Oil-soluble whitening composition with good light stability as well as preparation and application of oil-soluble whitening composition

Abstract

The invention relates to an oil-soluble whitening composition as well as preparation and application thereof. The composition is prepared from the following raw material components in parts by weight: 5 to 15 parts of phenylethyl resorcinol, 60 to 95 parts of an oily solvent, 0.1 to 0.3 part of silica silylate, 0.1 to 2.5 parts of isoamyl p-methoxycinnamate, 1 to 15 parts of 2-ethylhexyl syringyl malonate and 0.1 to 2.5 parts of an antioxidant. Compared with the prior art, the whitening composition disclosed by the invention can be basically not changed under daily irradiation, and can provide a lasting protection effect for phenylethyl resorcinol when being used in products for whitening and the like.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics and relates to an oil-soluble whitening composition with good light stability and a preparation method and application thereof. Background Art

[0002] As people's living standards improve, they pay more and more attention to adverse skin problems such as dull skin, pigmentation, and spots. Improving skin color has become an area that contemporary people pay more and more attention to, and the research and development of skin care products with whitening effects has also received much attention.

[0003] Phenylethyl Resorcinol (PER) is an organic compound commonly used as a whitening ingredient in cosmetics. It reduces the production of melanin by inhibiting the activity of tyrosinase, thereby achieving a whitening effect. In cosmetics, phenylethyl resorcinol is mainly used to brighten the skin, reduce pigmentation, and inhibit the activity of melanocytes. However, phenylethyl resorcinol is unstable under conditions such as light and is easily oxidized and discolored, which has become a major factor limiting its further application.

[0004] For example, Chinese patent CN202211286669.2 discloses a whitening composite microemulsion cosmetic intermediate and its application, wherein the whitening composite microemulsion cosmetic intermediate includes the following components by weight: PPG-6 decyl tetradecanol polyether-3022-25 parts, 1,2-hexanediol 20-30 parts, 4-7.5 parts of rosewood bark extract, 8-12 parts of phenethyl resorcinol, 13-22 parts of isononanoate and 2-6 parts of polyethylene glycol-8. This patent also does not consider the stability of phenethyl resorcinol under light, and cannot guarantee that the product will not change during storage. Summary of the invention

[0005] The purpose of the present invention is to provide an oil-soluble whitening composition and its preparation and application, which can basically remain unchanged under daily irradiation and can provide a lasting protective effect for phenylethyl resorcinol when used in whitening products.

[0006] The purpose of the present invention can be achieved by the following technical solutions:

[0007] In a first aspect, the present invention provides an oil-soluble whitening composition, comprising the following raw material components in parts by weight: 5 to 15 parts of phenylethylresorcinol, 0.1 to 0.3 parts of silica silylate, 0.1 to 2.5 parts of isopentyl p-methoxycinnamate, 1 to 15 parts of diethylhexyl syringylidenemalonate, and 0.1 to 2.5 parts of an antioxidant.

[0008] Furthermore, it also includes 60 to 95 parts of an oily solvent.

[0009] Furthermore, the oily solvent is caprylic / capric triglyceride or diisopropyl adipate.

[0010] Furthermore, the whitening composition comprises the following raw material components in parts by weight: 10 parts of phenylethylresorcinol, 75.8 parts of oily solvent, 0.2 parts of silica silylate, 2 parts of isopentyl p-methoxycinnamate, 10 parts of diethylhexyl syringylidenemalonate, and 2 parts of antioxidant.

[0011] Furthermore, the antioxidants are tocopherol and propyl gallate.

[0012] In a second aspect, the present invention also provides a method for preparing an oil-soluble whitening composition, first weighing phenylethyl resorcinol and dissolving it in an oily solvent, stirring it evenly under light-proof conditions, then adding silica silylate, isopentyl p-methoxycinnamate, diethylhexyl syringylidenemalonate and an antioxidant, and continuing to mix evenly.

[0013] Furthermore, the stirring process is carried out at room temperature.

[0014] In a third aspect, the present invention provides a use of an oil-soluble whitening composition in a whitening product.

[0015] Furthermore, when the oil-soluble whitening composition is used in whitening products, the added amount is 1-5%.

[0016] Compared with the prior art, the present invention optimizes the functional auxiliary agent component compounded with phenethyl resorcinol, so that the composition formed can be independent of the external stabilizer component and basically does not change within 24 hours under sunlight. Furthermore, when the composition is used in whitening products, it can provide a lasting protective effect for phenethyl resorcinol. DETAILED DESCRIPTION

[0017] The present invention is described in detail below in conjunction with specific embodiments. This embodiment is implemented based on the technical solution of the present invention, and provides a detailed implementation method and a specific operation process, but the protection scope of the present invention is not limited to the following embodiments.

[0018] In the following examples, unless otherwise specified, raw materials or processing techniques are conventional commercially available raw materials or conventional processing techniques in the art.

[0019] Example:

[0020] The invention provides a method for preparing an oil-soluble whitening composition. The method comprises the following steps: firstly weighing phenethyl resorcinol and adding it into caprylic acid / capric acid triglyceride (trade name: GTCC), stirring the mixture evenly under light-proof conditions, then adding silica silylate (trade name: VM-2270), isopentyl p-methoxycinnamate (component B1), diethylhexyl syringylidenemalonate (component B2) and tocopherol (component B3), an antioxidant, and continuing to mix the mixture evenly.

[0021] The addition ratios of all raw materials in each example are shown in Table 1.

[0022] Table 1 Raw material ratios of the compositions of the comparative examples (the units of each raw material are parts by weight)

[0023]

[0024] The performance of the oil-soluble whitening compositions prepared in the above examples was tested.

[0025] Among them, the test process of absorbance value change and ultraviolet absorption is:

[0026] Test samples were prepared according to the composition sample formulas of the above-mentioned embodiments (numbered 1 to 11 in sequence corresponding to the embodiments).

[0027] Place equal amounts of test samples in transparent bottles and simulate sunlight (light source CEL-S500, light intensity 100mW / cm 2 ) for 0 h, 3 h, 8 h, 16 h, and 24 h respectively. The samples were diluted 100 times with anhydrous ethanol and calibrated with anhydrous ethanol as the blank control sample (calibration with blank samples can avoid the influence of the matrix). The ultraviolet absorption of the samples before and after illumination was measured with an enzyme marker, and the changes in absorbance values ​​were recorded.

[0028] The absorbance value at the maximum absorption peak of each test sample (i.e., photoprotectant) is taken for calculation. When testing the combination of photoprotectants, the absorption curve in the range of 290-400nm is scanned by an ultraviolet spectrophotometer, and the absorbance value at the maximum absorption is selected from the absorption curve. The initial absorbance value, i.e., the absorbance value before irradiation, is recorded as A0, and the absorbance value after irradiation is recorded as A1. The calculation method of the absorbance reduction rate ΔA after different irradiation times is as follows:

[0029] ΔA=|1-A1 / A0|*100%. The larger the ΔA, the more light changes there are and the worse the light stability is.

[0030] The test results of the above groups of test samples are shown in Table 2 below.

[0031] Table 2 Performance results of test samples of Example 1-Example 11

[0032]

[0033]

[0034] Table 3 Performance results of the test samples of Examples 12 to 14

[0035]

[0036] Preferably, after 24 hours of sunlight exposure, the absorbance value change is less than 10% of the photoprotectant.

[0037] When a single photoprotectant was used, the absorbance change rates after adding different proportions of isoamyl p-methoxycinnamate and diethylhexyl syringylidenemalonate were all greater than 10% after 24 hours of sunlight irradiation, indicating that the protective effect of a single photoprotectant on phenylethylresorcinol was limited.

[0038] When a combined light protector is used, the absorbance change rate of adding 0.1% p-methoxycinnamic acid, 5% diethylhexyl syringylidene malonate and 0.1% tocopherol is 8.83%, and the absorbance change rate of 0.5% isoamyl p-methoxycinnamate + 10% diethylhexyl syringylidene malonate + 2% tocopherol is 1.53%, which significantly improves the stability of phenethyl resorcinol under light, indicating that the combined use of isoamyl p-methoxycinnamate, diethylhexyl syringylidene malonate and tocopherol has a better protective effect on phenethyl resorcinol.

[0039] In addition, by comparing Example 9 and Example 10 with Example 8, Example 12 to Example 14, etc., it can be seen that under equivalent conditions, the whitening composition using components B1, B2 and B3 has a significantly improved photostability effect compared to other single or two compound whitening compositions. For example, Example 10 has a better effect than Example 8 at a lower total addition amount, which shows that components B1, B2 and B3 have a significant synergistic effect on the photostability of phenylethylresorcinol.

[0040] In general, when the composition of the present invention is used in whitening products, such as the preparation of whitening lotions, it is introduced in the form of replacing the original single whitening ingredient phenylethyl resorcinol in an amount of 1-5wt%. In this way, when exposed to subsequent sunlight, the light stability of phenylethyl resorcinol can be effectively improved, thereby providing long-lasting ultraviolet protection, etc.

[0041] The above description of the embodiments is to facilitate the understanding and use of the invention by those skilled in the art. It is obvious that those skilled in the art can easily make various modifications to these embodiments and apply the general principles described herein to other embodiments without creative work. Therefore, the present invention is not limited to the above embodiments, and improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the present invention should be within the scope of protection of the present invention.

Claims

1. An oil-soluble whitening composition, characterized in that: The invention comprises the following raw material components in parts by weight: 5-15 parts of phenethylresorcinol, 0.1-0.3 parts of silica silylate, 0.1-2.5 parts of isopentyl p-methoxycinnamate, 1-15 parts of diethylhexyl syringylidenemalonate and 0.1-2.5 parts of antioxidant.

2. An oil-soluble whitening composition according to claim 1, characterized in that: The antioxidant is tocopherol.

3. An oil-soluble whitening composition according to claim 1, characterized in that: The invention comprises the following raw material components in parts by weight: 10 parts of phenethyl resorcinol, 75.8 parts of oily solvent, 0.2 parts of silica silylate, 2 parts of isopentyl p-methoxycinnamate, 10 parts of diethylhexyl syringylidenemalonate and 2 parts of antioxidant.

4. An oil-soluble whitening composition according to claim 1, characterized in that: It also includes 60 to 95 parts of an oily solvent.

5. An oil-soluble whitening composition according to claim 4, characterized in that: The oily solvent is caprylic / capric triglyceride.

6. The method for preparing the oil-soluble whitening composition according to any one of claims 1 to 5, characterized in that: First, weigh phenylethyl resorcinol and dissolve it in an oily solvent, stir it evenly under light-proof conditions, then add silica silylate, isopentyl p-methoxycinnamate, diethylhexyl syringylidenemalonate and an antioxidant, and continue to mix evenly.

7. The method for preparing the oil-soluble whitening composition according to claim 6, characterized in that: The stirring process was carried out at room temperature.

8. Use of the oil-soluble whitening composition according to any one of claims 1 to 5 in whitening products.

9. The use of the oil-soluble whitening composition according to claim 8, characterized in that: When the oil-soluble whitening composition is used in whitening products, the added amount is 1 to 5%.

10. The use of the oil-soluble whitening composition according to claim 8, characterized in that: The whitening products are whitening lotion, whitening cream and whitening essence.

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