Application of HLA (human leukocyte antigen) gene to judging white vulval lesions of Chinese han-nationality women

Abstract

The invention discloses application of an HLA (human leukocyte antigen) gene to judging white vulval lesions of Chinese han-nationality women, and belongs to the field of gynaecology and immunological genetics. The susceptible population of vulvar lichen sclerosus and vulvar squamous cell hyperplasia is judged by detecting and screening a susceptibility gene and a resistance gene through the HLA gene, and control study and judgment analysis are performed by observing conditions of alleles of HLA-B*5, HLA-DRB1*12, HLA-B*40, HLA-A*11, HLA-A*31, HLA-B*13, HLA-B*35, HLA-DRB1*01 and HLA-DRB1*03 of vulvar lichen sclerosus and vulvar squamous cell hyperplasia patients. The application is of important guiding significance on early-stage diagnosis, predication, prevention and treatment of vulvar dystrophy.

Description

technical field [0001] The invention belongs to the fields of gynecology and immunogenetics, and relates to a method for judging the white lesions of vulva of Chinese Han women by using HLA gene. Background technique [0002] Nonneoplastic intraepithelial lesions of the vulva are a group of chronic diseases characterized by pigmentation changes and degeneration of the skin and mucosa of the vulva in women, including lichen sclerosus (VLS), squamous cell hyperplasia, and other vulvar skin diseases. Because the vulvar skin and mucous membranes of patients with lichen sclerosus and squamous cell hyperplasia are mostly white, it is also called white lesions of vulva. According to statistics, its incidence rate is 1 / 300~1 / 1000. Lichen sclerosus of the vulva is a disease characterized by atrophy and thinning of the vulva and perianal skin, and is the most common white lesion of the vulva. It was found in 1.7% of patients in gynecological operations. In the later stage, it may d...

AI Technical Summary

Problems solved by technology

It was found that the incidence of lichen sclerosus patients in different races and different regions is related to HLA gene, but whether vulvar squamous epithelial hyperplasia is also related to immune genetics, and whether its correlation with HLA gene polymorphism is unknown at home and abroad. seen reported

However, there is no report on the association between Chinese Han women's lichen sclerosus and HLA-A\B\DRB1 gene polymorphisms

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