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Cyclophosphamide-containing pharmaceutical composition and application in treatment for breast cancer

A technology of cyclophosphamide and composition, applied in pharmaceutical composition and its application field in the treatment of cancer, can solve problems such as toxic and side effects, limited application and the like

Inactive Publication Date: 2014-07-23
徐鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that although cyclophosphamide is used as a first-line drug for tumor chemotherapy, it has a variety of serious side effects like most chemotherapy drugs, which limits its application.

Method used

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  • Cyclophosphamide-containing pharmaceutical composition and application in treatment for breast cancer
  • Cyclophosphamide-containing pharmaceutical composition and application in treatment for breast cancer
  • Cyclophosphamide-containing pharmaceutical composition and application in treatment for breast cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A pharmaceutical composition containing cyclophosphamide, which consists of cyclophosphamide, salidroside and acteosin-7-oxo-β-D-glucopyranoside, wherein cyclophosphamide, salidroside and acteoside The molar ratio of flavone-7-oxo-β-D-glucopyranoside was 20:15:5.

Embodiment 2

[0023] A pharmaceutical composition containing cyclophosphamide, which consists of cyclophosphamide, salidroside and acteosin-7-oxo-β-D-glucopyranoside, wherein cyclophosphamide, salidroside and acteoside The molar ratio of flavone-7-oxo-β-D-glucopyranoside was 40:25:15.

Embodiment 3

[0025] A pharmaceutical composition containing cyclophosphamide, which consists of cyclophosphamide, salidroside and acteosin-7-oxo-β-D-glucopyranoside, wherein cyclophosphamide, salidroside and acteoside The molar ratio of flavone-7-oxo-β-D-glucopyranoside was 30:20:10.

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PUM

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Abstract

The invention belongs to the field of medicines, and particularly relates to a cyclophosphamide-containing pharmaceutical composition, and an application thereof in treatment for cancer, in particular for breast cancer. The pharmaceutical composition is composed of cyclophosphamide, salidroside and calycosin-7-oxy-beya-D-glucopyranoside, wherein the molar ratio of cyclophosphamide to salidroside to calycosin-7-oxy-beya-D-glucopyranoside is (20-40): (15-25): (5-15). The pharmaceutical composition disclosed by the invention is capable of reducing the toxic and side effects of cyclophosphamide and remarkably enhancing the curative effect, provides a new thought and strategy for treatment of breast cancer, and has important clinical significance and wide application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition containing cyclophosphamide and its application in treating cancer, and the cancer is preferably breast cancer. Background technique [0002] In recent years, the morbidity and mortality of tumors have been increasing year by year. It is predicted that by 2020, with the world population reaching 8 billion, there will be 20 million new cancer cases each year, of which the death toll will reach 12 million. The development of cancer drugs is urgent. At present, all kinds of anti-tumor synthetic drugs used and proved by clinical practice generally have serious toxic and side effects, even anti-tumor drugs derived from natural products, such as paclitaxel, harringtonine, camptothecin, vincine, fallocytine, etc. Narcisine, cantharidin, etc. also have varying degrees of toxic and side effects. It is of great clinical significance to find and prepare ant...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P35/00A61K31/675A61K31/7032
Inventor 徐鹏杨诚张振华彭宗玉
Owner 徐鹏
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