A method for preparing thermosensitive polymer pnipam film by plasma-induced solution polymerization

Abstract

The invention discloses a method for preparing thermo-sensitive polymer PNIPAM film through plasma-induced solution polymerization, relates to a method for preparing the thermo-sensitive polymer PNIPAM film and aims at solving the problems of complex process, proneness to causing damage to shape and unstable chemical property of existing PNIPAM film synthesis methods. The method includes: step 1, dissolving N-isopropyl acrylamide crystal in ultrapure water, and adding N, N-methylene bisacrylamide; step 2, spreading a solution prepared in the step 1 on the surface of a glass substrate, putting the glass substrate in a quartz reaction kettle, sealing, and feeding argon; step 3, putting the quartz reaction kettle between two poles of a plasma generator for treatment to obtain a thin film, and cleaning and drying the thin film to complete preparation. Plasma-induced solution polymerization is adopted for film forming, so that the method is simple in process and few in step; film forming is independent from surface property of the substrate; the shape of the film is less prone to being damaged, and the film is stable in chemical property; the film is unitary in ingredient, biologically-nontoxic, conducive to modification and modifiable in structure and has great potential application prospect in many fields.

Description

technical field

[0001] The invention relates to a method for preparing a thermosensitive polymer PNIPAM film. Background technique

[0002] Stimuli-responsive polymers are a class of polymers that respond to environmental changes and produce changes in physical or chemical properties. As a stimuli-responsive polymer, poly-N-isopropylacrylamide (PNIPAM) has unique temperature-responsive behavior. The lower critical solution temperature (LCST) of PNIPAM is 32°C. When the temperature is lower than 32°C, PNIPAM is hydrophilic; when the temperature is higher than 32°C, PNIPAM is hydrophobic. Due to the effective temperature responsiveness of PNIPAM, it has broad application prospects in water treatment, drug controlled release, cell culture, etc.

[0003] At present, the more common PNIPAM membrane synthesis methods are as follows: self-assembled monolayer membranes (SAMs), atom transfer radical polymerization (ATRP), electron beam ionization, plasma graft polymerization, these...

Examples

specific Embodiment approach 1

[0023] Specific embodiment one: the method for the preparation of temperature-sensitive polymer PNIPAM membrane by a kind of plasma-initiated solution polymerization of this embodiment, realizes according to the following steps:

[0024] 1. Take 0.1-0.3g N-isopropylacrylamide crystal, dissolve it in 4-6mL ultrapure water, add 0.004-0.04g N,N-methylenebisacrylamide;

[0025] 2. Use a syringe to take 0.2-0.3mL of the solution prepared in step 1, spread it evenly on the surface of the glass substrate, then place it in a quartz reactor, seal it, and pass it into argon gas at a flow rate of 0-1L / min;

[0026] 3. Place the quartz reaction kettle in step 2 between the two poles of the plasma generator, adjust the voltage to 0-45V, and discharge at high voltage for 0-5 minutes to obtain a film visible to the naked eye, and then wash off the unreacted monolayer with ultrapure water. The body solution was vacuum-dried for 5-7h to complete the preparation of the temperature-sensitive pol...

specific Embodiment approach 2

[0030] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is that in step 1, take 0.2g of N-isopropylacrylamide crystals, dissolve them in 5mL of ultrapure water, add 0.03g of N,N-methylene bis Acrylamide. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0031] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that in Step 2, take 0.25 mL of the solution prepared in Step 1 with a syringe, and spread it evenly on the surface of the glass substrate. Other steps and parameters are the same as those in Embodiment 1 or Embodiment 2.

technical field

[0001] The invention relates to a method for preparing a thermosensitive polymer PNIPAM film. Background technique

[0002] Stimuli-responsive polymers are a class of polymers that respond to environmental changes and produce changes in physical or chemical properties. As a stimuli-responsive polymer, poly-N-isopropylacrylamide (PNIPAM) has unique temperature-responsive behavior. The lower critical solution temperature (LCST) of PNIPAM is 32°C. When the temperature is lower than 32°C, PNIPAM is hydrophilic; when the temperature is higher than 32°C, PNIPAM is hydrophobic. Due to the effective temperature responsiveness of PNIPAM, it has broad application prospects in water treatment, drug controlled release, cell culture, etc.

[0003] At present, the more common PNIPAM membrane synthesis methods are as follows: self-assembled monolayer membranes (SAMs), atom transfer radical polymerization (ATRP), electron beam ionization, plasma graft polymerization, these...

Examples

specific Embodiment approach 1

[0023] Specific embodiment one: the method for the preparation of temperature-sensitive polymer PNIPAM membrane by a kind of plasma-initiated solution polymerization of this embodiment, realizes according to the following steps:

[0024] 1. Take 0.1-0.3g N-isopropylacrylamide crystal, dissolve it in 4-6mL ultrapure water, add 0.004-0.04g N,N-methylenebisacrylamide;

[0025] 2. Use a syringe to take 0.2-0.3mL of the solution prepared in step 1, spread it evenly on the surface of the glass substrate, then place it in a quartz reactor, seal it, and pass it into argon gas at a flow rate of 0-1L / min;

[0026] 3. Place the quartz reaction kettle in step 2 between the two poles of the plasma generator, adjust the voltage to 0-45V, and discharge at high voltage for 0-5 minutes to obtain a film visible to the naked eye, and then wash off the unreacted monolayer with ultrapure water. The body solution was vacuum-dried for 5-7h to complete the preparation of the temperature-sensitive pol...

specific Embodiment approach 2

[0030] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is that in step 1, take 0.2g of N-isopropylacrylamide crystals, dissolve them in 5mL of ultrapure water, add 0.03g of N,N-methylene bis Acrylamide. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0031] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that in Step 2, take 0.25 mL of the solution prepared in Step 1 with a syringe, and spread it evenly on the surface of the glass substrate. Other steps and parameters are the same as those in Embodiment 1 or Embodiment 2.

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