Ixeris sonchifolia hance preparation with anti-gout effect

Abstract

The invention discloses an ixeris sonchifolia hance preparation with an anti-gout effect. Through the anti-gout effect of the ixeris sonchifolia hance preparation, the clinical indication of ixeris sonchifolia hance is increased, so that the ixeris sonchifolia hance preparation not only can be used for treating a coronary heart disease, cerebral thrombosis, angina pectoris, anti-tumor and the like, but also can be used for treating a gout disease. An ixeris sonchifolia hance extract is taken orally and by injection, has an obvious effect on a hyperuricemia model induced by sodium urate in miceand is close to an allopurinol positive control group in effect. The ixeris sonchifolia hance preparation disclosed by the invention has the benefits that the ixeris sonchifolia hance preparation isa pure traditional Chinese medicine preparation, is small in toxic and / or side effects, has a cardiovascular and cerebrovascular protection effect and is an ideal anti-gout drug.

Description

technical field

[0001] The invention relates to the application field of Kudiezi preparation, in particular to a Kudiezi preparation with anti-gout effect. technical background

[0002] Gout (scientific name: metabolic arthritis ) is a disease caused by the accumulation of uric acid due to purine metabolism disorder. It is a kind of arthritis, also known as metabolic arthritis. Clinical manifestations include hyperuricemia, gouty acute arthritis, tophi deposition, characteristic chronic arthritis and arthritic deformity, often involving the kidney, causing chronic interstitial nephritis and renal uric acid stones. Epidemiology shows that the prevalence of gout in Europe and America ranges from 0.2% to 1.7%. In my country, the incidence of gout has been on the rise in recent years, and the prevalence rate of the general population in my country is about 1.14%. The incidence of gout in rich areas of my country is significantly higher than that in rural areas. Gout has seri...

Examples

Embodiment 1

[0026] The steps of preparing the injection preparation for treating gout from Kudie include:

[0027]Take 1000g of the same batch of scorpion stalks, add 8 times the amount of water, decoct at 0.05 MPa and 81°C for 60 minutes, then add 5 times the amount of water and cook for 45 minutes under the same conditions, combine the decoctions, and concentrate under reduced pressure to 1500mL, let cool to 37°C, and set aside; add fresh calcium oxide milk to the decoction under stirring to adjust the pH value to 9.8, let it stand for 12 hours, centrifuge, suspend the precipitate in 5.3 times the amount of 90% ethanol, and dissolve it with sulfuric acid Adjust the pH value of the solution to 3.4, fully stir to complete the reaction, centrifuge, add sodium hydroxide solution to the centrifuged liquid to adjust the pH value to 6.8, filter, and recover the ethanol from the filtrate under reduced pressure, evaporate the ethanol, and concentrate to a relative density of 1.07 at 60°C Dilute ...

Embodiment 2

[0029] The steps of preparing the injection preparation for treating gout from Kudie include:

[0030] Step 1: Take 1000g of the same batch of scorpion stalks, add 10 times the amount of water, decoct at 0.052 MPa and 83°C for 90 minutes, then add 6 times the amount of water and decoct for 60 minutes under the same conditions, and combine the decoctions. Concentrate under reduced pressure to 1800mL, let cool to 39°C, and set aside; the operation of reduced-pressure extraction is simple and feasible, and the reduced-pressure extraction of Kudiezi can significantly increase the yield of adenosine in the active ingredient, prevent the degradation of adenosine, and at the same time It will not affect the yield of total flavonoids in the extract and active ingredients;

[0031] Step 2: Add milk of fresh calcium oxide to the decoction under stirring to adjust the pH to 10.2, place it for 18 hours, centrifuge, suspend the sediment in 6.5 times the amount of 95% ethanol, adjust the pH...

Embodiment 3

[0036] The steps of preparing the injection preparation for treating gout from Kudie include:

[0037] Step 1: Take 1000g of the same batch of scorpion stalks, add 10 times the amount of water, decoct at 0.052 MPa and 82°C for 80 minutes, then add 5 times the amount of water and decoct for 50 minutes under the same conditions, and combine the decoctions. Concentrate under reduced pressure to 1600mL, let cool to 38°C, and set aside; the operation of reduced-pressure extraction is simple and feasible, and the reduced-pressure extraction of Kudiezi can significantly increase the yield of adenosine in the active ingredient, prevent the degradation of adenosine, and at the same time It will not affect the yield of total flavonoids in the extract and active ingredients;

[0038] Step 2: Add milk of fresh calcium oxide to the decoction under stirring to adjust the pH value to 10, place it for 15 hours, centrifuge, suspend the sediment in 6 times the amount of 92% ethanol, adjust the ...

technical field

[0001] The invention relates to the application field of Kudiezi preparation, in particular to a Kudiezi preparation with anti-gout effect. technical background

[0002] Gout (scientific name: metabolic arthritis ) is a disease caused by the accumulation of uric acid due to purine metabolism disorder. It is a kind of arthritis, also known as metabolic arthritis. Clinical manifestations include hyperuricemia, gouty acute arthritis, tophi deposition, characteristic chronic arthritis and arthritic deformity, often involving the kidney, causing chronic interstitial nephritis and renal uric acid stones. Epidemiology shows that the prevalence of gout in Europe and America ranges from 0.2% to 1.7%. In my country, the incidence of gout has been on the rise in recent years, and the prevalence rate of the general population in my country is about 1.14%. The incidence of gout in rich areas of my country is significantly higher than that in rural areas. Gout has seri...

Examples

Embodiment 1

[0026] The steps of preparing the injection preparation for treating gout from Kudie include:

[0027]Take 1000g of the same batch of scorpion stalks, add 8 times the amount of water, decoct at 0.05 MPa and 81°C for 60 minutes, then add 5 times the amount of water and cook for 45 minutes under the same conditions, combine the decoctions, and concentrate under reduced pressure to 1500mL, let cool to 37°C, and set aside; add fresh calcium oxide milk to the decoction under stirring to adjust the pH value to 9.8, let it stand for 12 hours, centrifuge, suspend the precipitate in 5.3 times the amount of 90% ethanol, and dissolve it with sulfuric acid Adjust the pH value of the solution to 3.4, fully stir to complete the reaction, centrifuge, add sodium hydroxide solution to the centrifuged liquid to adjust the pH value to 6.8, filter, and recover the ethanol from the filtrate under reduced pressure, evaporate the ethanol, and concentrate to a relative density of 1.07 at 60°C Dilute ...

Embodiment 2

[0029] The steps of preparing the injection preparation for treating gout from Kudie include:

[0030] Step 1: Take 1000g of the same batch of scorpion stalks, add 10 times the amount of water, decoct at 0.052 MPa and 83°C for 90 minutes, then add 6 times the amount of water and decoct for 60 minutes under the same conditions, and combine the decoctions. Concentrate under reduced pressure to 1800mL, let cool to 39°C, and set aside; the operation of reduced-pressure extraction is simple and feasible, and the reduced-pressure extraction of Kudiezi can significantly increase the yield of adenosine in the active ingredient, prevent the degradation of adenosine, and at the same time It will not affect the yield of total flavonoids in the extract and active ingredients;

[0031] Step 2: Add milk of fresh calcium oxide to the decoction under stirring to adjust the pH to 10.2, place it for 18 hours, centrifuge, suspend the sediment in 6.5 times the amount of 95% ethanol, adjust the pH...

Embodiment 3

[0036] The steps of preparing the injection preparation for treating gout from Kudie include:

[0037] Step 1: Take 1000g of the same batch of scorpion stalks, add 10 times the amount of water, decoct at 0.052 MPa and 82°C for 80 minutes, then add 5 times the amount of water and decoct for 50 minutes under the same conditions, and combine the decoctions. Concentrate under reduced pressure to 1600mL, let cool to 38°C, and set aside; the operation of reduced-pressure extraction is simple and feasible, and the reduced-pressure extraction of Kudiezi can significantly increase the yield of adenosine in the active ingredient, prevent the degradation of adenosine, and at the same time It will not affect the yield of total flavonoids in the extract and active ingredients;

[0038] Step 2: Add milk of fresh calcium oxide to the decoction under stirring to adjust the pH value to 10, place it for 15 hours, centrifuge, suspend the sediment in 6 times the amount of 92% ethanol, adjust the ...