Method and device for extracting meta biomarkers

A technology of biomarkers and mass spectrometry data, applied in the field of biomarker extraction, can solve the problems such as the lack of universality of biomarkers and the statistical significance of the analysis results, so as to save the experimental cost, have versatility and The effect of robustness

Inactive Publication Date: 2013-10-02
NAT UNIV OF DEFENSE TECH
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Problems solved by technology

[0005] The purpose of the present invention is to provide a method and device for extracting meta-biomarkers to solve the problem that the analysis method for data from different sources in the pri

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  • Method and device for extracting meta biomarkers
  • Method and device for extracting meta biomarkers
  • Method and device for extracting meta biomarkers

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Embodiment Construction

[0047] The embodiments of the present invention will be described in detail below with reference to the accompanying drawings, but the present invention can be implemented in many different ways defined and covered by the claims.

[0048] figure 1 It is a schematic diagram of the composition of the device for extracting biomarkers in a preferred embodiment of the present invention.

[0049] Such as figure 1As shown, the device for extracting meta-biomarkers of the present invention includes a quantification module 1 , a difference comparison module 2 and a meta-analysis module 3 . in:

[0050] Quantification module 1 is used to obtain n disease mass spectrometry data sets related to the same disease, and perform protein quantification on the proteins in each disease mass spectrometry data set to obtain n protein quantification results, where n is a positive integer. Among them, the n disease mass spectrometry data sets related to the same disease are preferably data sets fr...

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Abstract

The invention discloses a method and a device for extracting meta biomarkers. The method comprises the steps that n disease mass spectrometric data sets relevant to the same disease are fetched; protein quantification is conducted on proteins in each disease mass spectrometric data set; n protein quantification results are obtained, wherein n is a positive integer; each protein quantification result is compared with a corresponding reference control group; statistical discrepancy probability values of the proteins in each protein quantification result are obtained; the proteins with the statistical discrepancy probability values less than preset remarkable thresholds serve as candidate biomarkers; m candidate biomarkers are obtained; meta-analysis is conducted on the m candidate biomarkers; and sets of the candidate biomarkers with statistical magnitude greater than preset statistical values in the n disease mass spectrometric data sets are extracted to serve as the meta biomarkers. The method and the device can conduct analysis by utilizing the mass spectrometric data sets which are relevant to the diseases, from separate sources and outputted by different laboratories, and the obtained meta biomarkers have better generality and robustness.

Description

technical field [0001] The present invention relates to the field of biomarker extraction, in particular, to a method and device for extracting meta-biomarkers. Background technique [0002] Biomarkers refer to biochemical indicators that can mark changes or possible changes in the structure or function of systems, organs, tissues, cells, and subcellular structures. . Biomarkers are usually obtained from tissues such as ex vivo tumors, blood, plasma or body fluids of patients. Biomarkers have important clinical application value and can be used for disease diagnosis, judgment of disease stage, or evaluation of the safety and effectiveness of new drugs or new therapies in the target population. [0003] Proteomics is an effective means to study the expression profiles of proteins contained in cells and tissues under specific spatio-temporal conditions, and it is also an important method to find biomarkers. The basic idea is to compare the difference of protein expression b...

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Application Information

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IPC IPC(8): G06F19/18
Inventor 刘伟谢红卫
Owner NAT UNIV OF DEFENSE TECH
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