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Method for preparing cortex eucommiae or salted cortex eucommiae formula granules by continuous dynamic countercurrent extraction process

A technology of dynamic countercurrent and extraction process, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc. It can solve the problems of eucommia ulmoides or salt eucommia formula granules that have not yet been seen, so as to improve the physical dissolution transfer rate and improve the extraction Transfer rate, effect of reducing degradation damage

Pending Publication Date: 2019-04-05
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on the preparation of eucommia ulmoides or salt eucommia formula granules by continuous dynamic countercurrent extraction process

Method used

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  • Method for preparing cortex eucommiae or salted cortex eucommiae formula granules by continuous dynamic countercurrent extraction process
  • Method for preparing cortex eucommiae or salted cortex eucommiae formula granules by continuous dynamic countercurrent extraction process
  • Method for preparing cortex eucommiae or salted cortex eucommiae formula granules by continuous dynamic countercurrent extraction process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A method for preparing eucommia formula granules by using a continuous dynamic countercurrent extraction process, comprising the steps of:

[0050] a. Continuous dynamic countercurrent extraction

[0051] The eucommia medicinal material is scraped off the residual rough skin, the impurities are removed by vibrating sieve, and broken into 0.5cm particles; the broken coarse particles are moistened with 2 times the amount of water, and are continuously input into the spiral continuous countercurrent extractor (two-stage type 10 Sectional tube structure), the material is continuously pushed forward to the slag outlet of the leaching tube through a set of spiral structures in the leaching tube, and 16 times the amount of 95 ℃ hot water continuous countercurrent extraction for 1.5h, the hot water and the material flow in reverse to the front end of the extraction tubes at all levels to collect the extraction liquid, squeeze the eucommia dregs to recover part of the liquid and...

Embodiment 2

[0059] A method for preparing eucommia formula granules by using a continuous dynamic countercurrent extraction process, comprising the steps of:

[0060] a. Continuous dynamic countercurrent extraction

[0061] The eucommia medicinal material is scraped off the residual rough skin, the impurities are removed by vibrating sieve, and broken into 0.5cm particles; the broken coarse particles are moistened with 2 times the amount of water, and are continuously input into the spiral continuous countercurrent extractor (two-stage type 10 Sectional tube structure), the material is continuously pushed forward to the slag outlet of the leaching tube through a set of spiral structures in the leaching tube, and 16 times the amount of 95 ℃ hot water continuous countercurrent extraction for 1.5h, the hot water and the material flow in reverse to the front end of the extraction tubes at all levels to collect the extraction liquid, squeeze the eucommia dregs to recover part of the liquid and...

Embodiment 3

[0069] A method for preparing eucommia formula granules by using a continuous dynamic countercurrent extraction process, comprising the steps of:

[0070] a. Continuous dynamic countercurrent extraction

[0071] The eucommia medicinal material is scraped off the residual rough skin, the impurities are removed by vibrating sieve, and broken into 0.5cm particles; the broken coarse particles are moistened with 2 times the amount of water, and are continuously input into the spiral continuous countercurrent extractor (two-stage type 10 Sectional tube structure), the material is continuously pushed forward to the slag outlet of the leaching tube through a set of spiral structures in the leaching tube, and 16 times the amount of 85 ℃ hot water continuous countercurrent extraction for 1.5h, the hot water and the material flow in reverse to the front end of the extraction tubes at all levels to collect the extraction liquid, squeeze the eucommia dregs to recover part of the liquid and...

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Abstract

The invention discloses a method for preparing cortex eucommiae or salted cortex eucommiae formula granules by a continuous dynamic countercurrent extraction process. The method comprises the steps that a, cortex eucommiae or salted cortex eucommiae is crushed into coarse particles, the coarse particles are continuously input into extraction pipes of a continuous countercurrent extraction machine,hot water is continuously and reversely added into the tail ends of the extraction pipes of each stage for continuous dynamic countercurrent extraction, an extracting solution is collected, and medicine dregs are discharged; b, the extracting solution is filtered and subjected to superhigh temperature instantaneous sterilization, and filtrate is concentrated under reduced pressure to form a clearpaste; c, excipients are added into the clear paste for dissolution, and spray drying is performed to obtain dry extract powder; and d, a pharmaceutical adjunct is added into the dry extract powder,and dry granulation is performed to obtain the cortex eucommiae or salted cortex eucommiae formula granules. The method adopts the production processes of continuous countercurrent extraction, high temperature instantaneous sterilization, concentration under the reduced pressure, spray drying and dry granulation, and performs research on various process parameters, so that the content of effectivecomponents in the formula granules is able to continuously and stably achieve a higher level, and the product quality of the cortex eucommiae or salted cortex eucommiae formula granules is improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a method for preparing eucommia ulmoides or salt eucommia formula granules by using a continuous dynamic countercurrent extraction process. Background technique [0002] Eucommia ulmoides is the dry bark of Eucommia ulmoides Oliv., a plant of the Eucommia family. It was recorded in the 2015 edition of "Chinese Pharmacopoeia". Dizziness, pregnancy bleeding, restless fetal movement. The main medicinal ingredients of Eucommia ulmoides and Eucommia salt are pinoresinol diglucoside, geniposide, geniposide, aucubin, chlorogenic acid, etc. Among them, pinoresinol diglucoside is the main antihypertensive component, which is the 2015 The index compound of the quality control of the annual edition of "Chinese Pharmacopoeia". According to relevant studies, glycoside components such as pinoresinol diglucoside in Eucommia ulmoides have poor ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/46A61K9/16A61K129/00
CPCA61K9/1611A61K9/1617A61K9/1652A61K36/46A61K2236/37A61K2236/51A61K2236/53
Inventor 魏梅程学仁刘燎原简丽丽梁志毅张正邓李红曾昭君蔡盛康
Owner GUANGDONG YIFANG PHARMA
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