Multifunctional Rodent Retainer and Method of Use

Abstract

The invention discloses a multifunctional rodent fixator and a use method thereof. The multifunctional rodent fixator comprises a fixator body shell, a base plate, a rotatable fixing plate located on the upper portion of the fixator body shell, four claw binding devices located on the rotatable fixing plate, limb fixing cableways located below the claw binding devices, a tail fixing device connected to one end of the fixator body shell, a lead plate protection cover arranged on the fixator body shell, a ray guide and positioning device arranged on the top of the protection over, a pitching angle adjusting mechanism arranged in the base plate, a rotating angle adjusting mechanism for controlling the rotating angle of the rotatable fixing plate and an auxiliary supporting rotating mechanism. By means of the multifunctional rodent fixator, just one researcher can fix an experimental rat to an experiment table easily, conveniently and firmly, the fixator is suitable for rats of various shapes, the pitching of the fixing angle and the rotating angle of experiment animals can be adjusted, and the requirements for various experiment postures are met; tails of the rats can be stably fixed, caudal vein blood enrichment and regulating can be achieved with one hand, and four pieces of caudal veins of a rat can be selected and exchanged freely.

Description

technical field [0001] The invention belongs to the technical field of animal experiment research equipment, and relates to a multifunctional rodent fixer which is simple and reliable in operation and can meet various research needs and a method for using the same. Background technique [0002] In the current mouse experiments, the researchers first need to fix the mice. At present, the status of the methods and devices for fixing the mice are as follows: [0003] 1. There are two ways to immobilize mice: one is to use a cylindrical container to squeeze and fix the mouse by narrowing the space in the container; the other is to bind and fix the limbs of the mouse with ropes, and then The rope is tied to the preset point, or connected to the slider through the rope, so that it can slide on the circular cylinder for fixing. However, the above method is relatively complicated to operate, and in most cases, two experimenters are required to cooperate at the same time to complete...

AI Technical Summary

Problems solved by technology

However, the above method is more complicated to operate, and in most cases, two experimenters are required to cooperate at the same time to complete the immobilization of mice, which not only wastes manpower, but also the immobilization effect is not ideal

[0004] 2. For the injection and blood collection of the tail vein of experimental animals, it is difficult to achieve stable fixation of the tail of experimental animals by using the existing fixation methods, let alone select the tail blood vessels when the trunk of the animal is fixed.

In the current practice, researchers often twist the tail to find the appropriate blood vessel while the animal's trunk is fixed, which is likely to cause tail injury, bruising or necrosis; in addition, due to the need for one hand to hold the Tail, resulting in the restriction of the needle insertion angle of the other hand. Because the tail vein is small, the blood vessel wall is thin and close to the skin, it often punctures the blood vessel and even poses a threat to the health of the operator.

The construction of animal models consumes time, energy and financial resources. If the animal model is damaged due to the mismatch of experimental auxiliary equipment, it will undoubtedly be a huge loss for scientific research.

[0005] 3. In the study of "the effect of radiotherapy in animal tumor models", most of the radiotherapy instruments come from instruments that have been eliminated after the application of human clinical treatment, and the size of the emitted ray beam is more suitable for human beings, and the size of the focus point of radiotherapy varies. Irregularity, due to the small size of the mice, the tumor organs or tissues in the constructed mouse tumor model are smaller. When using radiotherapy equipment for radiotherapy, it is difficult to irradiate various parts of the mouse body, let alone accurately locate the tumor The lesions were treated with fixed-point radiotherapy, which resulted in the death of mice receiving excessive radiotherapy or the unscientific results of the experiment due to the lack of concentration of radiotherapy sites.

[0006] 4. The current animal experiment technology is widely used in biomedicine and pharmaceutical research, etc., but the current experimental animal consoles are mostly flat plate fixed mode, that is, the mice are fixed horizontally on the console, and the mouse body position cannot be adjusted

However, during this operation, it is often difficult to take blood, waste of blood drops, pollution, and animal wounding incidents due to the poor fixed position of the mouse and the unstable fixation.

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