Traditional Chinese medicine preparation for treating liver cancer and preparation device thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to a traditional Chinese medicine preparation for treating liver cancer and a preparation device thereof, and the traditional Chinese medicine preparation comprises the following components in parts by weight: 1-3 parts of aconite, 15-25 parts of turmeric, 6-12 parts of anise, 6-12 parts of angelica sinensis, 12-15 parts of curcuma zedoary, 15-25 parts of astragalus membranaceus, 9-15 parts of codonopsis pilosula, 15-25 parts of bighead atractylodes rhizome, 6-12 parts of glossy privet fruit and 6-12 parts of lucid ganoderma. Through the synergistic effect of different types of traditional Chinese medicine components, various pathological mechanisms such as liver cancer cell proliferation, angiogenesis and apoptosis are effectively treated, and the treatment effect is remarkably improved; meanwhile, the preparation device integrates automatic medicinal material sorting and precise crushing technologies, ensures fine treatment of medicinal materials, improves the extraction efficiency of effective components, and stabilizes the quality of the preparation.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine pharmaceutical preparation, and in particular to a traditional Chinese medicine preparation for treating liver cancer and a preparation device thereof. Background Art

[0002] Liver cancer, as one of the most common malignant tumors in the world, poses a serious threat to human health due to its high morbidity and mortality. Liver cancer not only leads to a sharp decline in the quality of life of patients, manifested by severe abdominal pain, bloating, nausea, loss of appetite and other symptoms, but also greatly increases the economic burden on families and society. Traditional methods for treating liver cancer mainly include surgery, radiotherapy, chemotherapy, etc. Although these methods can prolong the survival of patients to a certain extent, they are often accompanied by high side effects and recurrence rates.

[0003] Traditional Chinese medicine has a long history and rich experience in the treatment of liver cancer, emphasizing the holistic concept and syndrome differentiation and treatment. Traditional Chinese medicine often uses a variety of methods such as clearing away heat and detoxification, strengthening the body and eliminating evil, promoting blood circulation and removing blood stasis, softening and dispersing nodules to treat liver cancer. By adjusting the internal environment of the body and enhancing immunity, it can achieve the purpose of inhibiting tumor growth, alleviating symptoms, and improving the quality of life. However, the existing Chinese medicine preparations for the treatment of liver cancer mostly focus on the exertion of a single drug effect, while the treatment of liver cancer often needs to deal with a variety of situations such as inhibiting the proliferation of liver cancer cells, inhibiting liver cancer angiogenesis, and inducing liver cancer cell apoptosis; in addition, the existing preparation device also has defects in the treatment of medicinal materials. The traditional preparation method is often unable to finely sort and control the particle size of the medicinal materials in the box under the control of an external controller, resulting in insufficient extraction of effective ingredients and unstable preparation quality. In particular, for smaller and scrap flake or fruit-shaped medicinal materials, traditional methods are difficult to effectively separate and utilize, resulting in waste of resources. At the same time, different medicinal materials have different medicinal properties, and the required crushing particle size should also be different, but the existing technology often cannot achieve precise control, which affects the efficacy of the preparation. In order to solve the problems of single efficacy and imprecise processing of medicinal materials in traditional Chinese medicine preparations for liver cancer treatment, a Chinese medicine preparation for comprehensive treatment of liver cancer and a Chinese medicine preparation device integrated with automatic sorting and precise crushing were proposed. Summary of the invention

[0004] To solve the above problems, the present invention provides a traditional Chinese medicine preparation for treating liver cancer and a preparation device thereof. Through the synergistic effect of different types of traditional Chinese medicine components, the preparation can effectively address various pathological mechanisms such as liver cancer cell proliferation, angiogenesis and apoptosis, and significantly improve the treatment effect. At the same time, the preparation device integrates automated medicinal material sorting and precision crushing technology to ensure fine processing of medicinal materials, improve the efficiency of effective ingredient extraction, and stabilize the quality of the preparation.

[0005] In order to achieve the above-mentioned purpose, the technical scheme of the present invention is as follows: A traditional Chinese medicine preparation for treating liver cancer comprises the following components in parts by weight: 1-3 parts of Aconitum, 15-25 parts of Curcuma, 6-12 parts of Star Anise, 6-12 parts of Angelica, 12-15 parts of Curcuma, 15-25 parts of Astragalus, 9-15 parts of Codonopsis, 15-25 parts of Atractylodes, 6-12 parts of Ligustrum lucidum and 6-12 parts of Ganoderma lucidum.

[0006] Furthermore, the preparation is a capsule, an injection or an oral solution, wherein the preparation steps of the capsule are:

[0007] Step 1, raw material pretreatment: take aconite, turmeric, star anise, angelica, curcuma, astragalus, codonopsis, atractylodes, glossy privet and ganoderma, after manually sorting out unqualified medicinal materials, add them into a preparation device for washing, drying and crushing, separate high-quality medicinal material powder and secondary medicinal material powder by the preparation device, and weigh 2 parts of aconite, 25 parts of turmeric, 12 parts of star anise, 12 parts of angelica, 15 parts of curcuma, 15 parts of astragalus, 9 parts of codonopsis, 20 parts of atractylodes, 6 parts of glossy privet and 6 parts of ganoderma in the high-quality medicinal material powder;

[0008] Step 2, supercritical fluid extraction: the pretreated raw materials are loaded into an extraction kettle, the carbon dioxide gas is pressurized by a high-pressure pump, and the temperature is increased by a heat exchanger to reach a set supercritical state, and then the supercritical carbon dioxide fluid is injected into the extraction kettle to dissolve the concentrated solution of the purified Chinese medicine;

[0009] Step 3, drying and purification: freeze-drying the obtained concentrated solution of the purified Chinese medicine extract to obtain a powder or granular solid purified Chinese medicine extract powder;

[0010] Step 4, filling and packaging: filling the dried purified Chinese medicine extract into capsules and performing packaging treatment to obtain Chinese medicine capsules for treating liver cancer.

[0011] Further, the preparation steps of the injection are:

[0012] Step 1, raw material pretreatment: weigh 3 parts of Aconitum, 20 parts of Curcuma, 6 parts of Star Anise, 6 parts of Angelica, 12 parts of Curcuma, 25 parts of Astragalus, 15 parts of Codonopsis, 25 parts of Atractylodes, 12 parts of Ligustrum lucidum and 12 parts of Ganoderma lucidum from the high-quality medicinal material powder processed by the preparation device;

[0013] Step 2, extraction and purification: the pretreated medicinal material is decocted with water, the decoction obtained is filtered, and 95% anhydrous ethanol is added to precipitate the effective components. When the final purity range reaches 60% to 90%, it is allowed to stand for 24 hours, and the precipitate is separated by a centrifuge. The precipitate is washed with 95% anhydrous ethanol to remove attached impurities and residual solvents, and the washed precipitate is freeze-dried to obtain a purified precipitate of traditional Chinese medicine;

[0014] Step 3, dissolving and preparing: dissolving the dried purified precipitate of traditional Chinese medicine in an appropriate amount of water for injection, heating and stirring to form a uniform solution, and mixing the dissolved active ingredient solution with a stabilizer to obtain an injection stock solution;

[0015] Step 4: Filtration and sterilization: Use a filtration device to perform a preliminary filtration on the injection stock solution to remove large particle impurities, use an ultrafiltration membrane to perform a fine filtration on the solution after the preliminary filtration, and perform a hot pressure sterilization treatment on the finely filtered solution;

[0016] Step 5: Packaging and sealing: the sterilized injection stock solution is packed into ampoules, and the packed containers are immediately sealed to obtain the Chinese medicine injection for treating liver cancer.

[0017] Further, the preparation steps of the oral solution are:

[0018] Step 1, weighing: weighing by weight: 1 part of Aconitum, 25 parts of Curcuma, 6 parts of Illustrated, 6 parts of Angelica, 12 parts of Curcuma, 25 parts of Astragalus, 9 parts of Codonopsis, 15 parts of Atractylodes, 6 parts of Ligustrum lucidum and 6 parts of Ganoderma lucidum from the secondary medicinal material powder processed by the preparation device;

[0019] Step 2, extraction and purification: extracting and collecting volatile components from Aconitum, Curcuma longa, Star anise, Angelica sinensis and Curcuma zedoaria by steam distillation, and decocting the residues of Aconitum, Curcuma longa, Star anise, Angelica sinensis and Curcuma zedoaria together with Astragalus membranaceus, Codonopsis pilosula, Atractylodes macrocephala, Ligustrum lucidum and Ganoderma lucidum for 1 to 2 hours each time, 2 to 3 times to obtain a Chinese medicine extract, centrifuging the Chinese medicine extract to obtain a refined liquid and mixing them;

[0020] Step 3, concentrated liquid preparation: the obtained refined liquid is heated and concentrated to a concentration level of 10 to 20 ml per dose, volatile components are added to the concentrated liquid, and a surfactant is added to evenly disperse the volatile components in the concentrated liquid to obtain a prepared liquid medicine;

[0021] Step 4, packaging and sterilization: before filling, the glass bottles are cleaned and sterilized, the prepared liquid medicine is filled into the glass bottles and capped and sealed, and the glass bottles containing the liquid medicine are sterilized again with circulating steam to obtain the oral liquid for treating liver cancer.

[0022] The above scheme has the following beneficial effects:

[0023] 1. In this scheme, the Chinese medicine preparation uses a scientific ratio of multiple Chinese medicinal materials, each of which plays a different role in different pathological links of liver cancer:

[0024] Inhibit the proliferation of liver cancer cells: Aconitum can inhibit the mitosis of cancer cells, thereby inhibiting the growth of liver cancer cells. Curcumin, the active ingredient of turmeric, can inhibit the proliferation of liver cancer cell lines. Its mechanism of action is to inhibit NF-kB p65 to regulate hTERT expression, thereby downregulating telomerase activity. Shikimic acid, the active ingredient of star anise, can induce cell apoptosis by reducing the Bcl-2 / Bax ratio, thereby causing a large number of human liver cancer HepG2 cell lines to be blocked in the G1 phase, and the number of cells entering the S phase is reduced, thereby inhibiting the proliferation of liver cancer cells.

[0025] Inhibiting liver cancer angiogenesis: Inhibiting tumor angiogenesis is also an important method for treating primary liver cancer. Among them, curcumin, sodium ferulate in angelica, and zedoaria have all shown significant effects. Specifically, curcumin not only works by inducing tumor cell apoptosis, but also effectively inhibits tumor angiogenesis. This mechanism of action is mainly attributed to its ability to downregulate the expression of genes closely related to angiogenesis, such as vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9). Similarly, sodium ferulate in angelica has also been found to significantly inhibit the growth of mouse H22 tumors and their angiogenesis process, while reducing the expression of VEGF. In addition, zedoaria has also been shown to have the ability to inhibit VEGF production, further confirming the presence of effective ingredients against liver cancer in curcumin, angelica, and zedoaria;

[0026] Regulate the body's immunity: Angelica polysaccharide's anti-tumor effect mainly inhibits or kills tumor cells by enhancing the body's immunity. Angelica polysaccharide can also inhibit the metastasis and invasion of liver cancer cells.

[0027] Inducing apoptosis of liver cancer cells: Inducing apoptosis is one of the ways to inhibit tumor growth. In vitro experiments have shown that the extract of Curcuma zedoaria promoted the apoptosis of liver cancer cells by inhibiting the expression of COX-2 and VEGF genes in HepG2 cells. Sodium ferulate in angelica can induce apoptosis of human EBL-7404 liver cancer cells and inhibit their proliferation.

[0028] Influencing the signal transduction pathway of liver cancer cells: Astragalus, Ganoderma lucidum and Ligustrum lucidum inhibit the binding of cyclin-dependent kinase 2 to cyclin E1, while positively regulating cyclins and endogenous CDK inhibitors to inhibit the enzymatic activity of cyclin E1-CDK2 complex, inhibit the phosphorylation level of downstream Rb, and thus prevent the proliferation of cancer cells; Codonopsis pilosula and Astragalus membranaceus play a preventive and therapeutic role in the occurrence and metastasis of primary liver cancer by regulating the tumor microenvironment and inhibiting the interleukin-17 signaling pathway;

[0029] In addition, the Atractylodes macrocephala polysaccharide in Atractylodes macrocephala can inhibit the phosphorylation of protein kinase B / glycogen synthase kinase-3β, reduce the accumulation of β-catenin in liver cancer cells, and thus inhibit the gene transcription and protein expression of its downstream target molecule matrix metalloproteinase 2, thus playing a therapeutic role in liver cancer.

[0030] Each of the above-mentioned medicinal materials plays its own role in different pathological links of liver cancer, and under the synergistic effect, it can not only effectively inhibit the growth of liver cancer cells, but also regulate the internal environment of the body and alleviate the patient's symptoms.

[0031] 2. In the preparation process of traditional Chinese medicine, the sorting and crushing of medicinal materials often rely on manual operation, and there are problems such as incomplete sorting and uneven crushing particle size. The preparation device in this scheme uses automated medicinal material sorting to sort high-quality medicinal materials for capsules and injections. Capsules are easy to carry and take, and are suitable for patients who need long-term treatment; injections can quickly enter the blood circulation and play a therapeutic role, and are suitable for patients with more serious conditions; and the medicinal properties in secondary medicinal materials can be used as portable oral liquids to provide patients with convenient pathological supplements. This diverse dosage form selection allows patients to choose the appropriate medication method according to their own conditions.

[0032] 3. In this solution, during the preparation process, the present invention adopts modern pharmaceutical technologies such as supercritical fluid extraction and freeze drying. Supercritical fluid extraction technology uses carbon dioxide in a supercritical state as a solvent, which can efficiently and environmentally extract the effective ingredients in medicinal materials, reduce solvent residues and the generation of harmful substances. Freeze drying technology can directly sublimate the water in the medicinal materials at low temperatures, retain the original form and active ingredients of the medicinal materials, and improve the purity and stability of the preparation.

[0033] 4. Compared with traditional methods for treating liver cancer, such as surgery, radiotherapy and chemotherapy, the Chinese medicine preparation of the present invention has lower side effects and recurrence rate. When used in combination with chemotherapy, the medicinal properties of Chinese medicinal materials reduce the patient's physical burden, allowing patients to reduce complications and recurrence risks while relieving the pain caused by chemotherapy. In addition, the preparation cost of Chinese medicine preparations is relatively low, and it is easy to promote and apply. This economical and effective treatment method not only reduces the economic burden of patients, but also improves the sustainability of treatment.

[0034] Furthermore, a Chinese medicine preparation device for treating liver cancer includes a box body and an external controller, the external controller is fixedly connected to the outer side wall of the box body, and the box body is connected to the external controller by signal; a vertical first partition is fixedly connected to the box body, the first partition divides the box body into a first processing chamber and a second processing chamber, a plurality of second partitions and a third partition are fixedly connected to the first processing chamber and the second processing chamber, respectively, the second partition and the third partition respectively divide the first processing chamber and the second processing chamber into a first cleaning chamber, a first drying chamber and a first recovery chamber and a second cleaning chamber, a second drying chamber and a second recovery chamber from top to bottom, a coupling is fixedly connected to the first partition, both ends of the coupling are respectively located in the first cleaning chamber and the second cleaning chamber and are respectively fixedly connected with a first cleaning component and a second cleaning component for cleaning medicinal materials.

[0035] Beneficial effects: Through the integrated control of the external controller, the entire Chinese medicinal material passes through the first cleaning component and the second cleaning component, and the cleaning process is automated, which greatly reduces the complexity and labor intensity of manual operation, while improving work efficiency; it is carefully divided into multiple processing areas by the first partition and the second and third partitions. This design enables each processing step to be carried out in an independent space, avoiding the mixing of high-quality medicinal powder and secondary medicinal powder after sorting, and facilitating the subsequent preparation of different preparations.

[0036] Furthermore, a symmetrically arranged inclined platform is fixedly connected to the bottom wall of the first cleaning chamber, and a first fan is fixedly connected to the inclined platform, a second fan is fixedly connected to the side of the first cleaning chamber away from the second cleaning chamber, a first isolation box is fixedly connected to the top of the first cleaning chamber, and a first one-way valve corresponding to the first fan and the second fan is opened on the side wall and the bottom of the first isolation box, a first motor is fixedly connected to the inner wall of the first cleaning chamber close to the second fan, a first rotating shaft is coaxially fixedly connected to the output shaft of the first motor, an end of the first rotating shaft away from the first motor passes through the first isolation box and is fixedly connected to the coupling, and the first cleaning component includes a first cleaning tank, a first A rotating shaft is located in the first isolation box and is coaxially fixedly connected to the first cleaning tank. The first cleaning tank is rotatably connected to the first isolation box. A feed port is provided on the top of the first cleaning tank. A feed pipe is connected to the feed port. The feed pipe passes through the first isolation box and the first cleaning chamber and extends to the outside of the box body. The feed port is connected to a first solenoid valve corresponding to the feed pipe. A plurality of first water inlet holes are provided on the side wall of the first cleaning tank. A first delivery pipe is provided in the first cleaning chamber. One end of the first delivery pipe is located in the first cleaning chamber and is connected to the first cleaning tank. The other end of the first delivery pipe extends into the first drying chamber. The first cleaning tank is connected to a first valve corresponding to the first delivery pipe.

[0037] Beneficial effects: 1. Through the cooperation of the first fan and the second fan, combined with the cleaning operation in the first cleaning tank, the medicinal materials can be sorted after being put into the material inlet. Because the slices of the slowly growing Chinese medicinal materials are correspondingly smaller in the early stage of the slice making process, and there will be scraps in the slices, the quality of these slices is lighter than that of normal slices. Correspondingly, the fruit-like medicinal materials are smaller in development and lighter in weight, and are easier to be blown up by the first fan and the second fan, and thus blown into the second cleaning chamber. The medicinal properties of the slowly growing medicinal materials will be lower than those of the normally growing medicinal materials to a certain extent, thereby realizing the automatic sorting of high-quality medicinal materials and secondary medicinal materials.

[0038] 2. The first cleaning tank is designed to be rotatable, which not only helps the medicinal materials to be washed evenly in the tank, but also helps the clean water and materials to fully contact through the rotating action, thereby improving the cleaning quality.

[0039] 3. After cleaning the medicinal materials in the first cleaning tank, the water is discharged, and the first fan and the second fan continue to blow air into the first cleaning tank to pre-dry the surface water of the medicinal materials in the first cleaning tank. At the same time, the first water inlet hole blocked by impurities of the medicinal materials during the cleaning and stirring process can be blown away to prevent the blockage of the first water inlet hole from affecting the subsequent cleaning of the medicinal materials.

[0040] Furthermore, a second partition plate between the first cleaning chamber and the second cleaning chamber is provided with a plurality of eccentric second solenoid valves, a second isolation box is fixedly connected to the top wall of the second cleaning chamber, a second rotating shaft is coaxially fixedly connected to one end of the coupling located in the second cleaning chamber, an end of the second rotating shaft away from the coupling passes through the second isolation box, and is rotatably connected to a side of the second cleaning chamber away from the second partition plate;

[0041] The second cleaning component includes a second cleaning tank, the part of the second rotating shaft located in the second isolation box is coaxially fixedly connected to the second cleaning tank, a plurality of second water inlet holes are opened on the side wall of the second cleaning tank, a third fan is fixedly connected to the bottom of the second cleaning chamber, a second one-way valve corresponding to the third fan is opened at the bottom of the second isolation box, a second delivery pipe is provided in the second cleaning chamber, one end of the second delivery pipe is located in the second cleaning chamber and is connected to the second cleaning tank, the other end of the second delivery pipe extends into the second drying chamber, and the second cleaning tank is connected with a second valve corresponding to the second delivery pipe.

[0042] Beneficial effects: Through the coupling, when the first cleaning tank rotates, the second cleaning tank also rotates accordingly to clean the secondary medicinal materials; by arranging a plurality of eccentric second solenoid valves on the second partition between the first cleaning chamber and the second cleaning chamber, the second solenoid valve is opened during sorting, so that the secondary medicinal materials blown by the first fan and the second fan enter the second cleaning tank, and the second solenoid valve is closed during cleaning and pre-drying, so that the first cleaning tank and the second cleaning tank operate independently, thereby improving the flexibility of cleaning.

[0043] Furthermore, a drying component is provided in the first drying chamber and the second drying chamber, and the drying components include a drying box, the top wall and the bottom wall of the drying box are respectively fixedly connected to the inner top wall and the inner bottom wall of the first drying chamber and the second drying chamber, and electric heating wires are evenly distributed on the inner side walls of the drying box, and a serpentine tube is arranged between the drying box and the first drying chamber and the second drying chamber, one end of the serpentine tube extends to the outside of the box body and is connected to a water tank, and the other end of the serpentine tube extends into the first cleaning tank and the second cleaning tank respectively, and is rotatably connected to the side walls of the first cleaning tank and the second cleaning tank respectively, and a drain pipe is provided in the first cleaning tank and the second cleaning tank, and one end of the drain pipe away from the first cleaning tank and the second cleaning tank extends to the outside of the box body, and one end of the drain pipe located in the first cleaning tank and the second cleaning tank is connected to a third valve, and a water pump is connected to the serpentine tube and the drain pipe.

[0044] Beneficial effects: 1. When sorting medicinal materials, the air is preheated by the electric heating wire in the drying box to form high-temperature hot air, so that the medicinal materials that enter the first drying box and the second drying box after cleaning can be quickly dried. This design not only improves the drying efficiency, but also ensures the uniformity of the drying effect, avoiding the problems of local overheating or insufficient drying that may occur in traditional drying methods.

[0045] 2. The design of the serpentine tube cleverly utilizes the heat generated during the cleaning process. The serpentine tube, which extends to the water tank at one end, can absorb and store the heat generated during the drying process, and then transfer this part of the heat to the water in the first cleaning tank and the second cleaning tank, realizing heat recovery and utilization, which not only reduces energy consumption, but also reduces waste heat emissions.

[0046] 3. In addition, when the first drying box and the second drying box are preheated, heat exchange is performed with the clean water in the external serpentine tube. The clean water becomes warm water during the heat exchange process and washes the medicinal materials in the first cleaning tank and the second cleaning tank respectively through the serpentine tube. Compared with cold water, warm water has a moderate temperature and will not cause the effective ingredients in the medicinal materials, such as volatile oils and alkaloids, to be lost rapidly due to overheating. At the same time, warm water will not be as difficult to penetrate the surface of the medicinal materials as cold water, thereby reducing the loss of effective ingredients during the cleaning process; warm water can moderately soften the tissue of the medicinal materials, increase the intercellular space, and facilitate the dissolution of effective ingredients during the subsequent decoction process; warm water can better dissolve impurities such as mud, dust, etc. on the surface of the medicinal materials, and improve the cleanliness of the medicinal materials.

[0047] Furthermore, a stirring assembly is fixedly connected to the first drying box and the second drying box, and the stirring assembly includes a second motor fixedly connected to the inner wall of the first drying box and the second drying box. The output shaft of the second motor is coaxially fixedly connected to the stirring shaft, and a plurality of blades are fixedly connected to the stirring shaft.

[0048] Beneficial effects: During the process of drying the medicinal materials, the stirring shaft and the blade thereon are driven to rotate by the second motor, and the medicinal material slices or fruit-shaped medicinal materials in the drying box are continuously turned over and stirred. This turning action can effectively avoid the problem of uneven heating of the medicinal materials due to accumulation during the drying process, and ensure that all parts of the medicinal materials can be evenly heated, thereby improving the drying efficiency. The stirring process not only turns the medicinal materials themselves, but also promotes the flow of hot air in the drying box, so that the heat is more evenly transferred to all parts of the medicinal materials, further improving the uniformity of the drying effect; due to the different medicinal properties of the medicinal materials, the particle size of the medicinal material powder to be obtained is also different. By controlling the speed of the second motor by an external controller, the particle size of the medicinal materials crushed by the blade can be different.

[0049] Furthermore, a third conveying pipe is connected between the first drying box and the first recovery chamber, a fourth valve corresponding to the third conveying pipe is connected on the first drying box, a fourth conveying pipe is connected between the second drying box and the second recovery chamber, a fifth valve corresponding to the fourth conveying pipe is connected on the second drying box, recovery bags are detachably connected in the first recovery chamber and the second recovery chamber, and recovery doors that can be connected to the outside of the box are provided on the side walls of the first recovery chamber and the second recovery chamber.

[0050] Beneficial effect: Medicinal powder dust may appear in the process of crushing medicinal materials. The crushed medicinal powder is collected by a recovery bag, so that the medicinal powder dust is isolated in the first drying box and the second drying box, thereby reducing the pollution to the working environment and the impact on the health of employees.

[0051] Additional aspects and advantages of the present invention will be given in part in the following description and in part will be obvious from the following description, or will be learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0052] Figure 1 A schematic diagram of the steps for preparing capsules of an embodiment of a Chinese medicine preparation for treating liver cancer according to the present invention;

[0053] Figure 2 A schematic diagram of the steps for preparing an injection of a Chinese medicine preparation for treating liver cancer according to an embodiment of the present invention;

[0054] Figure 3 A schematic diagram of the steps for preparing an oral solution of an embodiment of a Chinese medicine preparation for treating liver cancer according to the present invention;

[0055] Figure 4 It is a front cross-sectional schematic diagram of an embodiment of a device for preparing a traditional Chinese medicine preparation for treating liver cancer according to the present invention.

[0056] The figure marks in the drawings of the specification include: 1, box body; 2, first processing chamber; 3, first isolation box; 4, first cleaning tank; 5, first motor; 6, second fan; 7, drain pipe; 8, first fan; 9, inclined table; 10, serpentine pipe; 11, first drying chamber; 12, second motor; 13, stirring shaft; 14, blade; 15, first recovery chamber; 16, recovery bag; 17, first conveying pipe; 18, third conveying pipe; 19, first drying box; 20, first partition; 21, second recovery chamber; 22, fourth conveying pipe; 23, second drying box; 24, second conveying pipe; 25, third fan; 26, second isolation box; 27, second cleaning tank; 28, second rotating shaft; 29, second processing chamber; 30, coupling; 31, first solenoid valve; 32, feed pipe; 33, first rotating shaft; 34, second partition; 35, third partition. DETAILED DESCRIPTION

[0057] The technical solution of the present invention will be described clearly and completely below in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0058] In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance.

[0059] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0060] The following is further described in detail through specific implementation methods:

[0061] Embodiment 1:

[0062] As attached Figure 1 and Figure 4As shown: A traditional Chinese medicine preparation for treating liver cancer, comprising the following components by weight: 1-3 parts of Aconitum, 15-25 parts of Curcuma, 6-12 parts of Star Anise, 6-12 parts of Angelica, 12-15 parts of Curcuma, 15-25 parts of Astragalus, 9-15 parts of Codonopsis, 15-25 parts of Atractylodes, 6-12 parts of Ligustrum lucidum and 6-12 parts of Ganoderma lucidum.

[0063] The preparation is a capsule, an injection or an oral solution, wherein the preparation steps of the capsule are:

[0064] Step 1, raw material pretreatment: take aconite, turmeric, star anise, angelica, curcuma, astragalus, codonopsis, atractylodes, glossy privet and ganoderma, after manually sorting out unqualified medicinal materials, add them into a preparation device for washing, drying and crushing, separate high-quality medicinal material powder and secondary medicinal material powder by the preparation device, and weigh 2 parts of aconite, 25 parts of turmeric, 12 parts of star anise, 12 parts of angelica, 15 parts of curcuma, 15 parts of astragalus, 9 parts of codonopsis, 20 parts of atractylodes, 6 parts of glossy privet and 6 parts of ganoderma in the high-quality medicinal material powder;

[0065] Step 2, supercritical fluid extraction: the pretreated raw materials are loaded into an extraction kettle, the carbon dioxide gas is pressurized by a high-pressure pump, and the temperature is increased by a heat exchanger to reach a set supercritical state, and then the supercritical carbon dioxide fluid is injected into the extraction kettle to dissolve the concentrated solution of the purified Chinese medicine;

[0066] Step 3, drying and purification: freeze-drying the obtained concentrated solution of the purified Chinese medicine extract to obtain a powder or granular solid purified Chinese medicine extract powder;

[0067] Step 4, filling and packaging: filling the dried purified Chinese medicine extract into capsules and performing packaging treatment to obtain Chinese medicine capsules for treating liver cancer.

[0068] In step one, a Chinese medicine preparation device for treating liver cancer includes a housing 1 and an external controller, the external controller is welded to the outer wall of the housing 1, and the housing 1 is signal-connected to the external controller; a vertical first partition 20 is welded inside the housing 1, the first partition 20 divides the housing 1 into a first processing chamber 2 and a second processing chamber 29, a plurality of second partitions 34 and a third partition 35 are welded inside the first processing chamber 2 and the second processing chamber 29, respectively, the second partition 34 and the third partition 35 respectively divide the first processing chamber 2 and the second processing chamber 29 into a first cleaning chamber, a first drying chamber 11 and a first recovery chamber 15 and a second cleaning chamber, a second drying chamber and a second recovery chamber 21 from top to bottom, a coupling 30 is welded on the first partition 20, and both ends of the coupling 30 are respectively located in the first cleaning chamber and the second cleaning chamber and are respectively welded with a first cleaning component and a second cleaning component for cleaning medicinal materials.

[0069] A symmetrically arranged inclined platform 9 is welded to the bottom wall of the first cleaning chamber, and a first fan 8 is bolted to the inclined platform 9. A second fan 6 is bolted to the side of the first cleaning chamber away from the second cleaning chamber, and a first isolation box 3 is welded to the top of the first cleaning chamber. The side wall and the bottom of the first isolation box 3 are provided with first one-way valves corresponding to the first fan 8 and the second fan 6. A first motor 5 is bolted to the inner wall of the first cleaning chamber close to the second fan 6. A first rotating shaft 33 is coaxially welded to the output shaft of the first motor 5. The end of the first rotating shaft 33 away from the first motor 5 passes through the first isolation box 3 and is welded to the coupling 30. The first cleaning assembly includes a first cleaning tank 4. The first rotating shaft 33 is located in the first isolation box 3. The part inside the box 3 is coaxially welded with the first cleaning tank 4, the first cleaning tank 4 is rotatably connected to the first isolation box 3, a feed port is opened on the top of the first cleaning tank 4, and the feed port is connected with a feed pipe 32, the feed pipe 32 passes through the first isolation box 3 and the first cleaning chamber and extends to the outside of the box body 1, the feed port is connected with a first solenoid valve 31 corresponding to the feed pipe 32, a plurality of first water inlet holes are opened on the side wall of the first cleaning tank 4, a first conveying pipe 17 is provided in the first cleaning chamber, the first conveying pipe 17 is located at one end of the first cleaning chamber and is connected with the first cleaning tank 4, the other end of the first conveying pipe 17 extends into the first drying chamber 11, and the first cleaning tank 4 is connected with a first valve corresponding to the first conveying pipe 17.

[0070] A plurality of eccentric second solenoid valves are provided on the second partition 34 located between the first cleaning chamber and the second cleaning chamber, a second isolation box 26 is welded to the top wall of the second cleaning chamber, a second rotating shaft 28 is coaxially welded to one end of the coupling 30 located in the second cleaning chamber, an end of the second rotating shaft 28 away from the coupling 30 passes through the second isolation box 26, and is rotatably connected to a side of the second cleaning chamber away from the second partition 34.

[0071] The second cleaning assembly includes a second cleaning tank 27, the part of the second rotating shaft 28 located in the second isolation box 26 is coaxially welded to the second cleaning tank 27, a plurality of second water inlet holes are opened on the side wall of the second cleaning tank 27, a third fan 25 is bolted to the bottom of the second cleaning chamber, a second one-way valve corresponding to the third fan 25 is opened at the bottom of the second isolation box 26, a second delivery pipe 24 is provided in the second cleaning chamber, one end of the second delivery pipe 24 is located in the second cleaning chamber and is connected to the second cleaning tank 27, the other end of the second delivery pipe 24 extends into the second drying chamber, and the second cleaning tank 27 is connected with a second valve corresponding to the second delivery pipe 24.

[0072] A drying assembly is provided in the first drying chamber 11 and the second drying chamber, and the drying assembly includes a drying box. The top wall and the bottom wall of the drying box are respectively welded to the inner top wall and the inner bottom wall of the first drying chamber 11 and the second drying chamber, and electric heating wires are evenly distributed on the inner side walls of the drying box. A serpentine tube 10 is arranged between the drying box and the first drying chamber 11 and the second drying chamber, and one end of the serpentine tube 10 extends to the outside of the box body 1 and is connected to a water tank, and the other end of the serpentine tube 10 extends into the first cleaning tank 4 and the second cleaning tank 27 respectively, and is rotatably connected to the side walls of the first cleaning tank 4 and the second cleaning tank 27 respectively, and a drain pipe 7 is provided in the first cleaning tank 4 and the second cleaning tank 27, and one end of the drain pipe 7 away from the first cleaning tank 4 and the second cleaning tank 27 extends to the outside of the box body 1, and one end of the drain pipe 7 located in the first cleaning tank 4 and the second cleaning tank 27 is connected to a third valve, and a water pump is connected to the serpentine tube 10 and the drain pipe 7.

[0073] Stirring assemblies are welded inside the first drying box 19 and the second drying box 23. The stirring assemblies include a second motor 12 welded to the inner wall of the first drying box 19 and the second drying box 23. The output shaft of the second motor 12 is coaxially welded with a stirring shaft 13, and a plurality of blades 14 are welded on the stirring shaft 13.

[0074] A third conveying pipe 18 is connected between the first drying box 19 and the first recovery chamber 15, and a fourth valve corresponding to the third conveying pipe 18 is connected to the first drying box 19. A fourth conveying pipe 22 is connected between the second drying box 23 and the second recovery chamber 21, and a fifth valve corresponding to the fourth conveying pipe 22 is connected to the second drying box 23. Recovery bags 16 are detachably connected to the first recovery chamber 15 and the second recovery chamber 21, and recovery hatches that can be connected to the outside of the box body 1 are provided on the side walls of the first recovery chamber 15 and the second recovery chamber 21.

[0075] The specific implementation process is as follows: First, take the insect-free and rotten medicinal materials that have been manually picked, take Atractylodes macrocephala as an example, at this time, the first solenoid valve 31 is opened, and the materials are put into the first cleaning tank 4 through the feeding port, the first fan 8 and the second fan 6 are started, and the wind enters the first cleaning tank 4 through the first one-way valve. Due to the fact that in the early stage of the sheet-like Atractylodes macrocephala slice making process, the slices cut from the slower-growing medicinal materials are correspondingly smaller, and there will be scraps in the sheet-like medicinal materials, the quality of these sheet-like medicinal materials is lighter than that of normal sheet-like medicinal materials. Correspondingly, the fruit-like medicinal materials are smaller in development and lighter in weight, and are easier to be blown up by the first fan 8 and the second fan 6, and thus blown into the second cleaning chamber. The medicinal properties of the slower-growing medicinal materials will be lower than those of the normally-growing medicinal materials to a certain extent, thereby realizing the automatic sorting of high-quality medicinal materials and secondary medicinal materials.

[0076] When sorting Atractylodes macrocephala, the electric heating wires of the first drying box 19 and the second drying box 23 begin to preheat, and the external controller starts the water pump on the serpentine tube 10 to pump water from the water tank. When the clean water flows through the preheated drying box for heat exchange, the temperature of the clean water rises under the heat exchange, and flows into the first cleaning tank 4 and the second cleaning tank 27 respectively to clean the medicinal materials in the first cleaning tank 4 and the second cleaning tank 27 respectively. Compared with cold water, warm water has a moderate temperature and will not cause the effective ingredients in the medicinal materials, such as volatile oils and alkaloids, to be lost rapidly due to overheating. At the same time, warm water will not be as difficult to penetrate the surface of the medicinal materials as cold water, thereby reducing the loss of effective ingredients during the cleaning process; warm water can moderately soften the tissue of the medicinal materials, increase the intercellular space, and is conducive to the dissolution of effective ingredients in the subsequent decoction process; warm water can better dissolve impurities such as mud, sand, and dust on the surface of the medicinal materials, thereby improving the cleanliness of the medicinal materials.

[0077] After the water filling is completed, the first solenoid valve 31 on the side wall of the first clean water tank is closed, and the second solenoid valve is closed to isolate the first clean water tank from the second clean water tank. At this time, the external controller starts the first motor 5 to drive the first rotating shaft 33 to rotate, and simultaneously drives the second rotating shaft 28 to rotate through the coupling 30. The first cleaning tank 4 and the second cleaning tank 27 begin to rotate accordingly. This not only helps the material to be washed evenly in the tank, but also helps the clean water and the Atractylodes macrocephala slices to fully contact through the rotation action, thereby improving the cleaning quality. After the cleaning is completed, the external controller opens the drain pipe 7 to discharge the waste water to the outside of the box body 1.

[0078] After the medicinal materials in the first cleaning tank 4 and the second cleaning tank 27 are cleaned, the moisture is discharged, and the first fan 8, the second fan 6 and the third fan 25 are used to continuously blow air into the first cleaning tank 4 and the second cleaning tank 27 to pre-dry the moisture on the surface of the Atractylodes macrocephala slices in the first cleaning tank 4 and the second cleaning tank 27. At the same time, the medicinal material impurities that are blocked on the first water inlet hole and the second water inlet hole during the cleaning and stirring process can be blown away to prevent the first water inlet hole and the second water inlet hole from being blocked and affecting the subsequent medicinal material cleaning.

[0079] After pre-drying, the high-quality Atractylodes slices and the secondary Atractylodes slices enter the first drying box 19 and the second drying box 23 respectively. While the electric heating wire continues to heat and dry the Atractylodes slices, the external controller starts the second motor 12, and the second motor 12 drives the stirring shaft 13 and the blade 14 thereon to rotate, and continuously flips and stirs the Atractylodes slices in the first drying box 19 and the second drying box 23. This flipping action can effectively avoid the problem of uneven heating of the Atractylodes slices due to accumulation during the drying process, ensure that all parts of the Atractylodes slices can be evenly heated, thereby improving the drying efficiency. The stirring process not only flips the Atractylodes slices themselves, but also promotes the flow of hot air in the drying box, so that the heat is more evenly transferred to various parts of the Atractylodes slices, further improving the uniformity of the drying effect; due to the different medicinal properties of the medicinal materials, the particle size of the medicinal material powder to be obtained is also different. The external controller controls the speed of the second motor 12 to make the particle size of the medicinal materials crushed by the blade 14 different.

[0080] The high-quality Atractylodes macrocephala powder and the secondary Atractylodes macrocephala powder after being crushed into powder enter the recovery bag 16 of the first recovery chamber 15 and the second recovery chamber 21 through the third delivery tube 18 and the fourth delivery tube 22 respectively, so as to be used in subsequent different preparations.

[0081] Embodiment 2:

[0082] As attached Figure 2 As shown, the difference from Example 1 is that the preparation steps of the injection are:

[0083] Step 1, raw material pretreatment: weigh 3 parts of Aconitum, 20 parts of Curcuma, 6 parts of Star Anise, 6 parts of Angelica, 12 parts of Curcuma, 25 parts of Astragalus, 15 parts of Codonopsis, 25 parts of Atractylodes, 12 parts of Ligustrum lucidum and 12 parts of Ganoderma lucidum from the high-quality medicinal material powder processed by the preparation device;

[0084] Step 2, extraction and purification: the pretreated medicinal material is decocted with water, the decoction obtained is filtered, and 95% anhydrous ethanol is added to precipitate the effective components. When the final purity range reaches 60% to 90%, it is allowed to stand for 24 hours, and the precipitate is separated by a centrifuge. The precipitate is washed with 95% anhydrous ethanol to remove attached impurities and residual solvents, and the washed precipitate is freeze-dried to obtain a purified precipitate of traditional Chinese medicine;

[0085] Step 3, dissolving and preparing: dissolving the dried purified precipitate of traditional Chinese medicine in an appropriate amount of water for injection, heating and stirring to form a uniform solution, and mixing the dissolved active ingredient solution with a stabilizer to obtain an injection stock solution;

[0086] Step 4: Filtration and sterilization: Use a filtration device to perform a preliminary filtration on the injection stock solution to remove large particle impurities, use an ultrafiltration membrane to perform a fine filtration on the solution after the preliminary filtration, and perform a hot pressure sterilization treatment on the finely filtered solution;

[0087] Step 5: Packaging and sealing: the sterilized injection stock solution is packed into ampoules, and the packed containers are immediately sealed to obtain the Chinese medicine injection for treating liver cancer.

[0088] Embodiment 3:

[0089] As attached Figure 3 As shown, the difference from Example 2 is that the preparation steps of the oral liquid are:

[0090] Step 1, weighing: weighing by weight: 1 part of Aconitum, 25 parts of Curcuma, 6 parts of Illustrated, 6 parts of Angelica, 12 parts of Curcuma, 25 parts of Astragalus, 9 parts of Codonopsis, 15 parts of Atractylodes, 6 parts of Ligustrum lucidum and 6 parts of Ganoderma lucidum from the secondary medicinal material powder processed by the preparation device;

[0091] Step 2, extraction and purification: extracting and collecting volatile components from Aconitum, Curcuma longa, Star anise, Angelica sinensis and Curcuma zedoaria by steam distillation, and decocting the residues of Aconitum, Curcuma longa, Star anise, Angelica sinensis and Curcuma zedoaria together with Astragalus membranaceus, Codonopsis pilosula, Atractylodes macrocephala, Ligustrum lucidum and Ganoderma lucidum for 1 to 2 hours each time, 2 to 3 times to obtain a Chinese medicine extract, centrifuging the Chinese medicine extract to obtain a refined liquid and mixing them;

[0092] Step 3, concentrated liquid preparation: the obtained refined liquid is heated and concentrated to a concentration level of 10 to 20 ml per dose, volatile components are added to the concentrated liquid, and a surfactant is added to evenly disperse the volatile components in the concentrated liquid to obtain a prepared liquid medicine;

[0093] Step 4, packaging and sterilization: before filling, the glass bottles are cleaned and sterilized, the prepared liquid medicine is filled into the glass bottles and capped and sealed, and the glass bottles containing the liquid medicine are sterilized again with circulating steam to obtain the oral liquid for treating liver cancer.

[0094] 1. Experiment on Growth Inhibition of Mouse Hepatocellular Carcinoma Transplants

[0095] 1. Experimental subjects:

[0096] Male mice weighing 19-22 g were divided into 6 mice / group and divided into blank control group, control group A, high-dose group and low-dose group.

[0097] 2. Experimental process:

[0098] H 22 The cell line was placed in a 37°C, 5% CO2 incubator. Cells in the logarithmic growth phase were taken and digested with 0.25% trypsin to prepare 0.1 ml of cell suspension. 22The ascites of the liver cancer cell line was passaged in mice for 3 times, and an appropriate amount of ascites was taken and diluted with PBS solution at a ratio of 1:4 to prepare a cancer cell suspension. 0.2 ml of the cancer cell suspension was inoculated subcutaneously in the right anterior armpit of several groups of mice. 24 hours after inoculation, oral administration began. The control group A was given a Chinese medicine preparation for treating liver cancer on the market, the high-dose group was given an oral liquid prepared from high-quality powder in the present invention, and the low-dose group was given an oral liquid prepared from secondary powder in the present invention for 10 consecutive days. On the 11th day, the mice were weighed, and the mice were killed to remove the subcutaneous tumor mass for cell detection.

[0099] 3. Experimental results:

[0100] Table 1 Mouse H 22 Inhibitory effect on growth of transplanted liver cancer

[0101] Group Blank control group Control group A High dose group Low dose group Average tumor weight (g) 2.73±0.89 1.79±0.67 1.62±0.42 1.68±0.59 Tumor inhibition rate (%) 0 33.4 35.2 36.8

[0102] The experimental results (Table 1) show that the effect of the Chinese medicine preparation used in the present invention gradually increases with the improvement of the quality of Chinese medicinal materials. Both the high-dose group and the low-dose group have significant inhibitory effects compared with the control group A, and there is no significant difference in tumor weight between the high-dose and low-dose groups.

[0103] Obviously, the above embodiments are merely examples for the purpose of clear explanation, and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived therefrom are still within the scope of protection of the invention.

Claims

1. A Chinese medicine preparation for treating liver cancer, characterized in that: The invention comprises the following components in parts by weight: 1-3 parts of Aconitum, 15-25 parts of Curcuma, 6-12 parts of Star Anise, 6-12 parts of Angelica, 12-15 parts of Curcuma, 15-25 parts of Astragalus, 9-15 parts of Codonopsis, 15-25 parts of Atractylodes, 6-12 parts of Ligustrum lucidum and 6-12 parts of Ganoderma lucidum.

2. The Chinese medicine preparation for treating liver cancer according to claim 1, characterized in that: The preparation is a capsule, an injection or an oral solution, wherein the preparation steps of the capsule are: Step 1, raw material pretreatment: take aconite, turmeric, star anise, angelica, curcuma, astragalus, codonopsis, atractylodes, glossy privet and ganoderma, after manually sorting out unqualified medicinal materials, add them into a preparation device for washing, drying and crushing, separate high-quality medicinal material powder and secondary medicinal material powder by the preparation device, and weigh 2 parts of aconite, 25 parts of turmeric, 12 parts of star anise, 12 parts of angelica, 15 parts of curcuma, 15 parts of astragalus, 9 parts of codonopsis, 20 parts of atractylodes, 6 parts of glossy privet and 6 parts of ganoderma in the high-quality medicinal material powder; Step 2, supercritical fluid extraction: the pretreated raw materials are loaded into an extraction kettle, the carbon dioxide gas is pressurized by a high-pressure pump, and the temperature is increased by a heat exchanger to reach a set supercritical state, and then the supercritical carbon dioxide fluid is injected into the extraction kettle to dissolve the concentrated solution of the purified Chinese medicine; Step 3, drying and purification: freeze-drying the obtained concentrated solution of the purified Chinese medicine extract to obtain a powder or granular solid purified Chinese medicine extract powder; Step 4, filling and packaging: filling the dried purified Chinese medicine extract into capsules and performing packaging treatment to obtain Chinese medicine capsules for treating liver cancer.

3. The Chinese medicine preparation for treating liver cancer according to claim 2, characterized in that: The preparation steps of injection are as follows: Step 1, raw material pretreatment: weigh 3 parts of Aconitum, 20 parts of Curcuma, 6 parts of Star Anise, 6 parts of Angelica, 12 parts of Curcuma, 25 parts of Astragalus, 15 parts of Codonopsis, 25 parts of Atractylodes, 12 parts of Ligustrum lucidum and 12 parts of Ganoderma lucidum from the high-quality medicinal material powder processed by the preparation device; Step 2, extraction and purification: the pretreated medicinal material is decocted with water, the decoction obtained is filtered, and 95% anhydrous ethanol is added to precipitate the effective components. When the final purity range reaches 60% to 90%, it is allowed to stand for 24 hours, and the precipitate is separated by a centrifuge. The precipitate is washed with 95% anhydrous ethanol to remove attached impurities and residual solvents, and the washed precipitate is freeze-dried to obtain a purified precipitate of traditional Chinese medicine; Step 3, dissolving and preparing: dissolving the dried purified precipitate of traditional Chinese medicine in an appropriate amount of water for injection, heating and stirring to form a uniform solution, and mixing the dissolved active ingredient solution with a stabilizer to obtain an injection stock solution; Step 4: Filtration and sterilization: Use a filtration device to perform a preliminary filtration on the injection stock solution to remove large particle impurities, use an ultrafiltration membrane to perform a fine filtration on the solution after the preliminary filtration, and perform a hot pressure sterilization treatment on the finely filtered solution; Step 5: Packaging and sealing: the sterilized injection stock solution is packed into ampoules, and the packed containers are immediately sealed to obtain the Chinese medicine injection for treating liver cancer.

4. The Chinese medicine preparation for treating liver cancer according to claim 3, characterized in that: The preparation steps of oral solution are: Step 1, weighing: weighing by weight: 1 part of Aconitum, 25 parts of Curcuma, 6 parts of Illustrated, 6 parts of Angelica, 12 parts of Curcuma, 25 parts of Astragalus, 9 parts of Codonopsis, 15 parts of Atractylodes, 6 parts of Ligustrum lucidum and 6 parts of Ganoderma lucidum from the secondary medicinal material powder processed by the preparation device; Step 2, extraction and purification: extracting and collecting volatile components from Aconitum, Curcuma longa, Star anise, Angelica sinensis and Curcuma zedoaria by steam distillation, and decocting the residues of Aconitum, Curcuma longa, Star anise, Angelica sinensis and Curcuma zedoaria together with Astragalus membranaceus, Codonopsis pilosula, Atractylodes macrocephala, Ligustrum lucidum and Ganoderma lucidum for 1 to 2 hours each time, 2 to 3 times to obtain a Chinese medicine extract, centrifuging the Chinese medicine extract to obtain a refined liquid and mixing them; Step 3, concentrated liquid preparation: the obtained refined liquid is heated and concentrated to a concentration level of 10 to 20 ml per dose, volatile components are added to the concentrated liquid, and a surfactant is added to evenly disperse the volatile components in the concentrated liquid to obtain a prepared liquid medicine; Step 4, packaging and sterilization: before filling, the glass bottles are cleaned and sterilized, the prepared liquid medicine is filled into the glass bottles and capped and sealed, and the glass bottles containing the liquid medicine are sterilized again with circulating steam to obtain the oral liquid for treating liver cancer.

5. A Chinese medicine preparation device for treating liver cancer, comprising a housing (1) and an external controller, wherein the external controller is fixedly connected to the outer wall of the housing (1), and the housing (1) is signal-connected to the external controller; characterized in that: A vertical first partition (20) is fixedly connected inside the box body (1), and the first partition (20) divides the box body (1) into a first processing chamber (2) and a second processing chamber (29). A plurality of second partitions (34) and a third partition (35) are fixedly connected inside the first processing chamber (2) and the second processing chamber (29), respectively. The second partitions (34) and the third partitions (35) respectively divide the inside of the first processing chamber (2) and the second processing chamber (29) into a first cleaning chamber, a first drying chamber (11) and a first recovery chamber (15) and a second cleaning chamber, a second drying chamber and a second recovery chamber (21) from top to bottom. A coupling (30) is fixedly connected to the first partition (20), and two ends of the coupling (30) are respectively located in the first cleaning chamber and the second cleaning chamber and are respectively fixedly connected with a first cleaning component and a second cleaning component for cleaning medicinal materials.

6. The Chinese medicine preparation device for treating liver cancer according to claim 5, characterized in that: A symmetrically arranged inclined platform (9) is fixedly connected to the bottom wall of the first cleaning chamber, and a first fan (8) is fixedly connected to the inclined platform (9). A second fan (6) is fixedly connected to the side of the first cleaning chamber away from the second cleaning chamber. A first isolation box (3) is fixedly connected to the top of the first cleaning chamber. The side wall and the bottom of the first isolation box (3) are provided with first one-way valves corresponding to the first fan (8) and the second fan (6). A first motor (5) is fixedly connected to the inner wall of the first cleaning chamber on the side close to the second fan (6). The output shaft of the first motor (5) is coaxially fixedly connected to a first rotating shaft (33). An end of the first rotating shaft (33) away from the first motor (5) passes through the first isolation box (3) and is fixedly connected to a coupling (30). The first cleaning assembly includes a first cleaning tank (4). The first rotating shaft (33) is located at the first cleaning tank (4). A portion inside an isolation box (3) is coaxially fixedly connected to a first cleaning tank (4), the first cleaning tank (4) is rotatably connected to the first isolation box (3), a feed port is provided on the top of the first cleaning tank (4), a feed pipe (32) is connected to the feed port, the feed pipe (32) passes through the first isolation box (3) and the first cleaning chamber and extends to the outside of the box body (1), the feed port is connected to a first solenoid valve (31) corresponding to the feed pipe (32), a plurality of first water inlet holes are provided on the side wall of the first cleaning tank (4), a first delivery pipe (17) is provided in the first cleaning chamber, one end of the first delivery pipe (17) is located in the first cleaning chamber and is connected to the first cleaning tank (4), the other end of the first delivery pipe (17) extends into the first drying chamber (11), and a first valve corresponding to the first delivery pipe (17) is connected to the first cleaning tank (4).

7. The Chinese medicine preparation device for treating liver cancer according to claim 6, characterized in that: A second partition (34) located between the first cleaning chamber and the second cleaning chamber is provided with a plurality of eccentric second solenoid valves, a second isolation box (26) is fixedly connected to the top wall of the second cleaning chamber, a coupling (30) is coaxially fixedly connected to a second rotating shaft (28) at one end of the second cleaning chamber, an end of the second rotating shaft (28) away from the coupling (30) passes through the second isolation box (26) and is rotatably connected to a side of the second cleaning chamber away from the second partition (34); The second cleaning assembly comprises a second cleaning tank (27), a portion of the second rotating shaft (28) located in the second isolation box (26) is coaxially fixedly connected to the second cleaning tank (27), a plurality of second water inlet holes are opened on the side wall of the second cleaning tank (27), a third fan (25) is fixedly connected to the bottom of the second cleaning chamber, a second one-way valve corresponding to the third fan (25) is opened at the bottom of the second isolation box (26), a second delivery pipe (24) is arranged in the second cleaning chamber, one end of the second delivery pipe (24) is located in the second cleaning chamber and is connected to the second cleaning tank (27), the other end of the second delivery pipe (24) extends into the second drying chamber, and the second cleaning tank (27) is connected to a second valve corresponding to the second delivery pipe (24).

8. The Chinese medicine preparation device for treating liver cancer according to claim 7, characterized in that: The first drying chamber (11) and the second drying chamber are both provided with drying components, and the drying components both include drying boxes, the top wall and the bottom wall of the drying boxes are respectively fixedly connected to the inner top wall and the inner bottom wall of the first drying chamber (11) and the second drying chamber, and electric heating wires are evenly distributed on the inner side walls of the drying boxes. A serpentine tube (10) is arranged between the drying box and the first drying chamber (11) and the second drying chamber, and one end of the serpentine tube (10) extends to the outside of the box body (1) and is connected to the water tank, and the other end of the serpentine tube (10) extends to the first cleaning tank (4 ) and the second cleaning tank (27), and are rotatably connected to the side walls of the first cleaning tank (4) and the second cleaning tank (27), respectively; a drain pipe (7) is provided in each of the first cleaning tank (4) and the second cleaning tank (27); one end of the drain pipe (7) away from the first cleaning tank (4) and the second cleaning tank (27) extends to the outside of the box body (1); one end of the drain pipe (7) located in the first cleaning tank (4) and the second cleaning tank (27) is connected to a third valve; and a water pump is connected to the serpentine pipe (10) and the drain pipe (7).

9. The Chinese medicine preparation device for treating liver cancer according to claim 8, characterized in that: The first drying box (19) and the second drying box (23) are both fixedly connected with a stirring assembly, and the stirring assembly comprises a second motor (12) fixedly connected to the inner side wall of the first drying box (19) and the second drying box (23), and the output shaft of the second motor (12) is coaxially fixedly connected to a stirring shaft (13), and a plurality of blades (14) are fixedly connected to the stirring shaft (13).

10. The Chinese medicine preparation device for treating liver cancer according to claim 9, characterized in that: A third conveying pipe (18) is connected between the first drying box (19) and the first recovery chamber (15); a fourth valve corresponding to the third conveying pipe (18) is connected to the first drying box (19); a fourth conveying pipe (22) is connected between the second drying box (23) and the second recovery chamber (21); a fifth valve corresponding to the fourth conveying pipe (22) is connected to the second drying box (23); recovery bags (16) are detachably connected in the first recovery chamber (15) and the second recovery chamber (21); and recovery hatches that can be connected to the outside of the box body (1) are provided on the side walls of the first recovery chamber (15) and the second recovery chamber (21).

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