Influenza vaccine constructs

一种流感血凝素、结构域的技术，应用在抗体医疗成分、病毒/噬菌体、抗体模拟物/支架等方向，能够解决潜伏期短、病毒糖蛋白抗原性变化等问题

Inactive Publication Date: 2015-04-29
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Control of seasonal influenza A viruses is a challenge due to rapid viral transmission, short incubation period, and antigenic changes in viral glycoproteins

Method used

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  • Influenza vaccine constructs
  • Influenza vaccine constructs
  • Influenza vaccine constructs

Examples

Experimental program
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Embodiment 2

[0186] The rapid spread of the pandemic H1N1 influenza virus in 2009 has increased the need for a universal influenza vaccine that will broadly protect against multiple mutant strains. Recent efforts have focused on the highly conserved hemagglutinin (HA) stem domain. Although several groups have tried to generate the HA stem domain as a possible universal influenza vaccine antigen (Bommakanti et al. (2010) PNAS107(31): 13701-13706; Steel et al. (2010) Mbio 1(1); Wang et al. 2010) PNAS107(44):18979-18984), but this has proven to be technically challenging. The first challenge is that the HA stem domain has not evolved to fold and trimerize into independent units. Further, the simultaneous folding together with the head domain is likely to be in the first part of the stem, then the head, and finally the rest of the stem domain is extruded from the ER membrane and oriented through this association. Translation takes place. In this process, disulfide bonds must be formed in eac...

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Abstract

Vaccine compositions and methods of producing and using the same are provided, which compositions comprise a modified HA stem domain in a trimeric configuration.

Description

[0001] Federally funded research and development [0002] The present invention is supported by the government under the approval number A1057229 granted by the National Institutes of Health. The government has certain rights in the invention. Background of the invention [0003] Influenza is a major challenge to global public health. Although there are several different flu vaccines and medicines that can be used to prevent and treat influenza, there are 25-50 million flu cases and 30,000-40,000 deaths in the United States each year. Due to the rapid spread of the virus, short incubation period and antigenic changes in viral glycoproteins, the control of seasonal influenza A viruses is a challenge. [0004] Influenza A virus is an antisense, single-stranded, segmented RNA virus of the Orthomyxoviridae family. There are several subtypes, labeled according to the H number (for hemagglutinin type) and N number (for neuraminidase type). There are 16 different H antigens (H1 to H16) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/14
CPCA61K39/12C12N2760/16134A61K2039/5258A61K2039/6075A61K2039/64C07K2319/00C07K2319/70A61P31/16A61P37/04A61K39/00C07K14/00C07K14/005C07K2319/42C07K2319/50C12N7/00
Inventor 卢元J·R·斯沃茨
Owner THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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