Compact ion guide driving device and automatic radio frequency tuning method, equipment and medium thereof

A technology of ion guide and drive device, which is applied in the direction of automatic frequency control parts, electrical characteristic frequency control, particle separator tube parts, etc. The miniaturization of the whole machine, the limitation of system safety and reliability, etc., achieve the effect of automatic program adjustment and output monitoring, reduction of occupied space, and convenient debugging and maintenance

CN114785320AActive Publication Date: 2022-07-22SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2022-07-22

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Abstract

The invention relates to a compact ion guide driving device, an automatic radio frequency tuning method and equipment thereof, and a medium. The method comprises the following steps: acquiring a resonant frequency estimated value; determining an initial interval of resonant frequency searching; setting a radio frequency driving initial control quantity; the DDS output frequency is converted according to the frequency stepping value; recording the corresponding detection current value and judging whether the detection current value is smaller than a preset current value, if so, adjusting the interval endpoint through the change trend of the detection current value to obtain a new interval, and otherwise, reducing the initial control quantity; and if the width of the new interval reaches a set target, taking the midpoint of the new interval as a set value of the output resonant frequency of the DDS frequency generation module. The requirement of more channels of the driving circuit is met, the device is compact, the miniaturization of the mass spectrometer is promoted, and the application scene is expanded; output program control and feedback monitoring of the driving device are achieved, and flexibility and reliability are improved.
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Description

technical field

[0001] The invention relates to the technical field of mass spectrometry ion guidance, in particular to a compact ion guidance drive device and an automatic radio frequency tuning method, equipment and medium thereof. Background technique

[0002] Mass spectrometer is a high-end scientific instrument that is widely used in various disciplines to identify compounds by preparing, separating, and detecting gas-phase ions. It has extremely broad applications in environmental testing, homeland security, clinical analysis, organic synthesis, drug discovery, protein and metabolomics, and more.

[0003] At present, electrospray in almost all commercial instruments works at atmospheric pressure or near atmospheric pressure, while mass spectrometers require a high degree of vacuum, so a series of vacuum interfaces and ion guide devices are required to make the ions generated by electrospray. can enter the analyzer.

[0004] Due to the atmospheric pressure vacuum inte...

Examples

Embodiment 1

[0097] A compact ion guide drive such as figure 1 , figure 2 As shown, it includes: chassis, guide drive main control board, DC high voltage board, RF drive board, RF resonance and feedback board, detection adapter board, backplane; there are several sockets on the chassis, the guide drive main control board The board, DC high voltage board, RF driver board, and detection adapter board are all pluggable boards. The guide drive main control board, DC high voltage board, RF driver board, and detection adapter board are movably connected to the chassis through sockets. .

[0098] In this embodiment, the chassis is a PXI chassis, and PXI (PCI extensions for Instrumentation, PCI extensions for instrumentation systems) is a solid PC-based measurement and automation platform released by the PXI Alliance. PXI combines the electrical bus characteristics of PCI (Peripheral Component Interconnection-peripheral component interconnection) with the ruggedness, modularity and Eurocard mec...

Embodiment 2

[0122] An automatic radio frequency tuning method for a compact ion guide drive device, such as Figure 7 shown, including the following steps:

[0123] Obtain the estimated value of the resonant frequency; in this embodiment, according to the measured value or estimated value of the parameters such as the capacitance value of the guiding mechanism and the secondary inductance value of the resonant coil, the parallel resonance formula is applied , calculate the possible resonant frequency estimated value f0, or determine the resonant frequency estimated value f0 through tuning records, such as directly taking the previous tuning frequency as f0.

[0124] Calculate the starting interval of the resonance frequency search by the estimated value of the resonance frequency; if it can be based on experience, 0.8~1.2 times the estimated value of the resonance frequency f0 is determined as the starting interval of the resonance frequency search, that is, the starting interval is 0.8 ...

Embodiment 3

[0155] An electronic device 200, such as Figure 11 As shown, including but not limited to: a memory 201 having program code stored thereon; a processor 202 coupled to the memory and, when executed by the processor, implements a compact ion guide drive method. For the detailed description of the method, reference may be made to the corresponding description in the foregoing method embodiment, which is not repeated here.