The invention belongs to the field of medical instruments, and particularly relates to a flow rate setting and micro-adjustment device. According to the device, the infusion speed can be precisely and quickly adjusted, stability of control for the infusion speed after adjustment for the infusion speed is finished is guaranteed, and the infusion speed can be seen easily and quickly. The device is composed of an upper cover, a base, a handle and a dial, wherein the upper cover, the base and the handle are formed independently in an injection molding mode, and the handle is detachable. Due to the design of the handle in the flow rate setting and micro-adjustment device, the infusion speed can be adjusted by one hand, a vein needle wing and a Ruhr connector hook are arranged on the bottom of the handle, and a semi-circle clamping groove is arranged in the bottommost of the handle to fix a lower infusion pipe. A flow rate control principle is that a gap II and a spiral groove III on the device move to form different liquid passing areas so as to adjust liquid flow. Compared with the prior art, the device is attractive in appearance and simple in manufacture process, can precisely, quickly and stably control the infusion speed, and can visually and conveniently display the infusion speed. Additionally, operation can be carried out by one hand, the vein needle wing and the Ruhr connector hook can be arranged, medicine liquid flowing conditions in a speed-adjustment position of an infusion device can be clearly observed, and safety of the whole infusion device is improved.