Preparation method of traditional Chinese medicine preparation namely Liuwei Dihuang drop pills

A technology of Liuwei Dihuang and dripping pills, applied in the directions of pharmaceutical formulation, pill delivery, drug combination, etc., can solve the problem of unstable content and achieve the effect of stable content

Inactive Publication Date: 2019-03-15
江西省药明扬海医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the process of studying the existing methods, the inventors found that the contents of loganin, the main component of wine cornus, and 23-acetylalisalol B, the main component of Alisma, were often unstable, sometimes not up to the standard, and most of the existing detection methods Ignore the detection of these two components, for this reason, the present invention provides the method that detects these two components simultaneously, in order to make the content of these two components stable, the present invention further provides a kind of preparation method, by changing extraction process, effectively improve Alisma alisma The content of active ingredients, and the extraction and transfer rate of loganin in wine cornus, so as to improve the efficacy and quality of Liuwei Dihuang dripping pills

Method used

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  • Preparation method of traditional Chinese medicine preparation namely Liuwei Dihuang drop pills
  • Preparation method of traditional Chinese medicine preparation namely Liuwei Dihuang drop pills
  • Preparation method of traditional Chinese medicine preparation namely Liuwei Dihuang drop pills

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Effect test

Embodiment 1

[0022]

[0023] Preparation method:

[0024] (1) Preparation of Moutan Cortex volatile oil: take Moutan Cortex, add 15 times the amount of water to distill for 2 hours to obtain volatile oil, and collect the distilled aqueous solution in another device.

[0025] (2) Preparation of dry cream powder: take wine cornus, add 80% ethanol to reflux twice, each time for 2 hours, filter, and the filtrate is for later use; take Rehmannia glutinosa and Chinese yam, add water to decoct twice, add 10 times each time Measure water, 2 hours for the first time, 1 hour for the second time, filter the decoction, add the distilled aqueous solution of Moutan cortex to the filtrate, concentrate to a relative density of 1.15-1.20 (heat measurement at 50°C), add ethanol to make the alcohol content up to 70%, let it stand for 48 hours, take the supernatant and the reflux liquid of cornus cornus, combine and concentrate until there is no alcohol, and set aside; take Poria cocos and Alisma, add 8 ti...

Embodiment 2

[0028]

[0029] Preparation method:

[0030] (1) Preparation of Moutan Cortex volatile oil: take Moutan Cortex, add 15 times the amount of water to distill for 2 hours to obtain volatile oil, and collect the distilled aqueous solution in another device.

[0031] (2) Preparation of dry cream powder: take wine cornus, add 85% ethanol to reflux twice, each time for 2 hours, filter, and filtrate for later use; take Rehmannia glutinosa and yam, add water to decoct twice, add 10 times each time Measure water, 2 hours for the first time, 1 hour for the second time, filter the decoction, add the distilled aqueous solution of Moutan cortex to the filtrate, concentrate to a relative density of 1.15-1.20 (heat measurement at 50°C), add ethanol to make the alcohol content up to 70%, let it stand for 48 hours, take the supernatant and the reflux liquid of cornus cornus, combine and concentrate until there is no alcohol smell, and set aside; take Poria cocos and Alisma, add 8 times the a...

Embodiment 3

[0034]

[0035] Preparation method:

[0036] (1) Preparation of Moutan Cortex volatile oil: take Moutan Cortex, add 15 times the amount of water to distill for 2 hours to obtain volatile oil, and collect the distilled aqueous solution in another device.

[0037] (2) Preparation of dry paste powder: take wine cornus, add 90% ethanol to reflux twice, each time for 2 hours, filter, and the filtrate is for later use; take Rehmannia glutinosa and Chinese yam, add water to decoct twice, add 10 times each time Measure water, 2 hours for the first time, 1 hour for the second time, filter the decoction, add the distilled aqueous solution of Moutan cortex to the filtrate, concentrate to a relative density of 1.15-1.20 (heat measurement at 50°C), add ethanol to make the alcohol content up to 70%, let it stand for 48 hours, take the supernatant and the reflux liquid of cornus cornus, combine and concentrate until there is no alcohol smell, and set aside; take Poria cocos and Alisma, ad...

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Abstract

The invention belongs to the field of pharmacy and relates to a preparation method of Liuwei Dihuang drop pills. The preparation method is characterized by comprising the following steps: (1) Preparation of tree peony bark volatile oil: taking tree peony bark, adding water for distillation to obtain volatile oil, and collecting a water solution after distillation in another container. (2) Preparation of dry extract powder: taking common macrocarpium fruits, adding ethanol for refluxing, and carrying out filtering to obtain filtrate for later use; decocting prepared rehmannia root and Chinese yam in water, filtering decoction, adding filtrate into the water solution after distillation of the tree peony bark, carrying out concentration and ethanol precipitation, mixing supernatant of ethanolprecipitation with reflux liquid of the common macrocarpium fruits, and concentrating the mixture until there is no alcohol taste for later use; and taking poria cocos and oriental waterplantain rhizome, boiling the materials with water, carrying out filtering, mixing filtrate with the above concentrated solution, and carrying out concentrating, drying, and pulverizing to obtain dry extract powder. (3) Preparation of Liuwei Dihuang drop pills: adding PEG4000 into the dry extract powder, carrying out heating for melting, adding volatile oil, mixing the materials uniformly, and dripping cooleddimethicone.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a traditional Chinese medicine drop pill and a preparation method thereof, in particular to a Chinese medicine preparation Liuwei Dihuang drop pill and a preparation method thereof. Background technique [0002] Liuwei Dihuang Dropping Pills is a Chinese patent medicine that has been on the market. It is made of dry paste powder and volatile oil extracted from Rehmannia glutinosa, wine cornel, Moutan cortex, yam, Poria cocos, and Alisma, plus appropriate amount of auxiliary materials. Paste powder, add PEG 4000 , heat and melt at 80°C, add volatile oil, mix evenly, drop in cooled simethicone, make 1000 pellets or 200 pellets, remove the surface simethicone, pack, and get ready. Liuwei Dihuang dripping pills have the effect of nourishing yin and tonifying kidney. For dizziness and tinnitus, soreness of the waist and knees, nocturnal emission and night sweats. [0003] In the process of st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/20A61P1/08A61P27/16A61P43/00A61P15/08
CPCA61K9/2036A61K36/076A61K36/40A61K36/65A61K36/71A61K36/804A61K36/884A61K36/8945A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P1/08A61P15/08A61P27/16A61P43/00A61K2300/00
Inventor 邹武斌何平清彭常春
Owner 江西省药明扬海医药科技有限公司
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