Human body lubricating composition, human body lubricant, preparation method, application and related products thereof

Abstract

The present invention provides a human body lubricating composition, a human body lubricant and a preparation method thereof, an application and related products, and belongs to the technical field of lubricants. The human body lubricating composition provided by the present invention is composed of the following components by weight: 2.8-7.5 parts of aloe polysaccharide sulfate, 4.7-9 parts of sodium hyaluronate, 0.75-1.5 parts of snow lotus culture, 51.42-57.15 parts of water, 8.7-14.4 parts of moisturizing agent, 1.07-3.7 parts of thickener, 0.3-0.75 parts of antibacterial agent, 0.15-0.75 parts of antioxidant and 0.1-0.5 parts of anti-aging agent. The present invention adds aloe polysaccharide sulfate component in the human body lubricant, improves the durability and antimicrobial ability of the lubricating effect of the lubricant, and plays a synergistic effect by compounding the three components of aloe polysaccharide sulfate, sodium hyaluronate and snow lotus culture.

Description

Technical Field

[0001] The present invention belongs to the technical field of lubricants, and relates to a human body lubricating composition, a human body lubricant, a preparation method thereof, an application thereof and related products. Background Art

[0002] Human lubricants are lubricants designed specifically for the human body, which are different from those used in machines. Human lubricants were first used in human body examinations. Since many medical devices are prone to mechanical damage to the delicate mucous membranes when they penetrate the human body, the use of human lubricants with human-friendly ingredients can minimize the damage to body tissues and mucous membranes. Later, human lubricants were gradually used to assist human sexual life. According to the main ingredients, human lubricants are divided into oil-based human lubricants and water-based human lubricants. Oil-based human lubricants use natural oils such as vegetable oils and animal oils or mineral oil-based substances such as vaseline as base ingredients. Oil-based human lubricants are not easily absorbed by the human body, have high viscosity, and are not easy to clean. In addition, according to the principle of like dissolves like, oil-based lubricants easily dissolve and destroy latex-based condoms, causing condom failure. Water-based lubricants use glycerin, water and hydrophilic polymers as main ingredients. They have moderate pH and good skin affinity, and can effectively overcome the incompatibility problem with latex-based condoms. However, water-soluble lubricants also have the problems of short lubrication time and easy drying.

[0003] Chinese invention patent CN110898259A provides a human body-mimicking lubricant and its preparation method and application. The human body-mimicking lubricant contains compound polyol, sodium hyaluronate, thickener, moisturizer, desensitizer, and antibacterial agent; its components are calculated by mass percentage as follows: compound sodium hyaluronate: 0.02%-1.5%; compound polyol: 5%-50%; thickener: 0.2%-2%; moisturizer: 0.5%-10%; desensitizer: 0.01%-0.05%; antibacterial agent: 0.01%-0.05%; the rest is deionized water; wherein, the compound polyol The alcohol is any two or more of propylene glycol, glycerol, diglycerol and polyglycerol-10; the thickener is a mixture of carboxymethyl cellulose, hydroxyethyl cellulose and polyvinyl pyrrolidone; the compound sodium hyaluronate is composed of three different molecular weights of sodium hyaluronate, and the three different molecular weights are 200,000-300,000, 1 million-1.2 million, and 1.8 million-2 million; the moisturizer is a mixture of squalene, urea and lauroyl amide propyl betaine. However, this technology does not provide a human lubricant with a longer lubrication time.

[0004] Chinese invention patent CN118416315A provides a human lubricant with affinity, which can reduce inflammation and maintain the vaginal environment, comprising: 25 wt%-35wt% of polyol, 0.1 wt%-2wt% of lactic acid, 0.1 wt%-2wt% of oligosaccharide, 0.5 wt%-2wt% of xanthan gum, 0.001 wt%-0.01wt% of preservative and 60 wt%-70wt% of water. The human lubricant with affinity can also include 0.5 wt%-2wt% of carrageenan, and / or 1 wt%-3wt% of natural aloe juice. However, the technology does not provide a human lubricant with a longer lubrication time.

[0005] Aloe vera is a perennial evergreen herbaceous plant of the family Asphodelaceae in the order Liliales. The leaves of aloe vera are thick and juicy, and the juice is mucous, containing polysaccharides and proteins. Aloe vera extract has the effects of promoting healing, anti-aging, and promoting immunity. In recent years, with the in-depth study of aloe vera extract, people have found that the modified aloe vera extract has a unique effect. However, the prior art does not provide an application of a chemically modified aloe vera extract in a human body lubricant.

[0006] In summary, the prior art cannot provide a method for preparing a human lubricant that utilizes chemically modified aloe vera extracts to achieve a longer lubrication time. Summary of the invention

[0007] In view of this, the prior art still cannot provide a human body lubricant with a longer lubrication time. The purpose of the present invention is to provide a human body lubricating composition, a human body lubricant, and a preparation method, application and related products thereof. The human body lubricant provided by the present invention adds aloe polysaccharide sulfate component, which improves the lubricating effect and antimicrobial ability of the lubricant, and the compounding of the three components of aloe polysaccharide sulfate, sodium hyaluronate and snow lotus culture has a synergistic effect.

[0008] To achieve the above-mentioned object of the invention, on the one hand, the present invention provides a human body lubricating composition, which is composed of the following components by weight:

[0009] 2.8-7.5 parts of aloe polysaccharide sulfate, 4.7-9 parts of sodium hyaluronate, 0.75-1.5 parts of snow lotus culture, 51.42-57.15 parts of water, 8.7-14.4 parts of moisturizer, 1.07-3.7 parts of thickener, 0.3-0.75 parts of antibacterial agent, 0.15-0.75 parts of antioxidant and 0.1-0.5 parts of anti-aging agent.

[0010] Preferably, the antioxidant consists of 0.1-0.6 parts of urolithin A and 0.05-0.15 parts of spermidine by weight.

[0011] Preferably, the moisturizing agent is glycerin, the thickening agent is carbomer, the anti-aging agent is N-hydroxyethyl-2-imidazolidinone, and the antibacterial agent is caprylhydroxamic acid.

[0012] More preferably, and as an example of the present invention, the molecular weight of the sodium hyaluronate is 200,000-400,000.

[0013] More preferably, and as an example of the present invention, the carbomer is carbomer 980 type.

[0014] Preferably, the weight content of sulfate groups in the aloe polysaccharide sulfate calculated as sulfate ions is 7.43%-10.89%.

[0015] More preferably, the weight content of sulfate groups in the aloe polysaccharide sulfate calculated as sulfate ions is 9.26%.

[0016] Preferably, the human body lubricating composition comprises the following components by weight:

[0017] 3.2-6 parts of aloe polysaccharide sulfate, 5.85-8.1 parts of sodium hyaluronate, 0.8-1.3 parts of snow lotus culture, 52.82-56.66 parts of water, 9.7-13.4 parts of moisturizer, 1.45-3.36 parts of thickener, 0.46-0.64 parts of antibacterial agent, 0.28-0.62 parts of antioxidant and 0.2-0.4 parts of anti-aging agent.

[0018] More preferably, the antioxidant comprises 0.2-0.5 parts of urolithin A and 0.08-0.12 parts of spermidine by weight.

[0019] More preferably, the moisturizing agent is glycerin, the thickening agent is carbomer, the anti-aging agent is N-hydroxyethyl-2-imidazolidinone, and the antibacterial agent is caprylhydroxamic acid.

[0020] More preferably, and as an example of the present invention, the human body lubricating composition comprises the following components by weight:

[0021] 4.4 parts of aloe polysaccharide sulfate, 7.2 parts of sodium hyaluronate, 1 part of snow lotus culture, 55 parts of water, 12 parts of moisturizer, 1.77 parts of thickener, 0.5 parts of antibacterial agent, 0.45 parts of antioxidant and 0.3 parts of anti-aging agent.

[0022] Wherein, the antioxidant comprises 0.35 parts of urolithin A and 0.1 parts of spermidine by weight.

[0023] Wherein, the moisturizing agent is glycerin, the thickener is carbomer, the anti-aging agent is N-hydroxyethyl-2-imidazolidinone, and the antibacterial agent is caprylhydroxamic acid.

[0024] In another aspect, the present invention provides a personal lubricant made from the above-mentioned personal lubricating composition.

[0025] In another aspect, the present invention provides a method for preparing the above-mentioned human body lubricant, comprising the following steps:

[0026] S1, mixing pyridine, sulfur trioxide pyridine complex and aloe polysaccharide, heating and stirring to react, adjusting the pH, adding ethanol to precipitate, washing, and drying to obtain aloe polysaccharide sulfate;

[0027] S2, mixing the aloe polysaccharide sulfate, sodium hyaluronate, thickener and water obtained in step S1 to obtain a mixture A;

[0028] S3, mixing the snow lotus culture, the antibacterial agent, the anti-aging agent, the antioxidant and water to obtain a mixture B;

[0029] S4, mixing the mixture A obtained in step S2, the mixture B obtained in step S3 and a moisturizer, and stirring to obtain a human body lubricant.

[0030] Preferably, in step S1, the ratio of the volume of pyridine, the mass of the sulfur trioxide pyridine complex, and the mass of the aloe polysaccharide is 30-60:2.65-3.4:0.8-0.9, in units of mL:g:g; the temperature of the heating and stirring reaction is 80-90°C, and the time of the heating and stirring reaction is 2-3h.

[0031] Preferably, in step S1, the pH is adjusted to 6.9-7.5, and the reagent used for adjusting the pH is selected from one or more of sodium hydroxide, sodium carbonate, sodium bicarbonate, potassium hydroxide, potassium carbonate and potassium bicarbonate.

[0032] Preferably, in step S1, the adding of ethanol for precipitation is specifically adding 2.5-4 times the volume of ethanol aqueous solution with a mass concentration of 90%-99% for precipitation; the washing is specifically mixing the precipitate with water, dialyzing, adding acetone to precipitate after dialysis, filtering, and repeating 2-3 times; the drying is freeze-drying.

[0033] Preferably, step S4 is specifically:

[0034] The mixture A obtained in step S2 is stirred at a stirring speed of 300-400 rpm, and the mixture B obtained in step S3 is added to the mixture A obtained in step S2 while maintaining stirring, and the stirring speed is adjusted to 500-600 rpm. Glycerin is added, and the stirring speed is adjusted to 1000-1200 rpm. The mixture is stirred for 1.5-2.5 hours to obtain a human body lubricant.

[0035] In yet another aspect, the present invention provides use of the above-mentioned human lubricant or the human lubricant prepared by the above-mentioned preparation method in producing products with lubricating function.

[0036] The products with lubricating function include but are not limited to human lubricants, finger cots and condoms. The human lubricants include medical human lubricants and sexual aid human lubricants. The human lubricants are packaged in plastic bags, aluminum foil bags or bottles. The condoms include polymer film condoms such as plastic condoms and latex condoms, and the surface of the condoms is attached with human lubricants.

[0037] Preferably, the products with lubricating function include human lubricating fluids, finger cots and condoms.

[0038] Finally, the present invention provides a condom, comprising a condom body and a human lubricant, wherein the human lubricant is the above human lubricant or the human lubricant prepared by the above preparation method.

[0039] Preferably, the human lubricant is attached to the condom body, and the mass of the lubricant attached to each condom body is 0.05-0.5g.

[0040] Compared with the prior art, the present invention has the following beneficial effects:

[0041] (1) The present invention provides a method for preparing aloe polysaccharide sulfate, and the obtained aloe polysaccharide sulfate can be used as an effective ingredient of a human body lubricant.

[0042] (2) The present invention utilizes three core ingredients, namely, aloe polysaccharide sulfate, sodium hyaluronate and snow lotus culture, to compound the lubricant, thereby improving the durability of the lubricating effect and the antimicrobial effect of the lubricant. DETAILED DESCRIPTION

[0043] The following non-limiting examples can enable those skilled in the art to more fully understand the present invention, but do not limit the present invention in any way. The following content is merely an exemplary description of the scope of the present invention, and those skilled in the art can make various changes and modifications to the present invention based on the disclosed content, which should also fall within the scope of the present invention.

[0044] The present invention is further described below by way of specific examples. The various chemical reagents used in the examples of the present invention are obtained through conventional commercial channels unless otherwise specified. Unless otherwise specified, the contents described below are all weight contents. Unless otherwise specified, it is understood that the process is carried out at room temperature.

[0045] In the following examples, statistically significant differences were calculated using Graphpad Prism software, and the detection method was one-way ANOVA detection.

[0046] In the following examples, the sources of some reagents are shown in Table 1.

[0047] Table 1

[0048]

[0049] Example 1

[0050] Preparation of aloe polysaccharide sulfate.

[0051] Install a thermometer on the left interface of a 100mL three-necked flask, connect the right interface to a nitrogen cylinder, and connect the middle interface to a ground-mouth constant pressure funnel with a stopper on the top. Install the three-necked flask on a magnetic heating jacket and stir it with a magnet. Use nitrogen to purge the three-necked flask for 5 minutes before adding liquid to reduce water vapor. Use a syringe to take 30mL of pyridine, add it to the three-necked flask through a constant pressure funnel, and heat it to 85°C. Then add 3.12g of sulfur trioxide pyridine complex and 10mL of pyridine to the constant pressure funnel, and add them to the flask using a constant pressure funnel. After the temperature reaches 85°C, add 0.86g of aloe polysaccharide and 10mL of pyridine to the constant pressure funnel, and start timing when the temperature stabilizes at 85°C. React at a constant temperature of 85°C for 2.5h at 400rpm.

[0052] After the reaction is completed, the mixture is cooled to room temperature and the pH value of the mixture is adjusted to 7.0 using a 5% sodium hydroxide ethanol solution. Then 3 times the volume of a 95% ethanol aqueous solution is added. A large amount of precipitation can be seen. Centrifuge (13000rpm, 15min) to collect the precipitate.

[0053] The precipitate was mixed with 30 mL of water, ultrasonically dispersed, and loaded into a dialysis bag with a cut-off molecular weight of 500-1000. The dialysis bag was sealed and dialyzed in deionized water for 24 h. The purpose of dialysis was to remove the residual pyridine in the product. After dialysis, an equal volume of acetone was added for precipitation, and the precipitate was centrifuged (13000 rpm, 15 min). The above washing steps were repeated 3 times. The washed precipitate was freeze-dried to obtain aloe polysaccharide sulfate (0.41 g).

[0054] Example 2

[0055] Preparation of aloe polysaccharide sulfate.

[0056] Install a thermometer on the left interface of a 100mL three-necked flask, connect the right interface to a nitrogen cylinder, and connect the middle interface to a ground-mouth constant pressure funnel with a stopper on the top. Install the three-necked flask on a magnetic heating jacket and stir it with a magnet. Use nitrogen to purge the three-necked flask for 5 minutes before adding liquid to reduce water vapor. Use a syringe to take 10mL of pyridine, add it to the three-necked flask through a constant pressure funnel, and heat it to 80°C. Then add 3.4g of sulfur trioxide pyridine complex and 10mL of pyridine to the constant pressure funnel, and add them to the flask using a constant pressure funnel. After the temperature reaches 80°C, add 0.8g of aloe polysaccharide and 10mL of pyridine to the constant pressure funnel, and start timing when the temperature stabilizes at 80°C. React at a constant temperature of 80°C for 3h at 400rpm.

[0057] After the reaction is completed, the mixture is cooled to room temperature and the pH value of the mixture is adjusted to 7.0 using a 5% sodium hydroxide ethanol solution. Then 3 times the volume of a 95% ethanol aqueous solution is added. A large amount of precipitation can be seen. Centrifuge (13000rpm, 15min) to collect the precipitate.

[0058] The precipitate was mixed with 30 mL of water, ultrasonically dispersed, and loaded into a dialysis bag with a cutoff molecular weight of 500-1000. The dialysis bag was sealed and dialyzed in deionized water for 24 h. The purpose of dialysis was to remove the residual pyridine in the product. After dialysis, an equal volume of acetone was added for precipitation, and the precipitate was centrifuged (13000 rpm, 15 min). The above washing steps were repeated 3 times. The washed precipitate was freeze-dried to obtain aloe polysaccharide sulfate (0.37 g).

[0059] Example 3

[0060] Preparation of aloe polysaccharide sulfate.

[0061] Install a thermometer on the left interface of a 100mL three-necked flask, connect the right interface to a nitrogen cylinder, and connect the middle interface to a ground-mouth constant pressure funnel with a stopper on the top. Install the three-necked flask on a magnetic heating jacket and stir it with a magnet. Use nitrogen to purge the three-necked flask for 5 minutes before adding liquid to reduce water vapor. Use a syringe to take 40mL of pyridine, add it to the three-necked flask through a constant pressure funnel, and heat it to 90°C. Then add 2.65g of sulfur trioxide pyridine complex and 10mL of pyridine to the constant pressure funnel, and add them to the flask using a constant pressure funnel. After the temperature reaches 90°C, add 0.8g of aloe polysaccharide and 10mL of pyridine to the constant pressure funnel, and start timing when the temperature stabilizes at 90°C. React at a constant temperature of 90°C for 3h at 400rpm.

[0062] After the reaction is completed, the mixture is cooled to room temperature and the pH value of the mixture is adjusted to 7.0 using a 5% sodium hydroxide ethanol solution. Then 3 times the volume of a 95% ethanol aqueous solution is added. A large amount of precipitation can be seen. Centrifuge (13000rpm, 15min) to collect the precipitate.

[0063] The precipitate was mixed with 30 mL of water, ultrasonically dispersed, and loaded into a dialysis bag with a cut-off molecular weight of 500-1000. The dialysis bag was sealed and dialyzed in deionized water for 24 h. The purpose of dialysis was to remove the residual pyridine in the product. After dialysis, an equal volume of acetone was added for precipitation, and the precipitate was centrifuged (13000 rpm, 15 min). The above washing steps were repeated 3 times. The washed precipitate was freeze-dried to obtain aloe polysaccharide sulfate (0.41 g).

[0064] Test Example 1

[0065] Referring to the prior art "Establishment of a Method for Detecting Sulfate Groups of Fucoidan" (Li Pingping et al., Biochemical Engineering, October 2021, Vol. 7, No. 5, Article No.: 2096-0387 (2021) 05-0021-04), the sulfate groups in the aloe polysaccharide sulfate obtained in Examples 1, 2, and 3 and the sulfate groups in the raw material aloe polysaccharide were detected by ion chromatography after ashing. The results are shown in Table 2.

[0066] Table 2

[0067]

[0068] It can be seen that by adjusting the ratio of aloe polysaccharide raw material and sulfur trioxide pyridine complex, reaction temperature and other conditions, the content of sulfate groups in aloe polysaccharide sulfate can be increased, so as to improve the efficacy of the lubricant used in the human body.

[0069] It is worth noting that the preparation method of aloe polysaccharide sulfate provided in Example 1, Example 2, and Example 3 can increase the yield by repeating the experiment, expanding the experimental scale within a certain range, etc., and the product amount of the prepared aloe polysaccharide sulfate is not limited to the product grams provided in Example 1, Example 2, and Example 3.

[0070] Example 4-Example 8, Comparative Example 1-Comparative Example 2 provide formulas of human body lubricants, as shown in Table 3.

[0071] Table 3

[0072]

[0073] The human body lubricants of Examples 4 to 8, Comparative Examples 1 and 2 were prepared according to the following preparation method.

[0074] Aloe polysaccharide sulfate, sodium hyaluronate and carbomer are mixed with half of the water in the formula to obtain a mixture A; caprylhydroxamic acid, snow lotus culture, N-hydroxyethyl-2-imidazolidinone, urolithin A and spermidine are mixed with half of the water in the formula to obtain a mixture B; the mixture A is stirred at a stirring speed of 300-400 rpm, and the mixture B is added to the mixture A while maintaining the stirring, and the stirring speed is adjusted to 500-600 rpm, and glycerol is added, and the stirring speed is adjusted to 1000-1200 rpm, and the mixture is stirred for 2 hours to obtain a human body lubricant.

[0075] Using the aloe polysaccharide sulfate prepared in Example 1 and following the formula ratios of Example 4 to Example 8 and Comparative Example 1 to Comparative Example 2 and the above-mentioned preparation method, the obtained human body lubricants are respectively recorded as Le4-1, Le5-1, Le6-1, Le7-1, Le8-1, Lc1, and Lc2.

[0076] Using the aloe polysaccharide sulfate prepared in Example 2 and Example 3 and following the formula ratio of Example 4 and the above-mentioned preparation method, the obtained human body lubricants are respectively recorded as Le4-2 and Le4-3.

[0077] Comparative Example 3

[0078] Compared with Example 4, the difference is that sodium hyaluronate is replaced with 1,3-butanediol in equal parts by weight, and the rest is the same. The specific preparation method of the human body lubricant is as follows:

[0079] The aloe polysaccharide sulfate, 1,3-butylene glycol and carbomer prepared in Example 1 are mixed with half the amount of water to obtain a mixture A; caprylhydroxamic acid, snow lotus culture, N-hydroxyethyl-2-imidazolidinone, urolithin A and spermidine are mixed with half the amount of water to obtain a mixture B; the mixture A is stirred at a stirring speed of 300-400 rpm, and the mixture B is added to the mixture A while maintaining stirring, and the stirring speed is adjusted to 500-600 rpm, glycerol is added, and the stirring speed is adjusted to 1000-1200 rpm. Stir for 2 hours to obtain a human body lubricant recorded as Lc3.

[0080] Comparative Example 4

[0081] Compared with Example 4, the difference is that aloe polysaccharide sulfate is replaced by aloe polysaccharide of equal weight, and the rest are the same.

[0082] The specific preparation method of the human body lubricant is as follows:

[0083] Aloe polysaccharide, sodium hyaluronate and carbomer are mixed with half the amount of water to obtain mixture A; caprylhydroxamic acid, snow lotus culture, N-hydroxyethyl-2-imidazolidinone, urolithin A and spermidine are mixed with half the amount of water to obtain mixture B; mixture A is stirred at a stirring speed of 300-400 rpm, and mixture B is added to mixture A while maintaining stirring, and the stirring speed is adjusted to 500-600 rpm, glycerol is added, and the stirring speed is adjusted to 1000-1200 rpm. Stir for 2 hours to obtain a human body lubricant recorded as Lc4.

[0084] Comparative Example 5

[0085] Compared with Example 4, the difference is that aloe polysaccharide sulfate is replaced by an equal weight of aloe extract, and the rest is the same.

[0086] The preparation method of the aloe extract is as follows: the green epidermis of fresh aloe fleshy leaves is cut off, the transparent or translucent fleshy part is taken, freeze-dried, ground into powder, and passed through a 20-mesh sieve to obtain the extract.

[0087] The specific preparation method of the human body lubricant is as follows:

[0088] Aloe extract, sodium hyaluronate and carbomer are mixed with half the amount of water to obtain mixture A; caprylhydroxamic acid, snow lotus culture, N-hydroxyethyl-2-imidazolidinone, urolithin A and spermidine are mixed with half the amount of water to obtain mixture B; mixture A is stirred at a stirring speed of 300-400 rpm, and mixture B is added to mixture A while maintaining stirring, and the stirring speed is adjusted to 500-600 rpm, glycerol is added, and the stirring speed is adjusted to 1000-1200 rpm. Stir for 2 hours to obtain a human body lubricant recorded as Lc5.

[0089] Comparative Example 6

[0090] Compared with Example 4, the difference is that no snow lotus culture is added, the amount of sodium hyaluronate is changed from 7.2 parts by weight to 8.2 parts by weight, and the rest are the same.

[0091] The specific preparation method of the human body lubricant is as follows:

[0092] The aloe polysaccharide sulfate, sodium hyaluronate and carbomer prepared in Example 1 were mixed with half the amount of water to obtain a mixture A; caprylhydroxamic acid, N-hydroxyethyl-2-imidazolidinone, urolithin A and spermidine were mixed with half the amount of water to obtain a mixture B; the mixture A was stirred at a stirring speed of 300-400 rpm, and the mixture B was added to the mixture A while maintaining stirring, and the stirring speed was adjusted to 500-600 rpm, glycerol was added, and the stirring speed was adjusted to 1000-1200 rpm, and stirred for 2 hours to obtain a human body lubricant recorded as Lc6.

[0093] Comparative Example 7

[0094] Compared with Example 4, aloe polysaccharide sulfate is replaced with fucoidan in equal parts by weight, and the rest is the same. The specific preparation method of the human body lubricant is as follows:

[0095] Mix fucoidan, sodium hyaluronate and carbomer with half the amount of water to obtain mixture A; mix caprylhydroxamic acid, snow lotus culture, N-hydroxyethyl-2-imidazolidinone, urolithin A and spermidine with half the amount of water to obtain mixture B; stir mixture A at a stirring speed of 300-400 rpm, add mixture B to mixture A while maintaining stirring, adjust the stirring speed to 500-600 rpm, add glycerol, adjust the stirring speed to 1000-1200 rpm, stir for 2 hours, and obtain a human body lubricant recorded as Lc7.

[0096] Comparative Example 8

[0097] Compared with Example 4, the snow lotus culture was replaced by the snow lotus seed extract in equal parts by weight, and the rest was the same. The specific preparation method of the human body lubricant is as follows:

[0098] The aloe polysaccharide sulfate, sodium hyaluronate and carbomer prepared in Example 1 are mixed with half the amount of water to obtain a mixture A; caprylhydroxamic acid, saussurea sylvestris seed extract, N-hydroxyethyl-2-imidazolidinone are mixed with half the amount of water to obtain a mixture B; the mixture A is stirred at a stirring speed of 300-400 rpm, and the mixture B is added to the mixture A while maintaining stirring, and the stirring speed is adjusted to 500-600 rpm, glycerin is added, and the stirring speed is adjusted to 1000-1200 rpm. Stir for 2 hours to obtain a human body lubricant, which is recorded as Lc8.

[0099] Effect example

[0100] The performance of the human body lubricants Le4-1, Le5-1, Le6-1, Le7-1, Le8-1, Le4-2, Le4-3, Lc1, Lc2, Lc3, Lc4, Lc5, Lc6, Lc7, and Lc8 prepared in each embodiment and comparative example was tested, and the results are as follows:

[0101] 1. Product quality control parameters

[0102] 1.1. Lubricant pH value test

[0103] The pH values ​​of human lubricants Le4-1, Le5-1, Le6-1, Le7-1, Le8-1, Le4-2, Le4-3, Lc1, Lc2, Lc3, Lc4, Lc5, Lc6, Lc7 and Lc8 were tested by a pH meter, and the results are shown in Table 4.

[0104] Table 4

[0105]

[0106] It can be seen that the pH value of the human body lubricants Le4-1, Le4-2, Le4-3, Le5-1, Le6-1, Le7-1, and Le8-1 provided by the present invention is between 5.1 and 5.4. The pH value is between 4 and 6, which is adapted to the pH of the human vaginal environment.

[0107] 1.2 Lubricant sensitization test

[0108] The skin sensitization of lubricants was tested with reference to ISO10993-10:2010.

[0109] Healthy, newly grown, non-pregnant and unrestricted New Zealand rabbits of either sex were used as experimental animals for the experiment. Before the experiment, the New Zealand rabbits were kept in the experimental environment for 5 days to adapt to the environment. The back of the animal was depilated with depilatory cream (manufacturer: Veet) within 4-24 hours before the experiment. Dry cotton gauze 3cm×15cm was fixed in advance on the depilatory area. Then, 1mL of human lubricant Le4-1, Le5-1, Le6-1, Le7-1, Le8-1, Le4-2, Le4-3, Lc1, Lc2, Lc3, Lc4, Lc5, Lc6, Lc7 and Lc8 were dripped on the gauze respectively, so that the gauze was soaked with lubricant. After 4 hours of application, the cotton gauze patch was removed, and the skin in the application area was observed for abnormalities and scored. The scoring of each group was repeated 5 times and the average value was taken. The scoring standard is shown in Table 5.

[0110] Table 5

[0111]

[0112] The experimental average scores of the visual evaluation and tactile evaluation of each group of human lubricants are shown in Table 6.

[0113] Table 6

[0114]

[0115] It can be seen that the human body lubricants Le4-1, Le4-2, Le4-3, Le5-1, Le6-1, Le7-1, and Le8-1 provided in each embodiment of the present invention do not have skin sensitization. In comparison, the comparative example that does not use aloe polysaccharide sulfate, especially the direct use of aloe extract that has only been freeze-dried (i.e., the human body lubricant Lc5 prepared in comparative example 5), has certain sensitization to sensitive skin mucosa due to the irritation of fresh aloe juice. In addition, compared with the various embodiments using snow lotus culture, Lc8 prepared in comparative example 8 uses snow lotus seed extract instead, and its sensitization is slightly improved. It can be seen that the use of snow lotus culture in the present invention can effectively reduce the irritation of lubricants to sensitive skin, and this effect cannot be achieved by arbitrarily replacing plant part extracts.

[0116] 1.3 Storage performance

[0117] Test method: 10 mL of human lubricant Le4-1, Le5-1, Le6-1, Le7-1, Le8-1, Le4-2, Le4-3, Lc1, Lc2, Lc3, Lc4, Lc5, Lc6, Lc7 and Lc8 were added to colorless and transparent 20 mL glass bottles, respectively, and stored at 30°C with covers. The uniformity and water-oil phase separation or precipitation were observed on the 0th, 14th and 28th day of storage. The experimental results are shown in Table 7.

[0118] Table 7

[0119]

[0120] The storage performance of the human body lubricants Le4-1, Le5-1, Le6-1, Le7-1, Le8-1, Le4-2, and Le4-3 provided in Examples 4 to 8 of the present invention is relatively good. The experimental results of Lc1 and Lc2 show that the ratio of aloe polysaccharide sulfate, sodium hyaluronate, and snow lotus culture has a certain effect on the stability of the human body lubricant. The experimental results of Lc4, Lc5, and Lc7 show that compared with unmodified aloe polysaccharides, aloe extracts, and fucoidan, the use of aloe polysaccharide sulfate in the human body lubricant formula can improve the storage stability of the human body lubricant.

[0121] 1.4. Antibacterial performance test

[0122] The antibacterial properties of human lubricants Le4-1, Le5-1, Le6-1, Le7-1, Le8-1, Le4-2, Le4-3, Lc1, Lc2, Lc3, Lc4, Lc5, Lc6, Lc7 and Lc8 against Staphylococcus aureus, Escherichia coli and Candida albicans were tested respectively. The bacterial species used in the antibacterial property test were Staphylococcus aureus (ATCC6538), Escherichia coli (ATCC25922) and Candida albicans (ATCC10231). The recovery, amplification and culture methods of the above three bacterial species were all standard methods.

[0123] The specific experimental steps for testing the antibacterial properties of human lubricants are as follows:

[0124] On a sterile operating table, 0.05 mm thick latex film raw materials were disinfected with 75% alcohol, and after drying, they were cut into 2 cm × 2 cm square pieces. The latex film pieces were immersed in each group of human lubricants.

[0125] Take 1 mL of bacterial solution (concentration 2×10 8 CFU / mL-4×10 8 CFU / mL) was added to 200mL of 45-47℃ liquid nutrient agar medium, mixed quickly, and poured into a 6cm diameter culture dish while hot. After the culture medium solidified, the latex film pieces immersed in each group of human lubricants were gently removed with sterile tweezers, drained until the lubricant did not drip, and the latex film pieces with human lubricants were carefully placed in the center of the solidified culture medium surface, and gently pressed to avoid bubbles. Each culture dish was cultured at 37℃ for 48 hours, and the width of the antibacterial ring formed around the film pieces was measured. Each group of experiments was repeated 5 times, and the mean and standard deviation were calculated.

[0126] The widths of the inhibition zones of the personal lubricants against Staphylococcus aureus ATCC 6538, Escherichia coli ATCC 25992, and Candida albicans ATCC 10231 are shown in Table 8 (mean ± standard deviation).

[0127] Table 8

[0128]

[0129] Among them, the superscript The data in the same column are significantly different from those in Le4-1, and p<0.05; Indicates that the data in the same column are significantly different from the data in No. Le4-1, and p < 0.01; superscript Indicates that the data in the same column are significantly different from the data in Le4-1, and p < 0.001; superscript The data in the same column are significantly different from the data in No. Le4-1, and p < 0.0001.

[0130] It can be seen that, in general, the human lubricants Le4-1, Le5-1, Le6-1, Le7-1, Le8-1, Le4-2 and Le4-3 provided by the embodiments of the present invention have good killing effects on Staphylococcus aureus ATCC 6538, Escherichia coli ATCC 25992 and Candida albicans ATCC 10231, and are better than human lubricants Lc1-Lc8. This shows that the human lubricant provided by the present invention can effectively improve the antibacterial effect against Staphylococcus aureus, Escherichia coli and Candida albicans, and aloe polysaccharide sulfate, sodium hyaluronate and snow lotus culture have a synergistic effect. In particular, compared with Le4-1, Le4-2 and Le4-3, the only difference is that the sulfate group content of the aloe polysaccharide sulfate used is different. As shown in Table 8, the average width of the inhibition ring of Le4-1 is greater than that of Le4-2 and Le4-3, especially the width of the inhibition ring of Le4-1 and Le4-3 for ATCC 6538 and ATCC 10231 is significantly different. This shows that the antibacterial effect of aloe polysaccharide sulfate with a sulfate group content of 9.26%-10.89% is better than that of aloe polysaccharide sulfate with a sulfate group content of 7.43%.

[0131] 2. Lubrication durability test

[0132] The human body lubricants Le4-1, Le5-1, Le6-1, Le7-1, Le8-1, Le4-2, Le4-3, Lc1, Lc2, Lc3, Lc4, Lc5, Lc6, Lc7 and Lc8 were coated on the inside of natural latex condoms that were not treated with lubricants. The length of the condoms was 19 cm, the diameter was 33 mm, and the thickness was 0.05 mm. 0.2 g of human body lubricant was coated on the inside of each condom. The lubrication durability of the condoms coated with human body lubricants was tested as follows:

[0133] The dynamic friction coefficient is determined with reference to GB 10006-2021. Specifically, the stainless steel mold with the condom is placed in a container filled with physiological saline (water temperature 37°C). The upper edge of the condom is always kept above the water surface of the physiological saline and fixed vertically on the friction coefficient meter. At the same time, a rubber-coated annular clamp is used to apply a force of 2 Newtons to the surface of the condom on the stainless steel mold. The measurement range of the friction coefficient tester is 0-5 Newtons. When the mold movement speed is 150mm / min, the dynamic friction coefficient is measured.

[0134] The dynamic friction coefficient is calculated according to the following formula:

[0135] .

[0136] Among them, μ D is the coefficient of kinetic friction, which is a dimensionless quantity. D is the kinetic friction force, in Newton. F P is the normal force in Newtons.

[0137] The test results of the dynamic friction coefficient of the natural latex condom surface lubricated by each group of human lubricants are shown in Table 9.

[0138] Table 9

[0139]

[0140] It can be seen that, in general, the human lubricants Le4-1, Le5-1, Le6-1, Le7-1, Le8-1, Le4-2, and Le4-3 provided by the embodiments of the present invention can still maintain a high lubricity (dynamic friction coefficient is 0.0534-0.0945) after 15 minutes of friction, while the human lubricants Lc1, Lc2, Lc3, Lc4, Lc5, Lc6, Lc7, and Lc8 provided by the comparative examples have a significant decrease in lubricity (dynamic friction coefficient drops to 0.1239-0.1832) after 15 minutes of friction. This shows that the human lubricant provided by the present invention can effectively improve the durability of the lubrication effect, and aloe polysaccharide sulfate, sodium hyaluronate, and snow lotus culture have a synergistic effect.

[0141] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A human body lubricating composition, characterized in that: The composition is as follows by weight: 3.2-6 parts of aloe polysaccharide sulfate, 5.85-8.1 parts of sodium hyaluronate, 0.8-1.3 parts of snow lotus culture, 52.82-56.66 parts of water, 9.7-13.4 parts of moisturizing agent, 1.45-3.36 parts of thickener, 0.46-0.64 parts of antibacterial agent, 0.28-0.62 parts of antioxidant and 0.2-0.4 parts of anti-aging agent; the moisturizing agent is glycerol, the thickener is carbomer, the antioxidant is N-hydroxyethyl-2-imidazolidinone, and the antibacterial agent is caprylhydroxamic acid; the antioxidant is composed of 0.2-0.5 parts of urolithin A and 0.08-0.12 parts of spermidine by weight; the weight content of sulfate groups in the aloe polysaccharide calculated as sulfate ions is 7.43%-10.89%.

2. A personal lubricant, characterized in that: Made from the human body lubricating composition as claimed in claim 1.

3. The method for preparing the personal lubricant according to claim 2, characterized in that: The following steps are involved: S1, mixing pyridine, sulfur trioxide pyridine complex and aloe polysaccharide, heating and stirring to react, adjusting the pH, adding ethanol to precipitate, washing, and drying to obtain aloe polysaccharide sulfate; in step S1, the ratio of the volume of the pyridine, the mass of the sulfur trioxide pyridine complex, and the mass of the aloe polysaccharide is 30-60:2.65-3.4:0.8-0.9, in units of mL:g:g; the temperature of the heating and stirring reaction is 80-90°C, and the time of the heating and stirring reaction is 2-3h; S2, mixing the aloe polysaccharide sulfate, sodium hyaluronate, thickener and water obtained in step S1 to obtain a mixture A; S3, mixing the snow lotus culture, the antibacterial agent, the anti-aging agent, the antioxidant and water to obtain a mixture B; S4, mixing the mixture A obtained in step S2, the mixture B obtained in step S3 and a moisturizer, and stirring to obtain a human body lubricant.

4. The preparation method according to claim 3, characterized in that: Step S4 is specifically as follows: The mixture A obtained in step S2 is stirred at a stirring speed of 300-400 rpm, and the mixture B obtained in step S3 is added to the mixture A obtained in step S2 while maintaining stirring, and the stirring speed is adjusted to 500-600 rpm. A moisturizer is added, and the stirring speed is adjusted to 1000-1200 rpm. The mixture is stirred for 1.5-2.5 hours to obtain a human body lubricant.

5. Use of the human lubricant according to claim 2 or the human lubricant prepared by the preparation method according to any one of claims 3 to 4 in the production of products with lubricating function.

6. The use according to claim 5, characterized in that: The products with lubricating function include human body lubricating fluid, finger cots and condoms.

7. A condom, characterized in that: The condom comprises a condom body and a human lubricant, wherein the human lubricant is the human lubricant according to claim 2 or the human lubricant prepared by the preparation method according to any one of claims 3 to 4.

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