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Novel indoletriazole alkaloid as well as preparation method and antifungal application thereof

A technology of indole triazole and alkaloids, which is applied in the field of medicine, and can solve the problems of no antifungal activity of indole triazole alkaloid compounds

Active Publication Date: 2011-06-15
INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far there is no report on indoletriazole alkaloids and their antifungal activity

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  • Novel indoletriazole alkaloid as well as preparation method and antifungal application thereof
  • Novel indoletriazole alkaloid as well as preparation method and antifungal application thereof
  • Novel indoletriazole alkaloid as well as preparation method and antifungal application thereof

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Abstract

The invention relates to the technical field of medicines and discloses an indoletriazole alkaloid antifungal compound with a novel framework, i.e. fructus evodiae triazole alkali (3-[2-N-methyianiline]-triazolo[4,3-a]-3,4-dihydto-beta-carboline) which is a compound with a brand-new framework. The invention also relates to a preparation method and application of the indoletriazole alkaloid antifungal in the field of medicines. Particularly, the compound has strong antifungal activity, and compared with the antifungal medicaments clinically applied at present, the compound has the advantages of high efficiency, low toxicity, broad antifungal spectrum, and the like, opens a new approach for deeply researching and developing new antifungal medicaments and can be used for preparing new antifungal medicaments.

Description

A novel indoletriazole alkaloid and its preparation method and antifungal application 1. Technical field: The invention relates to the technical field of medicine, which is an indoletriazole alkaloid antifungal compound with a novel skeleton——Evodia rutaecarpa (3-[2-N-methylaniline]-triazolo[4,3-a] -3,4-dihydro-β-carboline) and its antifungal use in the field of medicine. It specifically relates to a series of indolequinazoline alkaloids extracted and isolated from Rutaceae (Rutaceae) Evodia plant Evodia, in which the compound retesinine undergoes a hydrazination reaction to obtain a novel skeleton described in the present invention The indoletriazole alkaloid compound of the present invention shows strong antifungal activity in the preparation of antifungal drugs. 2. Background technology: In recent years, with the extensive application of broad-spectrum antibiotics, antineoplastic drugs, and immunosuppressants, the widespread implementation of radiotherapy and organ tra...

Claims

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Application Information

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IPC IPC(8): C07D471/14C07D471/04A61K31/437A61P31/10
Inventor 王奇志冯煦王鸣陈雨管福琴单宇印敏赵兴增孙浩赵友谊
Owner INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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