The invention discloses a detonation system and method for detonator networking operation. Single-shot detection is carried out on to-be-networked electronic detonators before detonation operation, the blasting authority of the single-shot electronic detonators is verified in real time, function detection and authorization self-detection are carried out, the electronic detonators without the blasting authority and with defects are eliminated, the electronic detonators with qualified authority are recorded, the detonators in networking are subjected to disconnection, misconnection, detection ofunauthorized and downloaded authorized error-free electronic detonators and electric leakage detection of a networking network, a delay scheme is issued, finally, the networked detonators are subjected to secondary authorization verification, and charging and detonation work is carried out after errors are avoided. The detonation operation safety is high, quality defects, functional obstacles, disconnection, misconnection and unauthorized electronic detonators are effectively eliminated, multi-stage verification control ignition is achieved, and the detonation system and the detonation methodare high in electronic detonator networking information input efficiency, few in error, accurate in detonation control and high in safety coefficient.