21 results about "Platinum resistance" patented technology

The utility model provides a thermostatic bath test auxiliary device for temperature calibration, which belongs to the field of auxiliary test and comprises a mounting seat capable of being mounted in a thermostat; a test auxiliary component; the test auxiliary assembly comprises a circular groove penetrating through the mounting seat, a fixing mechanism matched with the center hole and the eccentric hole is mounted on the circular plate, the fixing mechanism comprises a fixing block fixed on the circular plate, and a clamping screw in threaded connection is arranged on the fixing block in a penetrating manner. According to the utility model, the rotating handle can drive the guide ring and the circular plate to rotate, so that the position of the movable platinum resistance thermometer can be adjusted, multi-point testing can be carried out, and the insertion depth of the fixed platinum resistance thermometer and the movable platinum resistance thermometer can be adjusted; and the defects that time and labor are wasted and potential safety hazards exist in manual operation in the prior art are overcome, the labor amount of workers is reduced, and the working efficiency is improved.

The present invention discloses a platinum resistance temperature measurement method and a temperature measurement device, which belongs to the field of temperature measurement technology and solves the problem that the existing platinum resistance temperature measurement method has high hardware requirements and complex calculation process. The temperature measurement method includes: obtaining the resistance value R of the platinum resistance temperature sensor in the platinum resistance temperature measurement circuit; t According to the formula T0=(R t / R0‑1) / A, solve to get the resistance value R t Corresponding temperature approximation T0: Perform regression correction on the temperature approximation T0; the regression correction process includes: setting the initial value of i to 0, and according to the formula δ i =B|T i | 2 Get the quadratic term value δ during the i-th regression correction i According to the formula T i+1 =(R t / R0‑1+|δ i |) / A obtains the temperature value T obtained by the i+1th regression correction i+1 ; If |T i+1 ‑T i |≤T th If the regression correction process is completed, the resistance value of the platinum resistance temperature sensor R t The corresponding temperature measurement value is T i+1 Otherwise, i=i+1, and jump to the formula (2) to obtain the quadratic term value δ at the time of the i-th regression correction i steps.

The present invention provides an anti-cancer vaccine comprising: (i) at least one peptide comprising the amino acid sequence of a neoantigen encoded by a mutant homologous recombination (HR) DNA repair gene selected from the group: BRCA1, BRCA2, PALB2, CDK12, RAD51B, RAD51C and RAD51D, wherein the mutant gene comprises a reversion mutation; and / or (ii) at least one polynucleotide encoding the at least one peptide of (i). Also provided are engineered T cells that recognise said neoantigen. Related methods and medical uses of the vaccine and / or engineered T cell are provided, including for the treatment of cancers, such as homologous recombination (HR) deficient cancers that acquire PARP inhibitor resistance or platinum resistance by development of reversion mutations in an HR DNA repair gene selected from the group: BRCA1, BRCA2, PALB2, CDK12, RAD51B, RAD51C and RAD51D.

The application relates to a refrigerator and a calibration method and device thereof. The refrigerator comprises a cabinet, a wall of which encloses a storage cavity; a platinum resistance fixed on the wall for detecting the ambient temperature in the storage cavity; a standard platinum resistance reserved hole is further arranged on the wall, the standard platinum resistance reserved hole is used for mounting a standard platinum resistance, the standard platinum resistance is used for calibrating the platinum resistance; and a main control board, which is provided with a standard platinum resistance interface in advance and is used for electrically connecting with the standard platinum resistance. The application solves the platinum resistance calibration problem of multiple low-temperature medical refrigerators by using one standard platinum resistance through the mode of adding the standard platinum resistance reserved hole on the cabinet and reserving the standard platinum resistance interface on the main board, and the cost is reduced. The low-temperature medical cabinet can be calibrated in a period, and the problem that the sample is scrapped due to the temperature deviation in the cabinet in the measurement period is solved.

The utility model relates to the technical field of platinum resistance thermometer fixing, in particular to a fixing device for a second-class standard platinum resistance thermometer of a thermostatic bath for calibration, which comprises a fixing seat and an adjusting part arranged on the fixing seat, and the adjusting part is used for fixing the fixing seat in the thermostatic bath. The fixing seat is used for fixing the thermostatic bath II standard platinum resistance thermometer, a supporting surface is erected on the fixing seat in the thermostatic bath, and the measuring ruler strip is connected with a through hole formed in the fixing seat in a penetrating manner. According to the utility model, the supporting surface can be erected at the top in the thermostatic bath, so that the second-class standard platinum resistance thermometer can be fixed between the auxiliary fixing part and the clamping part, and the measuring ruler strip is driven to lift through the driving part, so that the second-class standard platinum resistance thermometer can be synchronously driven to lift through the transverse connecting rod; in this way, the temperatures of media at different depths can be detected in real time in the calibration process, and the comprehensiveness and efficiency of data acquisition are improved.

The utility model belongs to the technical field of temperature sensor installation, and particularly relates to a platinum resistor temperature sensor protecting and fixing device, which comprises a preassembled piece, the preassembled piece is connected with a stabilizing piece, and the stabilizing piece is connected with a protecting piece. According to the utility model, through the arrangement of the stabilizing member and the protection member, on one hand, the protection member and the stabilizing member can be conveniently installed and used, and on the other hand, the protection member can be fixedly supported by the stabilizing member, so that the plurality of protection columns on the protection member can carry out enclosure protection on a temperature measurement element on the platinum resistance sensor; and the plurality of protection columns can disperse the flowing liquid around the temperature measurement element, and the temperature measurement work of the temperature measurement element is not influenced.

The invention discloses application of PCYOX1L as an ovarian cancer platinum resistance diagnostic marker in preparation of a diagnostic kit. Research finds that high expression of the isopentene cysteine oxidase 1-like protein (PCYOX1L) gene is related to ovarian cancer platinum resistance, and the expression level of the PCYOX1L remarkably affects proliferation and apoptosis processes of ovarian cancer cells, is remarkably and negatively related to prognosis of patients, can be used as a potential independent prognosis factor and a treatment target of the ovarian cancer, and can be used for preparing an ovarian cancer drug-resistant drug-resistant drug-resistant drug-resistant drug-resistant drug-resistant drug-resistant drug-resistant drug-resistant drug-resistant drug-resistant gene. And the marker is also a diagnostic marker for platinum resistance of ovarian cancer.

The present invention discloses an automatic calibration device for a platinum resistance thermometer and an automatic correction system for a pipeline medium temperature, relating to the field of new energy and energy-saving technologies. The device comprises a processing module, a platinum resistance thermometer, a patch thermometer, and an information storage module. The platinum resistance thermometer is used to collect the medium temperature of a medium in a heating pipeline, and the patch thermometer is used to collect the surface temperature of a wall of the heating pipeline. The processing module is used to determine a pipeline medium temperature correction parameter based on the obtained medium temperature and wall temperature when the heating pipeline is in a non-heating period. Then, when the heating pipeline is in a heating period, the pipeline medium temperature correction parameter is used to automatically correct the medium temperature obtained in real time to obtain a real-time medium temperature correction value. This allows regular calibration of the platinum resistance thermometer without manual intervention, greatly improving work efficiency, and avoiding the impact of errors caused by human factors.

The invention belongs to the technical field of biological medicine, and particularly relates to application of a miR-21 inhibitor loaded and iRGD peptide modified 293T cell exosome and a method for treating osteosarcoma cis-platinum resistance based on the modified 293T cell source exosome and combining with the miR-21 inhibitor. The miR-21 inhibitor is loaded into the exosome by using an electroporation technology, tumor cells are accurately targeted, activation of ferroptosis signal channels is promoted, the treatment effect of cis-platinum is remarkably enhanced, and the drug resistance of cis-platinum is overcome. The technology provides a novel drug delivery platform for precise treatment of osteosarcoma.

The present disclosure relates platinum(IV) and texaphyrin linked conjugates and compositions comprising a texaphyrin and a platinum(IV) agent. The present disclosure also provides pharmaceutical compositions of the conjugates and compositions. Also, provided herein are methods of using the instant compounds in the treatment of cancer such as a platinum resistant cancer.

The invention is entitled "Platinum Resistance Temperature Sensor with Floating Platinum Member". A platinum resistance temperature sensor is disclosed having a housing containing a platinum member. The housing includes a first substrate having a first support and a second support spaced apart from an upper surface of the first substrate. The first support of the first substrate supports a first portion of the platinum member and the second support supports a second portion of the platinum member. An intermediate portion of the platinum member is suspended above the upper surface of the first substrate between the first support and the second support.

The utility model discloses a shockproof platinum resistance thermometer, belongs to the technical field of platinum resistance thermometers, and aims to solve the problems that a structure for protecting a thermometer core body is lacked, and the thermometer core body is easy to suffer from external collision or vibration, so that the measurement error of the resistance thermometer is caused, and even the thermometer is damaged. Comprising a platinum resistance thermometer body, a protective sleeve, a connecting mechanism and a shockproof mechanism, the protective sleeve is arranged outside a thermal resistor below the platinum resistance thermometer body through the connecting mechanism, and the shockproof mechanism is arranged between the protective sleeve and the thermal resistor; the length of the protective sleeve can be adjusted through rotation of the movable ring in the threaded groove, the anti-skid sleeve can be suitable for platinum resistance thermometer bodies of different sizes, the application range and practicability of the product are improved, the protective sleeve is easy and fast to install and detach through the connecting mechanism, and the anti-skid sleeve is convenient to use. The practicability and the use convenience of the platinum resistance thermometer body are improved, and meanwhile, the installation stability is ensured.

The invention relates to an application of oligonucleotide based on NAT10 gene in preparation of drugs for reversing platinum drug resistance of non-small cell lung cancer. The antisense oligonucleotide provided by the invention not only can reverse platinum drug resistance, but also can inhibit proliferation of non-small cell lung cancer drug-resistant cells, and cell proliferation experiments prove that proliferation of chemotherapy drug-resistant cells is inhibited after treatment; according to the present invention, the tumor cell lipid metabolism abnormality is regulated, the lipid droplet staining results prove that the number of the treated cell lipid droplets is significantly reduced, and the tumor growth can be significantly inhibited, the expression of NAT10 in the tumor tissue can be reduced, the malignant development and metastasis of the tumor can be inhibited, and the anti-tumor effect can be provided in the animal experiment;

This invention discloses a novel application of undecanoic acid in inducing ferroptosis in laryngeal cancer cells and in the preparation of anti-laryngeal cancer drugs. For the first time, it was discovered that the known compound undecanoic acid can specifically target the mitochondria of laryngeal cancer cells, inducing mitochondrial structural damage and dysfunction. This, in turn, activates the ferroptosis pathway through multiple mechanisms, including increasing intracellular ferrous ion accumulation, increasing lipid peroxide levels, downregulating GPX4 / SLC7A11 expression, and upregulating ACSL4 expression, thereby effectively inhibiting the proliferation of laryngeal cancer cells. Based on this mechanism, this invention provides a pharmaceutical composition with undecanoic acid as the active ingredient, and its combined application with platinum-based drugs (such as cisplatin). This combined treatment exhibits a significant synergistic effect, particularly overcoming the platinum resistance of laryngeal cancer cells. This invention provides a novel drug selection and combination therapy strategy for the treatment and prevention of laryngeal cancer and precancerous lesions.

The present invention discloses a constant temperature calibration device for heat pipe fixed points, comprising: a constant temperature bath, at least four constant temperature accommodating cavities are arranged in the constant temperature bath, mercury, water, and gallium are successively contained in three of the constant temperature accommodating cavities, and the temperature detection end of a platinum resistance thermometer is placed in the other constant temperature accommodating cavity; a temperature adjusting device, which is used to adjust the temperature of the constant temperature bath. This constant temperature calibration device for heat pipe fixed points uses the melting points of three substances, mercury, water, and gallium, to calibrate the platinum resistance thermometer. Placing the three substances, mercury, water, and gallium, in the same constant temperature bath ensures the unity of temperature. Subsequently, the temperature in the constant temperature bath is successively increased from below -38.87°C to 29.80°C, and three electrical signal parameter values measured by the platinum resistance thermometer at the solid-liquid mixed states of mercury, water, and gallium are obtained respectively. By correspondingly marking the three electrical signals with three standard temperatures, three-point calibration of the platinum resistance thermometer can be achieved.

The utility model discloses a special calibration tool for an intracranial pressure sensor, which comprises a constant-temperature box, and a heating component is mounted at the bottom end in the constant-temperature box. By arranging the constant-temperature box, the calibration assembly, the platinum resistor and the air inlet assembly, when detection and calibration are conducted on the intracranial pressure sensors, a worker installs a vacuum sealing cover on a support and then installs the multiple sets of intracranial pressure sensors in an upper sealing seat at the same time, so that the vacuum sealing cover is located above the constant-temperature box; then certain gas pressure is injected into the vacuum sealing cover through the gas inlet assembly, pressure detection is conducted through the cranial pressure sensor, meanwhile, temperature detection is conducted on the cranial pressure sensor through warm water in the constant-temperature box, the platinum resistor can also measure the temperature, and therefore detection and calibration of the cranial pressure sensor are more accurate; the vacuum sealing cover is located above the constant-temperature box so that the risk that water in the constant-temperature box pollutes new products of the intracranial pressure sensors can be avoided, multiple sets of the intracranial pressure sensors can be measured at a time, and the measuring efficiency is improved.

The utility model discloses a protection device for placing a plurality of standard platinum resistance thermometers. The protection device comprises a base; a supporting column is vertically fixed to the base, the top end of the supporting column is connected with a rotary containing disc through a bearing, and a plurality of containing pipes are evenly distributed on the disc face of the containing disc in the circumferential direction in a penetrating and clamping mode. The top of each placing pipe is connected with a positioning and clamping mechanism, the supporting column is connected with a limiting mechanism, and wire containing grooves corresponding to the placing pipes one to one are vertically fixed to the outer edge of the placing disc. The utility model has the advantages that when the resistance thermometer is placed, the temperature measuring part of the resistance thermometer penetrates through the inner hole of the limiting plate and is placed in the placing pipe, the bottom end of the handle part of the resistance thermometer is propped against the top surface of the limiting plate, and the handle part of the resistance thermometer is clamped by the clamp, so that the structure is simple, and the temperature measuring effect is good during operation. The resistance thermometer is effectively protected through the containing pipe, the resistance thermometer is effectively limited through the positioning and clamping mechanism, and damage is avoided.

The utility model belongs to the technical field of temperature measurement, and particularly relates to a temperature calibration device for a standard thermostatic bath, which comprises a precision thermodetector, and a first platinum resistance thermometer and a second platinum resistance thermometer which are connected with the precision thermodetector and are fixed in the standard thermostatic bath through auxiliary fixing devices. The auxiliary fixing device comprises an outer ring fixedly arranged above the standard thermostatic bath and an inner ring coaxially arranged on the inner side of the outer ring in a sleeving mode, a transmission assembly is arranged between the outer ring and the inner ring and used for rotating the inner ring, a plurality of sliding ways are distributed on the inner side of the inner ring in a crossed mode, a sliding groove is formed between every two adjacent sliding ways, and fixing plug connectors are arranged on the sliding ways. A first platinum resistance thermometer is inserted into the fixed plug connector, a sliding plug connector is embedded in the sliding groove, a second platinum resistance thermometer is inserted into the sliding groove, the distance between the two platinum resistance thermometers is adjusted by moving the sliding plug connector, and limiting screws are arranged on the side faces of the fixed plug connector and the sliding plug connector in a penetrating mode. The limiting device is used for limiting the two platinum resistance thermometers.

The invention relates to the technical field of sensor manufacturing, and particularly discloses a film platinum resistor temperature sensor terminal glue pouring and curing device which comprises a rack, a pipe fixing module, a pipe bottom supporting plate and a heating module. The pipe fixing module comprises a mother board and a daughter board which can be staggered relative to the mother board, and an elastic piece is arranged between the daughter board and the mother board; a plurality of through holes are formed in the mother board and the daughter board; the pipe bottom supporting plate is located below the pipe fixing module and can ascend and descend. The film platinum resistor temperature sensor terminal glue pouring curing method comprises the following steps: aligning a through hole of a mother board with a through hole of a daughter board, and inserting a circular tube terminal into the through hole; clamping the circular tube terminal; glue is poured into the clamped circular tube terminal, and a sensor wire is inserted into the circular tube terminal; and ejecting a finished product after the colloid is cured. The scheme is used for facilitating glue pouring and curing use of the tubular sensor terminal with the sensor terminal being of a circular tube structure, and the problems that glue spills easily and demolding is inconvenient due to inclination of the circular tube terminal can be solved while batch production can be facilitated.

1. The name of the design product: platinum resistance temperature instrument (high precision). 2. The use of the design product: instrument for measuring temperature. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The utility model belongs to the technical field of temperature sensors, and particularly relates to a sleeve type platinum resistor temperature sensing device, which comprises a low-temperature pipeline and a mounting cylinder, and the mounting cylinder is fixedly arranged in the wall of the low-temperature pipeline. According to the utility model, the bottom end of the sealing cover plate is provided with the threaded groove which is in threaded connection with the sleeve, and the socket, the plug, the lead 1 and the lead 2 are arranged to be electrically connected with the platinum resistor temperature sensor for data transmission, so that the platinum resistor temperature sensor is totally closed while data transmission is ensured; meanwhile, a screw, a threaded hole I and a threaded hole II are arranged to connect the sealing cover plate with the mounting cylinder, so that a user can conveniently take out the sealing cover plate and the sleeve from the mounting cylinder; and then the sleeve is rotated and detached, and the platinum resistor temperature sensor, the heat conduction layer and the sleeve are maintained and replaced, so that the service life of the device is prolonged.