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Analyzing chemical and biological substances using nano-structure based spectral sensing

A nano-structure and nano-technology, applied in the field of substance detection, can solve the problem of limited detection of chemical substances and biochemical substances, and achieve the effect of improving detection sensitivity and specificity

Inactive Publication Date: 2014-04-02
OPTO TRACE SUZHOU TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the application of Raman scattering for the detection of chemical and biochemical substances has been very limited so far

Method used

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  • Analyzing chemical and biological substances using nano-structure based spectral sensing
  • Analyzing chemical and biological substances using nano-structure based spectral sensing
  • Analyzing chemical and biological substances using nano-structure based spectral sensing

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Embodiment Construction

[0070] Figures 1A-1C A system for detecting or detecting micro-trace chemical substances or biochemical substances using Surface-Enhanced Raman Scattering (SERS, or Nano-Enhanced Raman Scattering, NERS) is schematically illustrated respectively. see Figure 1A , a light scattering probe 100 includes a probe 110 and a detector 105 located next to the probe 110 . Detector 105 includes a nanosurface structure. For example, the nanosurface structure may include a plurality of nanopillars 108 ( Figure 1B shown), multiple nanopores, nanoparticle clusters in solution, or other nanoscale surface structures. In some embodiments, nanosurface structures can be fabricated by coating the surface of detector 105 with a colloidal suspension solution containing nanoparticles, as described below. The solution can then be evaporated and the nanoparticles deposited onto the surface. In the specification of the present invention, the term "nanoparticle" refers to a small particle having a s...

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Abstract

An integrated chromatography-immunoassay system for integrated chromatography-immunoassay system includes a chromatographic unit that receives labeled nano-structured probes comprising nano particles and antibodies attached to the nano particles, and a test membrane comprising coating antigens. The chromatographic unit allows the labeled nano-structured probes to diffuse there through and into the test membrane, wherein the antibodies on the nano particles are bound to the coating antigens. A laser device emits a laser light to illuminate the labeled nano-structured probes having the antibodies bound to the coating antigens on the test membrane. A spectral analyzer obtains a Raman spectrum from light scattered from the labeled nano-structured probes having the antibodies bound to the coating antigens on the test membrane, and to identify a spectral signature in the Raman spectrum associated with the antibody-antigen pair, which enables detection and identification of the antibody.

Description

[0001] This application is a continuation of, and claims priority from, commonly assigned pending U.S. Patent Application No. 13 / 442,835, entitled "Ensuring Food Safety Using Nanostructure-Based Spectroscopic Detection," filed on April 9, 2012. U.S. Patent Application No. US13 / 442,835 claims the priority of U.S. Provisional Application No. US61 / 507,592. The title of U.S. Patent Application No. 13 / 442,835 is "Analysis of Chemicals and Biochemicals by Spectroscopic Detection Based on Nanostructure", and the filing date is 2011 July 13. The disclosure of these related patent applications here is incorporated by reference into this application. technical field [0002] The invention relates to the field of substance detection, in particular to a method for detecting chemical substances, biochemical substances, radioactive substances and other substances by using a light scattering probe and a chemical detector. Background technique [0003] Light scattering techniques such as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/558G01N21/65
CPCG01N33/54346G01N33/54373
Inventor 汪泓郭浔刘春伟邓安平常化仿
Owner OPTO TRACE SUZHOU TECH
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