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Technology of extracting adenosin phosphoric acid from date

A cyclic adenosine monophosphate and process technology, which is applied in the field of extracting cyclic adenosine monophosphate from jujube, can solve the problems of high difficulty in industrialization of the cyclic adenosine monophosphate extraction process, complicated extraction process, and low product purity, achieving high extraction efficiency, Effect of reducing new pollution and improving purity

Inactive Publication Date: 2007-04-18
常月梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the problems that the existing cyclic adenosine monophosphate extraction process is difficult to industrialize, the extraction process is complicated, the efficiency is not high, and the product purity is low, the present invention provides a method that is suitable for industrialization with high extraction efficiency, high purity, simple process requirements, and low production cost. Process for extracting cyclic adenosine monophosphate from jujube

Method used

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  • Technology of extracting adenosin phosphoric acid from date
  • Technology of extracting adenosin phosphoric acid from date

Examples

Experimental program
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Effect test

Embodiment 1

[0032] After 1000g of jujubes were carefully cleaned and removed, the jujube pits were removed and crushed into 2 meshes, added with 3000g of distilled water, soaked and extracted at 16°C for 6 hours, filtered to obtain soaked and extracted jujube juice, and the filter residue was added to the same weight of distilled water for repeated soaking and extraction for a total of 3 The last time, after beating the obtained date dregs, add 1 times of distilled water for ultrasonic extraction for 30 minutes, and filter to obtain ultrasonically extracted jujube juice; combine all the extracted jujube juices and concentrate to a soluble solid content of 8%, stand for clarification for 1 hour to obtain clarified jujube juice 6300ml.

[0033] Clarify jujube juice is passed through anion-exchange column, and jujube juice is concentrated to get concentrated jujube juice after passing column; Ion-exchange column is eluted with 8% (wt / wt) formic acid aqueous solution, obtains eluent 2400ml for...

Embodiment 2

[0036]After 1000g of red dates are selected, cleaned and removed, the jujube pits are removed and crushed into 10 meshes, and 2000g of ethanol with a content of 5% (wt / wt) in ethanol aqueous solution is added, soaked and extracted at 6°C for 6 hours, press-filtered to soak and extract jujube juice, and the filter residue is added The same concentration of alcohol aqueous solution was soaked and extracted repeatedly for 5 times in total. After beating the obtained jujube dregs for the last time, add 1 times of distilled water for ultrasonic extraction for 30 minutes, and then filter to obtain ultrasonically extracted jujube juice; combine all the extracted jujube juice and concentrate until the content of soluble solids is 6 %, after standing for clarification for 1 hour, 6000ml of clarified jujube juice was obtained.

[0037] The clarified jujube juice is passed through an anion-exchange column, and the jujube juice is concentrated to obtain concentrated jujube juice after pass...

Embodiment 3

[0040] After 1000g of jujubes were carefully cleaned and removed, crushed into 2 meshes without removing the jujube core, added 1000g of ethanol with a content of 5% (wt / wt) ethanol solution, soaked and extracted at 15°C for 4 hours, and filtered to obtain jujube juice soaked and extracted, and the filter residue was as above Repeat soaking and extraction for a total of 3 times, add 1.5 times of distilled water for ultrasonic extraction for 40 minutes after beating the jujube dregs obtained in the last time, and filter to obtain ultrasonically extracted jujube juice; combine all extracted jujube juices and concentrate to a soluble solid content of 12%, and let it stand for clarification After 1 hour, 2800ml of clarified jujube juice was obtained.

[0041] Clarify jujube juice is passed through anion-exchange column, and jujube juice is concentrated to obtain concentrated jujube juice after passing through the column; Ion-exchange column is eluted with 5% (wt / wt) formic acid aqu...

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Abstract

The present invention relates to a technological process for extracting cyclophosphoadenosine from jujube. Said technological process includes the following steps: breaking, soaking, filtering soaking liquor, using ultrasonic technique to extract filter residue, combining extracts to obtain clear jujube juice; making the clear jujube juice be passed through ion exchange column, then making the eluent be again passed through ion exchange column, making the obtained secondary eluent be passed through chromatographic column, collecting solution containing cyclophosphoadenosine concentrating and crystallizing in ethyl alcohol so as to obtain high-purity cyclophosphoadenosine.

Description

technical field [0001] The invention relates to a process for extracting effective plant components, in particular to a process for extracting cyclic adenosine monophosphate from jujube. Background technique [0002] Jujube is the ripe fruit of the jujube tree of the Rhamnacene family (Rhamnacene), which originates in China. Traditional Chinese medicine theory and modern research have shown that jujube has the functions of invigorating the middle and replenishing qi, nourishing blood and calming the nerves. Jujube is very nutritious. In addition to containing a large amount of sugar, it also contains medicinal ingredients such as cyclic adenosine monophosphate and jujube flavonoid essence, among which cyclic adenosine monophosphate is the highest in known plants. Cyclic adenosine monophosphate (cAMP) is the second messenger in cells. By activating cAMP-dependent protein kinases, it brings various regulatory information to specific target sites in cells, and plays a role in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H19/213C07H1/08A61K36/725A61K131/00
Inventor 常月梅杜俊杰
Owner 常月梅
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