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Traditional Chinese medicine for treating keratoconjunctivitis sicca and preparation method thereof

A technology for corneal and conjunctival xerosis and traditional Chinese medicine, applied in the field of traditional Chinese medicine, can solve the problems of helpless corneal and conjunctival xerosclerosis, aggravating corneal and conjunctival xerosis symptoms, and conjunctival microcell damage, etc., and achieves significant curative effect, low drug toxicity, and disease severity. non-repetitive effects

Inactive Publication Date: 2014-05-07
QINGDAO CENT HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no particularly effective treatment for keratoconjunctival sicca. The principle of western medicine treatment for keratoconjunctiva sicca is to supplement artificial tears, stimulate tear secretion, and reduce tear loss. The main methods are: eye drops with artificial tears, wearing hydrophilic soft cornea Contact lenses, blocked or closed puncta, use of drugs to stimulate lacrimal secretion, etc. For mild and moderate patients, supplementary artificial tears are often used for symptomatic treatment. In addition to the above measures, severe patients are given punctal plugs, anti-inflammatory, immunosuppressants or surgery. , these are limited to the adjustment of the local state of the ocular surface, and eye drops are not vitamins, nor are they eye-care solutions. Abuse of eye drops will cause problems such as drug durability or adverse reactions. Long-term use is likely to damage the conjunctival microcells, accessory lacrimal gland etc. cause damage, but aggravate the symptoms of keratoconjunctival sicca, which is not conducive to the fundamental improvement of keratoconjunctival sicca, and has various disadvantages and inconveniences.

Method used

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preparation example Construction

[0064] The present invention provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is powder, it comprises the following steps:

[0065]In the first step, the raw materials in the traditional Chinese medicine composition are respectively sent to a pulverizer for pulverization, and then sent to a mixer to mix in proportion to obtain a mixture, adding ethanol with an alcohol concentration of 80% to 90%, and heating to reflux to extract 2 ~4 hours, filter to obtain the first filtrate, the addition ratio of the ethanol to the mixture is 3:1~5:1, add the ethanol with an alcohol concentration of 80%~90% to the filter residue again, heat and reflux to extract 2~5:1 4 hours, filter to obtain the second filtrate, the addition ratio of the ethanol to the mixture is 1:1 ~ 3:1, the first filtrate and the second filtrate are mixed to obtain the mixture filtrate;

[0066] The second step is to carry ou...

Embodiment 1

[0078] Embodiment 1 Chinese medicine composition powder 1

[0079] Houttuynia cordata 25g, dendrobium 55g, mulberry leaf 40g, medlar 75g, Eclipta 45g, cassia seed 50g, shouwu vine 25g, red bean 20g, mulberry 40g, jiulixiang 25g, ryepogon 40g, American ginseng 45g, plantain Grass 15g, Polygonatum 30g, Scrophulariaceae 30g, Rehmannia glutinosa 35g, Cinnabar root 30g, Gujingcao 40g, Mushizi 25g, Motherwort 25g and Licorice 25g were respectively sent to a pulverizer for crushing, sent to a mixer for mixing, and obtained The mixture was added with 3 kg of ethanol with an alcohol concentration of 90%, heated and refluxed for extraction for 4 hours, filtered to obtain the first filtrate, and the filter residue was added with 1.5 kg of ethanol with an alcohol concentration of 90%, heated and refluxed for 4 hours, filtered to obtain the second Filtrate, the first filtrate and the second filtrate are mixed to obtain the mixture filtrate, at a temperature of 75 ° C, vacuum concentration ...

Embodiment 2

[0080] Embodiment 2 Chinese medicine composition powder 2

[0081] Houttuynia cordata 28g, dendrobium 58g, mulberry leaf 43g, medlar 78g, Eclipta 48g, cassia seed 53g, Shouwu vine 28g, red bean 23g, mulberry 43g, mulberry 28g, ryepogon 43g, American ginseng 48g, plantain Grass 18g, Polygonatum 33g, Scrophulariaceae 33g, Rehmannia glutinosa 38g, Cinnabar root 33g, Gujingcao 43g, Mushizi 28g, Motherwort 28g and Licorice 28g were respectively sent to a pulverizer for crushing, and mixed in a mixer to obtain Add 4 kg of ethanol with an alcohol concentration of 90% to the mixture, heat and reflux for extraction for 4 hours, filter to obtain the first filtrate, add 1.8 kg of ethanol with an alcohol concentration of 90% to the filter residue again, heat and reflux for extraction for 4 hours, filter to obtain the second Filtrate, the first filtrate and the second filtrate are mixed to obtain the mixture filtrate, at a temperature of 75 ° C, vacuum concentration is carried out under th...

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PUM

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Abstract

The invention provides a Chinese medicinal composition for treating keratoconjunctivitis sicca, which comprises the following raw material drugs: heartleaf houttuynia herb, dendrobe, mulberry leaf, medlar, yerbadetajo herb, cassia seed, multiflower knotweed vine, red bean, mulberry, kamuning, liriope spicata, America ginseng, plantain herb, fragrant solomonseal rhizome, figwort root, raw rehmannia, coral ardisia root, buerger pipewort flower, papermulberry fruit, motherwort and liquorice. Compared with a western medicament, the Chinese medicinal composition has good curative effect, relapse prevention, small toxic and side effects and low residue rate in treating keratoconjunctivitis sicca, can regulate a whole human body to achieve the effect of treating both principal and secondary aspect of disease, and is a safe and reliable Chinese medicament for treating keratoconjunctivitis sicca with remarkable curative effect.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine for treating keratoconjunctival xerosis and a preparation method thereof. Background technique [0002] Keratoconjunctivitis sicca, also known as keratoconjunctivitis sicca and dry eye, is the most common clinical chronic ocular surface disease, which refers to the abnormal tear quality and quantity caused by various reasons, or abnormal tear fluid dynamics. A group of disorders in which tear film instability and ocular surface damage lead to ocular discomfort. Clinical manifestations include eye dryness, foreign body sensation, burning sensation, itching, vision fluctuations, blurred vision, red eyes, photophobia, and visual fatigue. With the change of people's living habits and working environment, the incidence of keratoconjunctiva sicca is getting higher and higher. In the United States, 14.16% of people over 65 years old s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61P27/02
Inventor 王惠芹潘敏
Owner QINGDAO CENT HOSPITAL
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