Method and apparatus for application of chemicals to insect, and use for selecting medicine in large scale therewith

Abstract

A method for applying method to insect in order to screen the medicine features that its medicine applicator is composed of a container for raising insect and a medicine-feeding tube with medicine-loading inlet and medicine-feeding outlet, and said medicine feeding tube is inserted in said container for applying the medicine to the insects raised in it through sucking by themselves.

Description

Technical field: [0001] The invention relates to an insect drug delivery method and device, and also relates to the application of the method and device in large-scale drug screening. Background technique: [0002] In scientific research and production practice, researchers often need to use various experimental animals, insects, etc. as experimental models for some experimental verification. Some insects are closely related to humans in evolution, occupy a relatively small space, and have a short life cycle. They are especially suitable for large-scale screening of therapeutic drugs for specific diseases, such as anti-aging and treatment of Alzheimer's drugs. [0003] People are familiar with the feeding and medication methods of common experimental animals. However, when insects with very small volumes are used as experimental objects, it is very difficult to control the method of feeding and the amount of drugs when they are fed and administered. [0004] For example, w...

AI Technical Summary

Problems solved by technology

In this method, the Drosophila medium must be heated and melted first, and then the serially diluted medicinal solution is added and stirred to make it uniform. The disadvantages are:

[0005] 1. The medium contains a variety of chemical components, which are prone to chemical reactions with the liquid medicine; moreover, the medium must be heated and melted when the liquid medicine is added to the food, and the hot environment is more likely to accelerate these chemical reactions, even for some The drug itself has a destructive effect, which reduces or changes the biological activity of the drug;

[0006] 2. During the cultivation process, the medium may sometimes become moldy, resulting in the biological destruction of the drug;

[0007] 3. The melted culture medium is viscous, which may easily cause uneven dilution, local overconcentration or too thin; in addition, after a small amount of medicine is added to a relatively large amount of medium, it will be greatly diluted, resulting in a decline in drug efficacy. causing waste of medicines;

[0008] 4. It is impossible to know the actual dosage of insects eating, and it is impossible to calculate the dosage;

[0009] 5. The operation of adding medicine to the culture medium is extremely cumbersome, and it is not easy to form a large-scale operation

[0011] 1. Filter paper will pollute the drug;

[0012] 2. The specific surface area of ​​the filter paper is large, and the liquid medicine usually evaporates quickly and cannot be sucked, so the amount to be taken cannot be controlled and calculated. At the same time, the liquid medicine cannot be fully utilized and is wasted

[0013] 3. This method requires repeated dosing on the filter paper, and the experimental insects need to be transferred multiple times, which is poor in operability and quite cumbersome, and cannot form a large-scale operation, so it is not suitable for large-scale screening of drugs

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