Medication for treating chronic nephritis and preparation method

Abstract

The invention discloses a medicine for treating chronic nephritis and a preparation method thereof. It is made of the following raw materials by weight: 20-100 parts of centella asiatica, 24-96 parts of astragalus and 10-40 parts of chuanxiong. The method comprises the following steps: a. weighing the original medicinal materials according to the following weight ratio: 20-100 parts of centella asiatica, 24-96 parts of astragalus, and 10-40 parts of chuanxiong; b. adding 8-10 times the amount of the above medicinal materials 40%-60% concentration of ethanol, reflux extraction, combined extracts, recovery ethanol; c. Add 3-5 times the amount of deionized water to the extract after recovering ethanol, boil, let cool, and let it stand for 10-24 hours. The above-mentioned active ingredients are added into conventional auxiliary materials to prepare pharmaceutical preparations. The invention can effectively reduce urine protein, blood creatinine and blood urea nitrogen, increase plasma protein and improve renal function, so it can be used for treating chronic nephritis.

Description

technical field

[0001] The invention relates to a medical preparation and a preparation method thereof, in particular to a medicine especially suitable for treating chronic nephritis and a preparation method thereof. Background technique

[0002] Chronic glomerulonephritis (chronic nephritis for short) is a group of immune diseases that originate in the glomeruli and are composed of various causes and pathological types. The clinical features are insidious onset, lengthy course of disease, varying degrees of proteinuria, hematuria, and casturia in routine urine tests, and most patients are accompanied by varying degrees of edema, hypertension, and renal dysfunction. The disease is often slowly progressing, difficult to treat, and poor prognosis. When the disease gradually develops to the late stage of chronic nephritis, due to the continuous damage of nephrons, there are fewer and fewer surviving nephrons, fibrous tissue hyperplasia, and renal atrophy, eventually leading to ...

Examples

Embodiment 1

[0077] Embodiment 1 capsule

[0078] Extract the active ingredients of the medicine: take the original medicinal materials according to the following weight ratio: Centella asiatica 100kg, Radix Astragali 96kg, Rhizoma Chuanxiong 40kg; Add the above medicinal materials to 8 times the ethanol of 40% concentration, reflux extraction, combine the extracts, reclaim the ethanol; recycle Add 3 times of deionized water to the extract after ethanol, boil, let cool, and let stand for 24 hours; take the supernatant and treat it with a weakly polar macroporous adsorption resin, and first elute with 3 times the column volume of deionized water, Then eluted with 20% ethanol of 3 times column volume, then eluted with 40% ethanol of 1 times column volume, and finally eluted with 95% ethanol of 3 times column volume, collected the fractions eluted with 95% ethanol, Recover ethanol under reduced pressure, evaporate to dryness, and obtain the dry extract of the active ingredient of the crude dr...

Embodiment 2

[0079] Example 2 tablet

[0080] Extract the active ingredients of the medicine: take the raw medicinal materials according to the following weight ratio: Centella asiatica 20kg, Radix Astragali 24kg, Rhizoma Chuanxiong 10kg;

[0081] Add 10 times of 60% ethanol to the above medicinal materials, reflux extraction, combine the extracts, and recover ethanol; add 5 times of deionized water to the extract after recovering ethanol, boil, let cool, and stand for 10 hours; take the supernatant After treatment with weakly polar macroporous adsorption resin, first elute with 2 times the column volume of deionized water, then 2 times the column volume of 30% ethanol, and then 1 times the column volume of 40%% ethanol , finally eluted with 80% ethanol of 2 times the column volume, collect the fractions eluted with 80% ethanol, reclaim the ethanol under reduced pressure, evaporate to dryness, and obtain the dry extract containing the active ingredient of the crude drug; the dry extract is...

technical field

[0001] The invention relates to a medical preparation and a preparation method thereof, in particular to a medicine especially suitable for treating chronic nephritis and a preparation method thereof. Background technique

[0002] Chronic glomerulonephritis (chronic nephritis for short) is a group of immune diseases that originate in the glomeruli and are composed of various causes and pathological types. The clinical features are insidious onset, lengthy course of disease, varying degrees of proteinuria, hematuria, and casturia in routine urine tests, and most patients are accompanied by varying degrees of edema, hypertension, and renal dysfunction. The disease is often slowly progressing, difficult to treat, and poor prognosis. When the disease gradually develops to the late stage of chronic nephritis, due to the continuous damage of nephrons, there are fewer and fewer surviving nephrons, fibrous tissue hyperplasia, and renal atrophy, eventually leading to ...

Examples

Embodiment 1

[0077] Embodiment 1 capsule

[0078] Extract the active ingredients of the medicine: take the original medicinal materials according to the following weight ratio: Centella asiatica 100kg, Radix Astragali 96kg, Rhizoma Chuanxiong 40kg; Add the above medicinal materials to 8 times the ethanol of 40% concentration, reflux extraction, combine the extracts, reclaim the ethanol; recycle Add 3 times of deionized water to the extract after ethanol, boil, let cool, and let stand for 24 hours; take the supernatant and treat it with a weakly polar macroporous adsorption resin, and first elute with 3 times the column volume of deionized water, Then eluted with 20% ethanol of 3 times column volume, then eluted with 40% ethanol of 1 times column volume, and finally eluted with 95% ethanol of 3 times column volume, collected the fractions eluted with 95% ethanol, Recover ethanol under reduced pressure, evaporate to dryness, and obtain the dry extract of the active ingredient of the crude dr...

Embodiment 2

[0079] Example 2 tablet

[0080] Extract the active ingredients of the medicine: take the raw medicinal materials according to the following weight ratio: Centella asiatica 20kg, Radix Astragali 24kg, Rhizoma Chuanxiong 10kg;

[0081] Add 10 times of 60% ethanol to the above medicinal materials, reflux extraction, combine the extracts, and recover ethanol; add 5 times of deionized water to the extract after recovering ethanol, boil, let cool, and stand for 10 hours; take the supernatant After treatment with weakly polar macroporous adsorption resin, first elute with 2 times the column volume of deionized water, then 2 times the column volume of 30% ethanol, and then 1 times the column volume of 40%% ethanol , finally eluted with 80% ethanol of 2 times the column volume, collect the fractions eluted with 80% ethanol, reclaim the ethanol under reduced pressure, evaporate to dryness, and obtain the dry extract containing the active ingredient of the crude drug; the dry extract is...

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