A kind of hawthorn and tuckahoe zinc oral liquid and preparation method thereof

Abstract

The present invention provides a hawthorn and tuckahoe zinc oral liquid and a preparation method thereof, and belongs to the field of medical technology. The hawthorn and tuckahoe zinc oral liquid of the present invention is composed of the following raw materials in parts by weight: 0.5-5 parts of hawthorn, 0.5-5 parts of malt, 0.5-5 parts of tuckahoe, 0.5-5 parts of radish seeds, 0.1-3 parts of chicken gizzard lining, 0.0008-0.002 parts of zinc gluconate, 0.1-5 parts of sugar, 0.1-5 parts of honey, and 0.001-0.01 parts of stevioside. The hawthorn and tuckahoe zinc oral liquid prepared by the present invention can effectively improve the symptoms of decreased appetite, partial eating, malnutrition and the like caused by indigestion, improve the body's immunity, and ensure the body's nutritional needs.

Description

Technical Field

[0001] The invention relates to the technical field of medicines, and in particular to a hawthorn and tuckahoe zinc oral liquid and a preparation method thereof. Background Art

[0002] Dyspepsia is a clinical syndrome caused by gastric motility disorders, including gastroparesis and esophageal reflux disease with poor gastric motility. When indigestion occurs, more food is retained in the stomach and intestines, and the gastrointestinal motility is poor, which can cause abdominal pain, vomiting, diarrhea and other discomfort symptoms, seriously affecting health. Long-term indigestion may cause chronic gastrointestinal diseases, such as antral gastritis, etc. If not treated in time, it will increase the difficulty of treatment, and it will also cause a decrease in appetite, gradually leading to malnutrition, decreased immunity, and the occurrence of various diseases. At present, there are many drugs and methods for treating indigestion, such as omeprazole, pantoprazole, metoclopramide, etc. Although they are fast-acting and have good efficacy, they have large side effects and are easy to cause gastrointestinal irritation. Traditional Chinese medicine has attracted much attention for its low toxicity and side effects, but it usually has problems such as insufficient efficacy and unclear effective ingredients. Summary of the invention

[0003] The purpose of the present invention is to provide a hawthorn and tuckahoe zinc oral liquid and a preparation method thereof. The hawthorn and tuckahoe zinc oral liquid prepared by the present invention can effectively improve symptoms such as decreased appetite, partial eating, malnutrition, etc. caused by indigestion, improve the body's immunity, and ensure the body's nutritional needs based on the rational compatibility and scientific proportion of the ingredients to strengthen the spleen and stomach, soothe the liver and regulate qi, and relieve food stagnation.

[0004] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0005] The invention provides a hawthorn and tuckahoe zinc oral liquid, which is prepared from the following raw materials in parts by weight: 0.5-5 parts of hawthorn, 0.5-5 parts of malt, 0.5-5 parts of tuckahoe, 0.5-5 parts of radish seeds, 0.1-3 parts of chicken gizzard lining, 0.0008-0.002 parts of zinc gluconate, 0.1-5 parts of sugar, 0.1-5 parts of honey and 0.001-0.01 parts of stevioside.

[0006] The present invention also provides a method for preparing the above-mentioned hawthorn and tuckahoe zinc oral liquid, comprising the following steps:

[0007] (1) adding water to decoct hawthorn, malt, radish seed, Poria cocos, and chicken gizzard lining, and performing solid-liquid separation and concentration to obtain a concentrated solution;

[0008] (2) dissolving zinc gluconate, stevioside and honey in water to obtain solvent A;

[0009] (3) dissolving sugar in water to obtain solvent B;

[0010] (4) The concentrated solution, solvent A and solvent B are mixed, and solid-liquid separation, liquid replenishment, canning and sterilization are performed to obtain the hawthorn and tuckahoe zinc oral liquid.

[0011] Preferably, the amount of water added in step (1) is 6 to 10 times the total mass of the hawthorn, malt, radish seeds, poria cocos, and chicken gizzard lining.

[0012] Preferably, the decoction in step (1) is performed 2 to 3 times, and the decoction time for each time is 1 to 3 hours.

[0013] Preferably, the density of the concentrated liquid is 1.06-1.08.

[0014] Preferably, the mass ratio of water to honey in step (2) is (1.5-3):1.

[0015] Preferably, the mass ratio of water to sugar in step (3) is (0.5-2):1.

[0016] Preferably, the temperature of the solvent B is 80-100°C.

[0017] Preferably, the volume mass ratio of the rehydrated solution to the hawthorn is 10 L: (0.5-5) kg.

[0018] The invention provides a hawthorn and tuckahoe zinc oral liquid and a preparation method thereof. The invention is based on the functions of strengthening the spleen and stomach, soothing the liver and regulating qi, and digesting food and removing stagnation, and uses hawthorn, malt, radish seeds, tuckahoe, and chicken gizzard lining as main raw materials, wherein hawthorn is rich in nutrients, such as protein, fat, carbohydrates, vitamins and minerals, and organic acids, and is used for meat stagnation, stomach fullness, diarrhea and abdominal pain, and diarrhea discomfort; malt is rich in zinc, antioxidants, and B vitamins and other important vitamins and minerals, and is used for food stagnation, abdominal fullness and pain, and spleen deficiency and poor appetite; radish seeds are rich in vitamins and minerals, including vitamin A, vitamin B 1 , Vitamin B 2, vitamin C, vitamin E, calcium, iron, zinc, potassium, etc., are used for descending qi and resolving phlegm, digesting food and guiding stagnation, treating food stagnation and qi stagnation, heaviness after dysentery, cough with phlegm, abdominal distension, diarrhea, and gas reversal and wheezing; Poria is rich in protein and materials such as Poria polysaccharide, Poria polysaccharide, Poria acid, fatty acids, lecithin, adenine, protease, triterpenoid compounds, etc., and is used for promoting water and dampness, strengthening the spleen and calming the heart, treating spleen deficiency and less food, loose stools and diarrhea, restlessness, palpitations and insomnia. Chicken's gizzard lining is rich in gastric hormones, keratin, amino acids, amylase and other ingredients, which can stimulate gastric juice secretion in large quantities and promote gastrointestinal peristalsis. The present invention adopts a scientific method to extract the effective ingredients in hawthorn, malt, radish seeds, Poria, and chicken's gizzard lining, and on this basis, with zinc gluconate, further promotes the body's absorption and utilization of the effective ingredients, so as to achieve effective improvement of the symptoms such as decreased appetite, partial eclipse, malnutrition caused by indigestion, improve the body's immunity, ensure the body's nutritional needs, and promote children's growth and development. DETAILED DESCRIPTION

[0019] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0020] Example 1

[0021] This embodiment provides a hawthorn and tuckahoe zinc oral liquid, and the specific preparation process is as follows:

[0022] Weigh 3kg of hawthorn, 3kg of malt, 2kg of Poria, 2kg of radish seeds, and 2kg of chicken gizzard lining, mix the above medicinal materials, add 120kg of water, boil for 2h, and filter to obtain the first decoction; then add 120kg of water, boil for 2h, and filter to obtain the second decoction. Combine the two decoctions, and concentrate under reduced pressure to a density of 1.08 (measured at 70°C) to obtain a concentrated solution.

[0023] 0.001 kg of zinc gluconate, 3 kg of honey, 0.01 kg of stevioside and 4.5 kg of water were mixed and stirred until all components were completely dissolved to obtain solvent A.

[0024] Mix 0.5 kg of white sugar with 1 kg of water, heat to 90° C., and stir evenly to obtain solvent B.

[0025] The concentrate, solvent A and solvent B were mixed and filtered, and the volume was supplemented with purified water to 10 L, and packaged into 1000 vials, each with 10 ml, and sterilized in a 115° C. steam sterilizer for 30 min to obtain hawthorn and tuckahoe zinc oral liquid.

[0026] Example 2

[0027] This embodiment provides a hawthorn and tuckahoe zinc oral liquid, and the specific preparation process is as follows:

[0028] Weigh 5kg of hawthorn, 5kg of malt, 0.5kg of Poria, 0.5kg of Radish Seed, and 0.2kg of Chicken Gizzard, mix the above medicinal materials, add 62kg of water, decoct for 2h, filter to obtain the first decoction; then add 62kg of water, decoct for 2h, filter to obtain the second decoction. Combine the two decoctions, and concentrate under reduced pressure to a density of 1.06 (measured at 70°C) to obtain a concentrated solution.

[0029] 0.002 kg of zinc gluconate, 0.5 kg of honey, 0.001 kg of stevioside and 0.3 kg of water were mixed and stirred until the components were completely dissolved to obtain solvent A.

[0030] Mix 1 kg of white sugar with 1 kg of water, heat to 80°C, and stir evenly to obtain solvent B.

[0031] The concentrate, solvent A and solvent B were mixed and filtered, and the volume was supplemented with purified water to 10 L, and packaged into 1000 vials, each with 10 ml, and sterilized in a 115° C. steam sterilizer for 30 min to obtain hawthorn and tuckahoe zinc oral liquid.

[0032] Example 3

[0033] This embodiment provides a hawthorn and tuckahoe zinc oral liquid, and the specific preparation process is as follows:

[0034] Weigh 0.5 kg of hawthorn, 0.5 kg of malt, 3 kg of Poria, 5 kg of radish seeds, and 3 kg of chicken gizzard lining, mix the above medicinal materials, add 50 kg of water, decoct for 2 hours, and filter to obtain the first decoction; then add 50 kg of water, decoct for 2 hours, and filter to obtain the second decoction. Combine the two decoctions, and concentrate under reduced pressure to a density of 1.07 (measured at 70°C) to obtain a concentrated solution.

[0035] 0.0008 kg of zinc gluconate, 0.5 kg of honey, 0.003 kg of stevioside and 7.5 kg of water were mixed and stirred until the components were completely dissolved to obtain solvent A.

[0036] Mix 0.5 kg of white sugar and 0.5 kg of water, heat to 100° C., and stir evenly to obtain solvent B.

[0037] The concentrate, solvent A and solvent B were mixed and filtered, and the volume was supplemented with purified water to 10 L, and packaged into 1000 vials, each with 10 ml, and sterilized in a 115° C. steam sterilizer for 30 min to obtain hawthorn and tuckahoe zinc oral liquid.

[0038] Comparative Example 1

[0039] The only difference between this comparative example and Example 1 is that Chinese yam and orange peel are also added, and the other operations are the same as those in Example 1.

[0040] Comparative Example 2

[0041] The only difference between this comparative example and Example 1 is that coix seeds, lotus seeds, jujubes and Liushenqu are also added, and the other operations are the same as those in Example 1.

[0042] Comparative Example 3

[0043] The difference between this comparative example and Example 1 is that malt is omitted, and other operations are the same as those in Example 1.

[0044] Comparative Example 4

[0045] The difference between this comparative example and Example 1 is that radish seeds are omitted, and other operations are the same as those in Example 1.

[0046] Comparative Example 5

[0047] The difference between this comparative example and Example 1 is that Gallus gallus domesticus is omitted, and other operations are the same as those in Example 1.

[0048] Comparative Example 6

[0049] The difference between this comparative example and Example 1 is that zinc gluconate is omitted, and other operations are the same as those in Example 1.

[0050] Test Example 1

[0051] In this test example, the oral liquids of Examples 1 to 3 and Comparative Examples 1 to 6 were subjected to accelerated stability tests. Ten bottles of each group of oral liquids were placed at 37°C and 75% humidity for 3 months. One bottle was taken for testing at 0, 1 and 3 months. The test indicators and test results are shown in Tables 1 to 5.

[0052] Table 1 Stability test indicators and test results of each group of oral liquid

[0053]

[0054] Table 2 Stability test indicators and test results of each group of oral liquid

[0055]

[0056] Table 3 Stability test indicators and test results of each group of oral liquid

[0057]

[0058] Table 4 Stability test indicators and test results of each group of oral liquid

[0059]

[0060] Table 5 Stability test indicators and test results of each group of oral liquid

[0061]

[0062] As can be seen from Tables 1 to 5, after the oral liquids in each group were accelerated for 3 months at 38°C and 75% humidity, there were no significant changes in the various indicators.

[0063] Test Example 2

[0064] This test example uses animal experiments to verify the digestion-promoting function of each group of oral liquids. The specific process is as follows:

[0065] 1. Select 100 SPF grade SD male rats (weight 120-140g, purchased from Changsha Tianle Biotechnology Co., Ltd.) and divide them into 10 groups, respectively, control group, embodiment 1 group, embodiment 2 group, embodiment 3 group, comparative example 1 group, comparative example 2 group, comparative example 3 group, comparative example 4 group, comparative example 5 group, comparative example 6 group, 10 rats in each group. Ordinary feed (purchased from Changsha Tianle Biotechnology Co., Ltd.) was used for normal feeding. Among them, the control group was gavaged with distilled water (1ml / 100g body weight) every day, and the remaining groups were gavaged with oral liquid of the corresponding group (1ml / 100g body weight) once a day for 21 consecutive days. The average weight of the rats was recorded every week, and the statistical results of weight change are shown in Table 6.

[0066] Table 6 Body weight changes of mice in each group (g)

[0067] Group Initial weight Week 1 Week 2 Week 3 Weight change Control group 135.6 182.5 219.6 266.5 130.9 Example 1 Group 137.2 181.9 223.8 271.7 134.5 Example 2 Group 129.6 185.0 221.6 266.1 136.5 Example 3 Group 139.2 183.9 220.7 265.3 126.1 Comparative Example 1 145.3 178.2 219.3 284.9 139.6 Comparative Example 2 138.0 180.4 222.2 270.3 132.3 Comparative Example 3 137.1 179.4 230.1 263.9 126.8 Comparative Example 4 142.7 179.0 218.7 271.2 128.5 Comparative Example 5 138.5 183.2 225.4 277.8 139.3 Comparative Example 6 137.6 178.5 231.0 268.7 131.1

[0068] As can be seen from Table 6, the effects of oral liquids in each group on the body weight and weight gain of rats were not significantly different from those in the control group, indicating that the oral liquids in each group would not affect the normal body.

[0069] After the experiment, the rats in each group were fasted for 24 hours, anesthetized with ether, and the gastric juice discharged within 4 hours was collected by pyloric ligation. 1 ml of gastric juice was put into a 50 ml conical flask, 15 ml of 0.05 mol / L hydrochloric acid solution was added and shaken, and two freshly made protein tubes were put in. The bottle mouth was plugged, and incubated in a 37°C constant temperature box for 24 hours. The protein tube was taken out, and the length (mm) of the transparent part at both ends of the protein tube was measured with a ruler. The average value of the four ends was used to calculate the pepsin activity and pepsin discharge. The calculation formula is as follows:

[0070] Pepsin activity (μ / ml) = average length of the transparent part of the four-terminal protein tube 2 *16

[0071] Pepsin output (μ / h) = pepsin activity * gastric fluid volume per hour

[0072] The calculation results of pepsin activity and pepsin excretion of mice in each group are shown in Table 7.

[0073] Table 7 Calculation results of pepsin activity and pepsin excretion in each group of mice

[0074]

[0075] As can be seen from Table 7, compared with the control group, the oral liquids in the remaining groups can increase the gastric juice discharge, pepsin activity and pepsin discharge of rats, among which the oral liquids in Examples 1 to 3 have the most obvious promoting effects on gastric juice discharge, pepsin activity improvement and pepsin discharge of rats. Among the comparative example groups, the gastric juice discharge, pepsin activity improvement and pepsin discharge of rats in Comparative Example 6 group are the least, indicating that the oral liquid prepared with only Chinese medicine ingredients has no obvious promoting effects on gastric juice discharge, pepsin activity improvement and pepsin discharge of rats.

[0076] 2. 110 male mice of Kunming strain (weight 18-22g, purchased from Changsha Tianle Biotechnology Co., Ltd.) were selected and divided into 10 groups, namely control group, model group, Example 1 group, Example 2 group, Example 3 group, Comparative Example 1 group, Comparative Example 2 group, Comparative Example 3 group, Comparative Example 4 group, Comparative Example 5 group, Comparative Example 6 group, 10 mice in each group. Among them, the control group and the model group were gavaged with a dose of normal saline (0.2ml / 10g body weight) every day, and the other groups were gavaged with a dose of oral solution of the corresponding group (0.2ml / 10g body weight), once a day, and the experiment lasted for 21 days. Before the end of the experiment, the animals in each group were fasted but not watered for 16 hours. On the day of the measurement, the control group and the model group were gavaged with distilled water once, and each group was gavaged with the oral solution of the corresponding group. After 30 minutes, except for the control group, the other groups were given 0.025% compound diphenoxylate (dosage of 0.2ml / 10g body weight), and the control group was given an equal amount of distilled water. After 30 minutes, each group was given ink again. After 25 minutes, the animals were killed by dislocating the cervical vertebrae, the abdominal cavity was opened to separate the mesentery, and the intestinal tube from the pylorus at the upper end to the ileocecal part at the lower end was cut and placed on a tray. The small intestine was gently pulled into a straight line, and the length of the intestinal tube was measured as the "total length of the small intestine", and the length from the pylorus to the front edge of the ink was the "ink advancement length". The ink advancement rate was calculated using the following formula:

[0077] Ink propagation rate (%) = ink propagation length (cm) / total length of small intestine * 100%

[0078] The calculation results of ink propagation rate of each group of mice are shown in Table 8.

[0079] Table 8 Calculation results of ink propulsion rate of mice in each group

[0080]

[0081] As can be seen from Table 8, compared with the control group, the ink propulsion rate of the mice in the model group was significantly reduced, and the ink propulsion rate of the mice in the Example 1-3 groups and the Comparative Example 1-6 groups was significantly higher than that in the model group, among which the ink propulsion rate of the mice in the Example 1-3 groups was higher than that in the Comparative Example 1-6 groups, indicating that the oral liquid of the present invention can better promote small intestinal motility. Among the groups of the comparative examples, the ink propulsion rate of the mice in the Comparative Example 6 group was the smallest, indicating that the oral liquid prepared with only Chinese medicinal ingredients did not have a significant promoting effect on the small intestinal motility of mice.

[0082] Test Example 3

[0083] This test example uses clinical experiments to verify the digestion-promoting function of the oral liquids of Examples 1 to 3 and Comparative Examples 1 to 6. The specific process is as follows:

[0084] Subject inclusion criteria:

[0085] Children aged 7 to 10 years old whose weight is less than 1 standard deviation from the average normal weight for the same age due to poor diet alone, accompanied by indigestion symptoms such as loss of appetite, decreased food intake, and picky eating.

[0086] Subject exclusion criteria:

[0087] Patients with acute or chronic diarrhea; patients with positive worm eggs in routine stool examination; patients with systemic diseases of cardiovascular, liver, kidney and hematopoietic systems; patients who take items related to the test function in a short period of time, which may affect the judgment of the results.

[0088] Test method:

[0089] The subjects were randomly divided into 4 groups, namely, control group, Example 1 group, Example 2 group, Example 3 group, comparative example group 1 group, comparative example group 2 group, comparative example group 3 group, comparative example group 4 group, comparative example group 5 group, comparative example group 6 group, 20 people in each group. The control group took a placebo every day, and the other groups took the oral solution of the corresponding group, 3 times a day, 1 bottle each time, for 7 consecutive days.

[0090] Detection indicators:

[0091] (1) Appetite:

[0092] Appetite improvement was mainly based on subjective description and was divided into three levels: good appetite (3 points), fair appetite (2 points), and poor appetite (1 point). After taking the oral solution, if the appetite changed from poor appetite to good appetite, poor appetite to fair appetite, or fair appetite to good appetite, it was effective; if there was no change in appetite, it was ineffective, and the effective rate was calculated. The appetite scores of all the children were calculated and statistically analyzed. The statistical results are shown in Table 9.

[0093] (2) Food intake:

[0094] The total food intake (including staple food, side dishes, vegetables and fruits) of each test child was recorded for 3 days before and after taking the medicine, and the average food intake per day was calculated by observing for 3 consecutive days. The calculation results are shown in Table 10.

[0095] (3) Picky eating:

[0096] The evaluation of partiality was divided into three levels: no partiality (not picky about food during meals, 3 points), moderate partiality (picky about food during meals but can eat after persuasion, 2 points), and partiality (severely picky about food during meals, still not eating after persuasion, 1 point). After taking the oral solution, the partiality evaluation changed from partiality to moderate partiality, partiality to no partiality, or moderate partiality to no partiality, which was effective; no change in partiality evaluation was ineffective, and the effective rate was calculated. The partiality score of all the children was calculated and statistically analyzed. The statistical results are shown in Table 11.

[0097] (4) Body weight measurement and hemoglobin content determination:

[0098] The body weight and hemoglobin content of all the children were measured before and after taking the medicine. The results are shown in Table 12.

[0099] Table 9 Statistical results of appetite of children in each group

[0100]

[0101] As can be seen from Table 9, compared with the control group, the oral liquids of Examples 1 to 3 and Comparative Examples 1 to 6 can significantly improve the appetite of the test children, among which the oral liquids of Examples 1 to 3 have the most obvious effect on improving the appetite of the test children.

[0102] Table 10 Statistical results of changes in food intake of children in each group

[0103]

[0104] As can be seen from Table 10, compared with the control group, the oral liquids of Examples 1 to 3 and Comparative Examples 1 to 6 can significantly increase the food intake of the test children, among which the oral liquids of Examples 1 to 3 have the most obvious effect on increasing the food intake of the test children.

[0105] Table 11 Statistical results of partial eclipse evaluation of each group of children

[0106]

[0107] It can be seen from Table 11 that compared with the control group, the oral liquids of Examples 1 to 3 and Comparative Examples 1 to 6 can significantly improve the picky eating of the test children, among which the oral liquids of Examples 1 to 3 have the most obvious effect on improving the picky eating of the test children.

[0108] Table 12 Changes in weight and hemoglobin content of the children in each group

[0109]

[0110] As can be seen from Table 12, compared with the control group, the oral liquids of Examples 1 to 3 and Comparative Examples 1 to 6 can significantly increase the weight of children, among which the oral liquids of Examples 1 to 3 have the most obvious effect on increasing the weight of the tested children. After taking the oral liquids of each group, the hemoglobin content of the tested children increased, but the change was not significant, indicating that the oral liquid of the present invention can increase the weight of children without causing damage to their health.

[0111] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A hawthorn and tuckahoe zinc oral liquid, characterized in that: The invention is prepared from the following raw materials in parts by weight: 0.5-5 parts of hawthorn, 0.5-5 parts of malt, 0.5-5 parts of poria, 0.5-5 parts of radish seeds, 0.1-3 parts of chicken gizzard lining, 0.0008-0.002 parts of zinc gluconate, 0.1-5 parts of sugar, 0.1-5 parts of honey, and 0.001-0.01 parts of stevioside; The preparation method of the hawthorn and tuckahoe zinc oral liquid comprises the following steps: (1) adding water to decoct hawthorn, malt, radish seed, Poria cocos, and chicken gizzard lining, and performing solid-liquid separation and concentration to obtain a concentrated solution; (2) dissolving zinc gluconate, stevioside and honey in water to obtain solvent A; (3) dissolving sugar in water to obtain solvent B; (4) The concentrated solution, solvent A and solvent B are mixed, and solid-liquid separation, liquid replenishment, canning and sterilization are performed to obtain the hawthorn and tuckahoe zinc oral liquid.

2. A method for preparing the hawthorn and tuckahoe zinc oral liquid according to claim 1, characterized in that: The steps include: (1) adding water to decoct hawthorn, malt, radish seed, Poria cocos, and chicken gizzard lining, and performing solid-liquid separation and concentration to obtain a concentrated solution; (2) dissolving zinc gluconate, stevioside and honey in water to obtain solvent A; (3) dissolving sugar in water to obtain solvent B; (4) The concentrated solution, solvent A and solvent B are mixed, and solid-liquid separation, liquid replenishment, canning and sterilization are performed to obtain the hawthorn and tuckahoe zinc oral liquid.

3. The preparation method according to claim 2, characterized in that: The amount of water added in step (1) is 6 to 10 times the total mass of the hawthorn, malt, radish seeds, poria cocos and chicken's gizzard lining.

4. The preparation method according to claim 3, characterized in that: The decoction in step (1) is performed 2 to 3 times, and the decoction time for each time is 1 to 3 hours.

5. The preparation method according to claim 4, characterized in that: The density of the concentrated liquid is 1.06-1.

08.

6. The preparation method according to claim 5, characterized in that: The mass ratio of water to honey in step (2) is (1.5-3):

1.

7. The preparation method according to claim 6, characterized in that: The mass ratio of water to sugar in step (3) is (0.5-2):

1.

8. The preparation method according to claim 7, characterized in that: The temperature of the solvent B is 80-100°C.

9. The preparation method according to claim 8, characterized in that: The volume mass ratio of the rehydration solution to the hawthorn is 10L:(0.5-5)kg.

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