40 results about "Platinum chemotherapy" patented technology

The invention relates to application of an anti-PD-1 antibody or an antigen binding fragment thereof in a medicine for treating squamous non-small cell lung cancer. The invention also provides a single drug dosage unit and a kit comprising an effective amount of an anti-PD-1 antibody or antigen-binding fragment thereof. The invention further provides application of the single drug dosage unit or the kit in preparation of drugs for treating squamous non-small cell lung cancer, and preferably, the squamous non-small cell lung cancer is advanced or metastatic squamous non-small cell lung cancer caused by failure of first-line platinum-containing chemotherapy.

The present disclosure relates gold carbene naphthoquinone compounds and salts thereof. In some aspects, these compounds can be used to treat cancer including cancers which are resistant to one or more other chemotherapeutic agents such as cisplatin or platinum chemotherapeutic agents. Also provided herein are pharmaceutical compositions comprising the gold carbene naphthoquinone compounds.

The invention belongs to the field of genetic engineering and oncology, and discloses a SNP marker related to myelosuppressive toxicity of platinum chemotherapy drugs and application thereof. 该标志物为rs12883763、rs13014982、rs6750741、rs11892526、rs430253、rs7610842、rs12639117、rs623393、rs2051802、rs11968978、rs9390164、rs1485282、rs1904023、rs11026144、rs830379、rs712476、rs8006004、rs6497934、rs6502373、rs9909179和rs2830451的组合。 The marker can be used to prepare a diagnostic kit for myelosuppressive toxicity of platinum chemotherapy drugs.

The invention relates to a traditional Chinese medicine composite with function of treating renal injury caused by cis-platinum, as well as a preparation method thereof. The composite is prepared from the following active pharmaceutical ingredients in parts by weight: 700 parts of radix rehmanniae recens, 400 parts of whitish honey, 200 parts of poria and 100 parts of radix ginseng. The preparation method comprises the following steps: accurately weighing 700 parts of radix rehmanniae recens, 400 parts of whitish honey, 200 parts of poria and 100 parts of radix ginseng; soaking radix rehmanniae recens, poria and radix ginseng with 8-fold water for 30 minutes, performing heating reflux for 4 hours, filtering and collecting a filtrate; then adding 8-fold water into filtering residues, performing heating reflux for 3 hours, filtering and collecting a filtrate; combining the two filtrates, and adding whitish honey; heating and concentrating until the heat density is 1.4kg / L (80DEG C), thus obtaining the traditional Chinese medicine. Animal experiments verify that the traditional Chinese medicine is stable in curative effect on the renal toxicity caused by cis-platinum chemotherapy, and has no influence on the cis-platinum chemotherapy effect.

The invention belongs to the field of circular RNA technology research, and specifically discloses the application of circular RNA hsa_circ_0008399. The nucleotide sequence of circular RNA hsa_circ_0008399 is shown in SEQ ID NO.1. Bladder cancer molecular marker, the molecular marker is the circular RNA hsa_circ_0008399. Cisplatin resistance inhibitors include preparations capable of knocking down or knocking out the expression of the circular RNA hsa_circ_0008399 gene. Cisplatin chemosensitivity enhancing drugs in neoplastic diseases, including cisplatin resistance inhibitors. The beneficial effect is: it provides an adjuvant treatment drug for tumor diseases; especially it can better alleviate the drug resistance in cisplatin chemotherapy.

The invention refers to the use of a sigma ligand, preferably a sigma ligand of formula (I), to prevent or treat emesis induced by a chemotherapeutic agent or radioactivity, especially emesis induced by taxanes, vinca alkaloids or platin chemotherapeutic drugs.