Method and device for extracting meta biomarkers

Abstract

The invention discloses a method and a device for extracting meta biomarkers. The method comprises the steps that n disease mass spectrometric data sets relevant to the same disease are fetched; protein quantification is conducted on proteins in each disease mass spectrometric data set; n protein quantification results are obtained, wherein n is a positive integer; each protein quantification result is compared with a corresponding reference control group; statistical discrepancy probability values of the proteins in each protein quantification result are obtained; the proteins with the statistical discrepancy probability values less than preset remarkable thresholds serve as candidate biomarkers; m candidate biomarkers are obtained; meta-analysis is conducted on the m candidate biomarkers; and sets of the candidate biomarkers with statistical magnitude greater than preset statistical values in the n disease mass spectrometric data sets are extracted to serve as the meta biomarkers. The method and the device can conduct analysis by utilizing the mass spectrometric data sets which are relevant to the diseases, from separate sources and outputted by different laboratories, and the obtained meta biomarkers have better generality and robustness.

Description

technical field [0001] The present invention relates to the field of biomarker extraction, in particular, to a method and device for extracting meta-biomarkers. Background technique [0002] Biomarkers refer to biochemical indicators that can mark changes or possible changes in the structure or function of systems, organs, tissues, cells, and subcellular structures. . Biomarkers are usually obtained from tissues such as ex vivo tumors, blood, plasma or body fluids of patients. Biomarkers have important clinical application value and can be used for disease diagnosis, judgment of disease stage, or evaluation of the safety and effectiveness of new drugs or new therapies in the target population. [0003] Proteomics is an effective means to study the expression profiles of proteins contained in cells and tissues under specific spatio-temporal conditions, and it is also an important method to find biomarkers. The basic idea is to compare the difference of protein expression b...

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method and device for extracting meta-biomarkers to solve the problem that the analysis method for data from different sources in the prior art is to simply average the data sets, and the analysis results do not have statistical significance , a technical problem that makes the resulting biomarkers not have obvious generalizability

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