Spray for treating rhinitis and preparation method thereof

Abstract

The invention belongs to the field of medicine, and provides a spray for treating rhinitis and a preparation method thereof, the spray comprises the following raw materials by weight: 5-20 parts of dahurian angelica root, 20-40 parts of Ligusticum wallichii, 10-20 parts of sea-buckthorn, 10-30 parts of Chinese angelica, 10-20 parts of cinnamon, 10-30 parts of wrinkled gianthyssop herb, 10-20 parts of cocklebur fruit, 10-20 parts of magnolia flower, 20-30 parts of chrysanthemum, 5-12 parts of mint, 6-15 parts of purple perilla and 5-20 parts of notopterygium root. When the spray is prepared, the raw materials are fully extracted according to the characteristics of the raw materials, so that effective components in the raw materials are extracted to the maximum extent, the drug effect of the product is improved, the nasal mucosa of a patient can be protected from drug stimulation by adding the nasal mucosa protective agent into the spray, and meanwhile, the effect is good. By controlling the range of the pH value of the spray in the preparation process of the spray, the stability and activity of the medicine can be maintained, meanwhile, stimulation and damage to nasal mucosa are reduced, and the safety and curative effect of the product are improved.

Description

Technical Field

[0001] The invention belongs to the field of medicine, in particular to a spray for treating rhinitis and a preparation method thereof. Background Art

[0002] Rhinitis is an inflammatory disease of the nasal cavity. It is an inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physical and chemical factors, and certain systemic diseases. The main pathological changes of rhinitis are congestion, swelling, exudation, hyperplasia, atrophy or necrosis of the nasal mucosa. The incidence of rhinitis is high, which seriously affects people's daily life. In severe cases, obstructive sleep apnea will occur, and even affect the development of maxillofacial region.

[0003] Currently, there are many medicines and sprays for treating rhinitis on the market, such as Chinese medicine sprays and Western medicine sprays for treating rhinitis.

[0004] However, existing nasal sprays still have many deficiencies in preparation methods and raw material selection. For example, some sprays fail to fully consider the characteristics of the raw materials when extracting active ingredients, resulting in low extraction efficiency or loss of active ingredients. In addition, some sprays may irritate the nasal mucosa during use, causing discomfort to patients.

[0005] Therefore, those skilled in the art have proposed a spray for treating rhinitis and a preparation method thereof to solve the problems raised by the background art. Summary of the invention

[0006] In order to solve the above technical problems, the present invention provides a spray for treating rhinitis and a preparation method thereof, so as to solve the problems in the prior art.

[0007] A spray for treating rhinitis comprises the following raw materials by weight: 5-20 parts of angelica dahurica, 20-40 parts of chuanxiong, 10-20 parts of seabuckthorn, 10-30 parts of angelica sinensis, 10-20 parts of cinnamon bark, 10-30 parts of patchouli, 10-20 parts of xanthium sibiricum, 10-20 parts of cyperus rotundus, 20-30 parts of chrysanthemum, 5-12 parts of mint, 6-15 parts of perilla and 5-20 parts of notopterygium wilfordii.

[0008] Preferably, the raw materials include the following components by weight: 10 parts of Angelica dahurica, 22 parts of Ligusticum chuanxiong, 16 parts of Hippophae rhamnoides, 25 parts of Angelica sinensis, 18 parts of Cinnamon bark, 12 parts of Patchouli, 16 parts of Xanthium sibiricum, 12 parts of Cynanchum cyrtonema, 22 parts of Chrysanthemum, 8 parts of Mint, 11 parts of Perilla frutescens and 13 parts of Notopterygium wilfordii.

[0009] A method for preparing a spray for treating rhinitis comprises the following steps:

[0010] S1, select each component raw material, weigh it, wash, cut and dry it;

[0011] S2, extracting the extract according to the characteristics of each component raw material;

[0012] S3, mixing the extracts of the components and adding physiological saline to obtain a mixed solution, and performing nano-scale dispersion treatment on the mixed solution using an ultrasonic disperser;

[0013] S4, adding a stabilizer, a preservative and a nasal mucosa protective agent to the mixed solution after the nano-scale dispersion treatment and stirring the mixture evenly;

[0014] S5, adding a regulator to the mixed solution to adjust the pH value;

[0015] S6. Get the product and package it.

[0016] Preferably, in step S1, the selected materials are fresh and high-quality dried medicinal materials, ensuring that they are free of impurities, mildew or insects.

[0017] Preferably, in step S2, angelica dahurica, ligusticum chuanxiong, angelica sinensis, cinnamon bark, patchouli, cyperus rotundus, chrysanthemum, perilla frutescens and notopterygium wilfordii in each component raw material are extracted by water extraction, seabuckthorn is extracted by pressing extraction, and Xanthium sibiricum and mint are extracted by steam distillation.

[0018] Preferably, in step S3, the amount of physiological saline added is 10-30% of the total amount of the extracts of each component.

[0019] Preferably, in step S4, the stabilizer is one of sodium hyaluronate or glycerol, and the amount of the stabilizer added is 2-5% of the mixed solution; the preservative is benzalkonium chloride, and the amount of the preservative added is 0.01-0.5% of the mixed solution; the nasal mucosa protective agent is sodium hyaluronate, and the amount of the nasal mucosa protective agent added is 0.1-1% of the mixed solution.

[0020] Preferably, in step S5, a regulator is added according to the pH value of the mixed solution to keep the pH value of the mixed solution between 4.5 and 7, and the regulator is one of an acidic regulator or an alkaline regulator.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] 1. When preparing the spray, the present invention fully extracts the raw materials according to their characteristics to ensure that the effective ingredients in the raw materials are extracted to the maximum extent and improve the efficacy of the product.

[0023] 2. The present invention can protect the patient's nasal mucosa from drug stimulation by adding a nasal mucosa protective agent to the spray. At the same time, by controlling the pH value range of the spray during the preparation of the spray, it helps to maintain the stability and activity of the drug, while reducing stimulation and damage to the nasal mucosa, thereby improving the safety and efficacy of the product.

[0024] 3. The spray prepared by the present invention acts on the nasal cavity through different mechanisms, which helps to relieve the symptoms of rhinitis. At the same time, all ingredients of the nasal spray are of natural origin, avoiding the side effects that may be caused by traditional drugs. It is suitable for long-term use, especially for patients who are sensitive to chemical drugs or pursue natural therapies. DETAILED DESCRIPTION

[0025] The following examples are used to illustrate the present invention, but they are not intended to limit the scope of the present invention.

[0026] Embodiment 1: The present invention provides a spray for treating rhinitis, comprising the following raw materials by weight: 5-20 parts of angelica dahurica, 20-40 parts of chuanxiong, 10-20 parts of sea buckthorn, 10-30 parts of angelica, 10-20 parts of cinnamon, 10-30 parts of patchouli, 10-20 parts of xanthium sibiricum, 10-20 parts of cyperus rotundus, 20-30 parts of chrysanthemum, 5-12 parts of mint, 6-15 parts of perilla and 5-20 parts of notopterygium wilfordii.

[0027] Furthermore, the raw materials include the following weight components: 10 parts of Angelica dahurica, 22 parts of Ligusticum chuanxiong, 16 parts of Hippophae rhamnoides, 25 parts of Angelica sinensis, 18 parts of cinnamon bark, 12 parts of Patchouli, 16 parts of Xanthium sibiricum, 12 parts of Cynanchum scabra, 22 parts of chrysanthemum, 8 parts of mint, 11 parts of Perilla frutescens and 13 parts of Notopterygium wilfordii.

[0028] Among them, Angelica dahurica has the effects of dispelling wind, dispelling wind and relieving pain, reducing swelling and pus, and relieving itching. It can inhibit bacterial growth, reduce inflammatory reactions, improve the congestion and edema of the nasal mucosa, and help relieve symptoms such as nasal congestion and runny nose.

[0029] The active ingredients in Chuanxiong have anti-inflammatory effects, can inhibit inflammatory responses and alleviate inflammatory symptoms, which may be helpful in relieving nasal mucosal inflammation caused by rhinitis.

[0030] Sea buckthorn has anti-inflammatory, immune-regulating, antitussive and expectorant, antispasmodic and antiasthmatic effects. At the same time, sea buckthorn can regulate the body's immune function and enhance the body's resistance.

[0031] Dong quai has anti-inflammatory properties, which can reduce inflammation and help relieve swelling and pain. This may be helpful in relieving swelling and inflammation of the nasal mucosa caused by rhinitis.

[0032] Cinnamon has certain anti-inflammatory and bactericidal effects, which can inhibit the growth and reproduction of pathogens in the nasal cavity, thereby alleviating the symptoms of rhinitis.

[0033] Patchouli has a certain therapeutic effect on acute rhinitis. Its antipyretic effect helps fight viruses and improve symptoms. In addition, Patchouli also has the effect of removing dampness, which can help relieve nasal congestion, headaches and other discomforts caused by dampness.

[0034] Xanthium sibiricum has anti-inflammatory, anti-allergic, antihistamine effects, and can reduce capillary permeability.

[0035] Xindihua has the effects of constricting nasal mucosal blood vessels, improving microcirculation, and resisting histamine.

[0036] Chrysanthemum clears away heat and detoxifies, reduces swelling and discharges pus, and has antibacterial, antiviral, antipyretic, analgesic and anti-inflammatory effects.

[0037] Mint has a cooling sensation and can relieve nasal discomfort, and reduce symptoms such as nasal congestion and runny nose.

[0038] Perilla has the effects of dispelling cold, promoting qi and harmonizing the stomach, and may relieve symptoms such as nasal congestion and runny nose caused by rhinitis to a certain extent.

[0039] Qianghuo has the effects of dispelling cold, removing wind and dampness, and relieving pain, and may help relieve the symptoms of rhinitis, especially rhinitis related to wind and cold.

[0040] From the above, it can be seen that the above raw materials work together on the nasal cavity through different mechanisms, which helps to relieve the symptoms of rhinitis. At the same time, all ingredients of this rhinitis spray are of natural origin, avoiding the side effects that may be caused by traditional drugs. It is suitable for long-term use, especially for patients who are sensitive to chemical drugs or pursue natural therapies.

[0041] Embodiment 2: This embodiment is basically the same as the previous embodiment, except that a method for preparing a spray for treating rhinitis comprises the following steps:

[0042] S1, select each component raw material, weigh it, wash, cut and dry it;

[0043] Through washing, cutting and drying, the purity and quality of the raw materials can be ensured, impurities, moldy or insect-infested parts can be removed, and high-quality raw materials can be provided for subsequent steps, thereby improving the efficacy and safety of the final product.

[0044] S2, extracting the extract according to the characteristics of each component raw material;

[0045] According to the characteristics of each component raw material, the appropriate extraction method can be used to extract the active ingredients in the raw materials to the maximum extent and improve the efficacy of the product. At the same time, different extraction methods can also avoid the interference of invalid or harmful components in the raw materials and ensure the safety and effectiveness of the product.

[0046] S3, mixing the extracts of the components and adding physiological saline to obtain a mixed solution, and performing nano-scale dispersion treatment on the mixed solution using an ultrasonic disperser;

[0047] Mixing the extracts of each component and adding an appropriate amount of physiological saline can make the components more evenly dispersed in the mixture. Nano-scale dispersion treatment by ultrasonic disperser can further reduce the particle size, improve the absorption efficiency and bioavailability of the product, and enable the drug to act on the nasal mucosa faster and exert a therapeutic effect.

[0048] S4, adding a stabilizer, a preservative and a nasal mucosa protective agent to the mixed solution after the nano-scale dispersion treatment and stirring the mixture evenly;

[0049] Adding stabilizers can improve the stability of the product and prevent the drug from deteriorating or degrading during storage and use. Preservatives can extend the shelf life of the product and prevent microbial contamination. Nasal mucosa protectants can protect the nasal mucosa from drug irritation and reduce discomfort. The addition of these additives can improve the safety and comfort of the product.

[0050] S5, adding a regulator to the mixed solution to adjust the pH value;

[0051] By adding a regulator to adjust the pH value of the mixture, it can be kept within an appropriate range, which helps maintain the stability and activity of the drug, while reducing irritation and damage to the nasal mucosa and improving the safety and efficacy of the product.

[0052] S6. Get the product and package it.

[0053] Furthermore, in step S1, the selected materials are fresh and high-quality dried medicinal materials, ensuring that they are free of impurities, mildew or insects.

[0054] Furthermore, in step S2, angelica dahurica, ligusticum chuanxiong, angelica sinensis, cinnamon bark, patchouli, cyperus rotundus, chrysanthemum, perilla frutescens and notopterygium wilfordii in each component raw material are extracted by water extraction, seabuckthorn is extracted by pressing extraction, and Xanthium sibiricum and mint are extracted by steam distillation.

[0055] Furthermore, in step S3, the amount of physiological saline added is 10-30% of the total amount of the extracts of each component.

[0056] Further, in step S4, the stabilizer is one of sodium hyaluronate or glycerol, and the amount of the stabilizer added is 2-5% of the mixed solution; the preservative is benzalkonium chloride, and the amount of the preservative added is 0.01-0.5% of the mixed solution; the nasal mucosa protective agent is sodium hyaluronate, and the amount of the nasal mucosa protective agent added is 0.1-1% of the mixed solution.

[0057] Furthermore, in step S5, a regulator is added according to the pH value of the mixed solution to keep the pH value of the mixed solution between 4.5 and 7, and the regulator is one of an acidic regulator or an alkaline regulator.

[0058] Experimental example:

[0059] Thirty rhinitis patients were divided into two groups, an experimental group and a control group. The experimental group used the spray prepared by the present invention, and the control group used normal saline. The method of use was to use it once in the morning and evening every day for two consecutive weeks. After two weeks, the symptoms of nasal congestion, runny nose, sneezing, and nasal itching of the two groups of patients were evaluated (the evaluation results were 0-3 levels, and the higher the level, the more severe it was). The results are shown in the following table:

[0060] Symptoms / Groups The average severity of the experimental group Severity of the control group Nasal congestion 0.9 2.0 Runny nose 0.7 1.8 sneeze 1.0 2.1 Itchy nose 0.8 1.9

[0061] As can be seen from the above table, after two weeks of treatment, the severity of each symptom in the experimental group was significantly lower than that in the control group, indicating that the nasal spray of the present invention has a significant therapeutic effect.

[0062] The embodiments of the present invention are provided for the purpose of illustration and description. Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are exemplary and cannot be understood as limitations of the present invention. Ordinary technicians in this field can change, modify, replace and modify the above embodiments within the scope of the present invention.

Claims

1. A spray for treating rhinitis, characterized in that: The raw material composition comprises the following ingredients by weight: 5-20 parts of angelica dahurica, 20-40 parts of chuanxiong, 10-20 parts of sea buckthorn, 10-30 parts of angelica sinensis, 10-20 parts of cinnamon bark, 10-30 parts of patchouli, 10-20 parts of xanthium sibiricum, 10-20 parts of cyathula capitata, 20-30 parts of chrysanthemum, 5-12 parts of mint, 6-15 parts of perilla and 5-20 parts of notopterygium wilfordii.

2. A spray for treating rhinitis as claimed in claim 1, characterized in that: The invention comprises the following raw materials by weight: 10 parts of angelica dahurica, 22 parts of chuanxiong, 16 parts of sea buckthorn, 25 parts of angelica sinensis, 18 parts of cinnamon bark, 12 parts of patchouli, 16 parts of xanthium sibiricum, 12 parts of cyperus rotundus, 22 parts of chrysanthemum, 8 parts of mint, 11 parts of perilla and 13 parts of notopterygium wilfordii.

3. A method for preparing a spray for treating rhinitis, the spray for treating rhinitis according to any one of claims 1-2, characterized in that: The following steps are involved: S1, select each component raw material, weigh it, wash, cut and dry it; S2, extracting the extract according to the characteristics of each component raw material; S3, mixing the extracts of the components and adding physiological saline to obtain a mixed solution, and performing nano-scale dispersion treatment on the mixed solution using an ultrasonic disperser; S4, adding a stabilizer, a preservative and a nasal mucosa protective agent to the mixed solution after the nano-scale dispersion treatment and stirring the mixture evenly; S5, adding a regulator to the mixed solution to adjust the pH value; S6. Get the product and package it.

4. A method for preparing a spray for treating rhinitis as claimed in claim 3, characterized in that: In step S1, the selected materials are fresh and high-quality dried medicinal materials, ensuring that they are free of impurities, mildew or insects.

5. A method for preparing a spray for treating rhinitis as claimed in claim 3, characterized in that: In step S2, angelica dahurica, chuanxiong, angelica sinensis, cinnamon bark, patchouli, cyperus rotundus, chrysanthemum, perilla frutescens and notopterygium wilfordii in the raw materials are extracted by water extraction, seabuckthorn is extracted by pressing extraction, and Xanthium sibiricum and mint are extracted by steam distillation.

6. A method for preparing a spray for treating rhinitis as claimed in claim 3, characterized in that: In step S3, the amount of physiological saline added is 10-30% of the total amount of the extracts of each component.

7. A method for preparing a spray for treating rhinitis as claimed in claim 3, characterized in that: In step S4, the stabilizer is one of sodium hyaluronate or glycerol, and the amount of the stabilizer added is 2-5% of the mixed solution; the preservative is benzalkonium chloride, and the amount of the preservative added is 0.01-0.5% of the mixed solution; the nasal mucosa protective agent is sodium hyaluronate, and the amount of the nasal mucosa protective agent added is 0.1-1% of the mixed solution.

8. The method for preparing a spray for treating rhinitis according to claim 3, characterized in that: In step S5, a regulator is added according to the pH value of the mixed solution to keep the pH value of the mixed solution between 4.5 and 7. The regulator is an acidic regulator or an alkaline regulator.