A kind of artificial bone for repairing tumor bone defect and preparation method thereof

A technology for artificial bone and bone defect, applied in medical science, prosthesis, tissue regeneration, etc., to achieve excellent bone repair performance, solve the effect of local residual tumor cell recurrence, and excellent biocompatibility

CN110237308BActive Publication Date: 2021-05-18THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2021-05-18

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Abstract

The invention discloses an artificial bone for repairing tumor bone defects, which consists of polylactic acid powder (PLA), hydroxyapatite powder (HA) and metformin powder (MET) in a mass ratio (8-10):1 : (3-5) composition. The present invention uses metformin as the main synergistic component to achieve the purpose of not only inhibiting tumor cells but also enhancing the ability of bone repair, and solves the current defect that tumor bone defects are prone to local recurrence, especially benign or borderline tumors, such as giant cell tumor of bone ; At the same time, the excellent bone repair performance solves the challenge of difficult self-repair of huge bone defects after tumor resection.
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Description

technical field

[0001] The invention belongs to the field of biomedical materials, and relates to an artificial bone for repairing tumor bone defects and a preparation method thereof. Background technique

[0002] Tumor bone defect is a huge bone defect caused by surgery for benign and malignant bone tumors and other diseases, and faces great challenges of difficult repair and tumor recurrence. At present, the commonly used bone repair materials include autologous bone, allogeneic bone and artificial bone. Among them, the source of autologous bone is limited, and it causes secondary trauma to the bone harvesting site. Allograft bone has the risk of infection and disease, so artificial bone is an important choice. Hydroxyapatite (HA) has good compressive strength and excellent bone conduction properties. It is the main component of human bones. Polylactic acid (PLA) has excellent biocompatibility and degradation properties. Metformin can promote bone marrow mesenchymal stem ...

Examples

Embodiment 1

[0031] 1. Composite powder preparation

[0032] (1) Mixing: Weigh PLLA and nHA at a ratio of 9:1, physically mix them, place them in a beaker filled with absolute ethanol, and disperse the mixture into a suspension by ultrasonic stirring. The particle size of the PLLA powder is 20-80μm, the viscosity is 1.8-2.5dL / g, the melting point is 170-185°C, the ultrasonic dispersion time is 30-60min, and the ultrasonic dispersion temperature is 40-60°C;

[0033] (2) Filtration: filter the suspension with a microporous membrane to obtain a mixed material;

[0034] (3) Drying: Dry the mixed material in a rotary dryer to obtain nHA / PLLA mixed powder. The drying temperature is 60-100°C. The mass percentage content of polylactic acid in the mixed powder is 90%, and the mass percentage content of hydroxyapatite is 10%.

[0035] 2. Selective laser sintering

[0036] (1) Preheating: spread the PLLA / nHA mixed powder on the laser sintering template, the thickness of each powder spreading is 0...

Embodiment 2

[0044] 1. Composite powder preparation

[0045] (1) Mixing: Weigh PLLA, nHA, and MET according to 9:1:2. After physical mixing, place them in a beaker filled with absolute ethanol, and disperse the mixture into a suspension by ultrasonic stirring. The particle size of the PLLA powder is 20-80μm, the viscosity is 1.8-2.5dL / g, the melting point is 170-185°C, the ultrasonic dispersion time is 30-60min, and the ultrasonic dispersion temperature is 40-60°C;

[0046](2) Filtration: filter the suspension with a microporous membrane to obtain a mixed material;

[0047] (3) Drying: Dry the mixed material in a rotary dryer to obtain MET / nHA / PLLA mixed powder. The drying temperature is 60-100°C. The mass percentage content of polylactic acid in the mixed powder is 75%, the mass percentage content of hydroxyapatite is 8.3%, and the mass percentage content of metformin is 16.7%.

[0048] 2. Selective laser sintering

[0049] (1) Preheating: Spread the MET / PLLA / nHA mixed powder on the l...

Embodiment 3

[0058] 1. Composite powder preparation

[0059] (1) Mixing: Weigh PLLA, nHA, and MET according to 9:1:4. After physical mixing, place them in a beaker filled with absolute ethanol, and disperse the mixture into a suspension by ultrasonic stirring. The particle size of the PLLA powder is 20-80μm, the viscosity is 1.8-2.5dL / g, the melting point is 170-185°C, the ultrasonic dispersion time is 30-60min, and the ultrasonic dispersion temperature is 40-60°C;

[0060] (2) Filtration: filter the suspension with a microporous membrane to obtain a mixed material;

[0061] (3) Drying: Dry the mixed material in a rotary dryer to obtain MET / nHA / PLLA mixed powder. The drying temperature is 60-100°C. The mass percentage content of polylactic acid in the mixed powder is 64.3%, the mass percentage content of hydroxyapatite is 7.1%, and the mass percentage content of metformin is 28.6%.

[0062] 2. Selective laser sintering

[0063] (1) Preheating: Spread the MET / PLLA / nHA mixed powder on th...