3 results about "Morphinan derivatives" patented technology

The invention provides a preparation method of a morphinan derivative and a salt thereof, and particularly relates to a preparation method of a compound A10 and an intermediate A09 thereof. The refining method of A09 provided by the invention is simple in post-treatment and relatively high in product purity and yield, the provided preparation method of the compound I adopts a continuous feeding reaction to convert the compound A08 into A09 and then directly performs a salt forming reaction, the method is simple to operate, the yield and the purity are simultaneously improved, the used solvent is high in safety, and the method is suitable for industrial application.

To provide a spirocyclic morphine derivative having κ-opioid receptor agonist activity. 【Solution means】 A compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: TIFF2026086955000362.tif5071 (In the formula, R 1 ~R 5 , R 7 ~R 1 3 represents a hydrogen atom, a C 1-6 alkyl group, etc., R 6 represents a hydrogen atom, a hydroxy group, etc., A represents a heterocycle which may contain at least one heteroatom selected from N, O and S as ring-constituting atoms, etc., W represents a C 1-6 alkylene group, etc., X represents a C 1-6 alkylene group, etc., Y represents a C 1-6 alkylene, etc., Z represents a C 3-7 saturated hydrocarbon ring, etc.).

To provide a pharmaceutical product useful for the treatment or prevention of opioid δ receptor-related diseases. [Solution] The present invention relates to a pharmaceutical composition comprising a morphinan derivative that exerts opioid δ receptor agonist activity. By administering the pharmaceutical composition provided by the present invention, opioid δ receptor-related diseases (e.g., headaches) may be treated or prevented.