Macrocyclic modulators of the ghrelin receptor
a ghrelin receptor and macrocyclic technology, applied in the field of macrocyclic compounds, can solve the problems of increasing ghrelin levels, lack of efficacy, and disappointing agents
USRE42013E1Inactive Publication Date: 2010-12-28OCERA THERAPEUTICS INC
Patent Information
- Authority / Receiving Office
- US · United States
- Current Assignee / Owner
- OCERA THERAPEUTICS INC
- Publication Date
- 2010-12-28
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.
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Claims
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