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Preparation method of semen persicae processed decoction piece formula granules

A technology of formula granules and decoction pieces, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of formula granules processed with peach kernels that have not yet been seen, and improve the extraction transfer rate, Reduce the effect of degradation damage

Inactive Publication Date: 2019-04-05
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the preparation of processed peach kernel decoction pieces formula granules by continuous dynamic countercurrent extraction process

Method used

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  • Preparation method of semen persicae processed decoction piece formula granules
  • Preparation method of semen persicae processed decoction piece formula granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A preparation method for the formula granules of peach kernels, comprising the steps of:

[0044] a, the peach kernel decoction pieces are broken into 0.5cm coarse particles;

[0045] b. Continuously input the coarse particles into the leaching tube of the spiral continuous countercurrent extractor (two-stage 10-section tube structure) through the feeding port at the front end, and continuously push the material forward to the leaching tube through a set of spiral structures in the leaching tube. The slag is discharged from the slag outlet of the extraction tube, and 14 times the amount of 95°C hot water is continuously added to the end of each level of extraction tube for continuous countercurrent extraction for 1 hour. The hot water and the material flow in reverse to the front end of each level of extraction tube. Extracting solution, discharge after extruding and reclaiming part of the medicinal liquid of the peach kernel dregs, the part of the medicinal liquid reco...

Embodiment 2

[0050] A preparation method for the formula granules of peach kernels, comprising the steps of:

[0051] a, the peach kernel decoction pieces are broken into 0.5cm coarse particles;

[0052] b. Continuously input the coarse particles into the leaching tube of the spiral continuous countercurrent extractor (two-stage 10-section tube structure) through the feeding port at the front end, and continuously push the material forward to the leaching tube through a set of spiral structures in the leaching tube. The slag is discharged from the slag outlet of the extraction tube, and 14 times the amount of 95°C hot water is continuously added to the end of each level of extraction tube for continuous countercurrent extraction for 1 hour. The hot water and the material flow in reverse to the front end of each level of extraction tube. Extracting solution, discharge after extruding and reclaiming part of the medicinal liquid of the peach kernel dregs, the part of the medicinal liquid reco...

Embodiment 3

[0057] A preparation method for the formula granules of peach kernels, comprising the steps of:

[0058] a, the peach kernel decoction pieces are broken into 0.5cm coarse particles;

[0059] b. Continuously input the coarse particles into the leaching tube of the spiral continuous countercurrent extractor (two-stage 10-section tube structure) through the feeding port at the front end, and continuously push the material forward to the leaching tube through a set of spiral structures in the leaching tube. The slag is discharged from the slag outlet of the extraction tube, and 14 times the amount of 95°C hot water is continuously added to the end of each level of extraction tube for continuous countercurrent extraction for 1 hour. The hot water and the material flow in reverse to the front end of each level of extraction tube. For extracting solution, the dregs of the peach kernels are discharged; the input speed of the coarse particles of the peach kernels is 100kg / h, and the fl...

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Abstract

The invention discloses a preparation method of semen persicae processed decoction piece formula granules. The preparation method of the semen persicae processed decoction piece formula granules comprises the steps that a, semen persicae processed decoction pieces are crushed or cut into coarse particles; b, the coarse particles are continuously input into extraction pipes of a continuous dynamiccountercurrent extraction machine, hot water is reversely and continuously added at the tail ends of the extraction pipes of each grade for continuous dynamic countercurrent extraction, and an extracting solution is collected; c, the extracting solution is filtered and subjected to superhigh temperature instantaneous sterilization, and filtrate is concentrated under reduced pressure to form a clear paste; d, excipients are added to the clear paste for dissolution, and spray drying is performed to obtain dry extract powder; and e, preparation excipients are added to the dry extract powder, anddry granulation is performed to obtain the semen persicae processed decoction piece formula granules. The preparation method adopts a production process of continuous countercurrent extraction, superhigh temperature instantaneous sterilization, pressure-reduced concentration, spray drying and dry granulation, and researches various processes, so that the content of effective elements in the semenpersicae processed decoction piece formula granules can continuously and stably achieve a higher level, and the product quality of the semen persicae processed decoction piece formula granules is improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a preparation method of formula granules processed from peach kernels. Background technique [0002] Peach kernel is Rosaceae plant peach Prunus persica (L.) Batsch or Hickory Prunus davidiana (Carr.) The dried mature seeds of Franch. are recorded in the 2015 edition of "Chinese Pharmacopoeia". Carbuncle, injury from falling, intestinal dryness and constipation, cough and asthma, are more commonly used Chinese medicine decoction pieces in clinical practice. Modern studies have shown that the main active ingredient of peach kernels and their processed products is amygdalin, which is an index component for content determination in quality control of the "Chinese Pharmacopoeia". Pharmacological effects such as acute lung injury, anti-inflammatory, anti-tumor and immune regulation. Amygdalin is easily decomposed by the amygdalin ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K9/16A61K47/36A61K47/40A61K47/26A61K131/00
CPCA61K9/1623A61K9/1652A61K36/736A61K2236/331A61K2236/51
Inventor 魏梅程学仁张雪兰邓李红陈伟媚梁丽金田清清谢明晏蔡盛康
Owner GUANGDONG YIFANG PHARMA
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