Cell culture device

Abstract

The utility model discloses a cell culture device. The cell culture device comprises a culture box, the culture box comprises a visual grabbing assembly and a culture table; at least one group of culture bottles are arranged on the culture tables; the visual grabbing assembly can monitor the state of the culture bottle and can grab the culture bottle. The culture box has the advantages that the culture tables are arranged in the culture box, the culture bottles can be supported and limited through the limiting assemblies on the culture tables, the culture tables can be vertically arranged in multiple layers, each layer of culture table can independently achieve autorotation, multiple sets of culture bottles can be stored in the culture tables, and the culture tables are convenient to use. The cell state of the culture bottles on each layer of culture table can be observed through the visual observation mechanism, the grown culture bottles can be grabbed through the clamping mechanism, intelligent storage and taking are achieved, the heat preservation effect of the culture box is good, and the working efficiency is greatly improved.

Description

Technical Field

[0001] The utility model relates to the technical field of cell culture, in particular to a cell culture device. Background Art

[0002] In vitro culture of cells and tissues has become an indispensable part of life research and practice. There are many types of cells to be cultured, from viruses to bacteria and fungi, from human cells to animal cells and plant cells. In addition to good transparency, non-toxicity and sterility, culture bottles also enable cells to adhere to the wall, divide and grow. Therefore, using culture bottles for culture is one of the common methods. During the culture process, the culture bottles are usually placed in an incubator.

[0003] The existing application number is CN2018103475710, and the patent name is a sample storage device for medical testing. It aims to address the problem that nutrients cannot be added to the sample under sealed conditions, the sealing conditions inside the storage box are poor, and it is easily affected by the external environment.

[0004] The following problems exist in the comparative documents: 1. The process of storing and retrieving culture bottles needs to be done manually, which is labor-intensive and inefficient; 2. The incubator has poor insulation effect and large temperature changes, which cannot meet the needs of more efficient cell culture. Therefore, a cell culture device is urgently needed. Summary of the invention

[0005] The purpose of this section is to summarize some aspects of the embodiments of the utility model and briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section and the specification abstract and invention title of this application to avoid blurring the purpose of this section, specification abstract and invention title, and such simplifications or omissions cannot be used to limit the scope of the utility model.

[0006] In view of the above problems or problems existing in the prior art, the present utility model is proposed.

[0007] Therefore, the purpose of the utility model is to provide a cell culture device, which can fully realize automatic storage and retrieval, can monitor the cell growth status, and can store large-capacity culture bottles, thereby greatly improving work efficiency.

[0008] In order to solve the above technical problems, the utility model provides the following technical solutions: a cell culture device, comprising a culture box;

[0009] The incubator includes a visual grasping component and an incubation table;

[0010] At least one group of culture bottles is arranged on the culture platform;

[0011] The visual gripping component can monitor the status of the culture bottle and can grip the culture bottle.

[0012] As a preferred solution of the cell culture device of the utility model, the multiple groups of culture platforms can rotate independently or simultaneously.

[0013] As a preferred solution of the cell culture device of the utility model, a transport channel is provided on the culture platform, and the visual grasping component can observe and grasp the culture bottle through the transport channel.

[0014] As a preferred solution of the cell culture device of the utility model, the culture box further comprises a rotating shaft, and a plurality of culture platforms are vertically arranged on the rotating shaft.

[0015] As a preferred solution of the cell culture device of the utility model, wherein: a clamping groove is arranged in a circumferential array on the culture platform.

[0016] As a preferred solution of the cell culture device of the utility model, wherein: a limiting component is arranged on the culture platform, the limiting component can limit the culture bottle, and the limiting components are arranged in a circular array.

[0017] As a preferred solution of the cell culture device of the utility model, wherein: the limiting assembly includes a first limiting block, a second limiting block, and a clamping portion;

[0018] The first limiting blocks are symmetrically arranged on both sides of the clamping groove, the second limiting block is arranged in front of the first limiting block, and the engaging portion is arranged in front of the clamping groove and close to the center of the culture platform.

[0019] As a preferred solution of the cell culture device of the utility model, the upper cross-section of the first limit block is an isosceles trapezoid with chamfered corners, and the first limit block and the second limit block are symmetrically arranged front to back.

[0020] As a preferred solution of the cell culture device of the utility model, wherein: the culture box also includes a first driving mechanism; the first driving mechanism is arranged on the inner wall of the culture box, and the first driving mechanism can drive the culture platform to rotate around the rotation axis.

[0021] As a preferred solution of the cell culture device of the utility model, each group of culture platforms is correspondingly provided with a first driving mechanism.

[0022] As a preferred solution of the cell culture device of the utility model, wherein: the visual grasping component includes a visual observation mechanism, a clamping mechanism, and a lifting mechanism;

[0023] The lifting mechanism can drive the visual observation mechanism and the clamping mechanism to lift and lower, the clamping mechanism can support the visual observation mechanism, and the clamping mechanism can grab the culture bottle on the culture table.

[0024] As a preferred solution of the cell culture device of the utility model, the clamping mechanism includes a first driving member, a movable slider, an upper clamping portion, a lower clamping portion and a lifting slider;

[0025] A first driving member is arranged above the upper clamping part, the first driving member passes through the upper clamping part and is connected to the movable slider, the movable slider is connected to the lower clamping part through a connecting rod, and the sides of the upper clamping part and the lower clamping part are connected to the lifting slider.

[0026] As a preferred solution of the cell culture device of the utility model, wherein: the visual observation mechanism includes an upper visual component and a lower visual component;

[0027] The upper end of the upper clamping part is connected to the upper visual component, and the lower end of the lower clamping part is connected to the lower visual component.

[0028] As a preferred solution of the cell culture device of the utility model, wherein: the lifting mechanism includes a second driving member and a support rod;

[0029] The second driving member can drive the lifting slide block to move up and down along the track on the side of the supporting rod.

[0030] As a preferred solution of the cell culture device of the utility model, the incubator further comprises a door opening mechanism, and the door opening mechanism can open the incubator door.

[0031] As a preferred solution of the cell culture device of the utility model, the culture box further comprises a sensor device, which can detect the storage status of the culture bottle.

[0032] The beneficial effects of the utility model are as follows: the utility model arranges a culture table in the incubator, and the culture bottles can be supported and limited by the limiting components on the culture table, and the culture table can be vertically arranged in multiple layers, each layer of the culture table can independently realize self-rotation, and the culture table can store multiple groups of culture bottles, and the cell status of the culture bottles on each layer of the culture table can be observed by the visual grasping component, and the culture bottles can be grasped, thereby realizing intelligent storage and retrieval, and the incubator has good thermal insulation effect, which greatly improves the work efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] In order to more clearly illustrate the technical solutions of the embodiments of the utility model, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.

[0034] in: Figure 1 Schematic diagram of the cell culture device.

[0035] Figure 2Schematic diagram of the interior of the cell culture device.

[0036] Figure 3 This is a schematic diagram of the interior of the cell culture device from another perspective.

[0037] Figure 4 This is a schematic diagram of the interior of the cell culture device from another perspective.

[0038] Figure 5 This is a partial enlarged view of the first driving mechanism of the cell culture device.

[0039] Figure 6 Schematic diagram of the culture platform of the cell culture device.

[0040] Figure 7 Schematic diagram of the visual grasping components of the cell culture device.

[0041] Figure 8 An enlarged view of the clamping mechanism of the cell culture device.

[0042] Fig. 9 An enlarged view of the door opening mechanism of the cell culture device. Implementation

[0043] In order to make the above-mentioned purposes, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below in conjunction with the accompanying drawings.

[0044] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein, and those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0045] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure or characteristic that may be included in at least one implementation of the present invention. The term "in one embodiment" that appears in different places in this specification does not necessarily refer to the same embodiment, nor does it refer to a separate or selective embodiment that is mutually exclusive with other embodiments. Example

[0046] Reference Figure 1~2 , which is the first embodiment of the utility model, and this embodiment provides a cell culture device, which includes an incubator 1; the incubator 1 includes a visual grasping component 101 and a culture table 102; a plurality of groups of culture bottles 911 can be stored through the culture table, and the state of the culture bottles 911 can be monitored and grasped through the visual grasping component 101.

[0047] Specifically, it includes an incubator 1;

[0048] The incubator 1 includes a visual capture component 101 and a culture table 102;

[0049] At least one group of culture bottles 911 is provided on the culture platform 102;

[0050] The visual grasping component 101 can monitor the status of the culture bottle 911 and grasp the culture bottle 911 .

[0051] In summary, the present invention arranges a visual grasping component 101 and a culture table 102 in the incubator 1, and multiple groups of culture bottles 911 can be stored on the culture table 102. The visual grasping component 101 can monitor the cell growth state in the culture bottle 911, and the culture bottle 911 that has grown well can be grasped. Example

[0052] Reference Figures 1 to 9 , which is the second embodiment of the utility model. In the previous embodiment, the cell culture device includes an incubator 1; the incubator 1 includes a visual grasping component 101 and a culture table 102; a plurality of groups of culture bottles 911 can be stored through the culture table, and the state of the culture bottles 911 can be monitored and grasped through the visual grasping component 101.

[0053] Specifically, it includes an incubator 1;

[0054] The incubator 1 includes a visual capture component 101 and a culture table 102;

[0055] At least one group of culture bottles 911 is provided on the culture platform 102;

[0056] The visual grasping component 101 can monitor the status of the culture bottle 911 and grasp the culture bottle 911 .

[0057] Furthermore, the multiple groups of culture platforms 102 can rotate individually or simultaneously.

[0058] Preferably, the culture platforms 102 can rotate around their own axes individually. The purpose of the rotation is to facilitate observation of the status of the culture bottles 911 and to facilitate grabbing of mature culture bottles 911. Of course, it is also possible to select multiple groups of culture platforms 102 to rotate simultaneously.

[0059] Furthermore, a transport channel 916 is provided on the culture platform 102 , and the visual grasping component 101 can observe and grasp the culture bottle 911 through the transport channel 916 .

[0060] Preferably, each layer of the culture platform 102 is provided with a transport channel 916 , and the visual capture component 101 can be raised and lowered through the transport channel 916 , and the status of the culture bottle 911 on the culture platform 102 can also be conveniently observed.

[0061] Furthermore, the incubator 1 further comprises a rotating shaft 103 , on which a plurality of culture tables 102 are vertically arranged.

[0062] Preferably, the rotating shaft 103 is vertically connected to the multiple groups of culture platforms 102 .

[0063] Furthermore, the incubator 1 further comprises a first driving mechanism 104 ; the first driving mechanism 104 is arranged on the inner wall of the incubator 1 , and the first driving mechanism 104 can drive the culture platform 102 to rotate around the rotating shaft 103 .

[0064] Preferably, the first driving mechanism 104 is a motor and a conveyor belt. The motor drives the conveyor belt to rotate by driving the conveyor belt shaft, and the conveyor belt drives the culture platform 102 to rotate through the conveyor belt shaft. Of course, other transmission methods can be adopted, such as chain transmission, or other driving methods can be used. Cylinders, hydraulic cylinders, cylinders, etc. are all possible. It is only necessary to drive the culture platform 102 to rotate.

[0065] Furthermore, each group of culture platforms 102 is correspondingly provided with a first driving mechanism 104 .

[0066] Preferably, each culture platform 102 is provided with a corresponding first driving mechanism 104, so that each culture platform 102 can be rotated independently.

[0067] Furthermore, a clamping groove 107 is arranged in a circular array on the culture platform 102 .

[0068] Preferably, a culture bottle 911 can be placed above the clamping groove 107 , support plates on both sides of the clamping groove 107 can support the culture bottle 911 , and the visual grasping component 101 can clamp the culture bottle 911 through the clamping groove 107 .

[0069] Furthermore, a limiting component 108 is provided on the culture platform 102 , and the limiting component 108 can limit the culture bottle 911 , and the limiting component 108 is arranged in a circular array.

[0070] Preferably, the culture bottle 911 is placed at the upper end of the clamping groove 107, and the limiting assembly 108 can prevent the culture bottle 911 from shaking and avoid falling off during the rotation process.

[0071] Furthermore, the limiting assembly 108 includes a first limiting block 1081, a second limiting block 1082, and a clamping portion 1083;

[0072] The first limit block 1081 is symmetrically arranged on both sides of the clamping groove 107 , the second limit block 1082 is arranged in front of the first limit block 1081 , and the locking portion 1083 is arranged in front of the clamping groove 107 and close to the center of the culture platform 102 .

[0073] Preferably, the first limit block 1081 and the second limit block 1082 are both symmetrically arranged in two groups. The culture bottle 911 can be limited and fixed by the first limit block 1081, the upper end of the culture bottle 911 can be fixed by the second limit block 1082, and the neck of the culture bottle 911 can be limited and supported by the snap-fit ​​portion 1083.

[0074] Furthermore, the upper cross-section of the first limiting block 1081 is a chamfered isosceles trapezoid, and the first limiting block 1081 and the second limiting block 1082 are symmetrically arranged front to back.

[0075] Preferably, the culture bottles 911 on both sides can be fixed at the same time by the chamfered isosceles trapezoid of the first limiting block 1081, and the second limiting block 1082 is an inverted isosceles trapezoid.

[0076] Further, the visual grasping assembly 101 includes a visual observation mechanism 1011, a clamping mechanism 1022, and a lifting mechanism 1023;

[0077] The lifting mechanism 1023 can drive the visual observation mechanism 1011 and the clamping mechanism 1022 to lift and lower. The clamping mechanism 1022 can support the visual observation mechanism 1011 , and the clamping mechanism 1022 can grab the culture bottle 911 on the culture platform 102 .

[0078] Preferably, the lifting mechanism 1023 can support the observation mechanism 1011 and the clamping mechanism 1022, and can drive the observation mechanism 1011 and the clamping mechanism 1022 to rise and fall.

[0079] Preferably, the visual observation mechanism 1011 can observe the cell growth status of the culture bottle 911.

[0080] Further, the clamping mechanism 1022 includes a first driving member 102201, a movable slider 102202, an upper clamping portion 102203, a lower clamping portion 102204 and a lifting slider 102205;

[0081] A first driving member 102201 is arranged above the upper clamping portion 102203. The first driving member 102201 passes through the upper clamping portion 102203 and is connected to the movable slider 102202. The movable slider 102202 is connected to the lower clamping portion 102204 through a connecting rod. The sides of the upper clamping portion 102203 and the lower clamping portion 102204 are connected to the lifting slider 102205.

[0082] Preferably, the first driving member 102201 can be a motor, an electric cylinder, or other driving mechanisms.

[0083] Preferably, the lower clamping portion 102204 can be slidably connected to the side of the lifting slider 102205, and the first driving member 102201 can drive the movable slider 102202 to drive the lower clamping portion 102204 to clamp the culture bottle 911 through the connecting rod.

[0084] Preferably, the upper clamping part 102203 and the lower clamping part 102204 can use a driving device in the prior art to clamp the culture bottle 911; for example, the upper clamping part 102203 and the lower clamping part 102204 can move at the same time to clamp the culture bottle 911; or the upper clamping part 102203 or the lower clamping part 102204 can be driven to move separately to achieve the clamping of the culture bottle 911;

[0085] Further, the visual observation mechanism 1011 includes an upper visual member 101101 and a lower visual member 101102;

[0086] The upper end of the upper clamping portion 102203 is connected to the upper visual component 101101 , and the lower end of the lower clamping portion 102204 is connected to the lower visual component 101102 .

[0087] Preferably, the upper visual component 101101 and the lower visual component 101102 can be cameras; or other existing technologies can be used as long as the cell growth status of the culture bottle 911 can be observed.

[0088] Furthermore, the lifting mechanism 1023 includes a second driving member 102301 and a support rod 102302;

[0089] The second driving member 102301 can drive the lifting slider 102205 to move up and down along the track on the side of the support rod 102302.

[0090] Preferably, the second driving member 102301 can be a motor driving a lead screw to rotate, and the lead screw is threadedly connected to the lifting slider 102205 to achieve lifting, or it can be other driving lifting devices in the prior art.

[0091] Furthermore, the incubator 1 further comprises a door opening mechanism 105 , and the door opening mechanism 105 can open the door of the incubator 1 .

[0092] Preferably, the inlet and outlet door of the incubator 1 can be opened by a door opening mechanism, which can ensure that the temperature inside the incubator 1 will not leak, and the incubator 1 adopts a double-layer insulation structure for further insulation.

[0093] Furthermore, the incubator 1 also includes a sensor device 106 , which can detect the storage status of the culture bottle 911 .

[0094] Preferably, each layer of the culture platform 102 is provided with a corresponding sensor device 106, which can sense whether there is an empty position on the culture platform 102 to place the culture bottle 911.

[0095] In summary, the utility model arranges a culture table 102 in the incubator 1, and the culture bottles can be supported and limited by the limiting components on the culture table 102, and the culture table 102 can be arranged in multiple layers vertically, and each layer of the culture table 102 can independently realize self-rotation, and the culture table 102 can store multiple groups of culture bottles 911. The cell status of the culture bottles 911 on each layer of the culture table 102 can be observed by the visual observation mechanism 1011, and the grown culture bottles 911 can be grabbed by the clamping mechanism 1022, thereby realizing intelligent storage and access, and the incubator 1 has good thermal insulation effect, which greatly improves the work efficiency.

[0096] Importantly, it should be noted that the construction and arrangement of the present application shown in a number of different exemplary embodiments are only exemplary. Although only a few embodiments are described in detail in this disclosure, it should be readily understood by those who refer to this disclosure that many modifications are possible (e.g., the size, scale, structure, shape and proportion of various elements, and parameter values ​​(e.g., temperature, pressure, etc.), mounting arrangements, use of materials, color, directional changes, etc.) without substantially departing from the novel teachings and advantages of the subject matter described in the application. For example, an element shown as integrally formed may be composed of multiple parts or elements, the position of the element may be inverted or otherwise changed, and the nature or number or position of the discrete element may be changed or changed. Therefore, all such modifications are intended to be included in the scope of the present utility model. The order or sequence of any process or method steps may be changed or reordered according to alternative embodiments. In the claims, any "device plus function" clause is intended to cover the structure described herein that performs the function, and is not only structurally equivalent but also an equivalent structure. Without departing from the scope of the present invention, other substitutions, modifications, changes and omissions may be made in the design, operating conditions and arrangement of the exemplary embodiments. Therefore, the present invention is not limited to a specific embodiment, but extends to various modifications that still fall within the scope of the appended claims.

[0097] Additionally, in order to provide a concise description of example embodiments, all features of an actual embodiment may not be described (ie, those features that are not relevant to the best mode presently contemplated for carrying out the invention or those that are not relevant to implementing the invention).

[0098] It will be appreciated that in the development of any actual implementation, as in any engineering or design project, numerous implementation-specific decisions may be made. Such a development effort may be complex and time-consuming, but will be a routine task of design, fabrication, and production for those of ordinary skill having the benefit of this disclosure without undue experimentation.

[0099] It should be noted that the above embodiments are only used to illustrate the technical solution of the utility model rather than to limit it. Although the utility model has been described in detail with reference to the preferred embodiments, ordinary technicians in the field should understand that the technical solution of the utility model can be modified or replaced by equivalents without departing from the spirit and scope of the technical solution of the utility model, which should be included in the scope of the claims of the utility model.

Claims

1. A cell culture device, characterized in that: Including an incubator (1); The incubator (1) comprises a visual grasping component (101) and a culture table (102); The culture platform (102) is provided with at least one group, and at least one group of culture bottles (911) is provided on the culture platform (102); The visual grasping component (101) can monitor the status of the culture bottle (911) and grasp the culture bottle (911).

2. The cell culture device according to claim 1, characterized in that: The multiple groups of culture platforms (102) can rotate individually or simultaneously.

3. The cell culture device according to claim 2, characterized in that: The culture platform (102) is provided with a transport channel (916), and the visual grasping component (101) can observe and grasp the culture bottle (911) through the transport channel (916).

4. The cell culture device according to claim 2 or 3, characterized in that: The incubator (1) further comprises a rotating shaft (103), on which a plurality of groups of culture tables (102) are vertically arranged.

5. The cell culture device according to claim 1 or 2, characterized in that: The culture platform (102) is provided with clamping grooves (107) in a circumferential array.

6. The cell culture device according to claim 5, characterized in that: The culture platform (102) is provided with a limiting component (108), and the limiting component (108) can limit the position of the culture bottle (911). The limiting components (108) are arranged in a circular array.

7. The cell culture device according to claim 6, characterized in that: The limiting assembly (108) comprises a first limiting block (1081), a second limiting block (1082), and a clamping portion (1083); The first limit block (1081) is symmetrically arranged on both sides of the clamping groove (107), the second limit block (1082) is arranged on the front side of the first limit block (1081), and the locking portion (1083) is arranged on the front side of the clamping groove (107) and close to the center of the culture platform (102).

8. The cell culture device according to claim 7, characterized in that: The upper cross-section of the first limiting block (1081) is a chamfered isosceles trapezoid, and the first limiting block (1081) and the second limiting block (1082) are arranged symmetrically front to back.

9. The cell culture device according to claim 4, characterized in that: The incubator (1) further comprises a first driving mechanism (104); the first driving mechanism (104) is arranged on the inner wall of the incubator (1), and the first driving mechanism (104) can drive the incubation platform (102) to rotate around a rotation axis (103).

10. The cell culture device according to claim 9, characterized in that: Each of the culture platforms (102) in a single group is correspondingly provided with a first driving mechanism (104).

11. The cell culture device according to claim 1, characterized in that: The visual grasping component (101) comprises a visual observation mechanism (1011), a clamping mechanism (1022), and a lifting mechanism (1023); The lifting mechanism (1023) can drive the visual observation mechanism (1011) and the clamping mechanism (1022) to lift and lower; the clamping mechanism (1022) can support the visual observation mechanism (1011); and the clamping mechanism (1022) can grab the culture bottle (911) on the culture platform (102).

12. The cell culture device according to claim 11, characterized in that: The clamping mechanism (1022) comprises a first driving member (102201), a movable slider (102202), an upper clamping portion (102203), a lower clamping portion (102204) and a lifting slider (102205); A first driving member (102201) is arranged above the upper clamping portion (102203), and the first driving member (102201) passes through the upper clamping portion (102203) and is connected to the movable slider (102202), and the movable slider (102202) is connected to the lower clamping portion (102204) via a connecting rod, and the side surfaces of the upper clamping portion (102203) and the lower clamping portion (102204) are connected to the lifting slider (102205).

13. The cell culture device according to claim 12, characterized in that: The visual observation mechanism (1011) comprises an upper visual component (101101) and a lower visual component (101102); The upper end of the upper clamping portion (102203) is connected to the upper visual component (101101), and the lower end of the lower clamping portion (102204) is connected to the lower visual component (101102).

14. The cell culture device according to claim 12, wherein: The lifting mechanism (1023) comprises a second driving member (102301) and a support rod (102302); The second driving member (102301) can drive the lifting slider (102205) to move up and down along the track on the side of the support rod (102302).

15. The cell culture device according to claim 1, wherein: The incubator (1) further comprises a door opening mechanism (105), wherein the door opening mechanism (105) can open the door of the incubator (1).

16. The cell culture device according to claim 2, characterized in that: The incubator (1) further comprises a sensor device (106), wherein the sensor device (106) can detect the storage status of the culture bottle (911).

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