Means for treating autoimmune diseases and method for the treatment thereof
a technology for autoimmune diseases and methods, applied in the field of medicine, can solve the problems of not using known compounds as means for treating autoimmune diseases, work that does not disclose the possibility of using tbg for diagnosing suppressor components, and the use of drugs according to said methods fails to prevent side effects
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example 1
Patient C., 29. Diagnosis: disseminated sclerosis (cerebromedullary form, prolonged remissions); the patient has received several treatments with corticosteroid preparations; the immunological study carried out during the remission stage snowed that stimulatory (countersuppressor) activity T-lymphocytes in peripheral blood was 28%. At the present stage the treatment with TBG should be avoided.
example 2
Patient B., 28, diagnosis: disseminated sclerosis (cerebromedullary form, remittent course, acute stage). Duration: 3 years. Neurological status: lateral nistagmus when looked right; vivid tendon reflexes; feet: D>S. Abdominal reflexes: upper low, medium and lower reflexes are not presented. Two-side toe (Babinsky's) symptom. Foot clonus is more rough to the right. No paresis of members, unchanged tonus are determined. Atactic walking. Unstable in Romberg position. Ataxia during knee-heel test, delayed urination.
Spinal liquor:
Protein--0.76%,
Lange reaction--66644322.
Oculist's inspection: pale temple sections of the discs.
T-suppressor activity in peripheral blood during TBG induction--17%.
Under aseptic conditions one 110 ml blood sample was taken from the patients arm vein. Mononuclear cells (MNCS) had been isolated according to the standard method in the density gradient of phycoll-urotrust. Isolated MNCs were cultivated with TBG in the concentration of 60 .mu.g / ml. After having been...
example 3
Patient H., 42, came to the hospital with the diagnosis of rheumatoid arthritis (polyarthritis, seropositive, A--P (stage 2) insufficient joints functioning (IJF). T-suppressor activity of peripheral blood under TBG induction was 22%.
The patient received TBG injections into the joints suffering pathological changes, each injection of 0.5 ml having the concentration of 60 .mu.g / ml. Remission was observed on the fourth day. Pain syndrome weakened. Insufficient joints functioning regressed. Restudy showed 47% increase in T-suppressors functional activity in periphedral blood under TBG induction. Ouhterloni tests performed on the 7th, 14th and 28th days had not determined anti-TBG antibodies in the patient.
The study of 105 donors and 154 patients suffering different autoimmune diseases showed that the use of TBG in the dosage less than 3 .mu.g / ml of blood produced insufficient effect, while the use of the dosages over 120 .mu.g / ml of blood was undesirable.
The normal value of suppressors...
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