Buccal tablet composition for adjuvant therapy of diabetes and preparation method thereof

Abstract

The invention provides a buccal tablet composition for adjuvant therapy of diabetes and a preparation method thereof, and relates to the technical field of medicinal and edible compositions. The composition is prepared from bee pollen, propolis, lyophilized royal jelly powder, cooked radix puerariae powder, a fermentation material and inulin, wherein the fermentation material is prepared by fermenting mulberry leaves and bitter gourds by adopting lactobacillus mucilaginosus and kluyveromyces marxianus together. According to the traditional Chinese medicine composition, the defects in the prior art are overcome, the side effects of medicine taking of the type 2 diabetes mellitus can be effectively relieved through extraction and preparation of natural components, meanwhile, a certain diabetes mellitus treatment effect is achieved, and an important direction is provided for treatment of patients with the type 2 diabetes mellitus.

Description

Technical Field

[0001] The invention relates to the technical field of medicine-food homologous composition, and in particular to a lozenge composition for auxiliary treatment of diabetes and a preparation method thereof. Background Art

[0002] Type 2 diabetes is a typical disease caused by endocrine disorders. It is a metabolic disease. Studies have shown that most patients have genetic characteristics. In recent years, the number of patients with type 2 diabetes has increased year by year. There are many reasons for this result. On the one hand, it is because people's living standards have improved, their diets have become richer, and their matching structure is unreasonable; on the other hand, the number of patients with type 2 diabetes is increasing sharply because the detection level of diabetes has increased. The blood sugar level of diabetic patients is higher than normal, and long-term high blood sugar symptoms will cause metabolic disorders of other related substances such as blood lipids and proteins in the patient's body, which will aggravate the patient's condition, such as causing the patient to suffer from coronary heart disease, cerebrovascular disease, renal failure, etc.

[0003] The current medications for patients with type 2 diabetes are generally sulfonylureas, glinides, biguanides, thiazolidinediones and other drugs, which are usually used in combination with insulin. They can significantly improve and treat type 2 diabetes, but the overall side effects are also quite obvious, including hypoglycemia, weight gain, skin allergies, upper abdominal discomfort, loss of appetite, abdominal distension and other adverse reactions, which bring certain pain to the actual treatment of patients.

[0004] In order to improve the medication situation of type 2 diabetes, clinical attempts have been made to develop drug ingredients with low side effects or alleviated side effects, which is of great significance to improving the treatment comfort of patients with type 2 diabetes. Summary of the invention

[0005] In view of the deficiencies in the prior art, the present invention provides an oral tablet composition for the auxiliary treatment of diabetes and a preparation method thereof. Through the extraction and preparation of natural ingredients, the side effects of taking type 2 diabetes drugs can be effectively alleviated, while playing a certain role in the treatment of diabetes, providing an important direction for the treatment of type 2 diabetes patients.

[0006] To achieve the above objectives, the technical solution of the present invention is implemented through the following technical solutions:

[0007] The invention discloses a lozenge composition for assisting the treatment of diabetes, the composition comprising the following raw materials in parts by weight: 3-6 parts of bee pollen, 0.2-0.5 parts of propolis, 1-2 parts of freeze-dried royal jelly powder, 1-4 parts of cooked kudzu root powder, 4-8 parts of fermented material, and 4-6 parts of inulin; the fermented material is prepared by co-fermenting mulberry leaves and bitter melon with fermented Lactobacillus mucilaginosus and Kluyveromyces marxianus.

[0008] Preferably, the preparation method of propolis comprises the following steps:

[0009] S1-1, weigh the raw rubber, freeze it, and crush it into 10-20 mesh particles for later use;

[0010] S1-2, adding the above particles to a 95% alcohol solution at a volume-to-liquid ratio of 1:4, leaving the solution at room temperature for 72 hours, and filtering through three layers of filter cloth to obtain a first extract and a first residue for later use;

[0011] S1-3, adding 85% alcohol solution to the first residue at a volume-to-liquid ratio of 1:4, leaving it at room temperature for 72 hours, and filtering it through three layers of filter cloth to obtain a second extract and a second residue for later use;

[0012] S1-4, adding 75% alcohol solution to the second residue at a volume-to-liquid ratio of 1:4, leaving it at room temperature for 72 hours, and then filtering it through three layers of filter cloth to obtain a third extract for later use;

[0013] S1-5, combining the first extract, the second extract and the third extract, and letting them stand at 0-4°C for 72 hours, and then filtering the supernatant through three layers of gauze to obtain a propolis filtrate for later use;

[0014] S1-6. Evacuate the propolis filtrate at a vacuum degree of -0.08MPa to -0.1MPa, control the temperature at 45 to 60°C, evaporate and remove excess water to obtain propolis.

[0015] Preferably, the method for preparing the cooked kudzu root powder comprises the following steps:

[0016] S2-1, peel the fresh kudzu root, immerse it in water and cook for 30-40 minutes, grind it into pulp with water after cooling, and prepare the cooked pulp for later use;

[0017] S2-2, filtering the cooked slurry, allowing the filtrate to stand at 5-15°C for 8-10 hours, separating the precipitate, and drying the precipitate at 25-35°C and then crushing it to obtain cooked kudzu root powder.

[0018] Preferably, the method for preparing the fermentation material comprises the following steps:

[0019] S3-1, preparing mulberry leaves and bitter melon in a mass ratio of 2:3, and grinding the mulberry leaves and bitter melon with water to form mulberry leaf slurry and bitter melon slurry for later use;

[0020] S3-2, inoculating the fermented mucus lactobacillus into the mulberry leaf slurry, fermenting for 12-24 hours, and then inoculating Kluyveromyces marxianus to continue fermenting for 16-20 hours to obtain the first fermentation material for standby use;

[0021] S3-3, adding the bitter melon slurry to the first fermentation material, and continuing the fermentation process for 4-8 hours to obtain the second fermentation material for standby use;

[0022] S3-4. Place the second fermentation material at a pressure of 2-4Mpa and a temperature of 109-115°C and stir for 10-15 minutes, then take it out, squeeze and filter it, concentrate and freeze-dry the filtrate to obtain the fermentation material.

[0023] Preferably, the inoculation amount of the fermented mucus lactobacillus inoculated into the mulberry leaf slurry in step S3-2 is 0.05%-0.1% of the total mass of the mulberry leaf slurry, and the number of viable bacteria of the fermented mucus lactobacillus is 10 6 -10 8 Pieces / g.

[0024] Preferably, the amount of Kluyveromyces marxianus inoculated in step S3-2 is 0.02%-0.05% of the total mass of the mulberry leaf slurry, and the number of viable Kluyveromyces marxianus is 10 7 -10 10 Pieces / g.

[0025] Preferably, the royal jelly decanoic acid content in the royal jelly freeze-dried powder is ≥ 6.0%.

[0026] The preparation method of the oral tablet composition for assisting the treatment of diabetes comprises the following steps:

[0027] (1) breaking the bee pollen wall by an ultra-fine wall-breaking pulverizer to obtain broken wall powder for later use;

[0028] (2) adding water to the above-mentioned broken cell powder and cooked kudzu root powder and stirring evenly to obtain a mixture for later use;

[0029] (3) adding water to the propolis, fermented material, and inulin to adjust the humidity to 20%-30%, and mixing to obtain a wet material for later use;

[0030] (4) adding the wet material to the mixed material, stirring thoroughly, and then drying and crushing to obtain a mixed powder;

[0031] (5) The mixed powder is compressed into tablets to prepare a buccal tablet composition.

[0032] Preferably, in step (2), the material-liquid ratio of the wall-broken powder mixed with the cooked kudzu root powder and water is 1:2-3.

[0033] Preferably, the drying and crushing in step (4) is carried out by drying at 30-35° C. until the moisture content is less than 8%, and then crushing through an 80-mesh sieve.

[0034] The present invention provides a buccal tablet composition for assisting the treatment of diabetes and a preparation method thereof, which has the following advantages over the prior art:

[0035] The invention adopts natural raw materials such as bee pollen, propolis, royal jelly freeze-dried powder, inulin, etc., and compounded with fermented materials of cooked kudzu root powder, mulberry leaves and bitter melon, which can effectively improve the metabolism of glucose and lipids, achieve a certain effect of lowering blood sugar, and alleviate the treatment side effects caused by drugs such as glibenclamide and metformin. The oral tablet composition is simple to use and can effectively improve the comfort of treatment for patients with type 2 diabetes. DETAILED DESCRIPTION

[0036] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention is clearly and completely described below in combination with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0037] In the following examples, the strain number of Lactobacillus mucilaginosus is CICC 22704, and the strain number of Kluyveromyces marxianus is CICC 1276, both of which were purchased from the China Industrial Microbiological Culture Collection Center.

[0038] Embodiment 1:

[0039] 1. Preparation of raw materials:

[0040] 1. Preparation of propolis:

[0041] (1) Weighing 100 kg of raw rubber (content greater than 45%), freezing it at -4°C for 24 hours and then crushing it into coarse particles of 10-20 mesh;

[0042] (2) adding the above particles to a 95% alcohol solution at a volume-to-liquid ratio of 1:4, leaving the solution at room temperature for 72 hours, and then filtering through three layers of filter cloth to obtain a first extract and a first residue for later use;

[0043] (3) adding 85% alcohol solution to the first residue at a volume-to-liquid ratio of 1:4, leaving the mixture at room temperature for 72 hours, and filtering through three layers of filter cloth to obtain a second extract and a second residue for later use;

[0044] (4) adding 75% alcohol solution to the second residue at a volume-to-liquid ratio of 1:4, leaving the mixture at room temperature for 72 hours, and filtering through three layers of filter cloth to obtain a third extract for later use;

[0045] (5) combining the first extract, the second extract and the third extract, and allowing to stand at 4° C. for 72 h, and then filtering the supernatant through three layers of gauze to obtain a propolis filtrate for later use;

[0046] (6) The propolis filtrate is evacuated to -0.1 MPa, the temperature is controlled between 45 and 60° C., and excess water is evaporated to obtain propolis.

[0047] 2. Preparation of Pueraria powder:

[0048] 2.1. Preparation of Pueraria lobata powder A:

[0049] (1) Peel the fresh kudzu root, immerse it in water and cook it at 90-100° C. for 30-40 minutes, and grind it into pulp with water after cooling to obtain the cooked pulp for later use;

[0050] (2) The cooked slurry was filtered, and the filtrate was allowed to stand at 10° C. for 10 h, and then the precipitate was separated. The precipitate was dried at 30° C. and then crushed to obtain Pueraria powder A.

[0051] 2.2. Preparation of Pueraria powder B:

[0052] (1) Peel the fresh kudzu root, immerse it in water, and grind it into a slurry with the water to prepare the slurry for later use;

[0053] (2) The slurry was filtered, and the filtrate was allowed to stand at 10° C. for 10 h, and then the precipitate was separated. The precipitate was dried at 30° C. and then crushed to obtain Pueraria powder B.

[0054] 3. Preparation of plant materials:

[0055] 3.1. Preparation of plant material A:

[0056] (1) preparing mulberry leaves and bitter melon in a mass ratio of 2:3, and grinding the mulberry leaves and bitter melon into mulberry leaf slurry and bitter melon slurry respectively with water for later use;

[0057] (2) Add 0.08% of the total mass of mulberry leaf slurry to the fermented mucus lactobacillus (10 6 -10 8 / g) were inoculated into the mulberry leaf slurry and fermented for 16 h, and then inoculated with 0.04% Kluyveromyces marxianus (10 7 -10 10 / g) and continue the fermentation process for 18h to obtain the first fermentation material for standby use;

[0058] (3) adding the bitter melon slurry to the first fermentation material, and continuing the fermentation process for 6 hours to obtain a second fermentation material for standby use;

[0059] (4) The second fermentation material is placed at a pressure of 3 MPa and a temperature of 110° C. and stirred for 15 minutes, then taken out, squeezed and filtered, and the filtrate is concentrated and freeze-dried to obtain plant material A.

[0060] 3.2. Preparation of plant material B:

[0061] (1) preparing mulberry leaves and bitter melon in a mass ratio of 2:3, and grinding the mulberry leaves and bitter melon into mulberry leaf slurry and bitter melon slurry respectively with water for later use;

[0062] (2) Add 0.08% of the total mass of mulberry leaf slurry to the fermented mucus lactobacillus (10 6 -10 8 / g) were inoculated into the mulberry leaf slurry and fermented for 16 h, and then inoculated with 0.04% Kluyveromyces marxianus (10 7 -10 10 / g) and continue the fermentation process for 18h to obtain the first fermentation material for standby use;

[0063] (3) adding the bitter melon slurry to the first fermentation material, and continuing the fermentation process for 6 hours to obtain a second fermentation material for standby use;

[0064] (4) The second fermented material is squeezed and filtered, and the filtrate is concentrated and freeze-dried to obtain plant material B.

[0065] 3.3. Preparation of plant material C:

[0066] (1) preparing mulberry leaves and bitter melon in a mass ratio of 2:3, and grinding the mulberry leaves and bitter melon into mulberry leaf slurry and bitter melon slurry respectively with water for later use;

[0067] (2) Add 0.08% of the total mass of mulberry leaf slurry to the fermented mucus lactobacillus (10 6 -10 8 100 g / ml) were inoculated into mulberry leaf slurry and fermented for 34 h to obtain the first fermentation material for standby use;

[0068] (3) adding the bitter melon slurry to the first fermentation material, and continuing the fermentation process for 6 hours to obtain a second fermentation material for standby use;

[0069] (4) The second fermentation material is placed at a pressure of 3 MPa and a temperature of 110° C. and stirred for 15 min. The material is then taken out, squeezed and filtered, and the filtrate is concentrated and freeze-dried to obtain plant material C.

[0070] 3.4. Preparation of plant material D:

[0071] (1) preparing mulberry leaves and bitter melon in a mass ratio of 2:3, and grinding the mulberry leaves and bitter melon into mulberry leaf slurry and bitter melon slurry respectively with water for later use;

[0072] (2) Add 0.04% Kluyveromyces marxianus (10 7 -10 10 / g) for 34 hours to obtain the first fermentation material for standby use;

[0073] (3) adding the bitter melon slurry to the first fermentation material, and continuing the fermentation process for 6 hours to obtain a second fermentation material for standby use;

[0074] (4) The second fermentation material is placed at a pressure of 3 MPa and a temperature of 110° C. and stirred for 15 min. The material is then taken out, squeezed and filtered, and the filtrate is concentrated and freeze-dried to obtain plant material D.

[0075] 3.5. Preparation of plant material E:

[0076] (1) Mix mulberry leaves and bitter melon in a mass ratio of 2:3, and grind them into slurry with water;

[0077] (2) The slurry was placed under a pressure of 3 MPa and a temperature of 110° C. and stirred for 15 min. The slurry was then taken out, squeezed and filtered, and the filtrate was concentrated and freeze-dried to obtain plant material E.

[0078] 2. Preparation of the composition:

[0079] (1) Prepare the following materials in parts by weight: 5 parts of bee pollen, 0.3 parts of propolis, 1.5 parts of freeze-dried royal jelly powder (the royal jelly has a 6.8% acetic acid content), 2.5 parts of cooked kudzu root powder, 6 parts of plant material, and 5 parts of inulin;

[0080] (2) breaking the bee pollen wall by an ultra-fine wall-breaking pulverizer to obtain broken wall powder for later use;

[0081] (3) Mix the above-mentioned broken wall powder with kudzu root powder, add water according to the material-liquid ratio of 1:2, and stir evenly to obtain a mixed material for later use;

[0082] (4) Add water to the propolis, fermented material, and inulin to adjust the humidity to 25%, and mix to obtain a wet material for later use;

[0083] (5) Add the above wet material to the mixed material, stir thoroughly, dry at 35°C until the water content is less than 8%, and then grind through an 80-mesh sieve to obtain a composite powder.

[0084] According to Table 1 below, different kudzu root powders and plant materials were selected, and different composite powders were prepared according to the above preparation method:

[0085] Table 1

[0086] Group Pueraria root powder Plant material Composition 1 Pueraria root powder A Plant material A Composition 2 Pueraria root powder B Plant material A Composition 3 Pueraria root powder A Plant material B Composition 4 Pueraria root powder A Plant material C Composition 5 Pueraria root powder A Plant material D Composition 6 Pueraria root powder A Plant material E

[0087] Detection:

[0088] 1. Detect the effect of the combined powder prepared by the above experimental groups 1-6 on improving glucose and lipid metabolism:

[0089] 1.1. Establishment of high glucose animal model and drug administration:

[0090] 80 healthy and clean grade Kunming male mice, weighing about 13-15g, were selected and kept in cages at 20-25℃. After one week of adaptive feeding, they were randomly divided into 8 groups, with 10 mice in each group. They were normal group, model group, experimental group 1, experimental group 2, experimental group 3, experimental group 4, experimental group 5, and experimental group 6.

[0091] The normal group was fed with a basic feed, and the other groups were fed with a high-fat feed. After 4 weeks, except for the normal group, the other groups were fasted but not watered for 12 hours, and streptozotocin (STZ) 35 mg / kg (based on mouse body weight) was intraperitoneally injected for 3 consecutive days to further enhance the metabolic disorder of the mice. The mice were fed with a high-fat feed for another week, and fasted for 24 hours after one week. The fasting blood sugar was measured. The mice with a blood sugar value greater than 11.0 mmol / L were T2DM model mice, and the unmodeled mice were eliminated and continued to be fed with a high-fat feed. The normal group and the model group were gavaged with distilled water (80 mg / kg) for 4 weeks, and the experimental groups 1-6 were gavaged with the combination (80 mg / kg) for 4 weeks;

[0092] After the last administration, the subjects were fasted for 12 hours. After ether anesthesia, the eyeballs were removed and blood was collected. The collected blood was kept at 4°C for 20 minutes, centrifuged at 12000r / min for 20 minutes, and the supernatant was aspirated as serum. The contents of serum TC, TG, HDL, and LDL were determined by an automatic biochemical analyzer; the content of fasting insulin (FINS) and fasting blood glucose (FBG) were determined by enzyme-linked immunosorbent assay (ELISA). The specific results are shown in Table 2 below:

[0093] Table 2

[0094] Group Drug administration Fasting blood sugar Fasting insulin Normal group Distilled water 3.75 7.02 Model Group Distilled water 18.49 14.52 Experimental Group 1 Composition 1 10.35 8.93 Experimental Group 2 Composition 2 12.33 10.51 Experimental Group 3 Composition 3 12.62 10.65 Experimental Group 4 Composition 4 11.49 10.25 Experimental Group 5 Composition 5 13.51 11.42 Experimental Group 6 Composition 6 14.30 12.01

[0095] It can be seen from the above table that composition 1 in experimental group 1 can effectively control the glucose and lipid metabolism of rats and reduce blood sugar.

[0096] 2. Typical cases:

[0097] The powder of the composition prepared from the above composition 1 is compressed into buccal tablets (2.5 g / tablet);

[0098] 2.1 Typical Case 1:

[0099] Ms. He, 63 years old, was diagnosed with type 2 diabetes in Shandong Hospital. The highest fasting blood sugar value reached 12.1mmol / L. She used gliclazide as prescribed by the doctor. The fasting blood sugar measured before medication was 9.0mmol / L, blood pressure was 90-150mmHg, and weight was 131 catties. One month after medication, fasting blood sugar was 6.2mmol / L, weight was 130 catties, and blood sugar returned to normal. She continued to take the medication for one year, and fasting blood sugar could be controlled at 5.5-6.5mmol / L; but after taking the medication for 6 months, she developed symptoms such as nausea and dizziness;

[0100] On August 10, 2020, he ensured to take the medicine normally every day, and took one tablet of the above-mentioned lozenge before going to bed every day. He continued to take it for 2 weeks. The nausea symptoms improved significantly, and the fasting blood sugar test was 4.5-5.2mmol / L.

[0101] 2.2 Typical Case 2:

[0102] Ms. Zhu, 55 years old, was diagnosed with type 2 diabetes for one year. She took metformin as prescribed by the doctor to control the condition. She had complications such as dizziness, blurred vision, numbness of hands and feet, dry mouth, frequent urination at night, and poor sleep quality. After taking western medicine to control the condition, her fasting blood sugar was 5-6mmol / L, and her blood sugar was 5.5-6.5mmol / L 2 hours after a meal. Later, the side effects were high, so she stopped taking the medication and took three tablets of the above-mentioned lozenges daily. For three consecutive months, her fasting blood sugar was detected at 4.5-6mmol / L, and her blood sugar was below 7.8mmol / L 2 hours after a meal. The complications were basically eliminated.

[0103] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A buccal tablet composition for adjuvant treatment of diabetes, characterized in that: The composition is composed of the following raw materials in parts by weight: 3-6 parts of bee pollen, 0.2-0.5 parts of propolis, 1-2 parts of freeze-dried royal jelly powder, 1-4 parts of cooked kudzu root powder, 4-8 parts of fermented material, and 4-6 parts of inulin; The fermented material is prepared by fermenting mulberry leaves and bitter melon by fermenting Lactobacillus mucilaginosus and Kluyveromyces marxianus.

2. The buccal tablet composition according to claim 1, characterized in that The preparation method of the propolis comprises the following steps: S1-1, weigh the raw rubber, freeze it, and crush it into 10-20 mesh particles for later use; S1-2, adding the above particles to a 95% alcohol solution at a volume-to-liquid ratio of 1:4, leaving the solution at room temperature for 72 hours, and filtering through three layers of filter cloth to obtain a first extract and a first residue for later use; S1-3, adding 85% alcohol solution to the first residue at a volume-to-liquid ratio of 1:4, leaving it at room temperature for 72 hours, and filtering it through three layers of filter cloth to obtain a second extract and a second residue for later use; S1-4, adding 75% alcohol solution to the second residue at a volume-to-liquid ratio of 1:4, leaving it at room temperature for 72 hours, and then filtering it through three layers of filter cloth to obtain a third extract for later use; S1-5, combining the first extract, the second extract and the third extract, and letting them stand at 0-4°C for 72 hours, and then filtering the supernatant through three layers of gauze to obtain a propolis filtrate for later use; S1-6. Evacuate the propolis filtrate at a vacuum degree of -0.08MPa to -0.1MPa, control the temperature at 45 to 60°C, evaporate and remove excess water to obtain propolis.

3. The buccal tablet composition according to claim 1, characterized in that The preparation method of the cooked kudzu root powder comprises the following steps: S2-1, peel the fresh kudzu root, immerse it in water and cook for 30-40 minutes, grind it into pulp with water after cooling, and prepare the cooked pulp for later use; S2-2, filtering the cooked slurry, allowing the filtrate to stand at 5-15°C for 8-10 hours, separating the precipitate, and drying the precipitate at 25-35°C and then crushing it to obtain cooked kudzu root powder.

4. The buccal tablet composition according to claim 1, characterized in that The preparation method of the fermentation material comprises the following steps: S3-1, preparing mulberry leaves and bitter melon in a mass ratio of 2:3, and grinding the mulberry leaves and bitter melon with water to form mulberry leaf slurry and bitter melon slurry for later use; S3-2, inoculating the fermented mucus lactobacillus into the mulberry leaf slurry, fermenting for 12-24 hours, and then inoculating Kluyveromyces marxianus to continue fermenting for 16-20 hours to obtain the first fermentation material for standby use; S3-3, adding the bitter melon slurry to the first fermentation material, and continuing the fermentation process for 4-8 hours to obtain the second fermentation material for standby use; S3-4. Place the second fermentation material at a pressure of 2-4Mpa and a temperature of 109-115°C and stir for 10-15 minutes, then take it out, squeeze and filter it, concentrate and freeze-dry the filtrate to obtain the fermentation material.

5. The buccal tablet composition according to claim 4, characterized in that: In step S3-2, the inoculation amount of the fermented mucus lactobacillus inoculated into the mulberry leaf slurry is 0.05%-0.1% of the total mass of the mulberry leaf slurry, and the number of viable bacteria of the fermented mucus lactobacillus is 10 6 -10 8 Pieces / g.

6. The buccal tablet composition according to claim 4, characterized in that: The amount of Kluyveromyces marxianus inoculated in step S3-2 is 0.02%-0.05% of the total mass of the mulberry leaf slurry, and the number of live bacteria of Kluyveromyces marxianus is 10 7 -10 10 Pieces / g.

7. The buccal tablet composition according to claim 1, characterized in that: The royal jelly lyophilized powder contains ≥6.0% royal jelly decanoic acid.

8. A method for preparing the buccal tablet composition according to any one of claims 1 to 7, characterized in that: The preparation method comprises the following steps: (1) breaking the bee pollen wall by an ultra-fine wall-breaking pulverizer to obtain broken wall powder for later use; (2) adding water to the above-mentioned broken cell powder and cooked kudzu root powder and stirring evenly to obtain a mixture for later use; (3) adding water to the propolis, fermented material, and inulin to adjust the humidity to 20%-30%, and mixing to obtain a wet material for later use; (4) adding the wet material to the mixed material, stirring thoroughly, and then drying and crushing to obtain a mixed powder; (5) The mixed powder is compressed into tablets to prepare a buccal tablet composition.

9. The preparation method according to claim 8, characterized in that: In the step (2), the material-liquid ratio of the wall-broken powder, the cooked kudzu root powder, the water and the stirring is 1:2-3.

10. The preparation method according to claim 8, characterized in that: The drying and pulverizing method in step (4) is to dry the product at a temperature of 30-35° C. until the moisture content is less than 8%, and then pulverize the product through an 80-mesh sieve.