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Synergistically active ternary anti-microbial mixtures

An antimicrobial and mixture technology, applied in the direction of drug combination, active ingredient of hydroxyl compound, application, etc., can solve the problems of antimicrobial effect, toxicological harmlessness, skin compatibility and stability without predictable relationship

Inactive Publication Date: 2013-05-08
SYMRISE GMBH & CO KG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, there is no foreseeable relationship between antimicrobial action, toxicological harmlessness, skin compatibility and stability of substances

Method used

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  • Synergistically active ternary anti-microbial mixtures
  • Synergistically active ternary anti-microbial mixtures
  • Synergistically active ternary anti-microbial mixtures

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Synergistic efficacy of the ternary mixture according to the invention

[0102] Comparison of adequate preservation of cosmetic preparations containing: 2-phenoxyethanol (commodity A, not according to the invention), 1,2-decanediol (product B, not according to the invention), 1,2 - hexanediol (product C, not according to the invention), binary mixture of 2-phenoxyethanol and 1,2-hexanediol (product D, not according to the invention), 2-phenoxyethanol and 1 , a binary mixture of 2-decanediol (product E, not according to the invention), a binary mixture of 1,2-decanediol and 1,2-hexanediol (product F, not according to the invention) and 2- Ternary mixture of phenoxyethanol, 1,2-decanediol and 1,2-hexanediol (product G, according to the invention).

[0103] Tested for adequate preservation according to the European Pharmacopoeia.

[0104] Thus, the test consists of the following steps: contaminating the preparation (if possible in its final part) with a specified inoculu...

Embodiment 2

[0141] Example 2: Practical example of cosmetics / dermatology

[0142] For application, the ternary mixtures containing synergistically active substances together with other cosmetic active substances and additives are applied in sufficient quantities to the skin and / or to the hair in a manner customary for cosmetics. Examples of advantageous formulations for some uses are given below:

[0143] Creams for regulating skin moisture:

[0144]

[0145] Sunscreen formula:

[0146]

[0147]

[0148] Shampoo formula:

[0149]

[0150]

[0151] Makeup formula:

[0152]

[0153]

[0154]

Embodiment 3

[0156] Other formulations containing the ternary antimicrobial mixture according to the invention

[0157] In the table below:

[0158] 3.1=Brightening Day Cream O / W

[0159] 3.2 = Skin soothing lotion with plant extracts O / W

[0160] 3.3 = after sun balm

[0161] 3.4 = body spray

[0162] 3.5 = sunscreen lotion (O / W), broadband protection

[0163] 3.6 = W / O night cream

[0164] 3.7 = Shampoo

[0165] 3.8 = Self-tanning cream

[0166] 3.9=Repair skin cream O / W

[0167] 3.10 = Antiperspirant / Deodorant Roll On

[0168]

[0169]

[0170]

[0171]

[0172]

[0173]

[0174]

[0175]

[0176]

[0177]

[0178]

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Abstract

The present invention relates to a synergistically active ternary anti-microbial mixture which comprises 2-phenoxyethanol and at least two different alkanediol comprising 1,2-decanediol, 1,2-octanediol, 1,2-hexanediol or 1,2-pentanediol. The invention further relates to the use of 2-phenoxyethanol for synergistically enhancing the antimicrobial efficacy of mixtures of at least two of the abovementioned alkanediols, a method for preservation or antimicrobial treatment of a perishable product, a method for the cosmetic treatment of certain microorganisms, as well as the use of an inventive mixture of therapeutic treatment of certain microorganisms.

Description

technical field [0001] The present invention relates to the field of antimicrobial active substances, in particular certain mixtures, formulations and food products comprising 2-phenoxyethanol and at least two different alkanediols selected from 1,2-decanediol , 1,2-octanediol, 1,2-hexanediol and 1,2-pentanediol. The present invention further relates to the use of 2-phenoxyethanol for the synergistic enhancement of the antimicrobial efficacy of mixtures of at least two of the aforementioned alkanediols, methods of preservation or antimicrobial treatment of perishable products, cosmetic treatment of certain microorganisms and the use of mixtures according to the invention for the therapeutic treatment of certain microorganisms. Background technique [0002] In the cosmetic, pharmaceutical and food industries, for the preservation of agents with antimicrobial properties, in particular for the preservation of otherwise perishable products such as cosmetics, pharmaceutical prod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K31/085A61K31/047A61P31/00A61P31/10A61P17/00A61P17/10A23L3/34A23B4/14A23B5/08A23B7/14A23B9/16
CPCA61Q5/02A61K31/085A01N31/14A01N31/02A61Q17/04A61K9/0014A61Q1/02A61K8/34A61K2800/5922A61K2800/524A61Q15/00A61K8/345A61K31/045A61Q19/00A61K31/047A61Q17/005A23L3/3481A61P17/00A61P17/10A61P31/00A61P31/04A61P31/10A61P43/00A01N2300/00A61K2300/00
Inventor 拉维库玛·皮莱安特耶·凯勒格哈德·施毛斯
Owner SYMRISE GMBH & CO KG
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