A compound prescription of Hui medicine for treating diabetic nephropathy and its application

A technology for diabetic nephropathy and fragrant medicine, which is applied in pharmaceutical formulations, urinary system diseases, and medical preparations containing active ingredients, etc. The effect of improving early and mid-term symptoms and improving renal function

Inactive Publication Date: 2015-10-21
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Second, the danger
① Disability and high mortality rate
②Heavy financial burden on medical care
[0005] At present, modern medical treatment measures for Diabetic Nephropathy (DN) are mainly exercise therapy, diet therapy, blood sugar control, blood pressure control, etc., but limited by the economic conditions in Ningxia and the special religion and lifestyle of the Hui people. Poor control of blood sugar and complications
Traditional Chinese medicine mostly regards "spleen and kidney deficiency" and "kidney deficiency and blood stasis" as the pathogenesis, and "tonifying the kidney and strengthening the spleen" and "activating blood to remove blood stasis" as the treatment principles, because most of the "deficiency and cold constitution" and "hyperlipidemia " (Basically equivalent to "phlegm dampness" in traditional Chinese medicine), and the curative effect is not ideal

Method used

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  • A compound prescription of Hui medicine for treating diabetic nephropathy and its application
  • A compound prescription of Hui medicine for treating diabetic nephropathy and its application
  • A compound prescription of Hui medicine for treating diabetic nephropathy and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Research on the influence of the Huiyao compound prescription of the present invention on glucose metabolism in alloxan-induced type 1 diabetic mice.

[0015] Seventy male Kunming mice of SPF grade, weighing (20±2) g, were purchased from the Experimental Animal Center of Ningxia Medical University.

[0016] Dosage determination: The drug concentrations of the low, medium and high dose groups are calculated according to the conversion method of human and animal body surface area and dose. The mice in the low, middle and high dose groups were given this compound back medicine 5g / kg, 10g / kg, 20g / kg respectively. After the medicinal materials are identified, they are decocted twice according to the traditional method, and concentrated to the corresponding dosage.

[0017] Eight rats were randomly selected as the normal control group. After fasting for 16 hours, the other mice were rapidly injected with freshly prepared 2% alloxan saline solution, 60m / kg, into the tail vei...

Embodiment 2

[0026] Effects of the Huiyao compound of the present invention on glucose metabolism in streptozotocin (STZ)-induced type 1 diabetic rats.

[0027] Male Wistar rats of SPF grade, weighing 180-220 g, were provided by the Experimental Animal Center of Ningxia Medical University.

[0028] Dosage determination: The drug concentrations of the low, medium and high dose groups are calculated according to the conversion method of human and animal body surface area and dose. Rats in the low, middle and high dose groups were given this compound back medicine 1g / kg, 2g / kg, 4g / kg respectively. After the medicinal materials are identified, they are decocted twice according to the traditional method, and then concentrated to the corresponding dosage.

[0029]8 rats were randomly selected as the normal control group; the remaining rats were injected with 0.1M sodium citrate buffer (pH=4.5) prepared streptozotocin (STZ, 60mg / kg), the blood glucose concentration was detected on the third da...

Embodiment 3

[0038] From October 2008 to October 2009, 224 patients with diabetes mellitus combined with urinary tract infection who met the diagnostic criteria of western medicine and inclusion criteria were selected, and the compound prescription of the present invention was used to continuously observe 3 courses of treatment, and followed up for 3 months. Baseline data analysis and TCM syndrome curative effect evaluation were carried out.

[0039] 1 Research object:

[0040] The cases came from patients with type 2 diabetes who visited the Department of Endocrinology of Yinchuan Hospital of Traditional Chinese Medicine from January 2006 to January 2008. Patients with clearly diagnosed diabetes and urinary tract infection were selected, regardless of gender, aged 45-75 years.

[0041] 1.1 Diagnostic criteria:

[0042] a. Western medicine diagnostic criteria for diabetes: refer to the criteria established by the International Diabetes Committee in November 2003.

[0043] b. Western medi...

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Abstract

The invention discloses a Hui medicine compound for treating diabetic nephropathy and an application thereof. The medical composition comprises the following raw materials in parts by weight: 100-500 parts of rhizoma nardostachyos, 160-600 parts of medlar, 200-1000 parts of aromatic medicine composition (Foeniculum vulgare: elecampane: Syzygium aromaticum: Agastache rugosus=4:3:2:1), 60-400 parts of pine mushroom, 160-580 parts of Semen Cuscutae, 40-240 parts of rheum officinale, 60-360 parts of aloe and 360-1000 parts of tonifying composition (ginseng: cistanche: flowers carthami=3:2:1). The compound provided by the invention has the advantages of exact curative effect and no remarkable toxic and side effects, and has the function of converting black hygroplasm in the body to red hygroplasm, yellow hygroplasm and white hygroplasm and has the effects of removing dampness by means of aromatics, eliminating phlegm and dredging collaterals and tonifying the kidney. The medicine compound is suitable for treating wet diabetic nephropathy with deficiency of the kidney and phlegm evil.

Description

technical field [0001] The invention relates to a compound prescription of Hui medicine for treating diabetic nephropathy and its application. Background technique [0002] Diabetes Mellitus (DM) has become a common and frequently-occurring disease worldwide. Diabetic Nephropathy (DN) is one of the most important microvascular complications of diabetes, and has become the main cause of global chronic kidney disease (CKD) and its resulting end-stage renal disease (ESRD). Patients can only rely on dialysis Or kidney transplantation to maintain life, which not only seriously affects survival and quality of life, but also brings heavy economic burden and mental pressure to the family and society. [0003] According to several large-scale DM epidemiological surveys in my country, the incidence of DM in Ningxia Hui Autonomous Region presents two characteristics: first, the incidence rate is high. ①The incidence rate in Ningxia ranks at a relatively high level in the country. Th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/886A61K36/896A61P3/10A61P13/12
Inventor 南一袁玲牛阳
Owner NINGXIA MEDICAL UNIV
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