3results about How to "Embody diversity" patented technology

The invention discloses a tanshinone IIA derivative as well as a preparation method and application thereof, and provides a set of systematic chemical synthesis route for overcoming the defects that tanshinone IIA is poor in water solubility and low in bioavailability and the antitumor activity needs to be improved. A series of novel derivatives with various structures and general formula structures and pharmaceutical salts thereof are prepared. The core of the technical scheme is that after a specific functional group is introduced into the derivative, the water solubility and the stability of the compound are remarkably improved, and the derivative particularly shows excellent anti-colorectal cancer activity, can effectively inhibit tumor cell proliferation and tumor growth in an animal model, and does not have obvious toxic or side effects. The invention also provides a pharmaceutical composition containing the derivative and application of the pharmaceutical composition in preparation of medicines for preventing, relieving or treating colorectal cancer, and provides an important candidate compound for developing a high-efficiency and low-toxicity novel anti-colorectal cancer medicine.

This application belongs to the technical field of toy structure, specifically relating to an eye module for a toy, including a fixing frame, an eyeball mounted on the fixing frame, and a spring-loaded component installed between the eyeball and the fixing frame. The eyeball is designed as a hollow semi-circular structure. In practical applications, an eyeball is provided on the eyeball, and the state of the eyeball can be changed by rotating the eyeball, which increases the interactivity and aesthetics of the toy to a certain extent. At the same time, the eyeball can move in the vertical axis direction, and the spring-loaded component can provide elastic force for the eyeball to return to its original position after being pressed down, increasing the playability of the toy. In addition, this application also discloses a head structure using the above-mentioned eye module.

The application provides a driver manipulation mode modeling method under ice and snow road surface. In the case of comprehensively considering the road surface condition under extreme ice and snow weather and the operation characteristics of the driver, a driver model considering the mental stress factor of the driver under ice and snow environment is established, so that the driver model can fully reflect the different behavior abilities of the driver under ice and snow road surface, and aims to solve the problem that the existing driver model under ice and snow road surface is insufficient to depict different behavior abilities, so as to obtain a better control effect for subsequent man-machine sharing direct control. The application comprises the following steps: regarding the driver model to be researched as a whole, utilizing the visual perception and motion perception of the driver, establishing a complete driver manipulation model through a two-point visual anticipation module and a compensation module, and selecting and adjusting each module and specific parameters in the model according to the different behavior abilities and manipulation characteristics of different drivers.