Gel binder for treating swelling and pain and its preparation method

A technology of gel ointment and ointment, which is applied in the field of swelling and pain gel ointment and its preparation, can solve the problems of slow development, etc., and achieve the effect of fast onset, comfortable use, and good sweat resistance

CN102406840AActive Publication Date: 2012-04-11YUNNAN INST OF MATERIA MEDICA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2012-04-11

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Abstract

The invention relates to a compound preparation of an external use pharmaceutical composition for treating swelling and pain, which is a gel binder for treating swelling, and also provides its preparation method. The gel binder is prepared by 20-50% of swelling and pain medicine of the external use pharmaceutical composition for treating swelling and pain as well as proper pharmaceutical excipients. The gel binder for treating swelling is composed of a back lining layer, an ointment-containing body and a cover lining layer. The ointment-containing body, namely the kernel part, is prepared from the swelling and pain medicine, a basic polymer, a cross-linking agent, an organic acid, an excipient, a humectant, an adhesive and the like in certain ratio. The gel binder has the advantages of fast effect, good moisture preservation, high permeability and comfortable use. The product has merits of convenient usage, small irritation on skin and high compliance of patients.
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Description

technical field

[0001] The invention relates to the technical field of medicines, in particular to a swelling and pain gel ointment (external preparation) which can be used for the treatment of bruises, rheumatic joint pain, frozen shoulder, gouty arthritis and breast lobular hyperplasia and a preparation method thereof. Background technique

[0002] Our Chinese patent 200510010901.X discloses an external pharmaceutical composition for treating swelling and pain (patent number ZL200510010901.X, patentee: Yunnan Institute of Materia Medica), which is an external dosage form made of the following raw materials in weight ratio : Aescin 160-200, Panax notoginseng 160-200, Artemisia spp. 160-200, Grape root 160-200, Gold leaf 160-200, Hemp grass 160-200, Golden iron lock 160-200, Diancao 160- 200, Torch flower root 160-200, Erigeron 160-200, Star anise lotus 160-200, Chonglou 160-200, Mist 160-200, Baiji 160-200, Angelica dahurica 160-200, Licorice 50-70, Borneol 50-70, Menthol ...

Examples

Embodiment 1

[0138] Backing layer: non-woven fabric

[0139] Lid lining: Embossed polyester film

[0140] The composition of the medicated ointment layer is as follows by weight percentage:

[0141]

[0142] Preparation:

[0143] (1) Weigh glycerin (moisturizing agent) according to the prescription amount, add polyacrylic acid NP-700 (basic polymer) and aluminum glycolate (crosslinking agent) of the prescription amount in the glycerin in turn, mix well, add swelling and pain medicine, Fully stir and mix under vacuum conditions to obtain ①;

[0144] (2) take purified water by prescription quantity, tartaric acid (organic acid), polyvinylpyrrolidone-K90 (bonding agent) of prescription quantity are dissolved in water to get ②;

[0145] (3) Add ② into ①, stir fully under vacuum conditions, and obtain a drug-containing plaster through cross-linking reaction, apply the drug-containing plaster (control the thickness of the drug-containing plaster layer at about 1.0mm), and cut it into a co...

Embodiment 2

[0147] Backing layer: non-woven fabric

[0148] Cover lining: aluminum foil-polyethylene composite film

[0149] The composition of the medicated ointment layer is as follows by weight:

[0150]

[0151] Preparation:

[0152] (1) Weigh glycerin (moisturizing agent) according to the prescription amount, add polyacrylic acid NP-600 (basic polymer) and aluminum hydroxide (crosslinking agent) of the prescription amount to glycerin in turn, mix well, add swelling and pain medicine, Fully stir and mix under vacuum conditions to obtain ①;

[0153] (2) Purified water is taken by prescription quantity, and lactic acid (organic acid) and sodium carboxymethyl cellulose (binding agent) of prescription quantity are dissolved in water to get ②;

[0154] (3) Add ② into ①, stir fully under vacuum conditions, and obtain a drug-containing plaster through cross-linking reaction, apply the drug-containing plaster (control the thickness of the drug-containing plaster layer at about 1.0mm), ...

Embodiment 3

[0156] Backing layer: non-woven fabric

[0157] Lid lining: Embossed polyethylene film

[0158]

[0159] Preparation:

[0160] (1) Weigh glycerin (moisturizing agent) according to the prescription amount, add polyacrylic acid F-500 (basic polymer) and aluminum glycolate (crosslinking agent) of prescription amount successively in glycerin, fully mix, add swelling and pain medicine, Fully stir and mix under vacuum conditions to obtain ①;

[0161] (2) take purified water by prescription quantity, the tartaric acid (organic acid) of prescription quantity is dissolved in water to get ②;

[0162] (3) Add ② into ①, stir fully under vacuum conditions, and obtain a drug-containing plaster through cross-linking reaction, apply the drug-containing plaster (control the thickness of the drug-containing plaster layer at about 1.0mm), and cut it into a conventional plaster specifications (for example: each patch is 9cm long x 6cm wide, and each patch contains 5.2 grams of swelling and...