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Application of cyclic adenosine monophosphate or its derivatives in postoperative subretinal hemorrhage

A technology of meglumine cyclic adenosine monophosphate and meglumine cyclic adenosine monophosphate, which is applied in the field of cyclic adenosine monophosphate or its derivatives, can solve the problems of slow hemostatic effect, danger to patients' lives and the like, and achieves enhanced anti-bleeding ability , The effect of reducing hemostasis time and reducing the degree of bleeding

Active Publication Date: 2018-08-07
SHANGHAI JINCHENG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the method of reducing postoperative subomental hemorrhage is mainly to inject hemostatic drugs during or after the operation, but the hemostatic effect of the current hemostatic drugs is slow, and they are often helpless when encountering sudden and large-scale bleeding, resulting in The patient is in danger of life and cannot meet the requirements

Method used

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  • Application of cyclic adenosine monophosphate or its derivatives in postoperative subretinal hemorrhage
  • Application of cyclic adenosine monophosphate or its derivatives in postoperative subretinal hemorrhage
  • Application of cyclic adenosine monophosphate or its derivatives in postoperative subretinal hemorrhage

Examples

Experimental program
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Effect test

Embodiment 1

[0026] 1. Main materials

[0027] Cyclic adenosine monophosphate (purchased from Shanghai Yuanye Biotechnology Co., Ltd.), normal saline, distilled water, syringe, optical microscope, homogenizing glass dish, and surgical instruments.

[0028] 2. Subjects

[0029] Adult male rats (purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.), male, weighing 280-350 g, were reared in a single cage before surgery, kept at a body temperature of 18-22 degrees Celsius, free to eat and drink, and raised in a quiet, dark environment .

[0030] 3. Experimental method

[0031] Adult healthy rats were divided into four groups as follows:

[0032] Operation group A: 10 rats, oppressed or knotted to block the blood vessels of intestinal blood, after 5 minutes, intestinal subomentum hemorrhage, did not relieve the oppressed or knotted, and then injected 2ml cyclic adenosine monophosphate solution (2mg cyclic adenosine monophosphate Adenosine is dissolved in 2ml 0.9% so...

Embodiment 2

[0040] This embodiment uses cyclic adenosine monophosphate meglumine to replace cyclic adenosine monophosphate, adopts the main materials of embodiment 1, the same experimental object of embodiment 1, and adopts the operation group A and control group B in the experimental method in embodiment 1 Experimental method to obtain the relationship between the amount of bleeding over time, such as image 3 shown.

Embodiment 3

[0042] This embodiment uses dibutyryl cyclic adenosine phosphate calcium to replace cyclic adenosine monophosphate, adopts the main materials of embodiment 1, the same experimental objects of embodiment 1, and adopts the experiment of operation group A and control group B in the experimental method in embodiment 1 method to obtain the relationship between the amount of bleeding over time, such as Figure 4 shown.

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Abstract

The present invention relates to the use of cyclic adenosine monophosphate or its derivatives, in particular to the application of cyclic adenosine monophosphate or its derivatives in postoperative subretinal hemorrhage. The low-dose cyclic adenosine monophosphate of the present invention Glycosides or derivatives thereof can effectively reduce the bleeding volume and area of ​​subretinal hemorrhage after surgery, reduce the hemostasis time of subretinal hemorrhage after surgery, and reduce the degree of damage to the body.

Description

technical field [0001] The present invention relates to the use of cyclic adenosine monophosphate or derivatives thereof, in particular to the application of cyclic adenosine monophosphate or derivatives thereof in postoperative subretinal hemorrhage. Background technique [0002] Cyclic adenosine monophosphate is cAMP, the CAS number is 60-92-4, and the chemical formula is C 10 h 12 N 5 o 6 P, is a derivative of nucleotides. It is an important substance that transmits nitrogen-containing hormones in the human body. When nitrogen-containing hormones are secreted from a certain cell, they travel to target cells with body fluids and act on specific receptors on the cell membrane to activate adenylyl cyclase in the cell membrane. , the enzyme in Mg 2+ or Ca 2+ Under the condition of existence, the adenosine triphosphate (ATP) in the cell is converted into cAMP, and then protein kinase is activated by cAMP, and various enzyme systems are activated by protein kinase to have...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7076A61P7/04A61P1/00
Inventor 傅苗青厉达中陈宇东
Owner SHANGHAI JINCHENG PHARMACEUTICAL CO LTD
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