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Application of Shen-Gui pills in preparation of drugs for tumor inhibition and combined chemotherapy drugs

A technology of tumor cells and combined chemotherapy, which is applied in the direction of drug combination, antineoplastic drugs, pill delivery, etc., can solve the problems of decreased spleen index and thymus index, decreased body immunity, leukopenia, etc., and can increase spleen index and thymus index , weaken the ability to tolerate hypoxia, and improve the effect of living conditions

Inactive Publication Date: 2013-07-17
GANSU UNIV OF CHINESE MEDICINE
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  • Description
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AI Technical Summary

Problems solved by technology

Traditional anticancer drugs can damage the normal cells of the body while killing malignant tumor cells, causing a serious decline in various functions such as the body's immunity, a decrease in the spleen index and thymus index, and a decrease in white blood cells.

Method used

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Effect test

Embodiment 1

[0078] The application of Shengui pills in the preparation of drugs for inhibiting tumor cells. The weight ratio of Shengui pills is 1:2, Angelica: Sophora flavescens. The medicinal form of Shengui pills is decoction, and the tumor cells are H22 liver cancer cells. The dosage of Shengui pills It is 9g per kilogram of body weight per day, and the administration method is intragastric administration, and the administration time is 14 days.

Embodiment 2

[0080] Application of Shengui Pills in the preparation of combined chemotherapy drugs for inhibiting tumor cells. The combined chemotherapy drugs are composed of Shengui Pills and cisplatin. The tumor cells are H22 liver cancer cells. The dosage of Shengui Pills is 9g per kilogram of body weight per day. The dosage is intragastric administration for 14 days. , The medication time is 14 days.

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Abstract

The invention discloses application of Shen-Gui pills in preparation of drugs for tumor inhibition and combined chemotherapy drugs. The application has the advantages that effective tumor inhibition rate of the Shen-Gui pills is 30%, effective body weight of cis-platinum chemotherapy tumor-bearing mouse is increased, living states of the tumor-bearing mouse are improved, reduction of neutrophile granulocyte and monocytes caused by cis-platinum chemotherapy is reduced, reduction of spleen and thymus indexes caused by cis-platinum chemotherapy can be resisted by the Shen-Gui pills, the spleen and thymus indexes can be increased, important immune organs of the mouse are protected to some extent, concentration of HIF-1alpha (hypoxia inducible factor-1 alpha) can be reduced, hypoxia resistance of tumor cells is weakened, death of the tumor cells is accelerated, activity of LDH (lactate dehydrogenase) is lowered, damages of LDH on normal cells are reduced, and toxic action of the cis-platinum chemotherapy can be alleviated.

Description

technical field [0001] The invention relates to the field of application of traditional Chinese medicines, in particular to the application of Shengui Pills in the preparation of drugs for inhibiting tumor cells and combined chemotherapy drugs. Background technique [0002] Shengui Wan was first seen in Volume 9 of "Ancient and Modern Medical Mirror". The formula is composed of 4 liang of Sophora flavescens (net end) and 2 liang of angelica (net end). It has the effect of clearing away heat and cooling blood. At present, searching for Shengui Pills in various databases yields only an article titled “Semi-bionic Extraction Process Conditions for Optimizing the Prescription of Danggui Kushen Pills by Uniform Design”, and there is no clinical or experimental report on the use of Shengui Pills for tumor treatment. Studies have proved that Angelica polysaccharides and their sulfate esters can directly promote the proliferation of activated T cells, Angelica polysaccharides can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61K9/20A61P35/00A61K33/24
Inventor 刘永琦
Owner GANSU UNIV OF CHINESE MEDICINE
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