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102 results about "Adenosine monophosphate.cyclic" patented technology

Method for extracting cyclic adenosine monophosphate (cAMP) from red jujubes

InactiveCN101525363AThe process consumes less energySimple processSugar derivativesUltrafiltrationFood additiveFiltration membrane
The invention relates to a method for extracting cyclic adenosine monophosphate (cAMP) from red jujubes, which comprises the steps of cleaning of the red jujubes, soaking of the red jujubes at normal temperature, precooking and pulping, zymohydrolysis on pectin mixed enzyme, filter pressing, anion resin combination, formic acid elution, nano-filtration and interception of formic acid with nano-filtration membrane, and purification, thus obtaining a finished product. The method solves the problems of complex current process, long period, low product purity and the like, and has the advantages of rich raw material sources, simple process, large processing amount, high extraction rate, high product purity and the like; the product is a natural non-toxic product; the finished product cAMP can be used for medical raw materials or used as food additive; the extracted byproduct red jujube juice can be continuously and deeply processed to promote the industrial chain of comprehensive development and achieve pollution-free production; the modern nano-filtration technology is applied to industrial production, therefore, not only the cost is reduced, but also a better path for deeply processing the red jujube raw material is provided, and the consumption of energy is greatly reduced; and the method not only has important economic benefit, but also has remarkable social benefits.
Owner:TIANJIN UNIV OF SCI & TECH

Preparation process of red date condensed juice high in cAMP content

The invention discloses a preparation process of red date condensed juice high in cAMP content. The preparation process includes the following steps of firstly, conducting separating, washing and smashing; secondly, conducting hot water extraction; thirdly, conducting cooling and heat preservation enzymic method oriented conversion; fourthly, adding composite enzyme preparations; fifthly, inactivating enzymes; sixthly, conducting centrifugation; seventhly, conducting filtration; eighthly, conducting concentration and pasteurization; ninthly, conducting filling. Compared with the prior art, the preparation process has the advantages that the process is simple, the production period is shortened, and the energy loss is reduced; extraction is conducted after smashing is conducted, and therefore extraction of nutritional ingredients in red dates can be improved; by means of the extraction and enzymolysis combined method, the juice yield is greatly improved, the processing time is greatly shortened, and the cyclic adenosine monophosphate content in red date juice is improved; date peel is utilized, and the cAMP content is improved; preparations of pectinase, cellulose and protease are used in a composite mode, and the hydrolysis capacity of enzymic preparations is improved; the step-by-step enzymolysis and extraction process is adopted, and interference between related enzyme preparations is avoided.
Owner:河北九维生物科技开发有限公司

Method for extracting cyclic adenosine monophosphate from fermentation liquid

The invention discloses a method for extracting cyclic adenosine monophosphate from a fermentation liquid, and belongs to the technical field of biological active substance extraction. The method comprises the following steps: heating the fermentation liquid, and filtering the fermentation liquid through a membrane to obtain an ultra-filtrate; adjusting the pH of the ultra-filtrate to be alkaline, and enabling the ultra-filtrate to pass through a carbon chromatography column for adsorbing; eluting by using ammonia water; collecting an eluting solution; adjusting the pH of the eluting solution to be alkaline; vacuumizing at 55 to 60 DEG C and performing suction filtration; adjusting the pH of the filtrate to be acidic; adding methyl alcohol in a flowing manner for crystallizing; drying crystals in vacuum to obtain crude cyclic adenosine monophosphate; re-crystallizing the crude cyclic adenosine monophosphate to obtain finished cyclic adenosine monophosphate. The cyclic adenosine monophosphate prepared by the method is stable in quality; the purity is up to 99 percent; the yield is up to 75 percent; a traditional ion exchange and resin chromatography process is replaced by adopting a carbon chromatographic method; the production cost is reduced; ammonia water eluting is favorable to treat wastewater.
Owner:XINYU PHARM CO LTD

High-content jujube cyclic adenosine monophosphate extract and preparation method thereof

The invention provides a high-content jujube cyclic adenosine monophosphate extract and a preparation method thereof. The concentration of cyclic adenosine monophosphate in the extract is more than 15mg / 100g, solid or semi-solid jujubes are taken as raw materials, and the preparation method comprises the steps of extracting by a continuous low-temperature extractor with high pressure difference, concentrating an extraction solution, performing vacuum drying and crushing to obtain a jujube crude extract; extracting the crude extract by adopting a supercritical extraction technology to obtain the jujube cyclic adenosine monophosphate extract. The jujube cyclic adenosine monophosphate extract has prominent effects in the aspects of hypoxia resistance, fatigue resistance and improvement of life quality. The preparation method has the following obvious advantages: (1) the extraction transfer rate is high; (2) the production efficiency is high; (3) the quality controllability is high; (4) the operation controllable degree is high; (5) the comprehensive utilization rate of resources is high; (6) the comprehensive operation cost is low; (7) the degree of automation is high; (8) the environmental pollution is little.
Owner:中恩(天津)医药科技有限公司

Method for extracting red date cyclic adenosine monophosphate through ultrasonic composite membrane technology

The invention relates to a method for extracting red date cyclic adenosine monophosphate through an ultrasonic composite membrane technology. The method solves the problem that the existing extraction technology has the defects of complex processes, low extraction rate, high industrialization difficulty and low product purity. The method comprises the following steps of removing date pits of cleaned red dates, crushing the red dates obtained by the previous step, adding an appropriate amount of an ethanol solvent into the crushed red dates, carrying out ultrasonic reinforcement extraction, repeatedly carrying out ultrasonic extraction of extracted filter residues, merging the extract obtained by the previous step, removing macromolecules of bacteria, proteins, pectin, polysaccharides and starch, and monosaccharides of glucose and fructose respectively through ultrafiltration and nanofiltration, intercepting cyclic adenosine monophosphate-rich concentrate, and carrying out pressure reduction condensation and spray drying to obtain 30% of a powdery cyclic adenosine monophosphate crude product. The method provided by the invention is easy for operation, is convenient for extraction, is fast, has short extraction time and a high cyclic adenosine monophosphate extraction rate, and is suitable for industrialized production. A product obtained by the method has high purity, is purely natural and does not produce chemical pollution. Therefore, the method provides an effective approach for comprehensive development of red date further processing.
Owner:食品行业生产力促进中心

Preparation method and application of cigarette spina date seed extract

InactiveCN106551422AWide range of sourcesNatural, environmentally friendly and harmlessTobacco preparationTobacco treatmentPlant sterolVitamin C
The invention discloses a preparation method and application of a cigarette spina date seed extract. The method comprises the following steps: obtaining a mixed bacteria liquid by mixing a Raoultella planticola seed culture solution with a Bacillus methylotrophicus VJ4-1 seed culture solution; inoculating the mixed bacteria liquid to a mixed extract, and obtaining a fragmentation broth through fragmentation; and performing deposition pumping filtration on the fragmentation broth, performing pressure-reduction concentration on a filtrate, and removing a solvent so as to prepare the cigarette spina date seed extract with relative density of 1.20 to 1.36. According to the invention, the mixed extract composed of a spine date seed extract, a grifola frondosus extract and a lychee seed extract is taken as the only carbon source, a nitrogen source and a substrate, alkaloid, triterpenes, flavonoids, seventeen amino acids and the like are included, ferulic acid, vitamin C, plant sterol, cyclic adenosine monophosphate and the like are also included, compared to a single carbon source, a microbial enzyme system is more easily utilized for fermentation and fragrance production, the source is wide and easily available, and the method and application also have the advantages of naturalness, environmental protection and zero harm.
Owner:HUBEI CHINA TOBACCO IND

Crystallization method of cyclic adenosine monophosphate

The invention discloses a crystallization method of cyclic adenosine monophosphate. The crystallization method comprises the following steps: adding an organic solvent used as an anti-solvent into 10-400g/L of a cyclic adenosine sodium phosphate aqueous solution at pH of 7.0-9.0 under the condition of stirring, carrying out pumping filtration after crystallization is completely finished, washing crystals by the use of ethanol, and carrying out vacuum drying to obtain cyclic adenosine sodium phosphate crystals; dissolving the above cyclic adenosine sodium phosphate crystals in water to obtain a saturated solution of the cyclic adenosine sodium phosphate crystals, adjusting pH of the solution to 4.0-5.5 by the use of acid while stirring, carrying out crystal growing for 0.5-8h, adjusting pH to 1.0-2.5, carrying out pumping filtration after crystallization is completely finished, washing crystals by the use of ethanol, and carrying out vacuum drying to obtain cyclic adenosine monophosphate crystals. By the adoption of the method provided by the invention, quality of the final product is obviously improved, yield of the crystal product is stably raised, and granular size of the crystals can be controlled by changing crystallization stirring speed or temperature. The method provided by the invention is simple to operate, has good repeatability, and is suitable for industrial production of cyclic adenosine sodium phosphate.
Owner:NANJING UNIV OF TECH

Method for extracting cyclic adenosine monophosphate and application of cyclic adenosine monophosphate

The invention discloses a method for extracting cyclic adenosine monophosphate and application of cyclic adenosine monophosphate, and belongs to the technical field of extraction of biological active substances. The method provided by the invention comprises the following steps: adjusting the pH of a fermentation liquor by using an alkaline liquor; performing centrifugal separation to obtain a supernatant; concentrating the supernatant, and performing first discoloration; fractionally precipitating a discolored solution by using an organic solvent; dissolving an obtained precipitate, and performing second discoloration; performing micro porous filtration, and concentrating a second discolored solution; adding the organic solvent for precipitating the concentrated second discolored solution; and performing centrifugal separation, and drying the precipitate in vacuum to obtain a finished product. By adopting the method provided by the invention, the conventional ionic exchange and resin chromatography processes can be replaced, and the waste water amount can be lowered by 82.5 percent; meanwhile, the production period is shortened greatly, and the production time is shortened by 36 percent; and the prepared cyclic adenosine monophosphate is stable in quality, can be over 97 percent in purity, and can be widely applied to the fields of medicine, foods, feeds and the like.
Owner:武利 +3

Compound nourishing wine and making method thereof

The invention discloses compound nourishing wine and a making method thereof. The compound nourishing wine comprises a nutrient extracting solution, wherein the nutrient extracting solution comprises a black date extracting solution prepared by performing solid fermentation on red dates, a black Chinese wolfberry fruit extracting solution, a black bean extracting solution, a black sesame extracting solution and a black garlic extracting solution; black dates obtained by performing solid fermentation on the red dates are characterized in that cane sugar content is lowered, fructose and glucose contents are increased, and fructo-oligosaccharide content is increased; total acid is increased, and mainly oxalic acid and citric acid are increased; flavonoid content and polyphenol content are high; cyclic adenosine monophosphate is abundant, and important physiological activity is achieved; moreover, the black date extracting solution obtained by performing solid fermentation on the red dates is obtained through treatment under an ultrahigh pressure of 100 to 150Mpa for 20 to 30 seconds; compared with an untreated black date, the treated black date has the advantages that the juice yield is increased by 10 to 15 percent, the active substance extracting rate is increased by 30 to 40 percent, and the effect of the nourishing wine is brought into play.
Owner:SHANDONG AGRICULTURAL UNIVERSITY

Technological process for extracting cyclic adenosine monophosphate (CAMP) from red dates

The invention provides a technological process for extracting cyclic adenosine monophosphate (CAMP) from red dates. The technological process sequentially comprises the following steps: 1, soaking and pulping the red dates, extracting with hot water at the temperature of 65-75 DEG C for 3-5 times, enzymolyzing with pectinase, lixiviating and filter pressing to obtain date juice; 2, mixing the date juice with anion exchange resin in a stirring tank and stirring for specific adsorption, and obtaining the anion exchange resin combined with the CAMP in the date juice; 3, filling the combined resin into an upper chromatographic column, and eluting with methanoic acid solution to obtain methanoic acid eluent; 4, distilling out methanoic acid from the methanoic acid eluent by a rotary evaporator or obtaining the methanoic acid through membrane separation, wherein, the obtained intercept substance contains the CAMP; and 5, purifying the intercept substance by a silicagel column chromatography purification technology, and finally obtaining the high-purity CAMP. The CAMP extracted from the red dates by the process has the advantages of high purity, high production efficiency, low production cost and no environmental pollution, and is applicable to industrial production.
Owner:TIANJIN FOOD RES INST

Production process of cyclic adenosine monophosphate

A production process of cyclic adenosine monophosphate is disclosed. The production process is characterized by comprising: a step 1) of filtering by utilization of a ceramic membrane to remove impurities, namely a step of filtering a cyclic adenosine monophosphate fermentation broth by a ceramic-membrane filtering device to leave hyphae, suspended matters, colloid and macromolecule organic compounds in filter residue so as to obtain a fermentation broth dialyzate; a step 2) of performing continuous fluid separation, namely a step of feeding the fermentation broth dialyzate into a continuous fluid separation system, allowing effective components to be adsorbed by resin and inactive components to be separated, and resolving and eluting the resin by using an eluant to obtain a cyclic adenosine monophosphate crude product; a step 3) of desalination and concentration, namely a step of subjecting the crude product to desalination and concentration to obtain a high-purity high-concentration cyclic adenosine monophosphate solution; and a step 4) of concentration and drying, namely a step of subjecting the cyclic adenosine monophosphate solution to vacuum concentration and drying to obtain the high-purity cyclic adenosine monophosphate. The production process is advantaged by reducing the cost, increasing the yield, improving product quality, and achieving continuous production.
Owner:XIAMEN STARMEM TECH
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