7 results about "Platinum resistance" patented technology

The present invention provides an anti-cancer vaccine comprising: (i) at least one peptide comprising the amino acid sequence of a neoantigen encoded by a mutant homologous recombination (HR) DNA repair gene selected from the group: BRCA1, BRCA2, PALB2, CDK12, RAD51B, RAD51C and RAD51D, wherein the mutant gene comprises a reversion mutation; and / or (ii) at least one polynucleotide encoding the at least one peptide of (i). Also provided are engineered T cells that recognise said neoantigen. Related methods and medical uses of the vaccine and / or engineered T cell are provided, including for the treatment of cancers, such as homologous recombination (HR) deficient cancers that acquire PARP inhibitor resistance or platinum resistance by development of reversion mutations in an HR DNA repair gene selected from the group: BRCA1, BRCA2, PALB2, CDK12, RAD51B, RAD51C and RAD51D.

The application relates to a refrigerator and a calibration method and device thereof. The refrigerator comprises a cabinet, a wall of which encloses a storage cavity; a platinum resistance fixed on the wall for detecting the ambient temperature in the storage cavity; a standard platinum resistance reserved hole is further arranged on the wall, the standard platinum resistance reserved hole is used for mounting a standard platinum resistance, the standard platinum resistance is used for calibrating the platinum resistance; and a main control board, which is provided with a standard platinum resistance interface in advance and is used for electrically connecting with the standard platinum resistance. The application solves the platinum resistance calibration problem of multiple low-temperature medical refrigerators by using one standard platinum resistance through the mode of adding the standard platinum resistance reserved hole on the cabinet and reserving the standard platinum resistance interface on the main board, and the cost is reduced. The low-temperature medical cabinet can be calibrated in a period, and the problem that the sample is scrapped due to the temperature deviation in the cabinet in the measurement period is solved.

The invention is entitled "Platinum Resistance Temperature Sensor with Floating Platinum Member". A platinum resistance temperature sensor is disclosed having a housing containing a platinum member. The housing includes a first substrate having a first support and a second support spaced apart from an upper surface of the first substrate. The first support of the first substrate supports a first portion of the platinum member and the second support supports a second portion of the platinum member. An intermediate portion of the platinum member is suspended above the upper surface of the first substrate between the first support and the second support.

The invention relates to an application of oligonucleotide based on NAT10 gene in preparation of drugs for reversing platinum drug resistance of non-small cell lung cancer. The antisense oligonucleotide provided by the invention not only can reverse platinum drug resistance, but also can inhibit proliferation of non-small cell lung cancer drug-resistant cells, and cell proliferation experiments prove that proliferation of chemotherapy drug-resistant cells is inhibited after treatment; according to the present invention, the tumor cell lipid metabolism abnormality is regulated, the lipid droplet staining results prove that the number of the treated cell lipid droplets is significantly reduced, and the tumor growth can be significantly inhibited, the expression of NAT10 in the tumor tissue can be reduced, the malignant development and metastasis of the tumor can be inhibited, and the anti-tumor effect can be provided in the animal experiment;

This invention discloses a novel application of undecanoic acid in inducing ferroptosis in laryngeal cancer cells and in the preparation of anti-laryngeal cancer drugs. For the first time, it was discovered that the known compound undecanoic acid can specifically target the mitochondria of laryngeal cancer cells, inducing mitochondrial structural damage and dysfunction. This, in turn, activates the ferroptosis pathway through multiple mechanisms, including increasing intracellular ferrous ion accumulation, increasing lipid peroxide levels, downregulating GPX4 / SLC7A11 expression, and upregulating ACSL4 expression, thereby effectively inhibiting the proliferation of laryngeal cancer cells. Based on this mechanism, this invention provides a pharmaceutical composition with undecanoic acid as the active ingredient, and its combined application with platinum-based drugs (such as cisplatin). This combined treatment exhibits a significant synergistic effect, particularly overcoming the platinum resistance of laryngeal cancer cells. This invention provides a novel drug selection and combination therapy strategy for the treatment and prevention of laryngeal cancer and precancerous lesions.

The utility model discloses a protection device for placing a plurality of standard platinum resistance thermometers. The protection device comprises a base; a supporting column is vertically fixed to the base, the top end of the supporting column is connected with a rotary containing disc through a bearing, and a plurality of containing pipes are evenly distributed on the disc face of the containing disc in the circumferential direction in a penetrating and clamping mode. The top of each placing pipe is connected with a positioning and clamping mechanism, the supporting column is connected with a limiting mechanism, and wire containing grooves corresponding to the placing pipes one to one are vertically fixed to the outer edge of the placing disc. The utility model has the advantages that when the resistance thermometer is placed, the temperature measuring part of the resistance thermometer penetrates through the inner hole of the limiting plate and is placed in the placing pipe, the bottom end of the handle part of the resistance thermometer is propped against the top surface of the limiting plate, and the handle part of the resistance thermometer is clamped by the clamp, so that the structure is simple, and the temperature measuring effect is good during operation. The resistance thermometer is effectively protected through the containing pipe, the resistance thermometer is effectively limited through the positioning and clamping mechanism, and damage is avoided.

The invention relates to the technical field of sensor manufacturing, and particularly discloses a film platinum resistor temperature sensor terminal glue pouring and curing device which comprises a rack, a pipe fixing module, a pipe bottom supporting plate and a heating module. The pipe fixing module comprises a mother board and a daughter board which can be staggered relative to the mother board, and an elastic piece is arranged between the daughter board and the mother board; a plurality of through holes are formed in the mother board and the daughter board; the pipe bottom supporting plate is located below the pipe fixing module and can ascend and descend. The film platinum resistor temperature sensor terminal glue pouring curing method comprises the following steps: aligning a through hole of a mother board with a through hole of a daughter board, and inserting a circular tube terminal into the through hole; clamping the circular tube terminal; glue is poured into the clamped circular tube terminal, and a sensor wire is inserted into the circular tube terminal; and ejecting a finished product after the colloid is cured. The scheme is used for facilitating glue pouring and curing use of the tubular sensor terminal with the sensor terminal being of a circular tube structure, and the problems that glue spills easily and demolding is inconvenient due to inclination of the circular tube terminal can be solved while batch production can be facilitated.