Automated safety locking biomedical sample experimental device and use method

Abstract

The invention relates to an automated and safely locked biomedical sample experimental device and a method for using the device, comprising a frame, a reaction box body, a box cover on the reaction box body, a lifting mechanism for driving the box cover to be lifted and lowered, a locking motor vertically installed in the middle of the box cover, a gear installed on the output shaft of the locking motor, racks are transversely arranged on the box cover at both the front and rear sides of the gear, the racks are slidably matched with the box cover, a pressure sensor A is embedded on the lower side of the box cover, a wedge-shaped portion is arranged at the outer end of the rack, and locking components matched with the wedge-shaped portion are installed on the left and right sides of the frame at the position where the box cover and the reaction box body are covered; the locking components comprise a base, a nut knob, a pressure sensor B, a spring and a wedge block connected in sequence from top to bottom, and a controller is installed on the frame. The device has low cost, is easy to operate and use, is locked and automated, and is suitable for small biomedical experimental reactions in multiple occasions.

Description

Technical Field

[0001] The invention relates to an automated safety-locked biomedical sample experimental device and a use method thereof. Background Art

[0002] There is a lack of small-scale automated biomedical experimental devices on the market. At present, the safety locking reaction devices for biomedical experiments on the market are divided into pure mechanization, semi-automation and full automation based on the level of automation. Most of them are cylindrical in shape. In biomedical experiments, such as immunohistochemistry experiments, gases will be produced. Due to the high-pressure gas generated inside the experiment, it becomes difficult to achieve automated safety locking. Purely mechanized experimental reaction devices can achieve safety locking, but the level of automation is low, and the efficiency will be relatively low in the face of small multi-sample experiments. Semi-automated experimental reaction devices mostly use motors to control simple up and down movements, and manual intervention is often used in the safety locking required for key experimental reaction devices, such as tightening bolts, folding locks, etc. Fully automated biomedical experimental reactions can achieve the minimum manual input, while taking into account safety locking, and achieve automatic closing and locking after manual feeding (placing the test sample), automatic discharge of internal high-pressure gas, and opening of the lid after the reaction is completed. However, the fully automatic reaction devices on the market currently have complex functional structures, and most of them are large-scale experimental devices, which are expensive. It seems to be a waste of resources and a waste of resources when faced with small-scale biomedical experimental reaction experiments. Summary of the invention

[0003] In order to solve the problems existing in the prior art, the present invention provides an automated safety-locked biomedical sample experimental device suitable for small-scale biomedical experiments and a method for using the device.

[0004] The solution adopted by the present invention to solve the technical problem is an automated and safely locked biomedical sample experimental device, comprising a frame, a reaction box body installed at the lower part of the frame, a box cover is provided on the reaction box body, a lifting mechanism for driving the box cover to lift and lower to open and close the reaction box body is installed at the upper end of the frame, a locking motor is vertically installed in the middle of the box cover, a gear is installed on the output shaft of the locking motor, racks are transversely arranged on both sides of the box cover at the front and rear of the gear, the racks are slidably matched with the box cover, a pressure sensor A is embedded on the lower side of the box cover, a wedge-shaped portion is provided at the outer end of the rack, and locking components matching the wedge-shaped portion are installed on the left and right sides of the frame at the position where the box cover and the reaction box body are covered;

[0005] The locking assembly includes a base, a nut knob, a pressure sensor B, a spring, and a wedge block connected in sequence from top to bottom, the nut knob is sleeved on the upper end of the base and threadedly matched therewith, the wedge block is sleeved on the lower end of the base, the lower end of the lower side surface of the wedge block is located below the base, and the lower side surface of the wedge block is provided with an inclined surface matched with the wedge-shaped portion;

[0006] A controller is installed on the frame, and the pressure sensor A, the pressure sensor B, the lifting mechanism, and the locking motor are all electrically connected to the controller.

[0007] Furthermore, two vertical through holes are provided on the box cover, an air pressure sensor is installed in one vertical through hole, and an electromagnetic exhaust valve is installed on the other vertical through hole, and the electromagnetic exhaust valve and the air pressure sensor are both electrically connected to the controller.

[0008] Furthermore, the lifting mechanism includes two through-type linear screw stepper motors that are symmetrically arranged on the left and right, and the lower ends of the screws of the through-type linear screw stepper motors are installed on the box cover via the bearing seat.

[0009] Furthermore, a button for controlling the operation of the lifting mechanism is installed on the frame, and the button is electrically connected to the controller.

[0010] Furthermore, a power interface electrically connected to the controller is installed on the rack.

[0011] Furthermore, guide protrusions are vertically arranged on the left and right sides, and vertical guide grooves for accommodating the guide protrusions on the same side are arranged on the left and right ends of the box cover.

[0012] Furthermore, a sealing ring is installed on the lower side of the box cover.

[0013] Furthermore, a mounting seat for mounting the test platform is provided in the middle of the lower side of the box cover.

[0014] Furthermore, the rack is mounted on a transverse slide rail, the rack is slidably matched with the transverse slide rail, and the transverse slide rail is fixedly mounted on the box cover.

[0015] The invention discloses a method for using an automated safety-locked biomedical sample experimental device: after power is turned on, an experiment is carried out, and a lifting mechanism is controlled to drive a box cover to descend, so that the box cover is arranged on the upper end of a reaction box body to seal the reaction box body; when a pressure sensor A measures that a specified pressure has been reached, the lifting mechanism stops; subsequently, a locking motor drives a gear to rotate, and the gear drives a rack to move horizontally outward; a wedge-shaped portion is arranged at the outer end of the rack to contact a wedge block of a locking assembly and drive the wedge block to move upward; when a pressure sensor B measures that a specified pressure has been reached, the locking motor stops, and at this time, the wedge-shaped portion at the outer end of the rack is locked with the wedge block; after the experiment is completed, the locking motor is controlled to reverse, and the gear drives the rack to move horizontally inward, so that the locking assembly of the wedge-shaped portion is separated; subsequently, the lifting mechanism is controlled to drive the box cover to rise, and the reaction box body is opened, and an operation experiment is completed.

[0016] Compared with the prior art, the present invention has the following beneficial effects: simple structure, reasonable design, low cost, easy operation and use, lock and automation, suitable for small biomedical experimental reactions in multiple occasions, high degree of mechanization of lock and structure, not easy to damage, and easy maintenance. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The present invention is further described below in conjunction with the accompanying drawings.

[0018] Figure 1 It is a structural schematic diagram of the device.

[0019] Figure 2 This is a structural cross-sectional view of the device.

[0020] Figure 3 It is a schematic diagram of the gear rack transmission structure of this device.

[0021] Figure 4 It is a structural schematic diagram of the locking component.

[0022] In the figure: 1-frame; 101-guide protrusion; 2-reaction box; 3-box cover; 301-vertical guide groove; 4-lifting mechanism; 401-through linear screw stepper motor; 402-screw; 5-locking motor; 6-locking assembly; 601-base; 602-nut knob; 603-pressure sensor B; 604-spring; 605-wedge block; 7-test platform; 8-mounting seat; 9-sealing ring; 10-gear; 11-rack; 1101-wedge portion; 12-lateral slide rail; 13-bearing seat; 14-air pressure sensor; 15-electromagnetic exhaust valve; 16-pressure sensor A. DETAILED DESCRIPTION

[0023] The present invention is further described below in conjunction with the accompanying drawings and specific embodiments.

[0024] like Figure 1-4 As shown, an automated safety locked biomedical sample experimental device comprises a frame 1, a reaction box 2 installed at the lower part of the frame, a box cover 3 is provided on the upper cover of the reaction box, a lifting mechanism 4 for driving the box cover to lift and lower to open and close the reaction box is installed at the upper end of the frame, a locking motor 5 is vertically installed in the middle of the box cover, a gear 10 is installed on the output shaft of the locking motor, racks 11 are transversely arranged on both sides of the box cover at the front and rear of the gear, the racks are slidably matched with the box cover, a pressure sensor A16 is embedded on the lower side of the box cover, a wedge-shaped portion 1101 is provided at the outer end of the rack, and locking components 6 matched with the wedge-shaped portion are installed on the left and right sides of the frame at the position where the box cover and the reaction box cover are covered;

[0025] The locking assembly includes a base 601, a nut knob 602, a pressure sensor B603, a spring 604, and a wedge 605 connected in sequence from top to bottom. The nut knob is sleeved on the upper end of the base and threadedly matched therewith, and the wedge is sleeved on the lower end of the base. The lower end of the lower side surface of the wedge is located below the base. The lower side surface of the wedge is provided with an inclined surface matched with the wedge-shaped portion. Considering the poor sealing performance of the reaction container after long-term use, the locking assembly can adjust the height of the wedge through the nut knob, thereby indirectly adjusting the extrusion force of the wedge through the wedge-shaped portion at the outer end of the rack to achieve enhanced sealing;

[0026] A controller is installed on the frame, and pressure sensor A, pressure sensor B, lifting mechanism, and locking motor are all electrically connected to the controller;

[0027] This device collects contact pressure through the pressure sensor A at the end cover position to realize automatic closing of the cover, and adopts the locking motor to drive the gear to drive the rack to move. The wedge-shaped part of the rack cooperates with the wedge block at the bottom of the locking component. Through the nut knob, it detects whether the pressure of the pressure sensor B at the bottom of the knob reaches the set value, thereby controlling the start and stop of the gear motor, and then realizing locking and automation.

[0028] In this embodiment, two vertical through holes are provided on the box cover, an air pressure sensor 14 is installed in one vertical through hole, and an electromagnetic exhaust valve 15 is installed on the other vertical through hole. The electromagnetic exhaust valve and the air pressure sensor are electrically connected to the controller. During the experimental reaction, high-pressure gas is generated inside. When the air pressure sensor detects that the pressure is too high, the electromagnetic exhaust valve is activated to achieve safe pressure relief.

[0029] In this embodiment, the lifting mechanism includes two through-type linear screw stepper motors 401 that are symmetrically arranged on the left and right. The lower end of the screw 402 of the through-type linear screw stepper motor is installed on the box cover through the bearing seat 13.

[0030] In this embodiment, a button for controlling the operation of the lifting mechanism is installed on the frame, and the button is electrically connected to the controller.

[0031] In this embodiment, a power interface electrically connected to the controller is installed on the rack.

[0032] In this embodiment, the left and right sides are provided with guide protrusions 101 in the vertical direction, and the left and right ends of the box cover are provided with vertical guide grooves 301 for accommodating the guide protrusions on the same side.

[0033] In this embodiment, a sealing ring 9 is installed on the lower side of the box cover.

[0034] In this embodiment, a mounting seat 8 for mounting the test platform is provided in the middle of the lower side surface of the box cover, and the test platform 7 is connected to the mounting seat via bolts.

[0035] In this embodiment, the rack is installed on the transverse slide rail 12, the rack and the transverse slide rail are slidably matched, and the transverse slide rail is fixedly installed on the box cover.

[0036] The invention discloses a method for using an automated safety-locked biomedical sample experimental device: after power is turned on, an experiment is carried out, and a lifting mechanism is controlled to drive a box cover to descend, so that the box cover is arranged on the upper end of a reaction box body to seal the reaction box body; when a pressure sensor A measures that a specified pressure has been reached, the lifting mechanism stops; subsequently, a locking motor drives a gear to rotate, and the gear drives a rack to move horizontally outward; a wedge-shaped portion is arranged at the outer end of the rack to contact a wedge block of a locking assembly and drive the wedge block to move upward; when a pressure sensor B measures that a specified pressure has been reached, the locking motor stops, and at this time, the wedge-shaped portion at the outer end of the rack is locked with the wedge block; after the experiment is completed, the locking motor is controlled to reverse, and the gear drives the rack to move horizontally inward, so that the locking assembly of the wedge-shaped portion is separated; subsequently, the lifting mechanism is controlled to drive the box cover to rise, and the reaction box body is opened, and an operation experiment is completed.

[0037] If this patent discloses or involves components or structural parts that are fixedly connected to each other, then, unless otherwise stated, the fixed connection can be understood as: a detachable fixed connection (such as connection using bolts or screws), or as: a non-detachable fixed connection (such as riveting, welding). Of course, the mutual fixed connection can also be replaced by an integrated structure (such as one-piece manufacturing using a casting process) (except where it is obviously impossible to use an integrated molding process).

[0038] In the description of this patent, it should be understood that the terms "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing this patent, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on this patent.

[0039] The preferred embodiments listed above further illustrate the objectives, technical solutions and advantages of the present invention in detail. It should be understood that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. An automated safety-locked biomedical sample experimental device, characterized in that: It comprises a frame, a reaction box body installed at the lower part of the frame, a box cover is provided on the reaction box body, a lifting mechanism for driving the box cover to lift and lower to open and close the reaction box body is installed at the upper end of the frame, a locking motor is vertically installed in the middle of the box cover, a gear is installed on the output shaft of the locking motor, racks are arranged on the box cover in the transverse direction at both the front and rear sides of the gear, the racks are slidably matched with the box cover, a pressure sensor A is embedded on the lower side of the box cover, a wedge-shaped portion is arranged at the outer end of the rack, and locking components matched with the wedge-shaped portion are installed on the left and right sides of the frame at the position where the box cover and the reaction box body are covered; The locking assembly includes a base, a nut knob, a pressure sensor B, a spring, and a wedge block connected in sequence from top to bottom, the nut knob is sleeved on the upper end of the base and threadedly matched therewith, the wedge block is sleeved on the lower end of the base, the lower end of the lower side surface of the wedge block is located below the base, and the lower side surface of the wedge block is provided with an inclined surface matched with the wedge-shaped portion; A controller is installed on the frame, and pressure sensor A, pressure sensor B, lifting mechanism, and locking motor are all electrically connected to the controller; The box cover is provided with two vertical through holes, an air pressure sensor is installed in one vertical through hole, and an electromagnetic exhaust valve is installed on the other vertical through hole, and the electromagnetic exhaust valve and the air pressure sensor are both electrically connected to the controller; The lifting mechanism comprises two through-type linear screw stepper motors which are symmetrically arranged on the left and right sides, and the lower ends of the screws of the through-type linear screw stepper motors are installed on the box cover via the bearing seat; A button for controlling the operation of the lifting mechanism is installed on the frame, and the button is electrically connected to the controller; The rack is provided with a power-on interface electrically connected to the controller; The left and right sides of the frame are provided with guide protrusions in the vertical direction, and the left and right ends of the box cover are provided with vertical guide grooves for accommodating the guide protrusions on the same side; A sealing ring is installed on the lower side of the box cover; A mounting seat for mounting the test platform is provided in the middle of the lower side of the box cover; The rack is installed on the transverse slide rail, the rack is slidably matched with the transverse slide rail, and the transverse slide rail is fixedly installed on the box cover.

2. A method for using the biomedical sample experimental device with automated safety locking as claimed in claim 1, characterized in that: The lifting mechanism is controlled to drive the box cover to descend, so that the box cover is set on the upper end of the reaction box body to close the reaction box body. When the pressure sensor A measures that the specified pressure has been reached, the lifting mechanism stops; then, the locking motor drives the gear to rotate, and the gear drives the rack to move horizontally outward. A wedge-shaped portion is provided on the outer end of the rack to contact the wedge block of the locking assembly and drive the wedge block to move upward. When the pressure sensor B measures that the specified pressure has been reached, the locking motor stops. At this time, the wedge-shaped portion at the outer end of the rack and the wedge block are locked together; after the experiment is completed, the locking motor is controlled to reverse, and the gear drives the rack to move horizontally inward to separate the wedge-shaped locking assembly. Then, the lifting mechanism is controlled to drive the box cover to rise, and the reaction box body is opened to complete an operation experiment.

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