Application of compound (I) in preparing medicament for improving atherosclerosis

Abstract

The invention relates to an application of a compound (I), with the chemical name of 20-(S)-protopanoxadiol-3-[O-beta-D-glucopyranose (1->2)-beta-D-glucopyranose]-20-O-beta-D-glucopyranoside, in preparing a medicament for improving atherosclerosis. Experiment results show that, at the beginning of building an atherosclerosis model generated by high-fat feeding of ApoE gene knockout mice, by preventively administrating the compound (I), an aortic plaque area can be reduced, macrophages in blood are restrained from absorbing lipid, and the bubbling process of the macrophages is restrained so as to reverse and delay formation of atherosclerosis induced by hyperlipidemia. The compound (I) can be prepared into oral or injection formulations and can be compounded with other medicaments for preparing a compound preparation, and when the preparation is made, the preparation comprises the compound (I) and a carrier or an excipient which are pharmaceutically acceptable.

Description

【Technical field】 The present invention relates to a compound (I), the chemical name is 20-(S)-protopanaxadiol-3-[O-β-D-glucopyranose (1→2)-β-D-glucopyranose] -20-O-β-D-glucopyranoside, the new application in pharmacy, specifically the application in the preparation of drugs for improving atherosclerosis. 【Background technique】 Atherosclerosis is an important pathological feature of many vascular diseases such as coronary heart disease, stroke, and diabetic nephropathy. Atherosclerosis (AS) is a cardiovascular disease that seriously threatens human health. Its main pathological features include early lipid streak formation and late atherosclerotic plaque formation. The exact etiology of atherosclerosis and The pathogenesis has not been fully clarified so far. It is generally believed that the main pathological process is as follows: Under the action of various pathogenic factors, the vascular intima is damaged. Transform into macrophages, a large number of macrophages gath...

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Problems solved by technology

The above results indicate that the variation and dysfunction of some ion channels on the cell membrane also participate in the occurrence and development of AS during the process of AS. However, little is known about the role of anions in the occurrence and development of atherosclerosis

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