Mosquito-repelling, itching-relieving and swelling-eliminating composition and preparation method thereof

Abstract

The invention relates to the technical field of sanitary pest control, and discloses a mosquito-repelling, itching-relieving and swelling-eliminating composition and a preparation method thereof.The mosquito-repelling, itching-relieving and swelling-eliminating composition comprises clerodendrum sativum hydrolat and tithonia diversifolia hydrolat, the clerodendrum sativum hydrolat is obtained through extraction with an ultrasonic and steam distillation combined method, and the tithonia diversifolia hydrolat is obtained through a rotary evaporator. Extracting under reduced pressure; the mosquito-repellent liquid is scientific and reasonable in formula, safe, efficient, low in price and simple in preparation process, and has triple effects of repelling mosquitoes, relieving itching and diminishing swelling.

Description

Technical Field

[0001] The invention relates to the technical field of prevention and treatment of sanitary pests, in particular to a mosquito-repelling, itching-relieving and swelling-removing composition and a preparation method thereof. Background Art

[0002] Culex pipiens pallens is an insect of the genus Culex in the family Culicidae. It is a major health pest in northern my country and can spread a variety of diseases such as epidemic encephalitis B, lymphatic filariasis, West Nile fever, and bancroftian filariasis. The prevention and control of Culex pipiens pallens has become an urgent problem to be solved. However, the current control methods of Culex pipiens pallens rely on chemical and plant-based mosquito repellent products, which have caused serious drug resistance in Culex pipiens pallens, and these products have no obvious effect on the itching and redness caused by the bites of Culex pipiens pallens. The development of safer and more efficient products that can also treat the itching and redness caused by mosquito bites has become a hot topic in current research. Summary of the invention

[0003] The invention provides a mosquito repellent, itching and swelling relieving composition and a preparation method thereof, and provides a plant hydrosol composition having the triple effects of mosquito repellent, itching and swelling relieving.

[0004] The scheme of the present invention is:

[0005] A mosquito repellent, itching and swelling-reducing composition, characterized in that it comprises Melaleuca alternifolia hydrosol and Tithonia scabra hydrosol, wherein the mass ratio of Melaleuca alternifolia hydrosol to Tithonia scabra hydrosol is 1:0.1-9.

[0006] As a preferred technical solution, the Melaleuca hydrosol is extracted by a combination of ultrasound and steam distillation, specifically: the fresh Melaleuca leaves are cut into pieces, distilled water is added at a ratio of 10g:200mL, an ultrasonic device is used to perform ultrasound at 100HZ and 25℃±5℃ for 30min, and then steam distillation is used to heat at 90-100℃ to extract the Melaleuca hydrosol.

[0007] As a preferred technical solution, the scutellaria hydrosol is obtained by reduced-pressure extraction using a rotary evaporator, specifically: after the fresh leaves of scutellaria are cut into pieces, distilled water is added according to 10g:500mL, and the mixture is extracted twice at a pressure of 0.7Pa and a temperature of 68°C, and the filtrate is collected each time to obtain the scutellaria hydrosol.

[0008] The present invention also discloses a mosquito repellent, itching and swelling-reducing composition, comprising the following raw materials in parts by weight:

[0009] 1 to 100 parts of Melaleuca Album hydrosol;

[0010] 1 to 100 parts of chrysanthemum hydrosol;

[0011] 1 to 1.5 parts of emulsifier;

[0012] Agar 0.3-0.8 parts;

[0013] 5-16 parts vegetable oil;

[0014] 0.1-0.4 parts of silicon dioxide;

[0015] Appropriate amount of water.

[0016] As a preferred technical solution, the vegetable oil is one or more of castor oil, soybean oil, rapeseed oil and olive oil.

[0017] As a preferred technical solution, the emulsifier is one or more of gum arabic, gelatin, tragacanth gum, calcium hydroxide and zinc hydroxide.

[0018] As a preferred technical solution, the preparation steps of the above-mentioned mosquito repellent, itching and swelling-reducing composition are as follows:

[0019] 1) mixing 1 to 100 parts by weight of Tithonia suffruticosa hydrosol and 1 to 100 parts by weight of Melaleuca alternifolia hydrosol to obtain a composition;

[0020] 2) mixing the composition, 5 to 16 parts by weight of vegetable oil, 0.1 to 0.4 parts by weight of silicon dioxide, 0.3 to 0.8 parts by weight of agar, and 1 to 1.5 parts by weight of an emulsifier, and grinding continuously in the same direction until a slight crackling sound is heard, thereby obtaining colostrum;

[0021] 3) Sodium benzoate and methylparaben are added to the colostrum, mixed evenly, and distilled water is added to make up to volume to obtain a mosquito repellent, itching and swelling relieving composition emulsion.

[0022] The invention also discloses a mosquito repellent, itching and swelling-reducing composition and an application of its emulsion. The composition and its emulsion have a repellent effect on Culex pipiens pallens, and have an itching and swelling-reducing effect on skin itching and redness caused by mosquito bites.

[0023] Advantages of the present invention:

[0024] The composition of the scutellaria baicalensis and the euphorbia pulex hydrosol prepared by the method of the present invention and the emulsion thereof have obvious repellent activity against Culex pipiens pallens, and have obvious therapeutic effect on skin redness, swelling and itching after mosquito bites. The components of the present invention are scientific and reasonable, and the effect is remarkable. The emulsion preparation method is simple and convenient to operate, the content of effective ingredients is high, the production cost is low, and the product has a significant mosquito repellent effect. DETAILED DESCRIPTION

[0025] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further described below in conjunction with specific embodiments.

[0026] Example 1

[0027] Mix fresh leaves of Scutellaria baicalensis with distilled water at a ratio of 10 g:500 mL, and use a rotary evaporator to extract twice at 68°C under reduced pressure (0.7 pa), each time for 20 min. Combine the pure dew to make 200 mL in total to obtain fresh leaf pure dew of Scutellaria baicalensis.

[0028] Example 2

[0029] Mix fresh Melaleuca alternifolia leaves with distilled water at a ratio of 10g:200mL, and ultrasonicate them in an ultrasonicator for 30min at an ultrasonic intensity of 100Hz and an ultrasonic temperature of 25°C. Then, perform steam distillation under normal pressure to extract the pure dew at an extraction temperature of 100°C. Extract twice, 100mL each time, and combine the pure dews to obtain Melaleuca alternifolia pure dew.

[0030] Example 3

[0031] 1) Mix fresh leaves of Cyperus rotundus with distilled water at a ratio of 10 g:500 mL, and extract twice at 68 °C under reduced pressure (0.7 pa) using a rotary evaporator for 20 min each time. Combine the extracts to make a total of 200 mL to obtain the hydrosol of fresh leaves of Cyperus rotundus.

[0032] 2) Mix the fresh leaves of Melaleuca alternifolia with distilled water at a ratio of 10 g:200 mL, ultrasonicate in an ultrasonicator for 30 min, with an ultrasonic intensity of 100 Hz and an ultrasonic temperature of 25°C, then perform steam distillation under normal pressure to extract the pure dew at a temperature of 100°C, extract twice, 100 mL each time, and combine to obtain the Melaleuca alternifolia pure dew.

[0033] 3) Mix the scutellaria hydrosol and the red calendula hydrosol in a mass ratio of 1:1 to obtain a composition. The scutellaria hydrosol and the red calendula hydrosol can also be mixed in a ratio of 1:3, 1:5, etc., and the obtained composition also has the effect of repelling mosquitoes, relieving itching and reducing swelling.

[0034] Example 4

[0035] 1) Mix fresh leaves of Cyperus rotundus with distilled water at a ratio of 10 g:500 mL, and extract twice at 68 °C under reduced pressure (0.7 pa) using a rotary evaporator for 20 min each time. Combine the extracts to make a total of 200 mL to obtain the hydrosol of fresh leaves of Cyperus rotundus.

[0036] 2) Mix the fresh leaves of Melaleuca alternifolia with distilled water at a ratio of 10 g:200 mL, ultrasonicate in an ultrasonicator for 30 min, with an ultrasonic intensity of 100 Hz and an ultrasonic temperature of 25°C, then perform steam distillation under normal pressure to extract the pure dew at a temperature of 100°C, extract twice, 100 mL each time, and combine to obtain the Melaleuca alternifolia pure dew.

[0037] 3) After uniformly mixing 4 parts by weight of Tithonia sutchuenensis hydrosol, 4 parts by weight of Melaleuca alternifolia hydrosol, 10 parts by weight of olive oil, 0.3 parts by weight of silicon dioxide, 0.8 parts by weight of agar, and 1.0 parts by weight of zinc hydroxide, grind continuously in the same direction until a slight crackling sound is heard to obtain Tithonia sutchuenensis hydrosol and Melaleuca alternifolia hydrosol colostrum, then add 0.1 parts by weight of sodium benzoate and 0.1 parts by weight of methylparaben, mix uniformly, and distilled water to make up to 50 ml to obtain a composite emulsion.

[0038] Experiment 1

[0039] Mosquito repellent experiment

[0040] The hydrosols of Tilia cordata, Melaleuca alternifolia and their compositions and emulsions of Examples 1 to 4 were applied to the skin of the backs of both hands with an area of ​​40 mm × 40 mm. The area on the right hand was evenly smeared with the hydrosols and emulsions, and the left hand was smeared with water as a blank control. The experimenter put his hand into a cage with 15 Culex pipiens for 2 minutes to observe whether there were mosquitoes landing on the area on the back of the hand to suck blood.

[0041] Human skin surface experiment:

[0042] People bitten by mosquitoes were smeared with Melaleuca alternifolia hydrosol (product in Example 2), Tilapia scabra hydrosol (product in Example 1), a 1:1 combination of Tilapia scabra hydrosol and Melaleuca alternifolia hydrosol (product in Example 3), a combination emulsion (product in Example 4), and compound dexamethasone (commercially available), and the time for itching and redness and swelling to subside was recorded. The evaluation is detailed in Table 1 below.

[0043] Table 1

[0044]

[0045]

[0046] Conclusion: After applying the hydrosol of scutellaria baicalensis, the hydrosol of red calendula, the combination of scutellaria baicalensis and red calendula (1:1), and the emulsion of the combination, the number of mosquito bites was significantly lower than that of commercial products. The hydrosol of scutellaria baicalensis, the hydrosol of red calendula, the combination of scutellaria baicalensis and red calendula (1:1), and the emulsion of the combination were applied to the parts of the human body bitten by mosquitoes, and it was found that the time for eliminating the itching and swelling caused by mosquito bites was significantly lower than that of commercial products. This shows that the hydrosol of scutellaria baicalensis and the combination of red calendula and the emulsion thereof of the present invention have a good prevention and control effect on Culex pipiens pallens, and have a good therapeutic effect on skin itching and swelling caused by mosquito bites.

[0047] The above shows and describes the basic principles, main features and advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A mosquito repellent, itching and swelling-reducing composition, characterized in that: It includes Melaleuca alternifolia hydrosol and Tithonia sutchuenensis hydrosol, and the mass ratio of Melaleuca alternifolia hydrosol to Tithonia sutchuenensis hydrosol is 1:0.1-9.

2. The mosquito repellent, itching and swelling-reducing composition according to claim 1, characterized in that: The Melaleuca alternifolia hydrosol is extracted by a combination of ultrasound and steam distillation, specifically, the fresh Melaleuca alternifolia leaves are chopped, distilled water is added at a ratio of 10 g:200 mL, an ultrasonic device is used to perform ultrasound at 100 Hz and 25°C±5°C for 30 minutes, and then steam distillation is used to heat at 90-100°C to extract the Melaleuca alternifolia hydrosol.

3. The mosquito repellent, itching and swelling-reducing composition according to claim 1, characterized in that: The scutellaria hydrosol is obtained by vacuum extraction using a rotary evaporator, specifically, the fresh scutellaria leaves are chopped, distilled water is added according to 10g:500mL, and the mixture is extracted twice at a pressure of 0.7Pa and a temperature of 68°C, and the filtrate is collected each time to obtain the scutellaria hydrosol.

4. The mosquito repellent, itching and swelling-reducing composition according to any one of claims 1 to 3, characterized in that: The invention comprises the following raw materials in parts by weight: 1 to 100 parts of Melaleuca Album hydrosol; 1 to 100 parts of chrysanthemum hydrosol; 1 to 1.5 parts of emulsifier; Agar 0.3-0.8 parts; 5-16 parts vegetable oil; 0.1-0.4 parts of silicon dioxide; Appropriate amount of water.

5. The mosquito repellent, itching and swelling-reducing composition according to claim 4, characterized in that: The vegetable oil is one or more of castor oil, soybean oil, rapeseed oil and olive oil.

6. The mosquito repellent, itching and swelling-reducing composition according to claim 4, characterized in that: The emulsifier is one or more of gum arabic, gelatin, gum tragacanth, calcium hydroxide and zinc hydroxide.

7. The mosquito repellent, itching and swelling-reducing composition according to claim 4, characterized in that: The preparation steps are as follows: 1) mixing 1 to 100 parts by weight of Tithonia suffruticosa hydrosol and 1 to 100 parts by weight of Melaleuca alternifolia hydrosol to obtain a composition; 2) mixing the composition, 5 to 16 parts by weight of vegetable oil, 0.1 to 0.4 parts by weight of silicon dioxide, 0.3 to 0.8 parts by weight of agar, and 1 to 1.5 parts by weight of an emulsifier, and grinding continuously in the same direction until a slight crackling sound is heard, thereby obtaining colostrum; 3) Sodium benzoate and methylparaben are added to the colostrum, mixed evenly, and distilled water is added to make up to volume to obtain a mosquito repellent, itching and swelling relieving composition emulsion.

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