New application of aloperin in pharmacy

A technology of aloperine and medicine, which is applied in the field of application of aloperine in the preparation of drugs for the treatment of digestive system cancer, can solve the problems of few pharmacological studies, achieve excellent effects and improve stability

Active Publication Date: 2014-06-11
GUANGZHOU HANFANG PHARMA
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few pharmacological studies on its anti-cancer, especially anti-digestive system cancer

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New application of aloperin in pharmacy
  • New application of aloperin in pharmacy
  • New application of aloperin in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 A pharmaceutical composition for treating cancer of the digestive system, the dosage form is an enteric-coated tablet

[0040] Prepared from the following raw materials:

[0041]

[0042]

[0043] The preparation method is:

[0044] 1. Put the prescription amount of matrine and microcrystalline cellulose in a fluidized bed; dissolve the prescription amount of povidone in an appropriate amount of ethanol to prepare the soft material as a binder;

[0045] 2. Mix the prescription amount of crospovidone, low-substituted hydroxypropyl cellulose and starch, granulate with starch slurry, dry, and sizing, and combine the sized granules with the prepared soft material and the prescription amount Mix the magnesium stearate and silicon dioxide of the same; compress tablets; obtain matrine tablets;

[0046] 3. Dissolve the prescription amount of hydroxypropyl methylcellulose in an appropriate amount of ethanol aqueous solution, and then add the prescription amount of propylene gly...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
weightaaaaaaaaaa
Login to view more

Abstract

The invention discloses the application of aloperin in the preparation of drugs for treating digestive cancers. An anticancer test of aloperin on a plurality of human digestive system cancer cell strains is carried out in the invention, and the result shows that aloperin has an obvious anticancer effect and has a more excellent effect than sophoridine, which is the well-recognized antineoplastic active component of Sophora alopecuroides. Therefore, aloperin can be used to prepare pharmaceutical compositions for treating digestive system cancers, so as to provide new therapeutic candidate drugs for patients with digestive system cancers. In addition, enteric coated tablets of the pharmaceutical compositions for treating digestive system cancers in the invention avoid aloperin to be released in stomach and destroyed by gastric acid, so as to raise the stability of aloperin as well as the drug concentration of aloperin on affecting positions.

Description

Technical field [0001] The invention belongs to the technical field of medicine. Specifically, the invention relates to the application of matrine in the preparation of drugs for treating cancers of the digestive system. Background technique [0002] Digestive system cancers, especially cancers of the rectum and colon in the stomach, small intestine, and large intestine are high in our country and even in the world, becoming a major disease threatening human health and life. As of 2005, the World Health Organization estimated that deaths from cancer accounted for 13% of the total deaths, and maintained a rapid upward trend. Cancers of the digestive system can be metastasized from ulcers or other parts of the cancer. Therefore, the cancer has a high rate of transformation, a wide range of lesions, and a protracted course of disease. It is difficult to cure, which seriously affects the quality of life of patients. In clinical treatment of cancer, western medicine or surgical resec...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4748A61K9/38A61K9/36A61K9/30A61P35/00A61P1/00
Inventor 蒋兆健刘洁瑜邓虹珠焦河玲李菁葛发欢
Owner GUANGZHOU HANFANG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap