120 results about "Phosphoramides" patented technology

The invention discloses an iridium complex with four types of different-site and different-quantity fluoro-substituted 2-phenylpyridine serving as main ligands, and bi(bisubstituent phenyl phosphoro)amine serving as an auxiliary ligand. The formula of the iridium complex is shown in the specification. Emission peaks of an EL (electroluminescence) spectrum of an electroluminescence device prepared from the iridium complex are respectively 497nm, 497nm and 495nm; maximum current efficiencies are respectively 43.95cd / A, 66.36cd / A and 37.36cd / A; maximum power efficiencies are respectively 28.51 lm / W, 48.20 lm / W and 19.11 lm / W; maximum power efficiencies are respectively 38827cd / m<2>, 47627cd / m<2> and 40319cd / m<2>. The invention discloses a preparation method of the iridium complex.

This invention relates to phosphoramidite compounds and catalyst complexes which can be used to provide enantioselective reactions including hydroamination reactions, etherification reactions and conjugate addition reactions and allylic substitution reactions, among others. In a first aspect, the present invention is directed to phosphoramidite and related compounds according to general structure (I), where Z is absent or is a group containing O, N or S, preferably O; R1 and R2 are independently an optionally substituted C1-12 alkyl group, an optionally substituted (CH2)n-aromatic group or (CH2)n-heteroaromatic group, or are linked together to form an optionally substituted aliphatic or (CH2)n-aromatic dianion of a diol, diamine, dithiol, aminoalcohol, aminohiolate or a alcoholthiol group; R3′ and R3 are each independently H, an optionally substituted C1-C12 alkyl group or an optionally substituted (CH2)n-aromatic group with the proviso that R3′ and R3 are not both H, or together R3′ and R3 form an optionally substituted C5-C15 saturated or unsaturated carbocyclic ring; R4 is H, an optionally substituted C1-C12 alkyl group or an optionally substituted (CH2)n-aromatic group; R5 is absent, H, an optionally substituted C1-C12 alkyl group or an optionally substituted (CH2)n-aromatic or (CH2)n-heteroaromatic group; Ra and Ra′ are each independently H or a C1-C3 alkyl group, or Ra and Ra′ together with the carbon to which they are attached form a optionally substituted C5-C15 saturated or unsaturated carbocyclic or heterocyclic ring, or an aromatic or heteroaromatic ring; R6 and R7 are each independently H, an optionally substituted C1-C12 alkyl group or an optionally substituted (CH2)n-aromatic group, with the proviso that R5, R6 and R7 cannot simultaneously be H, and when Ra and Ra′, together with the carbon to which they are attached, form a carbocyclic ring, heterocyclic ring or an aromatic or heteroaromatic ring, R5 is absent or is preferably H; R6 and R7 are preferably H or CH3; and each n is independently 0, 1, 2, 3, 4, 5 or 6 and wherein at least one of the carbon atoms attached to the nitrogen of the phosphoramidite group is a chiral center.

The present invention provides building blocks and methods for synthesizing very pure RNA in a form that can efficiently be modified at the 3′ end. Reverse RNA monomer phosphoramidites have been developed for RNA synthesis in 5′→3′ direction, leading to very clean oligo synthesis that allows for the introduction of various modifications at the 3′-end cleanly and efficiently. Higher coupling efficiency per step have been observed during automated oligo synthesis with the reverse RNA amidites disclosed herein, resulting in a greater ability to achieve higher purity and produce very long oligonucleotides. The use of the reverse RNA phosphoramidites in the synthetic process of this invention leads to oligonucleotides free of N+1 species.

The invention provides a reactive phosphorus-containing flame retardant. The flame retardant contains unsaturated double bonds and can react with polymer, and phosphate and phosphamide structural units are further introduced based on the structure with the unsaturated double bonds. After the obtained flame retardant is applied to unsaturated polyester resin, the highest level of vertical burning UL-94 reaches the level of V-1-V-0, the maximum value of the limit oxygen index LOI is 33.0%, and the peak of heat release rate (PHRR) and total heat release (THR) in cone calorimetry tests are lower than the PHRR and THR of pure unsaturated polyester; after the obtained flame retardant is applied to unsaturated polyester glass fiber composite materials, the highest level of vertical burning UL-94reaches the level of V-1-V-0, and the maximum value of the limit oxygen index LOI is 40%. The reactive phosphorus-containing flame retardant has good flame retardancy and little influences on the mechanical properties of the materials. The invention also provides a preparation method of the flame retardant. The preparation method of the flame retardant is simple, and has mild conditions and easy control.

The invention provides antisense antiviral compounds and methods of their use in inhibition of growth of human immunodeficiency virus-1 (HOV-1), as in treatment of a viral infection. The antisense antiviral compounds have morpholino subunits linked by uncharged phosphorodiamidate linkages interspersed with cationic phosphorodiamidate linkages. An exemplary embodiment of the invention provides an antisense compound directed to the HIV Vif gene, causing the production of defective HIV- 1 virions in an infected individual.

The invention relates to the technical field of chemical synthesis, in particular to thio-octyl phosphoramido ester and a synthetic method and application thereof. The synthetic method of the thio-octyl phosphoramido ester includes the step of: adopting thioctic acid as a raw material, performing a reduction reaction to obtain thio-octanol, and performing an esterification reaction to obtain the thio-octyl phosphoramido ester. When the thio-octyl phosphoramido ester is used as a DNA end-group modifier, DNA with sulfur-containing modified end groups can be prepared efficiently and massively, and the simple and efficient DNA end-group modifier with controllable cost can be provided for sulfur-containing modification of a 5' end of DNA; meanwhile, the synthetic method has the advantages of aconcise path, convenient operation, a simple method for purifying intermediates and the product, and requirements of scientific research and business can be fully met.

The invention discloses a mesoporous molecular sieve / phosphoramide composite material and a preparation method thereof. The mesoporous molecular sieve / phosphoramide composite material aims to solve the problems that existing SBA-15 molecular sieves are poor in uranyl adsorbing capacity. The mesoporous molecular sieve / phosphoramide composite material comprises components with percentage by mass: 75-97% of SBA-15 mesoporous molecular sieves and 3-25% of phosphamide perssad, wherein the phosphamide perssad and the SBA-15 are connected through covalent interaction. The invention substantially discloses an SBA-15 mesoporous molecular sieve- phosphoramide composite material and a preparation method thereof, the mesoporous molecular sieve / phosphoramide composite material has large specific surface area and excellent appetency to the uranyl, has excellent uranyl ion adsorption property, and can effectively solve the problem that existing SBA-15 molecular sieves are poor in uranyl adsorbing capacity. Simultaneously, the preparation method of the mesoporous molecular sieve / phosphoramide composite material is simple, low in production cost and high in yield, can meet the demands of large-scale industrialized application, has excellent application prospect, and is worthy of large-scale popularization and application.

The present disclosure relates to salts and compositions of isophosphoramide mustard and isophosphoramide mustard analogs. In one embodiment the salts can be represented by the formulawherein A+ represents an ammonium species selected from the protonated (conjugate acid) or quaternary forms of aliphatic amines and aromatic amines, including basic amino acids, heterocyclic amines, substituted and unsubstituted pyridines, guanidines and amidines; and X and Y independently represent leaving groups. Also disclosed herein are methods for making such compounds and formulating pharmaceutical compositions thereof. Methods for administering the disclosed compounds to subjects, particularly to treat hyperproliferative disorders, also are disclosed.

The invention relates free NH2-group-attached chiral phosphoramides, a chiral N-phosphonimines and the methods for forming the same. The free NH2-group-attached chiral phosphoramides, having the structure of formula (I) wherein R1 and R2 are independently any organic groups.

The invention discloses a method for synthesizing an indole terpene analogue through Heck / dearomatization cascade reaction, and belongs to the technical field of organic chemistry. Substituted 2-naphthol and N-substituted phenyl allene amine are used as raw materials, and in the presence of a palladium catalyst and a chiral phosphoramidite ligand, Heck / dearomatization cascade reaction is performed to obtain the indole terpene analogue. The method has the advantages of good chemical selectivity and enantioselectivity and high yield, and the product contains a chiral quaternary carbon center.

The invention discloses a biological probe as well as a preparation method and application thereof. The biological probe comprises a probe carrier and customized sialic acid ligand molecules connected with the probe carrier, the structural general formula of the customized sialic acid ligand molecule is as shown in formula I, wherein R1 is selected from hydroxyl, methoxyl or substituted methoxyl; r2 is selected from acetamido, substituted acetamido, benzamido, substituted benzoyl, alkoxycarbonylamido, triazolyl or substituted triazolyl, and R3 is selected from hydroxyl, methoxyl, substituted methoxyl, acetamido, substituted acetamido, sulfamido or phosphamido; n is selected from 0, 1, 2, 3, 4, 5, 6 and 7, and m is selected from 2, 3, 4, 5, 6, 7, 8 and 9. The biological probe can be used for directly detecting new coronavirus particles.

The present invention relates to novel impurities of cyclophosphamide having structure V, VI or VII, stabilized form of these novel impurities, a process of preparing a stabilized form and isolating thereof. The invention also relates cyclophosphamide formulations which include cyclophosphamide, at least one pharmaceutically acceptable excipient, and a certain level of these impurities having structure V, VI or VII. The invention further relate to method of using such stable liquid formulations of cyclophosphamide for parenteral administration in treating various cancer disorders.

The invention relates to a polypeptide synthesis method using a novel amino acid ionic liquid as a reactant and N, N '-diethylene-N-2-chloroethyl thiophosphoric amide (CTPA) as a special coupling agent. The amino acid ionic liquid is an ionic liquid which takes amino acid with a tert-butoxy protecting group as an anion and imidazolium as a cation. The polypeptide synthesis method mainly comprisesthe following steps: by taking preloaded resin for polypeptide synthesis as a starting material, CTPA as a coupling agent and amino acid ionic liquid as a recoverable reactant, carrying out amino acidcoupling reaction to generate the peptide compound. By adopting the synthesis method disclosed by the invention, a coupling reaction without residual alkali and other additives can be completed within 15 minutes at room temperature, less solvent is consumed, and a high-purity polypeptide product can be rapidly synthesized at high yield. The synthesis method disclosed by the invention is simple inprocess, green and environment-friendly, and extremely high in practicability and sustainability.