administration of the composition may reduce systolic blood pressure and / or diastolic blood pressure of the human.
[0023]In some implementations, the administration of the composition may also reduce diastolic blood pressure of the adult human subject.
Problems solved by technology
The available information on the role of NO in healthy subjects and in particular in athletes during work or exercise is both insufficient and contradictory.
Shen and colleagues showed that administration of NOS-inhibitors in vivo during submaximal exercise leads to increased oxygen consumption in dogs (SHEN, W. et al.
Evidence that brain nitric oxide inhibition increases metabolic cost of exercise, reducing running performance in rats.
In addition, studies in healthy humans are scarce.
Proposed harmful effects of these anions include promotion of gastric cancers and other malignancies and development of methemoglobinemia in infants.
Method used
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[0151]Although the invention has been described with regard to its preferred embodiments, which constitute the best mode presently known to the inventors, it should be understood that various changes and modifications as would be obvious to one having the ordinary skill in this art may be made without departing from the scope of the invention as set forth in the claims appended
[0152]The present inventors have been studying the effects of nitrate and nitrite on various physiological functions including blood pressure, glucose metabolism and energy expenditure in vivo. In the examples below, unless otherwise noted, nitrate was administered perorally and nitrite was administered intravenously (iv). Oxygen consumption was measured using indirect calorimetry.
1. Intravenous Sodium Nitrite and Resting Energy Expenditure
[0153]Resting energy expenditure (as measured by indirect calorimetry) is reduced by 10-25% after 10 min of iv infusion of sodium nitrite (n=4, FIG. 3). Prior to the test th...
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Abstract
Inorganic anions nitrate and nitrite influence metabolic rate and glucose homeostasis. Infusion of nitrite iv caused an acute drop in resting energy expenditure (oxygen consumption) and nitrate, when given perorally, caused a reduction in oxygen consumption during exercise and a depression of the increase in blood glucose observed after an oral glucose tolerance test. The doses of nitrate and nitrite did not cause any detectable change in methemoglobin levels of blood. Also, nitrate and nitrite did not alter lactate levels in blood. This discovery provides useful treatments to regulate the energy expenditure and glucose homeostasis of a mammal by administration of inorganic nitrite and / or nitrate.
Description
RELATED APPLICATIONS[0001]This application is a continuation application of earlier filed US. Utility Patent Application to Jon Lundberg and Eddie Weitzberg, titled “Compositions of Nitrates and Methods of Use Thereof,” application Ser. No. 17 / 308,007, filed May 4, 2021, now pending, which is a divisional application of earlier filed U.S. Utility Patent Application to Jon Lundberg and Eddie Weitzberg, titled “Compositions of Nitrates and Methods of Use Thereof,” application Ser. No. 17 / 061,321, filed Oct. 1, 2020, now issued as U.S. Pat. No. 11,083,747, which is a continuation application of earlier U.S. Utility Patent Application to Jon Lundberg and Eddie Weitzberg, titled “Compositions of Nitrates and Methods of Use Thereof,” application Ser. No. 15 / 966,508, filed Apr. 30, 2018, now issued as U.S. Pat. No. 10,842,813, which is a continuation-in-part application of earlier U.S. Utility Patent Application to Jon Lundberg and Eddie Weitzberg, titled “Use of Nitrites and Nitrates and ...
Claims
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IPC IPC(8): A61K33/00A61K31/375A61K36/21A23L33/105A61K45/06A23L33/135A23L2/52A61K9/00A61K36/185A23L33/16A23L2/02A61K33/30A61K33/14A61K31/05A61K31/198A61P9/12A61K9/08
CPCA61K33/00C01D9/00A61K36/21A23L33/105A61K45/06A23L33/135A23L2/52A61K9/0056A61K36/185A23L33/16A61K9/0095A23L2/02A61K33/30A61K33/14A61K31/05A61K31/198A61P9/12A61K9/08A23V2002/00A61K31/375A61K9/0019A61K9/0053A61K47/22A61K36/235A61K36/31A61K36/28A61K2300/00
InventorLUNDBERG, JONWEITZBERG, EDDIE
OwnerHEARTBEET LTD