Method for preparing L-lysine composite salt

A technology of lysine hydrochloride and lysine, which is applied in the preparation of organic compounds, chemical instruments and methods, and cyanide reaction preparation, etc., can solve the problems such as difficulty in guaranteeing product purity and quality, and achieve increased concentration and reduced Production cost, effect of efficient separation

Active Publication Date: 2013-12-11
CHANGZHOU XIAOGUO INFORMATION SERVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in this paper, 360 g L-lysine monomer and 240 g L-glutamic acid were used for compound reaction, and finally 492 g L-lysine L-glutamate was obtained. This result is questionable. According to L- Lysine (Mr146.19) and L-glutamic acid (Mr147.13) are compounded in an equimolar ratio, and only 478.47g of L-lysine L-glutamate can be obtained with a 100% extraction rate. What substance is 13.53g? In addition, the pI of L-lysine is 9.59, and the pI of L-glutamic acid is 3.22. In the preparation method of the paper, the L-lysine solution is dropped into the L-glutamic acid solution, and the pH value is controlled at 7.0 as the reaction end point. , the probability of adding excessive L-lysine will naturally increase, which will inevitably cause the purity and quality of the product to be difficult to guarantee

Method used

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  • Method for preparing L-lysine composite salt
  • Method for preparing L-lysine composite salt
  • Method for preparing L-lysine composite salt

Examples

Experimental program
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Effect test

example 1

[0039] 1. Weigh 50kg of feed-grade L-lysine hydrochloride, put it into a reaction tank with 1000L water, heat up to 60-70℃ under stirring to dissolve, wait until L-lysine hydrochloride is completely dissolved, add 3 ~ 8Kg activated carbon, decolorize for 30min, then input the solution into a carbon rod filter to filter to remove activated carbon, and the filtered clear liquid is about 1000L as the solution to be loaded on the column;

[0040] 2. Input the above solution into the exchange column filled with 732 cation exchange resin, control the flow rate at 5~8L / min, detect the intintrione reaction in the effluent, and stop loading the column after it shows that there is intintrione reaction;

[0041] 3. Wash with reverse osmosis water, control the flow rate of 8~10L / min, detect the chloride ion reaction of the effluent, and stop washing after showing no chloride ion reaction;

[0042] 4. Desorb L-lysine with 1-4mol / L ammonia water, control the flow rate at 2-4L / min, detect th...

example 2

[0052] 1. Weigh 50kg of feed-grade L-lysine hydrochloride, put it into a reaction tank with 1000L water, heat up to 60-70℃ under stirring to dissolve, wait until L-lysine hydrochloride is completely dissolved, add 3 ~ 8Kg activated carbon, decolorize for 30min, then input the solution into a carbon rod filter to filter to remove activated carbon, and the filtered clear liquid is about 1000L as the solution to be loaded on the column;

[0053] 2. Input the above solution into the exchange column filled with 732 cation exchange resin, control the flow rate at 5~8L / min, detect the intintrione reaction in the effluent, and stop loading the column after it shows that there is intintrione reaction;

[0054] 3. Wash with reverse osmosis water, control the flow rate of 8~10L / min, detect the chloride ion reaction of the effluent, and stop washing after showing no chloride ion reaction;

[0055] 4. Desorb L-lysine with 1-4mol / L ammonia water, control the flow rate at 2-4L / min, detect th...

example 3

[0065] 1. Weigh 50kg of feed-grade L-lysine hydrochloride, put it into a reaction tank with 1000L water, heat up to 60-70℃ under stirring to dissolve, wait until L-lysine hydrochloride is completely dissolved, add 3 ~ 8Kg activated carbon, decolorize for 30min, then input the solution into a carbon rod filter to filter to remove activated carbon, and the filtered clear liquid is about 1000L as the solution to be loaded on the column;

[0066] 2. Input the above solution into the exchange column filled with 732 cation exchange resin, control the flow rate at 5~8L / min, detect the intintrione reaction in the effluent, and stop loading the column after it shows that there is intintrione reaction;

[0067] 3. Wash with reverse osmosis water, control the flow rate of 8~10L / min, detect the chloride ion reaction of the effluent, and stop washing after showing no chloride ion reaction;

[0068] 4. Desorb L-lysine with 1-4mol / L ammonia water, control the flow rate at 2-4L / min, detect the ...

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Abstract

The invention belongs to the technical field of medicine and biology, and in particular, relates to a method for preparing an L-lysine composite salt. Feed-grade L-lysine salt and food-grade L-glutamic acid or L-aspartic acid are used as raw materials, and crystal L-lysine glutamate or L-lysine aspartate are obtained by the processes of ion exchange, membrane separation and concentration, composite reaction, crystallization, extraction and the like. The preparing method is characterized by comprising the following step of: combining L-lysine and L-glutamic acid or L-aspartic acid in equal molar ratio through ionic bonds under certain conditions to respectively form L-lysine glutamate and L-lysine aspartate crystal products. The products have the advantages of specific physical and chemical properties, good water solubility, peculiar smell resistance, perchloric acid poisoning resistance and the like, have the physiological functions of two amino acids, can enhance the physiological functions with each other in vivo, and have more excellent physical and chemical properties and more special physiological effects compared with monomer amino acid, so the products can be widely applied in the fields of medicine, food, cosmetics and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine and biology, and in particular relates to a preparation method of L-lysine compound salt. Background technique [0002] Since the 1970s, people have paid more and more attention to the physiological functions of amino acids in organisms. Coupled with the rapid progress in amino acid production technology, many amino acids can be obtained at low prices, so amino acids can be used more widely and in larger quantities in medicine, Food, cosmetics, animal husbandry and agriculture and other fields. However, in the application, the researchers found that some basic amino acid monomers have unsatisfactory application effects due to reasons such as drug efficacy, solubility, or peculiar smell. Therefore, it is conceived to combine with acidic amino acids to improve their application efficacy. So in the 1980s, a new category of amino acids, L-amino acid compound salts, which is different from dipept...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): C07C229/26C07C229/24C07C227/18
Inventor彭加平韦平和周锡樑
OwnerCHANGZHOU XIAOGUO INFORMATION SERVICES