High-content jujube cyclic adenosine monophosphate extract and preparation method thereof

A technology of jujube cyclic adenosine monophosphate and cyclic adenosine monophosphate, which is applied in the field of preparation of high-content jujube cyclic adenosine monophosphate extract, can solve the problems of low automation level, large solvent consumption, and many by-products, and achieve production efficiency High efficiency, high comprehensive utilization rate of resources, and reduced concentration cost

Active Publication Date: 2014-03-12
中恩(天津)医药科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] It can be seen that in view of the technical problems of large solvent consumption, long cycle time, low automation level, and many by-products in the chemical synthesis process in the prior art, it is very important to seek a new production process for cyclic adenosine monophosphate. significance

Method used

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  • High-content jujube cyclic adenosine monophosphate extract and preparation method thereof
  • High-content jujube cyclic adenosine monophosphate extract and preparation method thereof
  • High-content jujube cyclic adenosine monophosphate extract and preparation method thereof

Examples

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Embodiment 1

[0048] A high-content jujube cyclic adenosine monophosphate extract, its specific preparation steps are as follows:

[0049] (1) Place the materials: 10kg of Hebei Cangzhou Jinsixiaozao with a water content of 10% was crushed through a 65-mesh sieve to make the particle size 250μm, and placed in a high-pressure differential continuous low-temperature extractor;

[0050] (2) Vacuuming: Use the cooling water (95% (v / v) ethanol) in the peripheral condensation circulation system of the high-pressure differential continuous low-temperature extractor to make the reaction system temperature -7°C, in the high-pressure differential continuous low-temperature extractor A vacuum is formed inside, and the vacuum degree is maintained at -70pa. After constant pressure, 50% (v / v) ethanol aqueous solution is added and kept for 20 minutes, wherein the weight ratio of the raw material to 50% (v / v) ethanol aqueous solution is 1: 10;

[0051] (3) Vacuum reduction: Slowly introduce purified compr...

Embodiment 2

[0059] A high-content jujube cyclic adenosine monophosphate extract, its specific preparation steps are as follows:

[0060] (1) Place the material: choose Daxue jujube (Yimeng Mountain, Shandong) with a water content of 5% as the raw material, and crush the raw material so that the particle size is 180 μm (80 mesh);

[0061] (2) Vacuuming: At the temperature of the reaction system at 0°C, a vacuum is formed in the high-pressure differential continuous low-temperature extractor, and the vacuum degree is kept at -100 Pa. Add an aqueous solution and keep it for 30 minutes. The weight ratio of the raw material to the aqueous solution is 1:6;

[0062] (3) Vacuum reduction: Introduce purified compressed air to raise the pressure in the high-pressure differential continuous low-temperature extractor to 0Mpa and keep it for 10 minutes;

[0063] (4) Pressurization: Continue to feed compressed air to make the pressure in the high-pressure differential continuous low-temperature extrac...

Embodiment 3

[0070] A high-content jujube cyclic adenosine monophosphate extract, its specific preparation steps are as follows:

[0071] (1) Place the material: select Jinsixiaozao (Cangzhou, Hebei) with a water content of 30% as the raw material, and crush the raw material so that the particle size is 850 μm (24 mesh);

[0072] (2) Vacuuming: At the temperature of the reaction system -10°C, a vacuum is formed in the high-pressure differential continuous low-temperature extractor, and the vacuum degree is kept at -20 Pa. Add 5% (v / v) ethanol aqueous solution and keep it for 5 minutes. , the weight ratio of the raw material to 5% (v / v) ethanol aqueous solution is 1:20;

[0073] (3) Vacuum reduction: Introduce purified compressed air to raise the pressure in the high-pressure differential continuous low-temperature extractor to 0Mpa and keep it for 1min;

[0074] (4) Pressurization: Continue to feed compressed air to make the pressure in the high-pressure differential continuous low-temper...

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Abstract

The invention provides a high-content jujube cyclic adenosine monophosphate extract and a preparation method thereof. The concentration of cyclic adenosine monophosphate in the extract is more than 15mg / 100g, solid or semi-solid jujubes are taken as raw materials, and the preparation method comprises the steps of extracting by a continuous low-temperature extractor with high pressure difference, concentrating an extraction solution, performing vacuum drying and crushing to obtain a jujube crude extract; extracting the crude extract by adopting a supercritical extraction technology to obtain the jujube cyclic adenosine monophosphate extract. The jujube cyclic adenosine monophosphate extract has prominent effects in the aspects of hypoxia resistance, fatigue resistance and improvement of life quality. The preparation method has the following obvious advantages: (1) the extraction transfer rate is high; (2) the production efficiency is high; (3) the quality controllability is high; (4) the operation controllable degree is high; (5) the comprehensive utilization rate of resources is high; (6) the comprehensive operation cost is low; (7) the degree of automation is high; (8) the environmental pollution is little.

Description

technical field [0001] The invention relates to the field of extraction and enrichment of effective plant components, in particular to a method for preparing a high-content jujube cyclic adenosine monophosphate extract. Background technique [0002] Cyclic adenosine monophosphate (cAMP for short) is a protein kinase inhibitor that widely exists in tissues and cells of organisms. It is controlled by the neuroendocrine system and exerts biological effects as a second messenger for hormones such as peptide hormones, catecholamines, and prostaglandins. Basic medical and clinical medical research has proved that cAMP can improve sleep and memory by promoting brain cell metabolism, repairing aging and fatigued brain cells, and preventing brain cell aging; Function has an important regulatory role, thereby enhancing immunity, selectively inhibiting the body's immune response, improving immune functions such as allergic dermatitis, measles, asthma, etc.; inhibiting cell proliferati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61K31/7076A61P39/00A23L1/30A23L33/10
Inventor 吴乐斌周甄鸿胡晨旭刘红彦姜佳
Owner 中恩(天津)医药科技有限公司
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