Filtering equipment for biological pharmacy

Abstract

The invention discloses filtering equipment for biopharmacy, and relates to the technical field of biopharmacy filtering. The device comprises a filtering frame, a water inlet disc and a plurality of groups of membrane bags, the water inlet disc and the membrane bags can be stacked and pressed in the filtering frame, a water inlet cavity and a water drainage cavity are formed in the water inlet disc, a water inlet pipe and a water drainage pipe are arranged on the outer side of the water inlet disc, the water inlet pipe is communicated with the water inlet cavity, and the water drainage pipe is communicated with the water drainage cavity. And a deep filter element is fixedly mounted in the membrane bag. By controlling an adjusting ring plate to slide downwards, the adjusting ring plate extrudes an air ring, the air pressure in the air ring is increased, the air pressure is larger than the elastic force of a tension spring and a top spring, the air pressure pushes a valve plate to block a water outlet and drives a connecting ring to rise to be away from a second water guide hole below and away from a one-way rubber valve plate, and at the moment, the membrane bag and the membrane bag above do not participate in filtering; only the lower membrane bag participates in filtering and does not need to be disassembled, so that the use is convenient.

Description

Technical Field

[0001] The invention relates to the technical field of biopharmaceutical filtration, and in particular to a filtration device used for biopharmaceuticals. Background Art

[0002] In the biopharmaceutical industry, deep filtration is often used to remove large particles such as cell residues, suspended solids, protein fragments, fermentation residues, etc. It is usually used as part of post-fermentation treatment to help reduce the impurity load in subsequent purification steps. Deep filtration refers to the formation of filter cakes on the surface of the medium by particles larger than the pores of the medium. Particles smaller than the pores of the medium cannot form filter cakes on the surface of the filter medium. These particles enter the interior of the medium, approach the pore wall by inertia and diffusion, and settle under the action of static electricity, thereby separating from the fluid.

[0003] The utility model patent with announcement number CN220939389U discloses a stacked deep filter. This deep filter and the existing deep filter are both stacked for use. According to actual needs, different numbers of filter elements can be selected to be stacked together to form a stacked filter, and the filter elements are squeezed through the outer shell to form a seal, and the squeezing pressure is fed back through the hydraulic pressure. In actual use, pressure is applied from the top through the hydraulic cylinder. Since there are a large number of stacked filter elements, once one of them is tilted, it is easy to cause the filter element to fail to be effectively sealed. At the same time, when the number of filter elements needs to be changed, the equipment needs to be depressurized first, and then the corresponding number of filter elements are removed, and finally pressure is applied again. The operation steps are cumbersome and it is inconvenient to adjust the number of filter elements to be used. Summary of the invention

[0004] In order to solve the above problems, the present invention provides a filtering device for biopharmaceuticals.

[0005] In order to achieve the above-mentioned purpose, the present invention specifically adopts the following technical solutions: A filtering device for biopharmaceuticals, comprising a filter frame, a water inlet tray and a plurality of membrane packages, wherein the water inlet tray and the membrane packages can be stacked and pressed in the filter frame, a water inlet cavity and a water discharge cavity are provided inside the water inlet tray, a water inlet pipe and a water discharge pipe are provided outside the water inlet tray, the water inlet pipe is connected to the water inlet cavity, and the water discharge pipe is connected to the water discharge cavity; A deep filter element is fixedly installed inside the membrane package, and a water guide hole 2 is opened inside the deep filter element. A joint is provided on the top of the membrane package and the water inlet tray, and a connecting groove is opened at the bottom of the membrane package. An adjusting ring plate is slidably connected inside the connecting groove, and an air ring is fixedly installed at the bottom of the adjusting ring plate. A drain port and a water guide hole 1 are opened through the inner bottom of the membrane package. When the water inlet tray and the membrane package are stacked, the water guide hole 1 and the water guide hole 2 are connected with the water inlet cavity. A valve groove is opened on the inner wall of the drain port, and a telescopic air hole is opened on the inner wall of the valve groove. A valve plate is slidably connected inside the valve groove, and the valve plate can block the drain port. A piston rod is arranged on the outer side of the valve plate, and the piston rod is sealingly slidably connected in the telescopic air hole, and a tension spring is arranged between the valve plate and the inner wall of the valve groove; The inner wall of the water guide hole 1 is provided with a mounting ring, a transmission air cylinder is fixedly installed on the top of the mounting ring, a connecting ring is fixedly installed on the bottom of the telescopic end of the transmission air cylinder, a top spring is provided between the connecting ring and the mounting ring, when multiple groups of membrane packages are stacked, a water flow cavity is provided between the lower deep filter element and the bottom of the upper membrane package, and the height of the connecting ring is greater than the height of the water flow cavity, a one-way rubber valve sheet is provided at the bottom of the water guide hole 1, and the one-way rubber valve sheet can be opened when the connecting ring descends, and the telescopic air hole and the transmission air cylinder are connected to the air ring through the air pipe.

[0006] Furthermore, the filter frame includes a chassis, three groups of guide columns are fixedly installed on the top of the chassis, a top plate is fixedly installed on the top of the three groups of guide columns, a hydraulic cylinder is fixedly installed on the top of the top plate, an exhaust pressure plate is fixedly installed on the bottom of the telescopic end of the hydraulic cylinder, an exhaust hole is provided on the top of the exhaust pressure plate, and the exhaust pressure plate can be sealed and pressed on the top of the membrane package.

[0007] Furthermore, a locking plate is slidably connected to the top of the exhaust pressure plate, three groups of guide holes are opened inside the locking plate, guide posts pass through the guide holes, the cross-section of the guide holes is cam-shaped, and multiple groups of grooves are opened on the outside of the guide posts, and the outer diameter of the grooves is the same as the minimum radius of the guide holes. A locking hydraulic cylinder is fixedly installed on the top of the exhaust pressure plate, and the telescopic end of the locking hydraulic cylinder is fixedly connected to the locking plate.

[0008] Furthermore, a transmission cavity is provided inside the membrane package, a threaded hole is provided between the transmission cavity and the connecting groove, an adjusting screw is connected to the internal thread of the threaded hole, the adjusting screw is rotatably installed on the adjusting ring plate, a bevel gear is rotatably installed on the inner wall of the transmission cavity, the bevel gear is sleeved on the adjusting screw, a guide groove is provided on the outer side of the adjusting screw, a guide block is provided on the inner wall of the bevel gear, the guide block is slidably connected in the guide groove, a driving gear ring and a driving wheel are rotatably installed on the inner wall of the transmission cavity, the bevel gear and the driving wheel are respectively meshed below and above the driving gear ring.

[0009] Furthermore, a water pressure gauge is fixedly installed on the outside of the water inlet pipe.

[0010] Furthermore, a rocker is rotatably mounted on the outer side of the membrane package, and the rocker is fixedly connected to the driving wheel.

[0011] Furthermore, a driving motor is fixedly installed on the outer side of the membrane package, the output end of the driving motor is connected to the driving wheel, and the driving motor is electrically connected to the water pressure gauge through a PLC controller.

[0012] Furthermore, a barometer is provided on the outside of the membrane package, and the barometer is used to detect the air pressure inside the balloon.

[0013] Furthermore, three groups of positioning pieces are provided on the outer sides of the water inlet tray and the membrane package, and the positioning pieces can be inserted and sleeved on the guide pillars.

[0014] The beneficial effects of the present invention are as follows: 1. The present invention provides an air ring. When stacking membrane packages, the lower joint is inserted into the upper connection groove, and the joint squeezes the air ring. The air ring can not only improve the sealing between adjacent membrane packages, but also use the feedback of the internal air pressure of the air ring to accurately judge the sealing effect of each membrane package and ensure the overall sealing.

[0015] 2. The present invention controls the adjustment ring plate to slide downward, and the adjustment ring plate squeezes the air ring. The air pressure inside the air ring increases, and the air pressure is greater than the elastic force of the tension spring and the top spring. The air pressure pushes the valve plate to block the drain outlet, and drives the connecting ring to rise away from the second water guide hole below and away from the one-way rubber valve plate. At this time, the membrane package and the membrane package above it do not participate in the filtration, and only the membrane package below participates in the filtration. There is no need to disassemble the membrane package, and it is easy to use.

[0016] 3. The present invention enables the treated liquid to flow upward through water guide hole 1 and water guide hole 2 through the arrangement of the water inlet tray and the membrane package. The treated liquid passes through the deep filter element from top to bottom. The top deep filter element is first involved in the filtration and is also the first to be blocked. Combined with the arrangement of the blocking function of a single membrane package, the use time of the device can be greatly extended, and the filtration efficiency is high. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 It is a schematic diagram of the structure of the filter frame of the present invention; Figure 3 This is a schematic diagram of the stacking of the water inlet tray and the membrane package of the present invention; Figure 4 The present invention Figure 3 Schematic diagram of the cross-section structure; Figure 5 It is a schematic diagram of the structure of the water inlet tray of the present invention; Figure 6 It is a schematic diagram of the membrane package structure of the present invention; Figure 7 It is a schematic diagram of the cross-sectional structure of the membrane package of the present invention; Figure 8 The present invention Figure 7 Enlarged schematic diagram of part A in the middle.

[0018] Figure numerals: 1, chassis; 2, guide column; 21, groove; 3, top plate; 4, hydraulic cylinder; 5, exhaust pressure plate; 51, locking hydraulic cylinder; 6, locking plate; 61, guide hole; 7, water inlet plate; 71, water inlet cavity; 72, drainage cavity; 73, water inlet pipe; 74, drainage pipe; 75, water pressure gauge; 8, membrane package; 81, joint; 82, connection groove; 83, air ring; 84, adjusting ring plate; 85, bevel gear; 8 6. Adjusting screw; 87. Driving gear ring; 88. Driving wheel; 89. Rocker; 810. Drain port; 811. Valve slot; 812. Telescopic air hole; 813. Valve plate; 814. Tension spring; 815. Piston rod; 816. Water guide hole 1; 817. One-way rubber valve plate; 818. Transmission air cylinder; 819. Connecting ring; 820. Top spring; 821. Pressure gauge; 9. Deep filter element; 91. Water guide hole 2. DETAILED DESCRIPTION

[0019] To make the purpose, technical solution and advantages of the embodiments of the present invention more clear, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Embodiment 1

[0020] like Figure 1-Figure 8 As shown, a filtering device for biopharmaceuticals includes a filter frame, a water inlet tray 7 and a plurality of membrane packages 8. The water inlet tray 7 and the membrane packages 8 can be stacked and pressed in the filter frame. A water inlet cavity 71 and a drainage cavity 72 are provided inside the water inlet tray 7. A water inlet pipe 73 and a drainage pipe 74 are provided outside the water inlet tray 7. The water inlet pipe 73 is connected to the water inlet cavity 71, and the drainage pipe 74 is connected to the drainage cavity 72. A deep filter element 9 is fixedly installed inside the membrane package 8, and a water guide hole 91 is opened inside the deep filter element 9. A joint 81 is provided on the top of the membrane package 8 and the water inlet tray 7. A connection groove 82 is opened at the bottom of the membrane package 8. An adjusting ring plate 84 is slidably connected inside the connection groove 82. An air ring 83 is fixedly installed at the bottom of the adjusting ring plate 84. A drainage port 810 and a water guide hole 816 are opened through the inner bottom of the membrane package 8. When the water inlet tray 7 and the membrane package 8 are stacked, the water guide hole 816 The drain port 810 is connected to the water guide hole 91 and the water inlet chamber 71. A valve slot 811 is provided on the inner wall of the drain port 810. A telescopic air hole 812 is provided on the inner wall of the valve slot 811. A valve plate 813 is slidably connected inside the valve slot 811. The valve plate 813 can block the drain port 810. A piston rod 815 is provided on the outer side of the valve plate 813. The piston rod 815 is sealingly slidably connected in the telescopic air hole 812. A tension spring 814 is provided between the valve plate 813 and the inner wall of the valve slot 811. A mounting ring is provided on the inner wall of the water guide hole 816, a transmission air cylinder 818 is fixedly installed on the top of the mounting ring, a connecting ring 819 is fixedly installed on the bottom of the telescopic end of the transmission air cylinder 818, a top spring 820 is provided between the connecting ring 819 and the mounting ring, when multiple groups of membrane packages 8 are stacked, a water flow cavity is provided between the lower deep filter element 9 and the bottom of the upper membrane package 8, and the height of the connecting ring 819 is greater than the height of the water flow cavity, a one-way rubber valve plate 817 is provided at the bottom of the water guide hole 816, and the one-way rubber valve plate 817 can be opened when the connecting ring 819 descends, and the telescopic air hole 812 and the transmission air cylinder 818 are connected to the air ring 83 through the air pipe.

[0021] During installation, the water inlet tray 7 is placed at the bottom, and then the membrane packages 8 are stacked on the water inlet tray 7 in sequence. The lower joint 81 is inserted into the upper connection groove 82, and the upper connecting ring 819 is simultaneously inserted into the upper water guide hole 1 816 and the lower water guide hole 2 91. The water guide hole 1 816 and the water guide hole 2 91 are connected to the water inlet cavity 71. The setting of the air ring 83 can improve the sealing between adjacent membrane packages 8. At the same time, the air pressure feedback inside the air ring 83 can accurately judge the sealing of each membrane package 8 to ensure the overall sealing. When in use, treated water enters the water inlet chamber 71 through the water inlet pipe 73, and the water flows through the water inlet chamber 71, the first water guide hole 816 and the second water guide hole 91 to the topmost deep filter element 9, and then the water flows through the topmost deep filter element 9 after being filtered, and then discharged into the next layer of deep filter element 9 through the top drainage port 810, and finally enters the drainage chamber 72 through the bottom drainage port 810, and then is discharged through the drainage pipe 74, completing the deep filtration; When the number of filtration layers needs to be adjusted, the adjustment ring plate 84 in the membrane package 8 above the corresponding layer is controlled to descend, and the adjustment ring plate 84 squeezes the air ring 83. The air pressure in the air ring 83 increases, and the air pressure inside the telescopic air hole 812 and the transmission air cylinder 818 increases through the air pipe. The air pressure is greater than the elastic force of the tension spring 814 and the top spring 820. The air pressure pushes the piston rod 815 to slide, and the piston rod 815 pushes the valve plate 813 to block the drain port 810. The transmission air cylinder 818 drives the connecting ring 819 to rise, and the connecting ring 819 moves away from the lower water guide hole 91 and the one-way rubber valve sheet. 817, the one-way rubber valve plate 817 is restored, limiting the water flow from the bottom through the water guide hole 816. At this time, the drainage port 810 and the water guide hole 816 of the corresponding upper membrane package 8 are blocked. At the same time, when multiple groups of membrane packages 8 are stacked, a water flow cavity is set between the lower deep filter element 9 and the bottom of the upper membrane package 8. Therefore, when the connecting ring 819 rises, the water flow cavity is connected to the lower water guide hole 91. Therefore, the subsequent water flows into the water flow cavity and is filtered downward from the deep filter element 9 of this layer. The filter layer switching can be completed quickly without disassembling the device, which is convenient to use; Since the filtering method of the present invention is from top to bottom, the upper deep filter element 9 is blocked first, and the layer number control method of the present invention is also controlled from top to bottom, so when the top is blocked, the top deep filter element 9 is cut off, and the next layer serves as the top layer, which can increase the service life of the device and improve the filtering effect; It should be noted that the shells of the water inlet tray 7, the membrane package 8 and the deep filter element 9 of the present invention are all made of polypropylene (PP), which has the following characteristics: good chemical stability, acid and alkali resistance, suitable for low temperature and low pressure environment, relatively light, excellent corrosion resistance, and suitable for processing corrosive solutions. At the same time, the inner diameters of the telescopic air hole 812 and the transmission air cylinder 818 are both small, and only a small amount of gas is needed to complete the transmission, and the transmission speed is high.

[0022] Furthermore, a pressure gauge 821 is provided on the outside of the membrane package 8, and the pressure gauge 821 is used to monitor the internal air pressure of the air ring 83. The provision of the pressure gauge 821 facilitates observation of the internal air pressure of the air ring 83.

[0023] Furthermore, three sets of positioning pieces are provided on the outer sides of the water inlet tray 7 and the membrane package 8, and the positioning pieces can be inserted and sleeved on the guide pillars 2, so that stacking is convenient. Embodiment 2

[0024] On the basis of the above embodiment, the filter frame also includes a chassis 1, three groups of guide pillars 2 are fixedly installed on the top of the chassis 1, a top plate 3 is fixedly installed on the top of the three groups of guide pillars 2, a hydraulic cylinder 4 is fixedly installed on the top of the top plate 3, an exhaust pressure plate 5 is fixedly installed on the bottom of the telescopic end of the hydraulic cylinder 4, an exhaust hole is provided on the top of the exhaust pressure plate 5, and the exhaust pressure plate 5 can be sealed and pressed on the top of the membrane package 8.

[0025] During installation, place the water inlet tray 7 at the bottom, and then stack the membrane packages 8 on the water inlet tray 7 in sequence, the lower joint 81 is inserted into the upper connection groove 82, and the upper connecting ring 819 is simultaneously inserted into the upper water guide hole 1 816 and the lower water guide hole 2 91, the water guide hole 1 816 and the water guide hole 2 91 are connected to the water inlet chamber 71, and then control the operation of the hydraulic cylinder 4, and the hydraulic cylinder 4 drives the exhaust pressure plate 5 to seal and press on the top of the uppermost membrane package 8. Embodiment 3

[0026] On the basis of the above embodiment, it also includes that the top of the exhaust pressure plate 5 is slidably connected with a locking plate 6, three groups of guide holes 61 are opened inside the locking plate 6, the guide column 2 passes through the guide hole 61, the cross-section of the guide hole 61 is cam-shaped, and the outer side of the guide column 2 is provided with multiple groups of grooves 21, the outer diameter of the groove 21 is the same as the minimum radius of the guide hole 61, and a locking hydraulic cylinder 51 is fixedly installed on the top of the exhaust pressure plate 5, and the telescopic end of the locking hydraulic cylinder 51 is fixedly connected to the locking plate 6.

[0027] During installation, place the water inlet tray 7 at the bottom, and then stack the membrane packages 8 on the water inlet tray 7 in sequence, the lower joint 81 is inserted into the upper connection groove 82, and the upper connecting ring 819 is simultaneously inserted into the upper water guide hole 1 816 and the lower water guide hole 2 91, the water guide hole 1 816 and the water guide hole 2 91 are connected to the water inlet chamber 71, and then control the hydraulic cylinder 4 to operate, the hydraulic cylinder 4 drives the exhaust pressure plate 5 to seal and press on the top of the uppermost membrane package 8, and then control the locking hydraulic cylinder 51 to operate, the locking hydraulic cylinder 51 drives the locking disk 6 to slide, the minimum radius of the locking disk 6 is inserted into the groove 21, the locking disk 6 is locked on the guide column 2, the device is locked, and the stability of the device is improved. Embodiment 4

[0028] On the basis of the above embodiment, it also includes that a transmission cavity is opened inside the membrane package 8, a threaded hole is opened between the transmission cavity and the connecting groove 82, an adjusting screw 86 is connected to the internal thread of the threaded hole, the adjusting screw 86 is rotatably installed on the adjusting ring plate 84, a bevel gear 85 is rotatably installed on the inner wall of the transmission cavity, the bevel gear 85 is sleeved on the adjusting screw 86, a guide groove is opened on the outer side of the adjusting screw 86, a guide block is provided on the inner wall of the bevel gear 85, the guide block is slidably connected in the guide groove, a driving gear ring 87 and a driving wheel 88 are rotatably installed on the inner wall of the transmission cavity, and the bevel gear 85 and the driving wheel 88 are respectively meshed at the bottom and top of the driving gear ring 87.

[0029] By controlling the driving wheel 88 to rotate, the driving wheel 88 drives the driving gear ring 87 to rotate, the driving gear ring 87 drives the bevel gear 85 to rotate, and the bevel gear 85 drives the adjusting screw 86 to rotate. The adjusting screw 86 pushes the adjusting ring plate 84 down under the action of the threaded hole, and the adjusting ring plate 84 squeezes the air ring 83. The adjusting screw 86 and the bevel gear 85 can be arranged in a ring, so that the adjusting ring plate 84 is subjected to uniform and stable force, and multiple groups of bevel gears 85 can mesh with the driving gear ring 87 at the same time, and the transmission is stable. Embodiment 5

[0030] On the basis of the above embodiment, a water pressure gauge 75 is fixedly installed on the outside of the water inlet pipe 73. The water pressure gauge 75 is arranged to facilitate observation of the water pressure inside the device, and the clogging condition of the deep filter element 9 can be analyzed through the water pressure. Embodiment 6

[0031] On the basis of the above embodiment, a rocker 89 is rotatably installed on the outer side of the membrane package 8, and the rocker 89 is fixedly connected to the driving wheel 88. Through the setting of the rocker 89, it is convenient to drive the driving wheel 88 to rotate. The operator observes the data of the water pressure gauge 75 and manually isolates the deep filter element 9 above. Embodiment 7

[0032] On the basis of the above embodiment, a drive motor is fixedly installed on the outside of the membrane package 8, the output end of the drive motor is connected to the drive wheel 88, and the drive motor is electrically connected to the water pressure gauge 75 through a PLC controller. Through the arrangement of this embodiment, no manual control is required. According to the data feedback from the water pressure gauge 75, the deep filter element 9 above is automatically isolated without manual interference, and the control is convenient.

[0033] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A filtering device for biopharmaceuticals, comprising a filter frame, a water inlet tray (7) and a plurality of membrane packages (8), characterized in that: The water inlet tray (7) and the membrane package (8) can be stacked and pressed tightly in the filter frame, the water inlet tray (7) is provided with a water inlet cavity (71) and a water discharge cavity (72), the outside of the water inlet tray (7) is provided with a water inlet pipe (73) and a water discharge pipe (74), the water inlet pipe (73) is connected to the water inlet cavity (71), and the water discharge pipe (74) is connected to the water discharge cavity (72); A deep filter element (9) is fixedly installed inside the membrane package (8), and a water guide hole (91) is provided inside the deep filter element (9). A joint (81) is provided on the top of the membrane package (8) and the water inlet tray (7). A connection groove (82) is provided at the bottom of the membrane package (8). An adjusting ring plate (84) is slidably connected inside the connection groove (82), and an air ring (83) is fixedly installed at the bottom of the adjusting ring plate (84). A drainage port (810) and a water guide hole (816) are provided through the inner bottom of the membrane package (8). When the water inlet tray (7) and the membrane package (8) are stacked, the water guide hole (81) is provided in a manner that allows the water to flow freely. The first hole (816) and the second water guide hole (91) are connected to the water inlet chamber (71); the inner wall of the drain port (810) is provided with a valve slot (811); the inner wall of the valve slot (811) is provided with a telescopic air hole (812); a valve plate (813) is slidably connected inside the valve slot (811); the valve plate (813) can block the drain port (810); a piston rod (815) is provided on the outer side of the valve plate (813); the piston rod (815) is sealingly slidably connected in the telescopic air hole (812); a tension spring (814) is provided between the valve plate (813) and the inner wall of the valve slot (811); The inner wall of the water guide hole 1 (816) is provided with a mounting ring, a transmission air cylinder (818) is fixedly mounted on the top of the mounting ring, a connecting ring (819) is fixedly mounted on the bottom of the telescopic end of the transmission air cylinder (818), a top spring (820) is provided between the connecting ring (819) and the mounting ring, when multiple groups of membrane packages (8) are stacked, a water flow cavity is provided between the bottom of the lower deep filter element (9) and the upper membrane package (8), and the height of the connecting ring (819) is greater than the height of the water flow cavity, a one-way rubber valve plate (817) is provided at the bottom of the water guide hole 1 (816), and the one-way rubber valve plate (817) can be opened when the connecting ring (819) descends, and the telescopic air hole (812) and the transmission air cylinder (818) are both connected to the air ring (83) through an air pipe.

2. A filtering device for biopharmaceuticals according to claim 1, characterized in that: The filter frame comprises a chassis (1), three groups of guide pillars (2) are fixedly mounted on the top of the chassis (1), a top plate (3) is fixedly mounted on the top of the three groups of guide pillars (2), a hydraulic cylinder (4) is fixedly mounted on the top of the top plate (3), an exhaust pressure plate (5) is fixedly mounted on the bottom of the telescopic end of the hydraulic cylinder (4), an exhaust hole is arranged on the top of the exhaust pressure plate (5), and the exhaust pressure plate (5) can be sealed and pressed on the top of the membrane package (8).

3. A filtering device for biopharmaceuticals according to claim 2, characterized in that: The top of the exhaust pressure plate (5) is slidably connected to a locking plate (6), three groups of guide holes (61) are provided inside the locking plate (6), the guide pillars (2) pass through the guide holes (61), the cross-section of the guide holes (61) is cam-shaped, the outer side of the guide pillars (2) is provided with multiple groups of grooves (21), the outer diameter of the grooves (21) is the same as the minimum radius of the guide holes (61), and a locking hydraulic cylinder (51) is fixedly installed on the top of the exhaust pressure plate (5), and the telescopic end of the locking hydraulic cylinder (51) is fixedly connected to the locking plate (6).

4. A filtering device for biopharmaceuticals according to claim 1, characterized in that: A transmission cavity is provided inside the membrane package (8), a threaded hole is provided between the transmission cavity and the connection groove (82), an adjusting screw (86) is threadedly connected to the inner thread of the threaded hole, the adjusting screw (86) is rotatably mounted on the adjusting ring plate (84), a bevel gear (85) is rotatably mounted on the inner wall of the transmission cavity, the bevel gear (85) is sleeved on the adjusting screw (86), a guide groove is provided on the outer side of the adjusting screw (86), a guide block is provided on the inner wall of the bevel gear (85), the guide block is slidably connected in the guide groove, a driving gear ring (87) and a driving wheel (88) are rotatably mounted on the inner wall of the transmission cavity, the bevel gear (85) and the driving wheel (88) are respectively meshed below and above the driving gear ring (87).

5. A filtering device for biopharmaceuticals according to claim 4, characterized in that: A water pressure gauge (75) is fixedly mounted on the outer side of the water inlet pipe (73).

6. A filtering device for biopharmaceuticals according to claim 5, characterized in that: A rocker (89) is rotatably mounted on the outer side of the membrane package (8), and the rocker (89) is fixedly connected to the driving wheel (88).

7. The filtering device for biopharmaceuticals according to claim 5, characterized in that: A drive motor is fixedly mounted on the outside of the membrane package (8); an output end of the drive motor is connected to a drive wheel (88); and the drive motor is electrically connected to a water pressure gauge (75) via a PLC controller.

8. A filtering device for biopharmaceuticals according to any one of claims 1 to 7, characterized in that: A pressure gauge (821) is provided on the outside of the membrane package (8), and the pressure gauge (821) is used to detect the internal air pressure of the air ring (83).

9. A filtering device for biopharmaceuticals according to any one of claims 1 to 7, characterized in that: The outer sides of the water inlet tray (7) and the membrane package (8) are each provided with three sets of positioning pieces, and the positioning pieces can be inserted and sleeved on the guide pillars (2).

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