Plant compound essential oil composition, moisturizing and repairing emollient cream and preparation method of moisturizing and repairing emollient cream

Abstract

The invention discloses a plant compound essential oil composition, a moisturizing and repairing moisturizing cream and a preparation method thereof. The moisturizing and repairing emollient cream comprises a plant compound essential oil composition and composite trace repairing essential oil, wherein the composite trace repairing essential oil is prepared by blending and uniformly mixing an emulsifier combination liquid, glycosylglycerol, butanediol, a gentiana macrophylla extract, a swertia japonica extract, a gentiana scabra bunge extract and triethanolamine according to the mass part ratio of 0.5: 0.5: 0.5: 0.5: 0.5-1.5: 0-1.0: 0-1.0: 0.2. The moisturizing and repairing emollient cream prepared by taking the water-phase composite liquid, the oil-phase composite liquid and the composite trace repairing essential oil as raw materials shows an excellent skin repairing effect.

Description

Technical Field

[0001] The invention belongs to the field of daily cosmetics, and in particular relates to a plant compound essential oil composition, a moisturizing and repairing moisturizing cream and a preparation method thereof. Background Art

[0002] The skin barrier is a protective structure on the surface of the skin, mainly composed of sebum membrane, stratum corneum and microbial community. It can prevent water loss, resist external stimulation and invasion of pathogens, and maintain the health and stability of the skin. When this protective structure is damaged or its function is weakened, it may cause dry skin, sensitivity, red blood streaks, acne, spots and other problems.

[0003] Dry skin refers to the phenomenon that the skin looks and feels rough, itchy, or even flaky or scaly due to lack of sufficient moisture. There are many reasons for dry skin, including cold or dry weather, sunburn, frequent bathing with harsh soaps, natural changes caused by aging, endocrine disorders, and side effects of certain skin diseases or medications. To prevent and relieve dry skin, you can take a variety of measures, such as moisturizing, sun protection, drinking enough water, choosing mild cleansing products, eating a balanced diet, and getting enough sleep.

[0004] Plant compound essential oil is an extract made from a mixture of various natural plant essential oils, which has both aromatherapy and skin care effects. This type of essential oil helps to replenish the intercellular lipids in the skin barrier, especially linoleic acid, which is essential for maintaining the integrity and normal functioning of the skin barrier. Plant essential oils have the effects of sterilization, antiviral, inhibiting fungal growth and allergy relief. They can help regulate the skin's immune system and maintain the balance of the skin's microecology, thereby avoiding barrier damage and infection. In addition, plant compound essential oils can also provide the skin with necessary moisture and nutrients, increase skin moisture content, and improve its dryness and roughness. The water-soluble ingredients can form a water-locking film to reduce water evaporation; while the oil-soluble ingredients can deeply nourish and repair the underlying cells. By adjusting the ratio of oil and water, plant compound essential oils are suitable for all types of skin.

[0005] In general, plant compound essential oils are a relatively natural and effective means of repairing and moisturizing, which can promote the recovery of skin health both internally and externally. Summary of the invention

[0006] In view of the deficiencies in the prior art, the object of the present invention is to provide a plant compound essential oil composition, a moisturizing and repairing moisturizing cream and a preparation method thereof.

[0007] The purpose of the present invention is achieved through the following technical solutions: A plant compound essential oil composition is prepared by mixing, by mass, 66.6 parts of water, 5 parts of glycerin, 5 parts of isononyl isononanoate, 5 parts of argan oil, 5 parts of kiangsuan trifoliate seed oil, 2 parts of wormwood leaf extract, 2 parts of shea butter, 2 parts of polydimethylsiloxane, 2 parts of cetearyl glucoside / cetearyl alcohol, 1-1.5 parts of glyceryl stearate, 1 part of urea, 0.5 part of VE, 0.15-0.25 parts of methylparaben, 0.1-0.15 parts of chlorphenesin, 0.2 parts of propylparaben, 0.2-0.3 parts of acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer and 0.05 parts of sodium hyaluronate.

[0008] Preferably, the plant compound essential oil composition is prepared by mixing, by mass, 66.6 parts of water, 5 parts of glycerin, 5 parts of isononyl isononanoate, 5 parts of argan oil, 5 parts of qingchuan three seed oil, 2 parts of wormwood extract, 2 parts of shea butter, 2 parts of polydimethylsiloxane, 2 parts of cetearyl glucoside / cetearyl alcohol, 1 part of glyceryl stearate, 1 part of urea, 0.5 parts of VE, 0.2 parts of methylparaben, 0.15 parts of chlorphenesin, 0.2 parts of propylparaben, 0.2 parts of acrylic acid (esters) / C10-30 alkyl acrylate crosspolymer and 0.05 parts of sodium hyaluronate.

[0009] Preferably, the Qingchuan three-seed oil is composed of perilla (PERILLA OCYMOIDES) seed oil, camellia (CAMELLIA JAPONICA) seed oil, apricot (PRUNUS ARMENIACA) kernel oil and tocopherol (vitamin E) in a mass ratio of 20~40:30~50:20~40:0.1~0.5.

[0010] A moisturizing and repairing moisturizing cream comprises the above-mentioned plant compound essential oil composition and a composite trace repairing essential oil. The composite trace repairing essential oil is prepared by mixing an emulsifier combination liquid, glycerol glucoside, butylene glycol, a Gentiana macrophylla extract, a Swertia japonica extract, a Gentiana scabra extract and triethanolamine in the mass proportions of 0.5:0.5:0.5:0.5-1.5:0-1.0:0-1.0:0.2 and then uniformly dissolving the mixture.

[0011] Preferably, the composite trace repair essential oil is composed of an emulsifier combination liquid, glycerol glucoside, butylene glycol, gentiana macrophylla extract, swertia japonica extract, gentiana extract and triethanolamine in a mass ratio of 0.5:0.5:0.5:1.5:0.5:0.5:0.2.

[0012] Preferably, the mass ratio of water in the plant compound essential oil composition to the Gentiana macrophylla extract in the composite trace repair essential oil is 66.6:0.5-1.5.

[0013] Preferably, the mass ratio of water in the plant compound essential oil composition to the Gentiana macrophylla extract in the composite trace repair essential oil is 66.6:1.5.

[0014] Preferably, the emulsifier composition liquid is composed of polyacrylamide, C13-14 isoparaffin, laureth-7 and water in a mass ratio of 0.1-2:5-15:0.5-5:78-95.

[0015] The preparation method of the above-mentioned moisturizing and repairing cream comprises the following steps: (1) taking water, urea, sodium hyaluronate, glycerin, Artemisia argyi extract, acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer, methylparaben and chlorphenesin according to the mass ratio, stirring and mixing them evenly to obtain an aqueous phase composite liquid; (2) according to the mass ratio, isononyl isononanoate, argan oil, kiangsuan three seed oil, shea butter, cetearyl glucoside / cetearyl alcohol, dimethicone, glyceryl stearate, VE and propylparaben are mixed and stirred to obtain an oil phase composite liquid; (3) The aqueous phase composite liquid and the oil phase composite liquid are mixed and stirred continuously. During the stirring process, corresponding weight parts of butylene glycol, Gentiana macrophylla extract, Swertia japonica extract, Gentiana scabra extract, emulsifier combination liquid, glycerol glucoside and triethanolamine are added. Stirring is continued until the water and oil phases are fully emulsified.

[0016] Preferably, the stirring rate is 200-400 r / min.

[0017] Preferably, the stirring rate is continued at 600-800 r / min.

[0018] Compared with the prior art, the beneficial effects of the present invention include: The present invention prepares an aqueous composite liquid by compounding a plant compound essential oil composition with a suitable preservative and an antioxidant. In this way, without affecting the efficacy and use experience of the plant compound essential oil, its stability under conventional storage conditions is significantly improved. At the same time, the prepared oil phase composite liquid has little irritation to the skin and is not easy to cause skin allergies, which not only improves safety but also ensures a good use experience. In addition, the added composite trace repair essential oil can effectively promote keratinocyte proliferation. The moisturizing and repairing moisturizing cream prepared with the aqueous composite liquid, the oil phase composite liquid and the composite trace repair essential oil as raw materials shows an excellent skin repair effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 This is a bar graph comparing the effects of the composite trace repair essential oils No. 1 to No. 11 on the survival rate of human immortalized keratinocytes (HaCaT cells).

[0020] Figure 2 This is a bar graph comparing the transepidermal water loss (TEWL) values ​​of the subjects before and after using the product.

[0021] Figure 3 This is a bar graph comparing the difference in transepidermal water loss (TEWL) values ​​between the experimental group and the control group. DETAILED DESCRIPTION

[0022] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0023] For the convenience of subsequent description, the present invention has abbreviated some raw materials, as follows: C2020: Acrylates / C10-30 Alkyl Acrylate Crosspolymer HA: Sodium Hyaluronate Methyl ester: Methylparaben Propyl ester: Propylparaben Artemisia Argi leaf extract M68: Cetearyl Glucoside / Cetearyl Alcohol Monoglyceride: Glyceryl Stearate DC200: Polydimethylsiloxane 305 combination liquid: polyacrylamide, C13-14 isoparaffin, laureth-7, water Annoin: Glyceryl Glucoside TEA: triethanolamine Experiment on the ratio of aqueous phase composite liquid According to the mass proportions described in Table 1, 9 groups of different aqueous phase composite liquids were prepared, and the total mass of each aqueous phase composite liquid was 10 g.

[0024] Table 1 Proportion of aqueous phase composite liquid

[0025] The stability of the above 9 groups of aqueous composite liquids was tested, and the specific testing method was as follows: 4 small samples were prepared for each of the prepared groups 1 to 9, and the samples were stored at 50°C, 4°C, room temperature (25°C), and direct sunlight for 2 months, and their appearance was observed.

[0026] Test results: The samples of groups 1 to 3 became turbid under direct sunlight. The samples of groups 4 and 5 became turbid under 50°C, direct sunlight and room temperature. The samples of groups 6 and 9 were clear and stable under 50°C, direct sunlight and room temperature, without turbidity or deterioration. The samples of groups 7 and 8 produced a small amount of precipitation under direct sunlight, and the samples of groups 7 and 8 were clear and stable under other conditions, without turbidity or deterioration.

[0027] Therefore, in view of the usage, the aqueous phase composite liquids of groups 4, 5, 6, 7, 8 and 9 are better combinations; considering the comprehensive product cost perspective, choosing the composite ratio of group 6 can effectively prevent deterioration.

[0028] Experiment on the ratio of oil phase composite liquid According to the mass ratio described in Table 2, 9 groups of different oil phase composite liquids were prepared, and the total mass of each oil phase composite liquid was 10 g.

[0029] Table 2 Oil phase composite liquid ratio

[0030] The safety of the above 9 groups of oil phase complex liquids was tested in the following specific test method: soak 4 layers of 1cm² gauze of each group of oil phase complex liquids, then place them on the flexor side of the forearm, cover them with a layer of transparent cellophane slightly larger than the gauze, and fix them with adhesive tape for four weeks. After 48 hours, remove the covering and observe the local skin reaction. At 48 hours and 72 hours, the local skin manifestations were interpreted according to the standards in Table 3 to evaluate the safety of each matrix sample.

[0031] Table 3 Safety test standards

[0032] Test results: After 48 hours and 72 hours of testing, the local skin of the samples in Group 4 did not show any erythema, sensitivity or redness compared to the untested skin, and was graded as Level 0. The local skin of the samples in Group 5 showed slight erythema, which was graded as Level 1. The local skin of the samples in Groups 1 to 3, 6 and 7 showed erythema, occasionally accompanied by slight papules, which was graded as Level 2.

[0033] According to the above experimental results, the oil phase complexes of Group 4 and Group 5 have the least irritation to the skin and will not cause skin allergies. While ensuring safety, they also ensure a good sense of use. Furthermore, Group 4 performed the best.

[0034] Experiment on the ratio of compound trace repair essential oil According to the ratios shown in Table 4, 11 groups of different compound trace repair essential oils were prepared.

[0035] Table 4 Compound trace repair essential oil ratio

[0036] The repair ability of the composite trace repair essential oils No. 1 to No. 9 was tested, and the repair ability of the samples was reflected by evaluating the proliferation effect of different composite trace essential oils on keratinocytes.

[0037] The test steps are as follows: (1) Sample preparation Weigh 5 mg of each of the prepared composite trace repair essential oils, and dissolve them in the oil phase composite liquids numbered as group 4 in the [Experiment on the ratio of oil phase composite liquids] to prepare essential oil sample solutions; then take 1 μL from each essential oil sample solution and disperse it in 9 μL of cell culture grade DMSO to prepare the working solution of the sample to be tested.

[0038] (2) Cell culture Immortalized human keratinocytes (HaCaT cells) were seeded into 96-well plates, with 100 μL per well and a cell density of 5 × 10 3 cells / well, at 37°C, 5% CO 2 incubator for 24 hours.

[0039] (3) Sample testing 1. Drug intervention: After the cells are completely attached, replace the fresh culture medium with 100 μL per well. Add 1 μL of the working solution of the sample to be tested to each well for treatment. At the same time, set up a control group and add 1 μL PBS (pH=7.2~7.4) to each well. Set up 3 replicates for each sample and control group, and return them to the cell culture incubator for further culture for 24 hours.

[0040] 2. CCK-8 assay: 24 hours after drug intervention, aspirate the original culture medium. Add 100 μL of culture medium containing 10% CCK-8 to each well. Mix well and continue incubation for 1 hour.

[0041] 3. Absorbance determination: Use a microplate reader to measure the absorbance (OD value) of each well at a wavelength of 450 nm, and calculate the cell survival rate (%) = OD value of the sample group to be tested / OD value of the control group × 100%. The calculation results are shown in Figure 1 As shown. Figure 1It can be seen that samples No. 8, No. 9, No. 10 and No. 11 have a promoting effect on keratinocyte proliferation. Specifically: Sample No. 9: can effectively promote the proliferation of keratinocytes. Samples No. 8, No. 10 and No. 11: although they also show a certain promoting effect, the effect is not significant. Samples No. 1 to No. 3: basically have no effect on promoting keratinocyte proliferation. In summary, sample No. 9 performs best in promoting keratinocyte proliferation, while the effects of samples No. 8, No. 10 and No. 11 are relatively weak. No. 1 to No. 3 have almost no promoting effect.

[0042] Example 1 A method for preparing a moisturizing and repairing moisturizing cream, comprising the following steps: (1) Pour 133.2 g of pure water into a beaker, add 2 g of urea, 0.1 g of HA, 10 g of glycerol, 4 g of Ailuropoda, 0.4 g of C2020, 0.4 g of methylparaben, and 0.3 g of chlorphenesin in sequence while stirring, stir evenly, and mix thoroughly to make an aqueous plant complex solution.

[0043] (2) Take out another clean beaker and add 10g of isononyl isononanoate, 10g of argania spinosa kernel oil, 6g of kiyomizu-seed oil, 4g of avocado butter, 4g of cetearyl glucoside, 4g of dimethicone, 2g of glyceryl stearate, 1g of tocopheryl acetate, and 0.2g of propylparaben in sequence, stir evenly, and mix thoroughly to make an oil phase plant complex liquid.

[0044] (3) The above-mentioned aqueous plant complex liquid and oil-phase plant complex liquid are mixed and stirred continuously. A total of 6 g of butylene glycol, a mixture of Gentiana macrophylla extract, Swertia japonica extract and Gentiana scabra extract, 1 g of 305 combination liquid, 1 g of glyceryl glucoside and 0.4 g of triethanolamine are added in sequence during stirring to fully emulsify and blend the water-oil composition. A total of 200 g of moisturizing and repairing cream is prepared, and the moisturizing and repairing cream is divided and packaged for storage.

[0045] Example 2 Skin repair efficacy test Subjects: 50 subjects aged between 25 and 45 years old, with a male to female ratio of 1:1. The subjects had a variety of different skin types, including dry, oily, combination and sensitive skin.

[0046] This example evaluates the repairing efficacy of the sample by detecting the changes in the transepidermal water loss (TEWL) values ​​of the subjects at 0 days, 14 days, and 28 days of using the moisturizing and repairing moisturizing cream described in Example 1. The test results are shown in Tables 5 and 6.

[0047] Table 5 Descriptive statistics of transepidermal water loss (TEWL) values ​​before and after using the product

[0048] Table 6 Analysis of the difference in TEWL values ​​before and after using the product

[0049] Note: 1. Change rate = [(after using the product - before using the product) / before using the product] × 100%; 2. If the asymptotic significance of the normality test (two-sided value) is > 0.05, then the data series conforms to the normal distribution; 3. If the significance value of the difference test is <0.05, there is a statistically significant difference in the skin test parameters of the subjects before and after using the product; otherwise, there is no significant difference.

[0050] Figure 2 This is a bar graph comparing the TEWL values ​​of the subjects before and after using the product, where * indicates that there is a significant difference between the TEWL values ​​at each time point after using the product and the baseline value before using the product (P<0.05).

[0051] The descriptive statistics of the difference in TEWL values ​​between the experimental group (using moisturizing and repairing cream) and the control group (not using moisturizing cream) on the 14th and 28th days are shown in Table 7. The difference analysis of the difference in TEWL values ​​between the experimental group and the control group is shown in Table 8.

[0052] Table 7 Descriptive statistics of the difference in TEWL values ​​between the experimental group and the control group

[0053] Table 8 Analysis of the difference in TEWL values ​​between the experimental group and the control group

[0054] Note: 1. Difference = after using the product - before using the product.

[0055] 2. If the asymptotic significance of the normality test (two-sided value) is > 0.05, then the data series conforms to the normal distribution. 3. If the significance value of the difference test is <0.05, there is a statistically significant difference between the test area and the control area; otherwise, there is no significant difference.

[0056] Figure 3 This is a bar graph comparing the difference in transepidermal water loss (TEWL) between the experimental group and the control group. * indicates that there is a statistically significant difference between the experimental group and the control group (P<0.05).

[0057] In summary, we can confirm that compared with before use, the TEWL values ​​of the experimental group were significantly reduced after 14 days and 28 days of use (P<0.05), with a decrease of 9.28% after 14 days and 12.28% after 28 days; compared with the control group, the difference in TEWL values ​​of the experimental group was significantly better than that of the control group after 14 days and 28 days of use (P<0.05); it can be judged that the raw materials have a repair effect.

[0058] The specific implementation of the present invention described above does not constitute a limitation on the protection scope of the present invention. Any other corresponding changes and modifications made based on the technical concept of the present invention should be included in the protection scope of the claims of the present invention.

Claims

1. A plant compound essential oil composition, characterized in that: The composition is prepared by mixing, by mass, 66.6 parts of water, 5 parts of glycerin, 5 parts of isononyl isononanoate, 5 parts of argan oil, 5 parts of kiangsu trifoliate seed oil, 2 parts of mugwort leaf extract, 2 parts of shea butter, 2 parts of dimethicone, 2 parts of cetearyl glucoside / cetearyl alcohol, 1-1.5 parts of glyceryl stearate, 1 part of urea, 0.5 parts of VE, 0.15-0.25 parts of methylparaben, 0.1-0.15 parts of chlorphenesin, 0.2 parts of propylparaben, 0.2-0.3 parts of acrylic acid (esters) / C10-30 alkyl acrylate crosspolymer and 0.05 parts of sodium hyaluronate, and then uniformly blending.

2. The plant compound essential oil composition according to claim 1, characterized in that: In parts by mass, it is prepared by mixing 66.6 parts of water, 5 parts of glycerin, 5 parts of isononyl isononanoate, 5 parts of argan oil, 5 parts of kiangsuan three seed oil, 2 parts of mugwort extract, 2 parts of shea butter, 2 parts of dimethicone, 2 parts of cetearyl glucoside / cetearyl alcohol, 1 part of glyceryl stearate, 1 part of urea, 0.5 parts of VE, 0.2 parts of methylparaben, 0.15 parts of chlorphenesin, 0.2 parts of propylparaben, 0.2 parts of acrylates / C10-30 alkyl acrylate crosspolymer and 0.05 parts of sodium hyaluronate.

3. The plant compound essential oil composition according to claim 1, characterized in that: The Qingchuan three-seed oil is composed of perilla seed oil, camellia seed oil, almond oil and tocopherol in a mass ratio of 20-40:30-50:20-40:0.1-0.

5.

4. A moisturizing and repairing cream, characterized in that: The invention comprises the plant compound essential oil composition and the composite trace repair essential oil as described in any one of claims 1 to 3, wherein the composite trace repair essential oil is prepared by mixing an emulsifier combination liquid, glycerol glucoside, butylene glycol, gentiana macrophylla extract, swertia japonica extract, gentiana extract and triethanolamine in proportions of 0.5:0.5:0.5:0.5-1.5:0-1.0:0-1.0:0.2 by weight and then uniformly dispersing the mixture.

5. The moisturizing and repairing cream according to claim 4, characterized in that: The composite trace repair essential oil comprises an emulsifier combination liquid, glycerol glucoside, butylene glycol, gentiana macrophylla extract, swertia japonica extract, gentiana extract and triethanolamine in a mass ratio of 0.5:0.5:0.5:1.5:0.5:0.5:0.

2.

6. The moisturizing and repairing cream according to claim 4, characterized in that: The mass ratio of water in the plant compound essential oil composition to the gentiana macrophylla extract in the composite trace repair essential oil is 66.6:0.5-1.

5.

7. The moisturizing and repairing cream according to claim 6, characterized in that: The mass ratio of water in the plant compound essential oil composition to the gentiana macrophylla extract in the composite trace repair essential oil is 66.6:1.

5.

8. The moisturizing and repairing cream according to claim 4, characterized in that: The emulsifier combination liquid is composed of polyacrylamide, C13-14 isoparaffin, laureth-7 and water in a mass ratio of 0.1-2:5-15:0.5-5:78-95.

9. The method for preparing the moisturizing and repairing cream according to any one of claims 4 to 8, characterized in that: The steps include: (1) taking water, urea, sodium hyaluronate, glycerin, Artemisia argyi extract, acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer, methylparaben and chlorphenesin according to the mass ratio, stirring and mixing them evenly to obtain an aqueous phase composite liquid; (2) according to the mass ratio, isononyl isononanoate, argan oil, kiangsuan three seed oil, shea butter, cetearyl glucoside / cetearyl alcohol, dimethicone, glyceryl stearate, VE and propylparaben are mixed and stirred to obtain an oil phase composite liquid; (3) The aqueous phase composite liquid and the oil phase composite liquid are mixed and stirred continuously. During the stirring process, corresponding weight parts of butylene glycol, Gentiana macrophylla extract, Swertia japonica extract, Gentiana scabra extract, emulsifier combination liquid, glycerol glucoside and triethanolamine are added. Stirring is continued until the water and oil phases are fully emulsified.

10. The method for preparing the moisturizing and repairing cream according to claim 9, characterized in that: The continuous stirring rate is 200-400 r / min; The stirring speed is 600-800 r / min.

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